Claire Giles

Works (11)

Updated: September 29th, 2025 08:11

2025 article

Pharmacokinetics of a single dose of flunixin transdermal formulation in American bullfrogs (Lithobates catesbeianus)

Heniff, A. C., Mzyk, D. A., Giles, C. B., Minter, L. J., Baynes, R. E., & Balko, J. A. (2025, March 10). American Journal of Veterinary Research, Vol. 5.

By: A. Heniff n, D. Mzyk n , C. Giles n, L. Minter n, R. Baynes n  & J. Balko n

author keywords: amphibian; analgesia; flunixin meglumine; NSAID; transdermal
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Drug-Induced Adverse Reactions; Biotin and Related Studies
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 10, 2025

2024 article

Continuous sampling of healthy and mastitic quarters of lactating cattle by ultrafiltration after intramammary ceftiofur hydrochloride administration

Mzyk, D. A., Halleran, J. L., Sylvester, H. J., Giles, C. B., Jacob, M. E., Baynes, R. E., & Foster, D. M. (2024, August 12). Journal of Veterinary Internal Medicine, Vol. 8.

By: D. Mzyk n , J. Halleran n, H. Sylvester n, C. Giles n, M. Jacob n, R. Baynes n , D. Foster n 

author keywords: antimicrobial; dairy cattle; gland cistern; mastitis; pharmacokinetic
MeSH headings : Animals; Cephalosporins / pharmacokinetics; Cephalosporins / administration & dosage; Cephalosporins / therapeutic use; Cattle; Female; Mastitis, Bovine / drug therapy; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / therapeutic use; Milk / chemistry; Lactation; Ultrafiltration / veterinary; Mammary Glands, Animal
topics (OpenAlex): Milk Quality and Mastitis in Dairy Cows; Microbial infections and disease research; Animal Genetics and Reproduction
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 15, 2024

2024 article

Flunixin meglumine tissue residues after intravenous administration in goats

Giles, C. B., Ferdous, F., Halleran, J. L., Yeatts, J. L., Baynes, R. E., & Mzyk, D. A. (2024, January 9). Frontiers in Veterinary Science, Vol. 10.

By: C. Giles n, F. Ferdous n, J. Halleran n, J. Yeatts n, R. Baynes n  & D. Mzyk n 

author keywords: flunixin; goat; residues; tolerance limit method; withdrawal interval; withdrawal time
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Inflammatory mediators and NSAID effects; Pharmacogenetics and Drug Metabolism
TL;DR: Since any detection of flunixin residues at slaughter found in goat tissues is considered a violative residue, a conservative withdrawal interval of 17 days was calculated to ensure levels of flunixin fell below the regulatory limits of detection in liver, kidney, and muscle tissues. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 12, 2024

2023 article

Milk residues following multiple doses of meloxicam and gabapentin in lactating dairy cattle

Mzyk, D. A., Giles, C. B., Baynes, R. E., & Smith, G. W. (2023, September 21). Journal of the American Veterinary Medical Association, Vol. 261, pp. 1873–1879.

By: D. Mzyk n , C. Giles n, R. Baynes n  & G. Smith n 

author keywords: meloxicam; gabapentin; lactation; postpartum; dairy cattle
MeSH headings : Female; Cattle; Animals; Meloxicam / analysis; Milk; Lactation; Gabapentin; Anti-Inflammatory Agents, Non-Steroidal; Diet / veterinary
topics (OpenAlex): Reproductive Physiology in Livestock; Coccidia and coccidiosis research; Veterinary medicine and infectious diseases
TL;DR: Results of this study suggest that milk from cows treated with multiple doses of meloxicam alone or in combination with gabapentin will have low drug concentrations and falls below the reported limit of detection formeloxicam or gABapentin 120 and 60 hours respectively, following the final dose regardless of their stage of lactation. (via Semantic Scholar)
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13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 1, 2024

2021 article

EVALUATION OF THE PHARMACOKINETIC BEHAVIOR OF TULATHROMYCIN (DRAXXIN) IN FLORIDA MANATEES (TRICHECHUS MANATUS LATIROSTRIS) UNDERGOING MEDICAL REHABILITATION

Smith, L. N., Bublitz, C., Nixon, E., Yeatts, J., Ball, R. L., & Baynes, R. E. (2021, September 28). Journal of Zoo and Wildlife Medicine, Vol. 52, pp. 880–885.

By: L. Smith *, C. Bublitz n, E. Nixon n , J. Yeatts n, R. Ball * & R. Baynes n 

MeSH headings : Animals; Animals, Wild; Cattle; Disaccharides; Heterocyclic Compounds; Horses; Swine; Trichechus; Trichechus manatus
topics (OpenAlex): Meat and Animal Product Quality; Animal health and immunology; Marine animal studies overview
TL;DR: The pharmacokinetic behavior of tulathromycin in Florida manatees can be used to optimize dosage regimens in this species, and this antibiotic has also been used in manatee with positive clinical outcomes. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 2, 2021

2019 article

Comparative plasma and urine concentrations of flunixin and meloxicam in goats

Bublitz, C. M., Mzyk, D. A., Mays, T., Fajt, V. R., Hairgrove, T., & Baynes, R. E. (2019, March 6). Small Ruminant Research, Vol. 174, pp. 40–46.

