Christopher L. Mariani

Works (77)

Updated: August 16th, 2024 05:03

2024 article

Clinical and imaging findings in dogs with nerve root signature associated with cervical intervertebral disc herniation

Schachar, J., Bocage, A., Nelson, N. C., Early, P. J., Mariani, C. L., Olby, N. J., & Munana, K. R. (2024, January 12). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 1.

By: J. Schachar n, A. Bocage n, N. Nelson n, P. Early n, C. Mariani n , N. Olby n , K. Munana n 

author keywords: cervical radiculopathy; intraforaminal disc herniation; magnetic resonance imaging; thoracic limb lameness
TL;DR: NRS is most prevalent with C6‐C7 intervertebral disc involvement, suggesting that there might be unique anatomic factors that contribute to development of NRS at this site, but can be a clinical manifestation of IVDH occurring anywhere along the cervical spine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 13, 2024

2024 article

Implantation Corridors in Canine Thoracic Vertebrae: A Morphometric Study in Dogs of Varying Sizes

Sabol, J. C., & Mariani, C. L. (2024, January 22). VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY, Vol. 1.

By: J. Sabol n & C. Mariani n 

author keywords: spinal stabilization; spinal fracture; spinal subluxation; spinal malformation; computed tomography
TL;DR: The morphometrics of the thoracic vertebrae relating to an ideal trajectory for dorsolateral implant placement in a variety of dog sizes and to assess proximity to important adjacent critical anatomical structures using computed tomography (CT) studies are documented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 1, 2024

2024 journal article

Obstructive Hydrocephalus and Cardiomyopathy Secondary to Disseminated Protothecosis in a Boxer Dog

Case Reports in Veterinary Medicine.

By: A. Tauro n , J. Macri n, C. Gaudette  n, C. Mariani n  & B. Brenseke *

Ed(s): L. pez

Source: ORCID
Added: August 15, 2024

2024 article

Pharmacokinetics of subcutaneous ketamine administration via the Omnipod® system in dogs

Colon, C., Early, P., Munana, K., Olby, N., Mariani, C., Mancini, S., … Messenger, K. (2024, March 27). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 3.

By: C. Colon  n, P. Early n, K. Munana n , N. Olby n , C. Mariani n , S. Mancini n, G. Fefer n, Z. Li * ...

author keywords: analgesia; canine; ketamine; novel; veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024

2023 journal article

Gold Nanostars Obviate Limitations to Laser Interstitial Thermal Therapy (LITT) for the Treatment of Intracranial Tumors

CLINICAL CANCER RESEARCH, 29(16), 3214–3224.

By: E. Srinivasan, Y. Liu, R. Odion, P. Chongsathidkiet, L. Wachsmuth, A. Haskell-Mendoza, R. Edwards, A. Canning ...

UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023

2023 journal article

Magnetic resonance imaging characteristics of atlanto-axial subluxation in 42 dogs: Analysis of joint cavity size, subluxation distance, and craniocervical junction anomalies

OPEN VETERINARY JOURNAL, 13(9), 1091–1098.

By: K. Bray *, S. Platt, M. Kent *, N. Olby n , P. Early n, C. Mariani n , K. Munana n , S. Holmes

author keywords: Canine; Cervical; Congenital; Malformation; Myelopathy
TL;DR: Dogs with clinical signs of AA subluxation were significantly more likely to have intramedullary hyperintensity at the level of compression, an increased AA joint cavity size, and increased spinal cord compression at thelevel of dens and mid-body C2, according to MRI characteristics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: January 16, 2024

2023 article

Presumed pituitary apoplexy in 26 dogs: Clinical findings, treatments, and outcomes

Woelfel, C. W., Mariani, C. L., Nolan, M. W., Keenihan, E. K., Topulos, S. P., Early, P. J., … Olby, N. J. (2023, April 21). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 4.

By: C. Woelfel n, C. Mariani n , M. Nolan n, E. Keenihan n, S. Topulos n, P. Early n, K. Munana n , S. Musulin n , N. Olby n 

author keywords: adenoma; carcinoma; endocrionopathy; hemorrhage; magnetic resonance imaging; suprasellar; survival
MeSH headings : Dogs; Animals; Pituitary Apoplexy / therapy; Pituitary Apoplexy / veterinary; Pituitary Apoplexy / diagnosis; Pituitary Neoplasms / complications; Pituitary Neoplasms / diagnostic imaging; Pituitary Neoplasms / therapy; Pituitary Neoplasms / veterinary; Retrospective Studies; Hydrocephalus / veterinary; Infarction / veterinary; Magnetic Resonance Imaging / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / therapy
TL;DR: Dogs with pituitary apoplexy present with a variety of acute signs of neurological disease and inconsistent endocrine dysfunction and dogs that survive to discharge can have a favorable outcome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 22, 2023

2022 article

Inter-pathologist agreement on diagnosis, classification and grading of canine glioma

Krane, G. A., Shockley, K. R., Malarkey, D. E., Miller, A. D., Miller, C. R., Tokarz, D. A., … Mariani, C. L. (2022, July 30). VETERINARY AND COMPARATIVE ONCOLOGY, Vol. 7.

By: G. Krane  n, K. Shockley *, D. Malarkey*, A. Miller *, C. Miller *, D. Tokarz n, H. Jensen *, K. Janardhan *, M. Breen n , C. Mariani n 

author keywords: brain; cancer; dog; histopathology; immunohistochemistry
MeSH headings : Humans; Animals; Dogs; Oligodendroglioma / diagnosis; Oligodendroglioma / veterinary; Oligodendroglioma / pathology; Pathologists; Dog Diseases / diagnosis; Dog Diseases / pathology; Glioma / diagnosis; Glioma / veterinary; Glioma / pathology; Astrocytoma / veterinary; Brain Neoplasms / diagnosis; Brain Neoplasms / veterinary; Brain Neoplasms / pathology
TL;DR: Inter‐pathologist agreement utilising CBTC guidelines for canine glioma was moderate overall but varied from fair to almost perfect between pairs of pathologists, similar for oligodendrogliomas and astrocytomas but lower for undefined gliomas. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 8, 2022

2022 journal article

Novel subcutaneous cytarabine infusion with the Omnipod system in dogs with meningoencephalomyelitis of unknown etiology

AMERICAN JOURNAL OF VETERINARY RESEARCH, 83(9).

By: S. Mancini n, P. Early n, B. Slater*, N. Olby n , C. Mariani n , K. Munana n , C. Woelfel n, J. Schacher n, L. Zhong *, K. Messenger n

MeSH headings : Animals; Area Under Curve; Chromatography, High Pressure Liquid / veterinary; Cytarabine / therapeutic use; Dogs; Half-Life; Humans; Infusions, Intravenous / veterinary; North Carolina
TL;DR: An SC continuous-rate infusion of cytarabine via the Omnipod system is feasible in dogs and was able to achieve a steady-state concentration of more than 1 μg/mL 4 to 10 hours postinitiation of cyTarabine and a Cmax of 7,510 ng/mL, comparable to values reported previously with IV continuous- rate infusion administration in healthy research Beagles and dogs with meningoencephalomyelitis of unknown etiology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 1, 2022

2021 article

High-field MRI using standard pulse sequences has moderate to substantial interobserver agreement and good accuracy for differentiation between intracranial extra-axial histiocytic sarcoma and meningioma in dogs

Mai, W., Burke, E. E., Reetz, J. A., Hecht, S., Paek, M., Church, M. E., … Glass, E. N. (2021, December 8). VETERINARY RADIOLOGY & ULTRASOUND, Vol. 12.

By: W. Mai *, E. Burke*, J. Reetz *, S. Hecht *, M. Paek, M. Church *, S. Werre *, C. Mariani n , J. Griffin *, E. Glass

author keywords: brain; canine; neoplasia; reliability; round cell; sensitivity; specificity
MeSH headings : Animals; Dog Diseases / pathology; Dogs; Histiocytic Sarcoma / diagnostic imaging; Histiocytic Sarcoma / veterinary; Magnetic Resonance Imaging / methods; Magnetic Resonance Imaging / veterinary; Meningeal Neoplasms / diagnostic imaging; Meningeal Neoplasms / veterinary; Meningioma / diagnostic imaging; Meningioma / veterinary; Observer Variation; Reproducibility of Results; Retrospective Studies
TL;DR: The aim of this retrospective diagnostic accuracy and observer agreement study was to evaluate the accuracy and reliability of high-field MRI to differentiate between meningioma and histiocytic sarcoma, using standard pulse sequences and published MRI features. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: December 20, 2021

2021 article

Immunohistochemical evaluation of immune cell infiltration in canine gliomas

Krane, G. A., Carly A. O'Dea, Malarkey, D. E., Miller, A. D., Miller, C. R., Tokarz, D. A., … Mariani, C. L. (2021, July 1). VETERINARY PATHOLOGY, Vol. 7.

