Colleen Marie Connelly

Works (6)

Updated: July 11th, 2023 21:19

2015 article

A concise synthesis of the Lycopodium alkaloid cermizine D

Enamorado, M. F., Connelly, C. M., Deiters, A., & Comins, D. L. (2015, April 11). Tetrahedron Letters.

By: M. Enamorado n, C. Connelly n, A. Deiters n & D. Comins n

author keywords: Alkaloid synthesis; Lycopodium alkaloids; Nitrogen heterocycles; 1-Acylpyridinium salts; Asymmetric synthesis
topics (OpenAlex): Cholinesterase and Neurodegenerative Diseases; Chemical synthesis and alkaloids; Botanical Research and Chemistry
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Source: Web Of Science
Added: August 6, 2018

2015 article

Aryl amide small-molecule inhibitors of microRNA miR-21 function

Naro, Y., Thomas, M., Stephens, M. D., Connelly, C. M., & Deiters, A. (2015, July 17). Bioorganic & Medicinal Chemistry Letters.

By: Y. Naro*, M. Thomas*, M. Stephens n, C. Connelly n & A. Deiters *

author keywords: miR-21; MicroRNA; Small-molecule inhibitors; Cancer; Gene regulation; Post-transcriptional regulation
MeSH headings : Amides / chemical synthesis; Amides / chemistry; Amides / pharmacology; Cell Line, Tumor; Dose-Response Relationship, Drug; HeLa Cells; Humans; MicroRNAs / antagonists & inhibitors; MicroRNAs / genetics; Molecular Structure; Small Molecule Libraries / chemical synthesis; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology; Structure-Activity Relationship
topics (OpenAlex): MicroRNA in disease regulation; RNA Interference and Gene Delivery; Advanced biosensing and bioanalysis techniques
TL;DR: Using a luciferase-based reporter assay under the control of miR-21 expression, a high-throughput screen of >300,000 compounds led to the discovery of a new aryl amide class of small-molecule miR -21 inhibitors, thus affording a new chemical probe for future studies. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 article

Thiourea-Based Fluorescent Chemosensors for Aqueous Metal Ion Detection and Cellular Imaging

Vonlanthen, M., Connelly, C. M., Deiters, A., Linden, A., & Finney, N. S. (2014, June 12). The Journal of Organic Chemistry.

By: M. Vonlanthen *, C. Connelly n, A. Deiters n, A. Linden * & N. Finney n

MeSH headings : Fluorescent Dyes / chemistry; HeLa Cells; Humans; Ions / chemistry; Mercury / analysis; Mercury / chemistry; Metals / analysis; Metals / chemistry; Molecular Imaging; Spectrometry, Fluorescence; Thiourea / chemistry; Water / chemistry
topics (OpenAlex): Molecular Sensors and Ion Detection; Advanced biosensing and bioanalysis techniques; Luminescence and Fluorescent Materials
TL;DR: It is shown that a thiourea-based chemosensor can be employed for fluorescence microscopy imaging of Hg(2+) ion concentrations in living mammalian cells. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 article

High-Throughput Luciferase Reporter Assay for Small-Molecule Inhibitors of MicroRNA Function

Connelly, C. M., Thomas, M., & Deiters, A. (2012, March 13). SLAS DISCOVERY.

By: C. Connelly n, M. Thomas n & A. Deiters n

author keywords: high-throughput assay; cell-based assay; luciferase; microRNA; small-molecule inhibitor
MeSH headings : Antineoplastic Agents / pharmacology; Antiviral Agents / pharmacology; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / metabolism; Cell Line, Tumor; Gene Expression; Genes, Reporter; Hepacivirus / metabolism; Hepatitis C / genetics; Hepatitis C / metabolism; High-Throughput Screening Assays / methods; Humans; Liver Neoplasms / genetics; Liver Neoplasms / metabolism; Luciferases, Renilla / genetics; Luciferases, Renilla / metabolism; MicroRNAs / antagonists & inhibitors; MicroRNAs / metabolism; Oligonucleotides, Antisense; Small Molecule Libraries / pharmacology; Transfection
topics (OpenAlex): MicroRNA in disease regulation; RNA Interference and Gene Delivery; Advanced biosensing and bioanalysis techniques
TL;DR: A high-throughput screen for potential small-molecule regulators of the liver-specific microRNA miR-122, which is involved in hepatocellular carcinoma development and hepatitis C virus infection, is developed. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 article

Spatiotemporal control of microRNA function using light-activated antagomirs

Connelly, C. M., Uprety, R., Hemphill, J., & Deiters, A. (2012, September 3). Molecular BioSystems.

By: C. Connelly n, R. Uprety n, J. Hemphill n & A. Deiters n

MeSH headings : Antagomirs; Apoptosis / drug effects; Apoptosis / radiation effects; Cell Differentiation / drug effects; Cell Differentiation / radiation effects; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Proliferation / radiation effects; Humans; Light; MicroRNAs / antagonists & inhibitors; MicroRNAs / metabolism; MicroRNAs / radiation effects; Oligonucleotides / chemistry; Oligonucleotides / pharmacology; Oligonucleotides / radiation effects; Photochemistry; Ultraviolet Rays
topics (OpenAlex): Photochromic and Fluorescence Chemistry; Advanced biosensing and bioanalysis techniques; Luminescence and Fluorescent Materials
TL;DR: The presented approach enables the precise regulation of miRNA function and miRNA networks with unprecedented spatial and temporal resolution using UV irradiation and can be extended to any miRNA of interest. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2010 article

Small Molecule Modifiers of MicroRNA miR-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma

Young, D. D., Connelly, C. M., Grohmann, C., & Deiters, A. (2010, May 19). Journal of the American Chemical Society.

By: D. Young n, C. Connelly n, C. Grohmann n & A. Deiters n

MeSH headings : Apoptosis / drug effects; Base Sequence; Carcinoma, Hepatocellular / drug therapy; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / pathology; Enoxacin / pharmacology; HeLa Cells; Hepatitis C / drug therapy; Hepatitis C / genetics; Humans; Liver Neoplasms / drug therapy; Liver Neoplasms / genetics; Liver Neoplasms / pathology; MicroRNAs / antagonists & inhibitors; MicroRNAs / genetics; MicroRNAs / metabolism; Oligonucleotides, Antisense / genetics; Oligonucleotides, Antisense / pharmacology; Virus Replication / drug effects; Virus Replication / genetics
topics (OpenAlex): MicroRNA in disease regulation; Circular RNAs in diseases; RNA modifications and cancer
TL;DR: The authors' small molecule inhibitors reduce viral replication in liver cells and represent a new approach to the treatment of HCV infections and small molecule activation of miR-122 in liver cancer cells selectively induced apoptosis through caspase activation, thus having implications in cancer chemotherapy. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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