By: C. Bublitz n, D. Mzyk n , T. Mays*, V. Fajt *, T. Hairgrove * & R. Baynes n 

topics (OpenAlex): Drug Transport and Resistance Mechanisms; Inflammatory mediators and NSAID effects; Antibiotics Pharmacokinetics and Efficacy
TL;DR: The information from this study represents a potential worst-case scenario for urine depletion and helps determine the withdrawal intervals needed for flunixin meglumine in show goats when administered in this extra label manner. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 4, 2019

2019 article

Impact of bovine respiratory disease on the pharmacokinetics of danofloxacin and tulathromycin in different ages of calves

Mzyk, D. A., Bublitz, C. M., Martinez, M. N., Davis, J. L., Baynes, R. E., & Smith, G. W. (2019, June 24). (D. Gladue, Ed.). PLoS ONE, Vol. 14, p. e0218864.

By: D. Mzyk n , C. Bublitz n, M. Martinez *, J. Davis*, R. Baynes n  & G. Smith n 

Ed(s): D. Gladue

MeSH headings : Age Factors; Animals; Area Under Curve; Bronchoalveolar Lavage Fluid / chemistry; Cattle; Cattle Diseases / drug therapy; Disaccharides / administration & dosage; Disaccharides / pharmacokinetics; Extracellular Fluid / chemistry; Female; Fluoroquinolones / administration & dosage; Fluoroquinolones / pharmacokinetics; Heterocyclic Compounds / administration & dosage; Heterocyclic Compounds / pharmacokinetics; Pasteurella Infections / drug therapy; Pasteurella Infections / veterinary; Pasteurella multocida / pathogenicity; Respiration Disorders / drug therapy; Respiration Disorders / veterinary
topics (OpenAlex): Microbial infections and disease research; Antibiotics Pharmacokinetics and Efficacy; Pneumonia and Respiratory Infections
TL;DR: Age was determined to be a significant covariate for calves administered danofloxacin and tulathromycin for plasma PK parameters and potential reasons for age-related differences on plasma concentration–time profiles and the impact of disease on the partitioning of the drug from the blood to the lungs and ISF as a function of age are explored. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 30, 2019

2018 article

Effect of age on plasma protein binding of several veterinary drugs in dairy calves 2

Mzyk, D. A., Bublitz, C. M., Hobgood, G. D., Martinez, M. N., Davis, J. L., Smith, G. W., & Baynes, R. E. (2018, October 13). Research in Veterinary Science, Vol. 121, pp. 59–64.

By: D. Mzyk n , C. Bublitz n, G. Hobgood n, M. Martinez *, J. Davis*, G. Smith n , R. Baynes n 

author keywords: Protein binding; Calves; Alpha-1-acid glycoprotein; Albumin
MeSH headings : Age Factors; Animals; Blood Proteins / metabolism; Cattle / metabolism; Protein Binding; Veterinary Drugs / metabolism
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Animal health and immunology
TL;DR: Findings from these calves suggest that age is not an important factor in the binding of these drugs to plasma proteins, and statistically significant age-effects on plasma protein binding were not observed for any of the drugs evaluated. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 17, 2018

2018 article

Short communication: Use of an ultrafiltration device in gland cistern for continuous sampling of healthy and mastitic quarters of lactating cattle for pharmacokinetic modeling

Mzyk, D. A., Bublitz, C. M., Sylvester, H., Mullen, K. A. E., Hobgood, G. D., Baynes, R. E., & Foster, D. M. (2018, September 7). Journal of Dairy Science, Vol. 101, pp. 10414–10420.

By: D. Mzyk* , C. Bublitz, H. Sylvester*, K. Mullen n, G. Hobgood, R. Baynes* , D. Foster* 

MeSH headings : Administration, Intravenous / veterinary; Animals; Cattle; Chromatography, High Pressure Liquid / veterinary; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Feasibility Studies; Female; Lactation; Mammary Glands, Animal / metabolism; Mass Spectrometry / veterinary; Mastitis, Bovine / diagnosis; Milk / chemistry; Ultrafiltration / veterinary
topics (OpenAlex): Milk Quality and Mastitis in Dairy Cows; Reproductive Physiology in Livestock; Animal health and immunology
TL;DR: Collection of ultrafiltration samples from the mammary gland of cows provides a viable means to continuously assess drug concentrations in the milk while continuing to milk the cow normally, and demonstrates the utility of continuous sampling of milk via ultraFiltration for future pharmacokinetic studies in cattle. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: November 5, 2018

journal article

Comparative urine residues of flunixin and meloxicam in show goats

Bublitz, C. M., Mzyk, D. A., Mays, T., Fajt, V. R., Hairgrove, T., & Baynes, R. E. Journal of Veterinary Pharmacology and Therapeutics, 41, 24–24.

By: C. Bublitz, D. Mzyk , T. Mays, V. Fajt, T. Hairgrove & R. Baynes 

Source: NC State University Libraries
Added: August 6, 2018

journal article

Impact of bovine respiratory disease on the pharmacokinetics of danofloxacin and tulathromycin in different ages of calves

Mzyk, D. A., Bublitz, C. M., Martinez, M. N., Davis, J. L., Baynes, R. E., & Smith, G. W. Journal of Veterinary Pharmacology and Therapeutics, 41, 33–33.

By: D. Mzyk , C. Bublitz, M. Martinez, J. Davis, R. Baynes  & G. Smith 

Source: NC State University Libraries
Added: August 6, 2018

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