By: G. Krane  n, . Carly A. O'Dea*, D. Malarkey*, A. Miller *, C. Miller *, D. Tokarz*, H. Jensen *, K. Janardhan * ...

author keywords: astrocytoma; brain; dogs; cancer; immunohistochemistry; immunology; lymphocytes; macrophages; oligodendroglioma
MeSH headings : Animals; Antigens, CD20; Dog Diseases; Dogs; Glioma / veterinary; Immunohistochemistry; Lymphocytes, Tumor-Infiltrating; T-Lymphocytes, Regulatory
TL;DR: The distribution of immune cells infiltrating spontaneous intracranial canine gliomas was determined and there was a significant increase in tumor area fraction of CD163 compared to Mac387, and this ratio was greater in high- grade tumors than in low-grade tumors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 2, 2021

2021 journal article

Outcomes and prognostic indicators in 59 paraplegic medium to large breed dogs with extensive epidural hemorrhage secondary to thoracolumbar disc extrusion

VETERINARY SURGERY, 50(3), 527–536.

By: C. Woelfel n, J. Robertson n , C. Mariani n , K. Munana n , P. Early n & N. Olby n 

MeSH headings : Animals; Cohort Studies; Dog Diseases / diagnosis; Dog Diseases / surgery; Dogs; Female; Hematoma, Epidural, Spinal / complications; Hematoma, Epidural, Spinal / surgery; Hematoma, Epidural, Spinal / veterinary; Intervertebral Disc Degeneration / complications; Intervertebral Disc Degeneration / surgery; Intervertebral Disc Degeneration / veterinary; Laminectomy / statistics & numerical data; Laminectomy / veterinary; Male; Paraplegia / diagnosis; Paraplegia / surgery; Paraplegia / veterinary; Prognosis; Recovery of Function; Retrospective Studies; Species Specificity; Treatment Outcome; Walking
TL;DR: Paraplegic medium to large breed dogs with DEEH have a less favorable outcome after surgical decompression than paraplegic dogs with TL-IVDE, and loss of pain perception and increased HASTEi are associated with a poor outcome, while more extensive decompression improves outcome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 8, 2021

2021 article

Subaxial cervical articular process subluxation and dislocation: Cervical locked facet injuries in dogs

Woelfel, C. W., Bray, K. Y., Early, P. J., Mariani, C. L., & Olby, N. J. (2021, November 24). VETERINARY SURGERY, Vol. 11.

By: C. Woelfel n, K. Bray*, P. Early n, C. Mariani n  & N. Olby n 

MeSH headings : Animals; Cervical Vertebrae; Dogs; Joint Dislocations / veterinary; Neck; Retrospective Studies
TL;DR: In these dogs, locked facet injuries affected the caudal cervical vertebrae in small breeds and could be identified on imaging through the presence of dorsal displacement of a cranial articular process. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 6, 2021

2021 journal article

Use of Top Hat Audience Response Software in a Third-Year Veterinary Medicine and Surgery Course

JOURNAL OF VETERINARY MEDICAL EDUCATION, 48(1), 27–32.

By: C. Mariani*  & S. Roe* 

author keywords: audience response; learning technology; diagnostic imaging
MeSH headings : Animals; Curriculum; Education, Veterinary; Educational Measurement; Humans; Learning; Software; Students; Teaching
TL;DR: The software was used in a multi-specialty, multi-instructor medicine and surgery course in the third year of a veterinary curriculum and allowed rapid identification of areas of student knowledge and misunderstandings, which facilitated the direction of further discussion and clarification of important learning issues. (via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 22, 2021

2021 article

Vascular endothelial growth factor concentrations in the cerebrospinal fluid of dogs with neoplastic or inflammatory central nervous system disorders

Mariani, C. L., Niman, Z. E., Boozer, L. B., Ruterbories, L. K., Early, P. J., Munana, K. R., & Olby, N. J. (2021, June 9). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 6.

By: C. Mariani n , Z. Niman n, L. Boozer n, L. Ruterbories n, P. Early n, K. Munana n , N. Olby n 

author keywords: biomarker; brain tumor; meningoencephalitis; meningomyelitis
MeSH headings : Animals; Case-Control Studies; Central Nervous System Diseases / veterinary; Cerebrospinal Fluid; Dog Diseases; Dogs; Hospitals, Animal; Hospitals, Teaching; Vascular Endothelial Growth Factor A
TL;DR: Concentrations of VEGF in CSF are higher in dogs with central nervous system (CNS) neoplasia compared to those with meningoencephalomyelitis and other neurologic disorders and may serve as a marker of neoplastic and inflammatory CNS disorders relative to other conditions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 10, 2021

2020 article

Accuracy and safety of three-dimensionally printed animal-specific drill guides for thoracolumbar vertebral column instrumentation in dogs: Bilateral and unilateral designs

VETERINARY SURGERY.

By: J. Guevar*, J. Bleedorn *, T. Cullum*, S. Hetzel*, J. Zlotnick n & C. Mariani n 

MeSH headings : Animals; Bone Screws / veterinary; Cadaver; Dogs / surgery; Lumbar Vertebrae / surgery; Printing, Three-Dimensional / instrumentation; Safety; Thoracic Vertebrae / surgery; Tomography, X-Ray Computed / veterinary
TL;DR: A unilateral drill guide design may be a safe alternative to bilateral guides for unilateral stabilization of the thoracolumbar vertebral column in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: January 4, 2021

2020 journal article

Accuracy of three-dimensionally printed animal-specific drill guides for implant placement in canine thoracic vertebrae: A cadaveric study

VETERINARY SURGERY, 50(2), 294–302.

By: C. Mariani n , J. Zlotnick n, O. Harrysson n , D. Marcellin-Little n, K. Malinak n, A. Gavitt n, J. Guevar n

MeSH headings : Animals; Bone Screws / veterinary; Cadaver; Dogs / surgery; Printing, Three-Dimensional; Thoracic Vertebrae / surgery; Tomography, X-Ray Computed / veterinary
TL;DR: 3-D printed drill tracts yielded drill tracts with small linear and angular errors from intended paths and 100% accuracy for placement within vertebral pedicles and bodies may allow safe and accurate implant placement for surgeons with varying experience levels. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 19, 2021

2020 journal article

Association between anesthesia duration and outcome in dogs with surgically treated acute severe spinal cord injury caused by thoracolumbar intervertebral disk herniation

Journal of Veterinary Internal Medicine.

By: J. Fenn *, H. Ru  n, N. Jeffery *, S. Moore *, A. Tipold *, F. Soebbeler*, A. Wang‐Leandro *, C. Mariani n  ...

author keywords: canine; extrusion; hemilaminectomy; prognosis; surgery
MeSH headings : Anesthesia / adverse effects; Anesthesia / veterinary; Animals; Cohort Studies; Dog Diseases / surgery; Dogs; Female; Intervertebral Disc Degeneration / veterinary; Intervertebral Disc Displacement / veterinary; Laminectomy / veterinary; Male; Operative Time; Pain / veterinary; Paraplegia / rehabilitation; Paraplegia / surgery; Paraplegia / veterinary; Retrospective Studies; Spinal Cord Injuries / surgery; Spinal Cord Injuries / veterinary; Treatment Outcome; Walking
TL;DR: A negative association between increased duration of anesthesia and outcome in dogs with absent pain perception treated surgically for acute thoracolumbar intervertebral disk herniation is supported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: May 18, 2020

2020 journal article

Cerebrospinal fluid lactate concentrations in dogs with seizure disorders

Journal of Veterinary Internal Medicine.

By: C. Mariani n , C. Nye  n, L. Ruterbories n, D. Tokarz  n, L. Green  n, J. Lau  n, N. Zidan  n, P. Early  n ...

author keywords: acute repetitive seizures; biomarker; cluster seizures; epilepsy; status epilepticus
MeSH headings : Animals; Dog Diseases; Dogs; Epilepsy / veterinary; Humans; Lactic Acid; Seizures / veterinary; Status Epilepticus / veterinary
TL;DR: Cerebrospinal fluid lactate concentration is minimally affected by seizure activity in dogs and increased concentrations are more likely associated with the underlying disease process. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: November 3, 2020

2020 journal article

Continuous rate infusion of midazolam as emergent treatment for seizures in dogs

Journal of Veterinary Internal Medicine.

