Works (3)

Updated: July 5th, 2023 14:23

2022 article

Tauroursodeoxycholic Acid Inhibits Clostridioides difficile Toxin-Induced Apoptosis

Pike, C. M., Tam, J., Melnyk, R. A., & Theriot, C. M. (2022, July 7). INFECTION AND IMMUNITY.

By: C. Pike n, J. Tam*, R. Melnyk* & C. Theriot n

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
author keywords: Clostridioides difficile; apoptosis; bile acids; tauroursodeoxycholic acid; toxin; ursodeoxycholic acid
MeSH headings : Anti-Bacterial Agents / pharmacology; Antibodies, Bacterial / pharmacology; Apoptosis; Bile Acids and Salts / pharmacology; Caco-2 Cells; Clostridioides difficile; Clostridium Infections / microbiology; Humans; Inflammation; Taurochenodeoxycholic Acid; Ursodeoxycholic Acid / pharmacology
Source: Web Of Science
Added: July 26, 2022

2021 journal article

Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota

NATURE COMMUNICATIONS, 12(1).

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Anti-Bacterial Agents / adverse effects; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Bacterial Toxins / genetics; Bacterial Toxins / immunology; Bacterial Toxins / metabolism; Bacteroides / drug effects; Bacteroides / metabolism; Clostridioides difficile / genetics; Clostridioides difficile / immunology; Clostridioides difficile / metabolism; Clostridium Infections / immunology; Clostridium Infections / microbiology; Clostridium Infections / pathology; Disease Models, Animal; Extracellular Matrix / metabolism; Female; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / immunology; Gene Expression Regulation, Bacterial / immunology; Host-Pathogen Interactions / genetics; Host-Pathogen Interactions / immunology; Humans; Intestinal Mucosa / immunology; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Male; Matrix Metalloproteinases / metabolism; Mice; Nutrients / metabolism; Proteolysis; RNA, Bacterial / genetics; RNA, Bacterial / isolation & purification; RNA-Seq; Sigma Factor / genetics; Sigma Factor / immunology; Sigma Factor / metabolism; Transcriptome / immunology
Sources: Web Of Science, ORCID
Added: January 20, 2021

2021 journal article

Mechanisms of Colonization Resistance Against Clostridioides difficile

JOURNAL OF INFECTIOUS DISEASES, 223, S194–S200.

By: C. Pike n & C. Theriot n

co-author countries: United States of America 🇺🇸
author keywords: bacteria; bile acids; Clostridioides difficile; microbiota; short-chain fatty acids
MeSH headings : Animals; Anti-Bacterial Agents / immunology; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / therapeutic use; Antibiosis; Bile Acids and Salts / immunology; Bile Acids and Salts / metabolism; Clostridioides difficile / drug effects; Clostridioides difficile / growth & development; Clostridioides difficile / metabolism; Clostridium Infections / drug therapy; Clostridium Infections / immunology; Clostridium Infections / microbiology; Fatty Acids, Volatile / immunology; Fatty Acids, Volatile / metabolism; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / physiology; Humans; Nutrients / immunology; Nutrients / metabolism
Source: Web Of Science
Added: October 18, 2021

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