Colleen Pike

Works (4)

Updated: April 12th, 2024 05:00

2023 journal article

The microbial-derived bile acid lithocholate and its epimers inhibit <i>Clostridioides difficile</i> growth and pathogenicity while sparing members of the gut microbiota

JOURNAL OF BACTERIOLOGY, 205(9).

By: S. Kisthardt n, R. Thanissery  n, C. Pike n, M. Foley n & C. Theriot n

author keywords: lithocholate; Clostridioides difficile; epimers; secondary bile acids; gut microbiota
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Source: Web Of Science
Added: April 8, 2024

2022 article

Tauroursodeoxycholic Acid Inhibits Clostridioides difficile Toxin-Induced Apoptosis

Pike, C. M., Tam, J., Melnyk, R. A., & Theriot, C. M. (2022, July 7). INFECTION AND IMMUNITY.

By: C. Pike n, J. Tam *, R. Melnyk * & C. Theriot n

author keywords: Clostridioides difficile; apoptosis; bile acids; tauroursodeoxycholic acid; toxin; ursodeoxycholic acid
MeSH headings : Anti-Bacterial Agents / pharmacology; Antibodies, Bacterial / pharmacology; Apoptosis; Bile Acids and Salts / pharmacology; Caco-2 Cells; Clostridioides difficile; Clostridium Infections / microbiology; Humans; Inflammation; Taurochenodeoxycholic Acid; Ursodeoxycholic Acid / pharmacology
TL;DR: It is demonstrated that bile acid conjugation can have profound effects on C. difficile as well as the host and that conjugated and unconjugated bile acids may exert different therapeutic mechanisms against CDI. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: July 26, 2022

2021 journal article

Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota

NATURE COMMUNICATIONS, 12(1).

By: J. Fletcher n, C. Pike n, R. Parsons  n, A. Rivera n, M. Foley n, M. McLaren n , S. Montgomery *, C. Theriot n

MeSH headings : Animals; Anti-Bacterial Agents / adverse effects; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Bacterial Toxins / genetics; Bacterial Toxins / immunology; Bacterial Toxins / metabolism; Bacteroides / drug effects; Bacteroides / metabolism; Clostridioides difficile / genetics; Clostridioides difficile / immunology; Clostridioides difficile / metabolism; Clostridium Infections / immunology; Clostridium Infections / microbiology; Clostridium Infections / pathology; Disease Models, Animal; Extracellular Matrix / metabolism; Female; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / immunology; Gene Expression Regulation, Bacterial / immunology; Host-Pathogen Interactions / genetics; Host-Pathogen Interactions / immunology; Humans; Intestinal Mucosa / immunology; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Male; Matrix Metalloproteinases / metabolism; Mice; Nutrients / metabolism; Proteolysis; RNA, Bacterial / genetics; RNA, Bacterial / isolation & purification; RNA-Seq; Sigma Factor / genetics; Sigma Factor / immunology; Sigma Factor / metabolism; Transcriptome / immunology
TL;DR: Insight is provided into how toxin-induced inflammation alters C. difficile metabolism, host tissue gene expression and gut microbiota, together influencing a beneficial niche for infection. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 20, 2021

2020 journal article

Mechanisms of Colonization Resistance Against Clostridioides difficile

JOURNAL OF INFECTIOUS DISEASES, 223, S194–S200.

By: C. Pike n & C. Theriot n

author keywords: bacteria; bile acids; Clostridioides difficile; microbiota; short-chain fatty acids
MeSH headings : Animals; Anti-Bacterial Agents / immunology; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / therapeutic use; Antibiosis; Bile Acids and Salts / immunology; Bile Acids and Salts / metabolism; Clostridioides difficile / drug effects; Clostridioides difficile / growth & development; Clostridioides difficile / metabolism; Clostridium Infections / drug therapy; Clostridium Infections / immunology; Clostridium Infections / microbiology; Fatty Acids, Volatile / immunology; Fatty Acids, Volatile / metabolism; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / physiology; Humans; Nutrients / immunology; Nutrients / metabolism
TL;DR: Commensal gut microbes are critical for providing colonization resistance against C. difficile, and can be leveraged as non-antibiotic alternative therapeutics for the prevention and treatment of CDI. (via Semantic Scholar)
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Source: Web Of Science
Added: October 18, 2021

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