By: K. Bray  n, C. Mariani n , P. Early  n, K. Muñana n  & N. Olby n 

author keywords: acute repetitive seizures; anticonvulsant; benzodiazepine; canine; cluster seizures; epilepsy; status epilepticus
MeSH headings : Animals; Anticonvulsants / adverse effects; Dog Diseases / drug therapy; Dogs; Hospitals, Animal; Hospitals, Teaching; Midazolam / therapeutic use; Retrospective Studies; Seizures / drug therapy; Seizures / veterinary
TL;DR: Midazolam CRI is apparently safe and might be an effective treatment in dogs with CS or SE, and dogs with idiopathic/unknown epilepsy were more likely to survive than those with structural epilepsy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: December 17, 2020

2020 journal article

Influence of Duration of Injury on Diffusion Tensor Imaging in Acute Canine Spinal Cord Injury

JOURNAL OF NEUROTRAUMA, 37(21), 2261–2267.

By: M. Lewis* , P. Early n, C. Mariani n , K. Munana n  & N. Olby n 

author keywords: dog; fractional anisotropy; imaging biomarker; intervertebral disc herniation; mean diffusivity
MeSH headings : Animals; Diffusion Tensor Imaging / methods; Dogs; Intervertebral Disc Displacement / diagnostic imaging; Intervertebral Disc Displacement / pathology; Intervertebral Disc Displacement / veterinary; Spinal Cord Injuries / diagnostic imaging; Spinal Cord Injuries / pathology; Spinal Cord Injuries / veterinary; Time Factors
TL;DR: Investigating the impact of duration of injury on DTI indices in dogs with acute, spontaneous SCI due to thoracolumbar intervertebral disc herniation and explore associations with clinical severity found MD might differentiate injury severity in the acute setting and be worthy of development as an imaging biomarker. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 31, 2020

2020 journal article

Personalized-induced neural stem cell therapy: Generation, transplant, and safety in a large animal model

BIOENGINEERING & TRANSLATIONAL MEDICINE, 6(1).

By: H. Bomba*, K. Sheets*, A. Valdivia *, S. Khagi *, L. Ruterbories n, C. Mariani n , L. Borst n , D. Tokarz n, S. Hingtgen *

author keywords: glioblastoma; neural stem cells; stem cell delivery
TL;DR: This study generates the first canine‐induced neural stem cells (iNSCs) engineered to carry TNFα‐related apoptosis‐inducing ligand and thymidine kinase (TK), as well as magnetic resonance imaging (MRI) contrast agents for in vivo tracking. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 3, 2020

2020 journal article

Traumatic skull fractures in dogs and cats: A comparative analysis of neurological and computed tomographic features

JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(5), 1975–1985.

By: P. Amengual-Batle*, R. Jose-Lopez *, A. Durand n, M. Czopowicz *, E. Beltran *, J. Guevar n, K. Lazzerini *, S. De Decker * ...

author keywords: canine; computed tomography; feline; skull fractures
MeSH headings : Animals; Cat Diseases / diagnostic imaging; Cats; Dog Diseases / diagnostic imaging; Dogs; Retrospective Studies; Skull / diagnostic imaging; Skull Fractures / diagnostic imaging; Skull Fractures / veterinary; Tomography, X-Ray Computed / veterinary
TL;DR: The cranial vault fractures were associated with neurological deficits and worse survival, and the presence of TSF alone should not be considered a negative prognostic factor because most affected animals survived the first week. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 3, 2020

2019 journal article

Cerebrospinal fluid lactate in dogs with inflammatory central nervous system disorders

Journal of Veterinary Internal Medicine, 33(6), 2701–2708.

By: C. Mariani n , C. Nye  n, D. Tokarz  n, L. Green  n, J. Lau  n, N. Zidan  n, P. Early  n, J. Guevar  n ...

author keywords: canine; encephalitis; meningitis; meningo; meningoencephalitis; myelitis
MeSH headings : Animals; Dog Diseases / cerebrospinal fluid; Dogs; Inflammation / cerebrospinal fluid; Inflammation / veterinary; Lactic Acid / cerebrospinal fluid; Meningoencephalitis / cerebrospinal fluid; Meningoencephalitis / drug therapy; Meningoencephalitis / pathology; Meningoencephalitis / veterinary; Reference Values; Retrospective Studies; Steroids / therapeutic use
TL;DR: Cerebrospinal fluid lactate concentrations could serve as a rapid biomarker of inflammatory CNS disease in dogs as well as humans with inflammatory central nervous system disorders. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 25, 2019

2019 journal article

Clinical characteristics, breed differences, and quality of life in North American dogs with acute steroid‐responsive meningitis‐arteritis

Journal of Veterinary Internal Medicine, 33(4), 1719–1727.

By: J. Lau  n, J. Nettifee  n, P. Early  n, C. Mariani n , N. Olby n  & K. Muñana n 

author keywords: aseptic meningitis; CSF analysis; immune-mediated disease; treatment response
MeSH headings : Animals; Arteritis / cerebrospinal fluid; Arteritis / drug therapy; Arteritis / veterinary; Canada / epidemiology; Dog Diseases / cerebrospinal fluid; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Female; Genetic Predisposition to Disease; Male; Meningitis / cerebrospinal fluid; Meningitis / drug therapy; Meningitis / veterinary; Neutrophils; Quality of Life; Recurrence; Retrospective Studies; Steroids / administration & dosage; Steroids / adverse effects; Steroids / therapeutic use; Surveys and Questionnaires; United States / epidemiology
TL;DR: Golden Retrievers and Wirehaired Pointing Griffons should be considered among the breeds recognized to develop SRMA, and treatment with higher corticosteroid dosages is correlated with more severe adverse effects and worse QoL. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: June 8, 2019

2019 journal article

Presence of cerebrospinal fluid antibodies associated with autoimmune encephalitis of humans in dogs with neurologic disease

Journal of Veterinary Internal Medicine, 33(5), 2175–2182.

By: E. Stafford n, A. Kortum n, A. Castel  n, L. Green  n, J. Lau  n, P. Early  n, K. Muñana n , C. Mariani n , J. Yoder n , N. Olby n 

author keywords: immunofluorescent assay; meningoencephalitis; MUE; NMDA receptor encephalitis
MeSH headings : Animals; Autoantibodies / cerebrospinal fluid; Central Nervous System Diseases / cerebrospinal fluid; Central Nervous System Diseases / immunology; Central Nervous System Diseases / veterinary; Dog Diseases / cerebrospinal fluid; Dog Diseases / immunology; Dogs; Female; Fluorescent Antibody Technique, Indirect / veterinary; Humans; Male; Meningoencephalitis / cerebrospinal fluid; Meningoencephalitis / immunology; Meningoencephalitis / therapy; Neurons / immunology; Receptors, N-Methyl-D-Aspartate / immunology
TL;DR: Defining antigenic targets associated with encephalitis in dogs might allow diagnostic categorization of MUE antemortem and further evaluation of the prevalence and clinical relevance of CSF and serum antibodies to neuronal cell surface antigens is warranted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 9, 2019

2019 journal article

Risk factors associated with progressive myelomalacia in dogs with complete sensorimotor loss following intervertebral disc extrusion: a retrospective case-control study

BMC Veterinary Research, 15(1).

By: A. Castel*, N. Olby n , H. Ru n, C. Mariani n , K. Muñana n  & P. Early n

author keywords: Ascending-descending myelomalacia; Spinal cord injury; Intervertebral disk disease; Paraplegia
MeSH headings : Animals; Case-Control Studies; Dog Diseases / etiology; Dog Diseases / pathology; Dog Diseases / physiopathology; Dogs; Female; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / veterinary; Logistic Models; Male; Multivariate Analysis; Paraplegia / etiology; Paraplegia / physiopathology; Paraplegia / veterinary; Retrospective Studies; Risk Factors; Spinal Cord Diseases / etiology; Spinal Cord Diseases / pathology; Spinal Cord Diseases / physiopathology; Spinal Cord Diseases / veterinary
TL;DR: Dogs with lumbar intumescence IVDE are at increased risk of progressive myelomalacia and timing of surgery and corticosteroid use warrant further investigations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: February 10, 2020

2019 journal article

Time course and prognostic value of serum GFAP, pNFH, and S100β concentrations in dogs with complete spinal cord injury because of intervertebral disc extrusion

Journal of Veterinary Internal Medicine, 33(2), 726–734.

By: N. Olby n , J. Lim*, N. Wagner *, N. Zidan  n, P. Early  n, C. Mariani n , K. Muñana n , E. Laber  n

author keywords: biomarker; intervertebral disc disease; myelomalacia; prognosis
MeSH headings : Animals; Biomarkers / blood; Dogs / blood; Dogs / injuries; Glial Fibrillary Acidic Protein / blood; Intermediate Filaments / metabolism; Intervertebral Disc Degeneration / veterinary; Intervertebral Disc Displacement / veterinary; Paralysis / blood; Paralysis / veterinary; Phosphorylation; Prognosis; Prospective Studies; S100 Calcium Binding Protein beta Subunit / blood; Spinal Cord Injuries / blood; Time Factors
TL;DR: Serum GFAP concentrations can be used to predict outcome in clinically complete SCI with an accuracy of 76.7%‐89% depending on sample timing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 20, 2019

2018 journal article

A randomized, blinded, prospective clinical trial of postoperative rehabilitation in dogs after surgical decompression of acute thoracolumbar intervertebral disc herniation

Journal of Veterinary Internal Medicine, 32(3), 1133–1144.

By: N. Zidan n, C. Sims n, J. Fenn *, K. Williams  n, E. Griffith n , P. Early n, C. Mariani n , K. Munana n  ...

author keywords: ataxia; gait training; locomotion; plasticity; spinal cord injury
MeSH headings : Animals; Decompression, Surgical / methods; Decompression, Surgical / veterinary; Dog Diseases / surgery; Dogs; Female; Intervertebral Disc Displacement / rehabilitation; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Lumbar Vertebrae / surgery; Male; Postoperative Care / veterinary; Recovery of Function; Thoracic Vertebrae / surgery
TL;DR: Early postoperative rehabilitation after surgery for TL‐IVDH is safe but doesn't improve rate or level of recovery in dogs with incomplete SCI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2018 journal article

Strategies Used for Making Healthy Eating Choices among Veterinary Medical Students

Journal of Veterinary Medical Education, 45(3), 364–380.

By: K. Royal n , S. Hunt n, V. Scharf n, M. Correa  n & C. Mariani n 

author keywords: academic affairs; administration; educational methods; outcomes; psychology; SKAs; student affairs; student health & well-being
MeSH headings : Adult; Animals; Education, Veterinary; Feeding Behavior; Female; Humans; Male; Motivation; North Carolina; Students, Medical / psychology; Surveys and Questionnaires
TL;DR: It is concluded that while most students report eating a relatively healthy diet, variation in strategies used suggests room for improvement for many, and potential intervention strategies to promote healthy eating among veterinary students are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: October 19, 2018

2018 journal article

The Effect of Electromagnetic Fields on Post-Operative Pain and Locomotor Recovery in Dogs with Acute, Severe Thoracolumbar Intervertebral Disc Extrusion: A Randomized Placebo-Controlled, Prospective Clinical Trial

Journal of Neurotrauma, 35(15), 1726–1736.

By: N. Zidan n, J. Fenn *, E. Griffith n , P. Early n, C. Mariani n , K. Muñana n , J. Guevar n, N. Olby n 

Contributors: N. Zidan n, J. Fenn *, E. Griffith n , P. Early n, C. Mariani n , K. Muñana n , J. Guevar n, N. Olby n 

author keywords: biomarker; GFAP; hemilaminectomy; pain; spinal cord injury
MeSH headings : Animals; Decompression, Surgical; Dog Diseases / therapy; Dogs; Female; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / surgery; Lumbar Vertebrae; Magnetic Field Therapy / methods; Male; Pain, Postoperative / etiology; Pain, Postoperative / therapy; Random Allocation; Recovery of Function / radiation effects; Spinal Cord Injuries / etiology; Spinal Cord Injuries / therapy; Thoracic Vertebrae
TL;DR: It is concluded that PEMF reduced incision-associated pain in dogs post-surgery for IVDE and may reduce extent of SCI and enhance proprioceptive placing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2018 journal article

Toxicity associated with ingestion of a polyacrylic acid hydrogel dog pad

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 30(5), 708–714.

By: D. Dorman n, M. Foster n, B. Olesnevich n, B. Bolon  n, A. Castel n, M. Sokolsky-Papkov  n, C. Mariani n 

author keywords: Dogs; hydrogel; neurotoxicity; poisoning; sodium polyacrylate
MeSH headings : Acrylic Resins / poisoning; Acrylic Resins / toxicity; Animals; Dog Diseases / chemically induced; Dogs; Eating; Female; Hydrogels / poisoning; Hydrogels / toxicity; Male; North Carolina; Rats; Rats, Sprague-Dawley
TL;DR: Results from an experimental study in rats support the conclusion that some pet pad hydrogel products can induce acute neurotoxicity in animals under high-dose exposure conditions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 16, 2018

2018 journal article

Validation of a portable monitor for assessment of cerebrospinal fluid lactate in dogs

VETERINARY CLINICAL PATHOLOGY, 47(1), 108–114.

By: C. Nye  n & C. Mariani n 

author keywords: Canine; central nervous system; point-of-care systems; reference interval
MeSH headings : Animals; Dogs / cerebrospinal fluid; Female; Lactic Acid / cerebrospinal fluid; Male; Monitoring, Ambulatory / instrumentation; Monitoring, Ambulatory / veterinary; Reference Values; Reproducibility of Results
TL;DR: The Lactate Plus has acceptable accuracy and precision for the quantification of CSF lactate in dogs as a subset of samples show variation with storage although most stored samples show acceptable variation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

Associations Between Anesthetic Variables and Functional Outcome in Dogs With Thoracolumbar Intervertebral Disk Extrusion Undergoing Decompressive Hemilaminectomy

Journal of Veterinary Internal Medicine, 31(3), 814–824.

By: J. Fenn *, E. Laber n, K. Williams n, C. Rousse n, P. Early n, C. Mariani n , K. Munana n , S. Decker * ...

Contributors: J. Fenn *, E. Laber n, K. Williams n, C. Rousse n, P. Early n, C. Mariani n , K. Muñana n , S. De Decker *, H. Volk *, N. Olby n 

author keywords: Anesthesia; Canine; Intervertebral disk extrusion; Prognosis; Spinal cord injury
MeSH headings : Anesthesia, General / adverse effects; Anesthesia, General / methods; Anesthesia, General / veterinary; Animals; Bradycardia / chemically induced; Bradycardia / veterinary; Decompression, Surgical / methods; Decompression, Surgical / veterinary; Dog Diseases / surgery; Dogs; Female; Hypotension / chemically induced; Hypotension / veterinary; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Laminectomy / methods; Laminectomy / veterinary; Male; Retrospective Studies; Thoracic Vertebrae / surgery; Treatment Outcome
TL;DR: Across all outcome measures, regression tree analysis highlighted functional grade at presentation as the primary determining factor, and among pain perception negative dogs, there was a possible association between increased duration of surgery and poorer outcome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

Clinical Characteristics of Dogs with Progressive Myelomalacia Following Acute Intervertebral Disc Extrusion

Journal of Veterinary Internal Medicine, 31(6), 1782–1789.

By: A. Castel n, N. Olby n , C. Mariani n , K. Muñana n  & P. Early n

Contributors: A. Castel n, N. Olby n , C. Mariani n , K. Muñana n  & P. Early n

author keywords: Ascending-descending myelomalacia; Intervertebral disc disease; Spinal cord injury
MeSH headings : Animals; Disease Progression; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Female; Intervertebral Disc Degeneration / diagnostic imaging; Intervertebral Disc Degeneration / pathology; Intervertebral Disc Degeneration / veterinary; Intervertebral Disc Displacement / diagnostic imaging; Intervertebral Disc Displacement / pathology; Intervertebral Disc Displacement / veterinary; Magnetic Resonance Imaging / veterinary; Male; Myelography / veterinary; Retrospective Studies; Spinal Cord Diseases / mortality; Spinal Cord Diseases / pathology; Spinal Cord Diseases / veterinary; Tomography, X-Ray Computed / veterinary
TL;DR: The majority of dogs developed PMM within 2 days of presentation and was euthanized within another 3 days, however, onset can be delayed up to 5 days after presentation with progression to euthanasia taking as long as 2 weeks. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

Optic neuritis in dogs: 96 cases (1983-2016)

Veterinary Ophthalmology, 21(5), 442–451.

By: S. Smith n, H. Westermeyer n , C. Mariani n , B. Gilger n  & M. Davidson n

author keywords: causes of canine optic neuritis; dogs; granulomatous meningoencephalitis; meningoencephalitis of unknown etiology; ocular GME; optic neuritis
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / epidemiology; Dog Diseases / etiology; Dog Diseases / therapy; Dogs; Female; Magnetic Resonance Imaging; Male; Medical Records; Meningoencephalitis / complications; Meningoencephalitis / veterinary; North Carolina / epidemiology; Optic Neuritis / epidemiology; Optic Neuritis / veterinary
TL;DR: Optic neuritis was most commonly associated with multifocal MUE or was isolated as the sole neurologic finding, with a similar incidence between the two groups. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: November 12, 2018

2016 journal article

Clinical and Diagnostic Imaging Features of Brain Herniation in Dogs and Cats

Journal of Veterinary Internal Medicine, 30(5), 1672–1680.

By: M. Lewis n , N. Olby n , P. Early n, C. Mariani n , K. Muñana n , G. Seiler n, E. Griffith n 

MeSH headings : Animals; Body Size; Brain / diagnostic imaging; Brain / pathology; Cat Diseases / diagnostic imaging; Cat Diseases / pathology; Cats; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Magnetic Resonance Imaging / veterinary; Retrospective Studies
TL;DR: Brain herniation can be quantified on MRI and more severe CTH based on TTX is associated with a worse short‐term outcome, compared with more severe foramen magnum based on FMH. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: NC State University Libraries, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

Effect of Cranberry Extract on the Frequency of Bacteriuria in Dogs with Acute Thoracolumbar Disk Herniation: A Randomized Controlled Clinical Trial

Journal of Veterinary Internal Medicine, 31(1), 60–68.

By: N. Olby n , S. Vaden n, K. Williams n, E. Griffith n , T. Harris n, C. Mariani n , K. Muñana n , P. Early n ...

Contributors: N. Olby n , S. Vaden n, K. Williams n, E. Griffith n , T. Harris n, C. Mariani n , K. Muñana n , P. Early n ...

author keywords: Escherichia coli; Incontinence; Proanthocyanidins; Spinal cord injury
MeSH headings : Administration, Oral; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / therapeutic use; Bacteriuria / complications; Bacteriuria / drug therapy; Bacteriuria / urine; Bacteriuria / veterinary; Dog Diseases / drug therapy; Dogs; Female; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / veterinary; Male; Plant Extracts / administration & dosage; Plant Extracts / therapeutic use; Prospective Studies; Single-Blind Method; Thoracic Vertebrae; Treatment Outcome; Urinary Tract Infections / complications; Urinary Tract Infections / drug therapy; Urinary Tract Infections / urine; Urinary Tract Infections / veterinary; Vaccinium macrocarpon
TL;DR: This clinical trial did not show a benefit of oral cranberry extract but had low power, but a possible association between urine AAA and lower risk of E. coli bacteriuria was identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

Evaluation of the Lactate Plus monitor for plasma lactate concentration measurement in dogs

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 27(1), 66–70.

By: C. Nye  n, S. Musulin n , R. Hanel n & C. Mariani n 

author keywords: canine; metabolic acidosis; perfusion; point of care; shock; validation
MeSH headings : Animals; Blood Gas Analysis / instrumentation; Blood Gas Analysis / veterinary; Dogs; Emergency Medical Services; Female; Lactic Acid / blood; Male; Monitoring, Physiologic / instrumentation; Monitoring, Physiologic / veterinary; Point-of-Care Systems; Prospective Studies; Reproducibility of Results
TL;DR: The Lactate Plus provides a fast and affordable method to measure plasma lactate concentration in dogs and shows excellent agreement with the reference analyzer and precision of the instrument was acceptable. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Recovery of stepping and coordination in dogs following acute thoracolumbar intervertebral disc herniations

The Veterinary Journal, 213, 59–63.

By: C. Rousse n, N. Olby n , K. Williams n, T. Harris n, E. Griffith n , C. Mariani n , K. Muñana n , P. Early n

Contributors: C. Rousse n, N. Olby n , K. Williams n, T. Harris n, E. Griffith n , C. Mariani n , K. Muñana n , P. Early n

author keywords: Canine; Gait; Locomotion; Paralysis; Spinal cord injury
MeSH headings : Acute Disease; Animals; Dog Diseases / etiology; Dog Diseases / surgery; Dogs; Female; Forelimb / physiology; Hindlimb / physiology; Intervertebral Disc / pathology; Intervertebral Disc / surgery; Intervertebral Disc Displacement / etiology; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Male; Prospective Studies; Spinal Cord Injuries / etiology; Spinal Cord Injuries / surgery; Spinal Cord Injuries / veterinary; Walking
TL;DR: Recovery of coordination was incomplete in dogs that showed good recovery of stepping in the 6 weeks following surgical decompression of dogs with TL-IVDH. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

Use of posaconazole for treatment of disseminated protothecosis in a dog

Veterinary Record Case Reports, 4(2), e000350.

By: B. Enders, N. Olby*  & C. Mariani* 

TL;DR: The clinical improvement produced by posaconazole in this case suggests it may be an effective therapy for this typically fatal disease, but it may currently be cost prohibitive. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2020

2015 journal article

A Placebo-Controlled, Prospective, Randomized Clinical Trial of Polyethylene Glycol and Methylprednisolone Sodium Succinate in Dogs with Intervertebral Disk Herniation

JOURNAL OF VETERINARY INTERNAL MEDICINE, 30(1), 206–214.

By: N. Olby n , A. Muguet-Chanoit n, J. Lim n, M. Davidian n , C. Mariani n , A. Freeman*, S. Platt *, J. Humphrey n ...

Contributors: N. Olby n , A. Muguet-Chanoit n, J. Lim n, M. Davidian n , C. Mariani n , A. Freeman*, S. Platt *, J. Humphrey n ...

author keywords: Neuroprotection; Paraplegia; Secondary injury; Spinal cord injury
MeSH headings : Animals; Anti-Inflammatory Agents / administration & dosage; Anti-Inflammatory Agents / therapeutic use; Dog Diseases / drug therapy; Dogs; Female; Intervertebral Disc Displacement / drug therapy; Intervertebral Disc Displacement / veterinary; Male; Methylprednisolone Hemisuccinate / administration & dosage; Methylprednisolone Hemisuccinate / therapeutic use; Nociception / drug effects; Polyethylene Glycols / administration & dosage; Polyethylene Glycols / therapeutic use
TL;DR: This clinical trial did not show a benefit of either MPSS or PEG in the treatment of acute, severe thoracolumbar IVDH when used as adjunctive medical treatment administered to dogs presenting within 24 hours of onset of paralysis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Histiocytic Sarcoma with Central Nervous System Involvement in Dogs: 19 Cases (2006-2012)

Journal of Veterinary Internal Medicine, 29(2), 607–613.

By: C. Mariani n , M. Jennings n, N. Olby n , L. Borst n , J. Brown  n, I. Robertson n, G. Seiler n, E. MacKillop

author keywords: Brain tumor; Malignant histiocytosis; Round cell tumor; Spinal cord tumor
MeSH headings : Animals; Central Nervous System Neoplasms / pathology; Central Nervous System Neoplasms / veterinary; Dog Diseases / pathology; Dogs; Female; Histiocytic Sarcoma / pathology; Histiocytic Sarcoma / veterinary; Male; Retrospective Studies
TL;DR: Some unique imaging and clinicopathologic characteristics, particularly brain herniation, profound meningeal enhancement, and pleocytosis in combination with 1 or more mass lesions, might help to differentiate this neoplasm from others involving the CNS, although this requires further study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Identification of Novel Genetic Risk Loci in Maltese Dogs with Necrotizing Meningoencephalitis and Evidence of a Shared Genetic Risk across Toy Dog Breeds

PLOS ONE, 9(11).

By: I. Schrauwen *, R. Barber*, S. Schatzberg*, A. Siniard*, J. Corneveaux*, B. Porter *, K. Vernau *, R. Keesler * ...

MeSH headings : Animals; Breeding; Chromosomes, Mammalian; Dog Diseases / genetics; Dog Diseases / immunology; Dog Diseases / pathology; Dogs; F-Box Proteins / genetics; F-Box Proteins / immunology; Female; Genetic Loci; Genetic Predisposition to Disease; Genome-Wide Association Study; Haplotypes; Histocompatibility Antigens Class II / genetics; Histocompatibility Antigens Class II / immunology; Male; Meningoencephalitis / genetics; Meningoencephalitis / immunology; Meningoencephalitis / pathology; Meningoencephalitis / veterinary; Polymorphism, Single Nucleotide; Receptors, Interleukin-7 / genetics; Receptors, Interleukin-7 / immunology; Risk Factors
TL;DR: The first genetic risk factors for NME development in the Maltese, chromosome 4 and chromosome 15, are identified and evidence for a shared genetic risk between breeds associated with chromosome 15 and DLA II is provided. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Perianesthetic morbidity and mortality in dogs undergoing cervical and thoracolumbar spinal surgery

VETERINARY ANAESTHESIA AND ANALGESIA, 41(2), 137–144.

By: L. Posner n, C. Mariani n , C. Swanson n, M. Asakawa n, N. Campbell n & A. King n

author keywords: surgery; spinal; morbidity; cervical; mortality; dog
MeSH headings : Anesthesia / adverse effects; Anesthesia / veterinary; Animals; Dogs; Female; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Male; Perioperative Period / adverse effects; Perioperative Period / veterinary; Postoperative Complications / veterinary
TL;DR: Overall, dogs undergoing cervical spinal surgery were less likely to survive until discharge compared with dogs undergoing thoracolumbar spinal surgery, anddogs undergoing cervical intervertebral disc decompression surgery should be considered at risk for aspiration pneumonia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2013 journal article

Chronic Compressive Myelopathy and Progressive Neurologic Signs Associated with Melarsomine Dihydrochloride Administration in a Dog

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 49(6), 389–393.

By: S. Moore  n, C. Mariani n , A. Van Wettere n & L. Borst n 

MeSH headings : Animals; Arsenicals / administration & dosage; Arsenicals / adverse effects; Decompression, Surgical / veterinary; Diagnosis, Differential; Dog Diseases / diagnosis; Dog Diseases / etiology; Dogs; Epidural Abscess / chemically induced; Epidural Abscess / diagnosis; Epidural Abscess / veterinary; Injections, Intramuscular / veterinary; Lumbar Vertebrae; Male; Spinal Cord Compression / chemically induced; Spinal Cord Compression / diagnosis; Spinal Cord Compression / veterinary; Thoracic Vertebrae; Triazines / administration & dosage; Triazines / adverse effects
TL;DR: A 7 yr old castrated male Great Dane presented with a history of progressive myelopathy following the intramuscular injection of melarsomine dihydrochloride 8 wk previously, necessitating surgical decompression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2013 journal article

Frameless stereotactic radiosurgery for the treatment of primary intracranial tumours in dogs

VETERINARY AND COMPARATIVE ONCOLOGY, 13(4), 409–423.

By: C. Mariani* , T. Schubert *, R. House*, M. Wong *, A. Hopkins, H. Heller *, R. Milner *, N. Lester* ...

author keywords: brain tumour; canine; meningioma; radiation oncology; small animal
MeSH headings : Animals; Brain Neoplasms / mortality; Brain Neoplasms / surgery; Brain Neoplasms / veterinary; Cranial Nerve Neoplasms / mortality; Cranial Nerve Neoplasms / surgery; Cranial Nerve Neoplasms / veterinary; Dog Diseases / mortality; Dog Diseases / surgery; Dogs; Female; Male; Meningioma / mortality; Meningioma / surgery; Meningioma / veterinary; Pituitary Neoplasms / mortality; Pituitary Neoplasms / surgery; Pituitary Neoplasms / veterinary; Radiosurgery / methods; Radiosurgery / veterinary; Retrospective Studies; Survival Analysis; Trigeminal Nerve Diseases / mortality; Trigeminal Nerve Diseases / surgery; Trigeminal Nerve Diseases / veterinary
TL;DR: Frameless SRS was used successfully to treat tumours in 51 dogs with a variety of head sizes and shapes and resulted in survival times comparable to conventional radiation therapy, but with fewer acute adverse effects and only a single anaesthetic episode required for therapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2013 review

Terminology and Classification of Seizures and Epilepsy in Veterinary Patients

[Review of ]. TOPICS IN COMPANION ANIMAL MEDICINE, 28(2), 34–41.

By: C. Mariani n 

author keywords: seizure; epilepsy; classification
MeSH headings : Animals; Cat Diseases / classification; Cat Diseases / physiopathology; Cats; Dog Diseases / classification; Dog Diseases / physiopathology; Dogs; Epilepsy / classification; Epilepsy / physiopathology; Epilepsy / veterinary; Humans; Seizures / classification; Seizures / physiopathology; Seizures / veterinary; Terminology as Topic; Veterinary Medicine / methods
TL;DR: A set of definitions and terminology for use in veterinary patients is proposed, which includes a glossary of descriptive terminology for ictal semiology and a diagnostic scheme for classification of individual patients. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Evaluation of Levetiracetam as Adjunctive Treatment for Refractory Canine Epilepsy: A Randomized, Placebo-Controlled, Crossover Trial

JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(2), 341–348.

By: K. Munana n , W. Thomas*, K. Inzana*, J. Nettifee-Osborne n, K. McLucas*, N. Olby n , C. Mariani n , P. Early n

Contributors: K. Muñana n , W. Thomas*, K. Inzana*, J. Nettifee-Osborne n, K. McLucas*, N. Olby n , C. Mariani n , P. Early n

author keywords: Clinical pharmacology; CNS disorders; Dog; Epilepsy; Neurology; Seizures
MeSH headings : Animals; Anticonvulsants / administration & dosage; Anticonvulsants / adverse effects; Anticonvulsants / blood; Cross-Over Studies; Dog Diseases / blood; Dog Diseases / drug therapy; Dogs; Double-Blind Method; Epilepsy / blood; Epilepsy / drug therapy; Epilepsy / veterinary; Female; Levetiracetam; Male; Piracetam / administration & dosage; Piracetam / adverse effects; Piracetam / analogs & derivatives; Piracetam / blood; Quality of Life; Seizures / blood; Seizures / drug therapy; Seizures / veterinary; Statistics, Nonparametric
TL;DR: Adjunctive treatment with LEV appears safe in epileptic dogs and effectiveness over placebo was not demonstrated, although the power of the study was limited. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Evaluation of matrix metalloproteinase-2 and-9 in the cerebrospinal fluid of dogs with intracranial tumors

AMERICAN JOURNAL OF VETERINARY RESEARCH, 74(1), 122–129.

By: C. Mariani n , L. Boozer n, A. Braxton n, S. Platt, K. Vernau, J. McDonnell*, J. Guevar *

MeSH headings : Animals; Brain Neoplasms / cerebrospinal fluid; Brain Neoplasms / enzymology; Brain Neoplasms / pathology; Brain Neoplasms / veterinary; Dog Diseases / cerebrospinal fluid; Dog Diseases / enzymology; Dog Diseases / pathology; Dogs; Electrophoresis, Polyacrylamide Gel / veterinary; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Matrix Metalloproteinase 2 / cerebrospinal fluid; Matrix Metalloproteinase 9 / cerebrospinal fluid
TL;DR: D detection of MMP in CSF may prove useful as a marker of intracranial neoplasia or possibly to monitor response of tumors to therapeutic intervention. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Isolation and characterization of neural progenitor cells from adult canine brains

American Journal of Veterinary Research, 73(12), 1963–1968.

By: J. Lim n, S. Koh*, N. Olby* , J. Piedrahita*  & C. Mariani* 

MeSH headings : Animals; Cell Culture Techniques / veterinary; Cell Differentiation; Cell Lineage; Dogs; Female; Hippocampus / cytology; Hippocampus / metabolism; Immunohistochemistry / veterinary; Lateral Ventricles / cytology; Lateral Ventricles / metabolism; Male; Neural Stem Cells / cytology; Neural Stem Cells / physiology; RNA / analysis; Reverse Transcriptase Polymerase Chain Reaction
TL;DR: Results suggested the persistence of SOX2- Positive, nestin-positive, GFAP- positive,GFAP-Positive, OCT4-negative, and NANOG-negative neural progenitor cells in the SVZ and SGZ regions of mature canine brains, which are capable of producing multiple cell lineages. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2011 journal article

Characterization of Immune Cell Infiltration Into Canine Intracranial Meningiomas

VETERINARY PATHOLOGY, 49(5), 784–795.

By: L. Boozer n, T. Davis n, L. Borst n , K. Zseltvay n, N. Olby n  & C. Mariani n 

author keywords: brain; dog; immunohistochemistry; lymphocyte; meningioma; microglia; Toll-like receptor; tumor
MeSH headings : Animals; Antigens, CD / analysis; Antigens, CD / immunology; Biomarkers, Tumor / metabolism; Cytokines / metabolism; Dog Diseases / immunology; Dog Diseases / pathology; Dogs; Female; Forkhead Transcription Factors / metabolism; Immunohistochemistry / veterinary; Lymphocyte Subsets / immunology; Lymphocytes, Tumor-Infiltrating / immunology; Macrophages / immunology; Male; Meningeal Neoplasms / immunology; Meningeal Neoplasms / pathology; Meningeal Neoplasms / veterinary; Meningioma / immunology; Meningioma / pathology; Meningioma / veterinary; Paraffin Embedding / veterinary; Toll-Like Receptor 4 / metabolism; Toll-Like Receptor 9 / metabolism
TL;DR: Investigation of the presence of a variety of immune cell subsets within canine intracranial meningiomas suggests that evaluation of this immune cell infiltrate may provide important prognostic information and may be useful in the design of novel therapies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

The Cutaneous Trunci Muscle Reflex: A Predictor of Recovery in Dogs with Acute Thoracolumbar Myelopathies Caused by Intervertebral Disc Extrusions

Veterinary Surgery, 41(2), 200–206.

By: A. Muguet-Chanoit n, N. Olby n , J. Lim n, R. Gallagher, Z. Niman*, S. Dillard*, J. Campbell n, P. Early n ...

Contributors: A. Muguet-Chanoit n, N. Olby n , J. Lim n, R. Gallagher, Z. Niman*, S. Dillard*, J. Campbell n, P. Early n ...

MeSH headings : Animals; Cohort Studies; Dog Diseases / physiopathology; Dogs; Female; Intervertebral Disc Degeneration / veterinary; Intervertebral Disc Displacement / veterinary; Male; Muscle, Skeletal / physiology; Muscular Diseases / physiopathology; Muscular Diseases / veterinary; Predictive Value of Tests; Reflex / physiology
TL;DR: Postoperative changes of the caudal border of the CTM reflex are an early indicator of outcome in dogs with severe acute IVDE and cranial movement of theCTM reflex is significantly associated with improvement, but not associated with a long-term successful outcome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2010 journal article

Diazepam pharmacokinetics after nasal drop and atomized nasal administration in dogs

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 34(1), 17–24.

By: S. Musulin n , C. Mariani n  & M. Papich n 

MeSH headings : Administration, Intranasal; Animals; Anticonvulsants / administration & dosage; Anticonvulsants / blood; Anticonvulsants / pharmacokinetics; Diazepam / administration & dosage; Diazepam / blood; Diazepam / pharmacokinetics; Dogs; Dosage Forms; Drug Administration Routes; Female; Half-Life; Male; Nordazepam / blood; Nordazepam / metabolism; Oxazepam / blood; Oxazepam / metabolism
TL;DR: This study confirms that i.n. administration of diazepam yields rapid anticonvulsant concentrations of d Xanax in the dog before a hepatic first-pass effect, and exceeds previously published bioavailability data for rectal administration ofdiazepam in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

Generation and Characterization of Neurospheres from Canine Adipose Tissue-Derived Stromal Cells

CELLULAR REPROGRAMMING, 12(4), 417–425.

By: J. Lim n, L. Boozer n, C. Mariani n , J. Piedrahita n  & N. Olby n 

MeSH headings : Adipose Tissue / metabolism; Animals; Biomarkers / metabolism; Blotting, Western; Bone and Bones / cytology; Bone and Bones / metabolism; Cell Differentiation; Cell Lineage; Cells, Cultured; Dogs; Flow Cytometry; Neurons / metabolism; Osteogenesis; Phenotype; RNA, Messenger / genetics; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells / cytology; Stromal Cells / metabolism
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 chapter

Neuromuscular Junction Disease

In S. J. Ettinger & E. C. Feldman (Eds.), Textbook of Veterinary Internal Medicine (7th edition., pp. 1473–1477). St. Louis, MO: Saunders Elsevier.

By: C. Mariani 

Ed(s): S. Ettinger & E. Feldman

Source: NC State University Libraries
Added: August 13, 2021

2010 chapter

Peripheral Nerve Disorders

In S. J. Ettinger & E. C. Feldman (Eds.), Textbook of Veterinary Internal Medicine (7th edition., pp. 1462–1467). St. Louis, MO: Saunders Elsevier.

By: C. Mariani 

Ed(s): S. Ettinger & E. Feldman

Source: NC State University Libraries
Added: July 11, 2019

2009 journal article

IDH1 and IDH2 hotspot mutations are not found in canine glioma

International Journal of Cancer, 127(1), 245–246.

By: Z. Reitman *, N. Olby n , C. Mariani n , R. Thomas n, M. Breen n , D. Bigner *, R. McLendon *, H. Yan *

Contributors: Z. Reitman *, N. Olby n , C. Mariani n , R. Thomas n, M. Breen n , D. Bigner *, R. McLendon *, H. Yan *

MeSH headings : Animals; Brain Neoplasms / genetics; Brain Neoplasms / veterinary; Dogs; Glioma / genetics; Glioma / veterinary; Isocitrate Dehydrogenase / genetics; Isoenzymes / genetics; Mutation
TL;DR: Human diffuse and anaplastic astrocytomas, well-differenti-ated and anaPLastic oligodendrogliomas and secondary glio-blastomas frequently contain somatic mutations of the R132 codon of the cytoplasmic NADPþ-dependent iso-citrate dehydrogenase (IDH1) or the corresponding R172codon in its homolog, IDH2. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2009 journal article

Intracranial Meningioma in dogs and cats. A comparative review

Compendium of Continuing Education for Veterinarians, 31(7), 330–339.

By: K. Sessums & C. Mariani 

Source: NC State University Libraries
Added: September 18, 2021

2009 journal article

Intracranial meningioma in dogs and cats: A comparative review

Compendium-Continuing Education for Veterinarians, 31(7), 330–339.

By: K. Sessums & C. Mariani 

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Bromodeoxyuridine Inhibits Cancer Cell Proliferation In Vitro and In Vivo

Neoplasia, 10(8), 804–IN13.

By: L. Levkoff*, G. Marshall *, H. Ross*, M. Caldeira*, B. Reynolds *, M. Cakiroglu*, C. Mariani* , W. Streit *, E. Laywell*

MeSH headings : Administration, Oral; Animals; Bromodeoxyuridine / administration & dosage; Bromodeoxyuridine / pharmacology; Bromodeoxyuridine / therapeutic use; Cell Cycle / drug effects; Cell Proliferation / drug effects; Disease Progression; Glioma / drug therapy; Glioma / pathology; Humans; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Neoplasms, Experimental / drug therapy; Neoplasms, Experimental / pathology; Nucleosides / pharmacology; Rats; Rats, Inbred F344; Time Factors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays
TL;DR: The results suggest that BrdU may have an important role as an adjunctive therapeutic for a wide variety of cancers based on new insights into its effect as a negative regulator of cell cycle progression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: July 21, 2019

2007 journal article

Head Trauma

Standards of Care, Emergency and Critical Care Medicine, 9(6), 1–8,16.

By: M. Holawaychuk, B. Hansen, R. Hanel, S. Marks & C. Mariani 

Source: NC State University Libraries
Added: September 18, 2021

2007 journal article

Nonspecific immunotherapy with intratumoral lipopolysaccharide and zymosan A but not GM-CSF leads to an effective anti-tumor response in subcutaneous RG-2 gliomas

JOURNAL OF NEURO-ONCOLOGY, 85(3), 231–240.

By: C. Mariani n , D. Rajon*, F. Bova * & W. Streit *

author keywords: glioblastoma multiforme; rat; brain tumor; radiation therapy; toll-like receptor; denditic cells; macrophages
MeSH headings : Adjuvants, Immunologic / administration & dosage; Animals; Brain Neoplasms / immunology; Brain Neoplasms / mortality; Brain Neoplasms / radiotherapy; Brain Neoplasms / therapy; Combined Modality Therapy; Dendritic Cells / immunology; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Screening Assays, Antitumor; Female; Glioma / immunology; Glioma / mortality; Glioma / radiotherapy; Glioma / therapy; Granulocyte-Macrophage Colony-Stimulating Factor / administration & dosage; Granulocyte-Macrophage Colony-Stimulating Factor / immunology; Immunotherapy / methods; Injections, Intralesional; Injections, Subcutaneous; Lipopolysaccharides / administration & dosage; Lipopolysaccharides / immunology; Macrophages / immunology; Male; Neoplasms, Experimental; Rats; Rats, Inbred F344; Rats, Nude; Subcutaneous Tissue / pathology; Survival Analysis; Treatment Outcome; Zymosan / administration & dosage; Zymosan / immunology
TL;DR: Direct IT treatment with the TLR ligands LPS and ZymA are effective in generating an anti-tumor response, and appear to require T cells for a successful outcome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

Teratoma in the Cervical Spinal Cord of a Dog

Journal of the American Animal Hospital Association, 43(5), 292–297.

By: M. Wong *, C. Mariani* , J. Powe* & R. Clemmons*

MeSH headings : Animals; Decompression, Surgical / methods; Decompression, Surgical / veterinary; Dog Diseases / diagnosis; Dog Diseases / surgery; Dogs; Fatal Outcome; Female; Intervertebral Disc Displacement / diagnosis; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Paresis / etiology; Paresis / veterinary; Spinal Cord Neoplasms / diagnosis; Spinal Cord Neoplasms / surgery; Spinal Cord Neoplasms / veterinary; Teratoma / diagnosis; Teratoma / surgery; Teratoma / veterinary; Treatment Failure
TL;DR: An 11-year-old, spayed female giant schnauzer was presented for evaluation of chronic, progressive tetraparesis, and diagnostic imaging suggested an intramedullary mass at the level of the sixth cervical vertebra. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: July 21, 2019

2007 journal article

The Neurologic Examination and Neurodiagnostic Techniques for Reptiles

Veterinary Clinics of North America: Exotic Animal Practice, 10(3), 855–891.

By: C. Mariani n 

MeSH headings : Animals; Diagnostic Techniques, Neurological / veterinary; Female; Male; Nervous System Diseases / diagnosis; Nervous System Diseases / pathology; Nervous System Diseases / veterinary; Neurologic Examination / methods; Neurologic Examination / veterinary; Reptiles / anatomy & histology; Reptiles / physiology; Species Specificity
TL;DR: This article will focus on specifics of performing the neurologic examination and neurodiagnostic testing in reptiles, and how these examinations differ from those performed in more conventional species. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: July 21, 2019

2006 journal article

Rejection of RG-2 gliomas is mediated by microglia and T lymphocytes

Journal of Neuro-Oncology, 79(3), 243–253.

By: C. Mariani* , J. Kouri* & W. Streit *

author keywords: allograft; brain tumor; glioblastoma multiforme; immunohistochemistry; immunotherapy; MRI
MeSH headings : Animals; Brain / immunology; Brain / pathology; Brain Neoplasms / immunology; Brain Neoplasms / pathology; CD4 Antigens / metabolism; CD8 Antigens / metabolism; Cell Line, Tumor; Glioma / immunology; Glioma / pathology; Graft Rejection / immunology; Immunohistochemistry; Magnetic Resonance Imaging; Male; Microglia / immunology; Neoplasm Transplantation; Neoplasms, Experimental / immunology; Neoplasms, Experimental / pathology; Rats; Rats, Inbred F344; Rats, Wistar; T-Lymphocytes / immunology; Transplantation, Homologous; Transplantation, Isogeneic
TL;DR: Tumor regression was associated with greater numbers of T cells and CD8 positive cells and increases in MHC I and CD4 positive microglia, and the combined mobilization of peripheral and CNS endogenous immune cells is required for eradicating large intracranial tumors. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: July 21, 2019

2005 journal article

Role of microglia in the central nervous system's immune response

Neurological Research, 27, 685–691.

By: W. Streit, J. Conde, S. Fendrick, B. Flanary & C. Mariani 

Source: NC State University Libraries
Added: September 18, 2021

2004 journal article

Clinical signs, underlying cause, and outcome in cats with seizures: 17 cases (1997-2002)

Journal of the American Veterinary Medical Association, 225(11), 1723–1726.

By: H. Barnes*, C. Chrisman*, C. Mariani* , M. Sims* & A. Alleman*

MeSH headings : Animals; Brain / pathology; Cat Diseases / etiology; Cat Diseases / pathology; Cat Diseases / therapy; Cats; Epilepsy / complications; Epilepsy / veterinary; Female; Hepatic Encephalopathy / complications; Hepatic Encephalopathy / veterinary; Male; Meningoencephalitis / complications; Meningoencephalitis / veterinary; Neoplasms / complications; Neoplasms / veterinary; Neurologic Examination / veterinary; Prognosis; Retrospective Studies; Seizures / etiology; Seizures / pathology; Seizures / therapy; Seizures / veterinary; Survival Analysis
TL;DR: Cats with probably symptomatic epilepsy may have a good long-term prognosis, according to clinical signs, results of diagnostic testing, underlying cause, and outcome in cats with seizures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: July 21, 2019

2003 journal article

Diagnosis of a porto-azygous shunt using helical computed tomography angiography.

Veterinary Radiology and Ultrasound, 44(3), 287–291.

By: M. Thompson*, J. Graham * & C. Mariani* 

MeSH headings : Angiography / veterinary; Animals; Azygos Vein / diagnostic imaging; Biliary Fistula / diagnostic imaging; Biliary Fistula / veterinary; Diagnosis, Differential; Dog Diseases / diagnostic imaging; Dog Diseases / surgery; Dogs; Female; Image Processing, Computer-Assisted; Portal Vein / diagnostic imaging; Tomography, X-Ray Computed / veterinary
TL;DR: Computer-generated multiplanar and three-dimensional HCT angiographic images were helpful in the diagnosis and accurate anatomic characterization of a porto-azygous shunt. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: April 4, 2021

2003 journal article

Full recovery following delayed neurologic signs after smoke inhalation in a dog

Journal of Veterinary Emergency and Critical Care, 13(4), 235–239.

By: C. Mariani* 

author keywords: ataxia; canine; carbon monoxide; coma; stupor; tetraparesis
TL;DR: A 1-year-old Australian shepherd dog found unconscious in a house fire regained full neurologic function after approximately one week and was diagnosed with delayed neurological sequelae secondary to smoke inhalation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 21, 2019

2003 book

Neurology for the Small Animal Practitioner

Jackson, Wyoming: Teton NewMedia.

By: C. Chrisman, C. Mariani , S. Platt & R. Clemmons

Source: NC State University Libraries
Added: September 18, 2021

2003 chapter

Spongy Degeneration

In CD Canis. Kansas City: Vetstream, Inc.

By: C. Mariani 

Source: NC State University Libraries
Added: September 18, 2021

2002 journal article

Cerebral Phaeohyphomycosis Caused by Cladosporium spp. in Two Domestic Shorthair Cats

Journal of the American Animal Hospital Association, 38(3), 225–230.

By: C. Mariani* , S. Platt *, T. Scase*, E. Howerth *, C. Chrisman* & R. Clemmons*

MeSH headings : Animals; Cat Diseases / cerebrospinal fluid; Cat Diseases / diagnosis; Cat Diseases / pathology; Cats; Central Nervous System Fungal Infections / diagnosis; Central Nervous System Fungal Infections / veterinary; Cladosporium / isolation & purification; Diagnosis, Differential; European Union; Evoked Potentials, Auditory; Female; Telencephalon
TL;DR: Two domestic shorthair cats presented for clinical signs related to multifocal central nervous system dysfunction and postmortem diagnoses of phaeohyphomycosis secondary to Cladosporium spp. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: April 4, 2021

2001 journal article

Atypical Reaction to Acetaminophen Intoxication in a Dog

Journal of Veterinary Emergency and Critical Care, 11(2), 123–126.

By: C. Mariani*  & R. Fulton

TL;DR: Acetaminophen intoxication may have the potential to cause acute keratoconjunctivitis sicca in dogs, and may be associated with severe erythrocytic oxidative damage in the absence of detectable hepatic injury in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 28, 2019

2001 journal article

Magnetic resonance imaging of cerebral cortical necrosis (polioencephalomalacia) in a dog.

Veterinary Radiology Ultrasound, 42(6), 524–531.

By: C. Mariani* , S. Platt *, S. Newell *, S. Terrell*, C. Chrisman* & R. Clemmons*

author keywords: dog; canine; cerebral cortical necrosis; polioencephalomalacia; seizures; magnetic resonance imaging
MeSH headings : Animals; Cerebral Cortex; Diagnosis, Differential; Dog Diseases / pathology; Dogs; Encephalomalacia / complications; Encephalomalacia / pathology; Encephalomalacia / veterinary; Female; Magnetic Resonance Imaging / veterinary; Seizures / etiology
TL;DR: A 3-year-old neutered female mixed breed dog was examined because of severe, generalized seizure activity, tetraparesis, and encephalopathic signs, but the dog never regained normal mentation and euthanasia was performed 10 weeks after initial evaluation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: January 21, 2021

2001 journal article

Magnetic resonance imaging of spongy degeneration of the central nervous system in a Labrador retriever

Veterinary Radiology & Ultrasound, 42(4), 285–290.

By: C. Mariani* , R. Clemmons*, J. Graham *, L. Phillips* & C. Chrisman*

author keywords: dog; canine; spongy degeneration; Labrador Retrievers; Canavan's disease; cerebellum; MRI
MeSH headings : Animals; Canavan Disease / diagnostic imaging; Canavan Disease / physiopathology; Canavan Disease / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / physiopathology; Dogs; Female; Magnetic Resonance Imaging; Radiography
TL;DR: A 7-month-old, neutered female Labrador Retriever was evaluated for tetraparesis and subtle cerebellar dysfunction and lesions consistent with spongy degeneration of Labrador Retrievers were identified. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: April 4, 2021

1999 journal article

Paraneoplastic polyneuropathy and subsequent recovery following tumor removal in a dog

Journal of the American Animal Hospital Association, 35(4), 302–305.

By: C. Mariani* , S. Shelton & J. Alsup

MeSH headings : Adenoma / surgery; Adenoma / veterinary; Animals; Dog Diseases / surgery; Dogs; Female; Lung Neoplasms / surgery; Lung Neoplasms / veterinary; Paraneoplastic Syndromes / surgery; Paraneoplastic Syndromes / veterinary
TL;DR: To the authors' knowledge, this is the first reported case in the veterinary literature of improvement following therapy of a suspected paraneoplastic neuropathy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: July 28, 2019

Employment

Updated: December 27th, 2022 18:43

2007 - present

NC State University Raleigh, NC, US
Professor of Veterinary Neurology & Neurosurgery Clinical Sciences

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