Carlos Pinto

Works (8)

Updated: August 11th, 2023 21:15

2011 journal article

Long-Term Efficacy Following Readministration of an Adeno-Associated Virus Vector in Dogs with Glycogen Storage Disease Type Ia

HUMAN GENE THERAPY, 23(4), 407–418.

By: A. Demaster*, X. Luo *, S. Curtis *, K. Williams*, D. Landau*, E. Drake*, D. Kozink n, A. Bird* ...

MeSH headings : Animals; Dependovirus / genetics; Dogs; Genetic Therapy; Genetic Vectors; Glucose-6-Phosphatase / genetics; Glucose-6-Phosphatase / metabolism; Glycogen Storage Disease Type I / genetics; Glycogen Storage Disease Type I / metabolism; Glycogen Storage Disease Type I / therapy; Hypoglycemia / genetics; Hypoglycemia / metabolism; Hypoglycemia / therapy; Liver / metabolism
TL;DR: Preclinical data support the further translation of AAV vector-mediated gene therapy in GSD-Ia and support the demonstrated risk for recurrent hypoglycemia and mortality from waning efficacy of the AAV2/9 vector. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 journal article

Rescue administration of a helper-dependent adenovirus vector with long-term efficacy in dogs with glycogen storage disease type Ia

GENE THERAPY, 19(4), 443–452.

By: B. Crane n, X. Luo *, A. Demaster*, K. Williams*, D. Kozink n, P. Zhang*, T. Brown n, C. Pinto n ...

author keywords: glycogen storage disease; von Gierke disease; glucose-6-phosphatase; adenovirus vector; renal dysfunction
MeSH headings : Adenoviridae / genetics; Animals; Body Weight; Dog Diseases / therapy; Dogs; Genetic Therapy / adverse effects; Genetic Therapy / methods; Genetic Vectors; Glucose-6-Phosphatase / genetics; Glycogen Storage Disease Type I / therapy; Glycogen Storage Disease Type I / veterinary; Hypoglycemia / complications; Hypoglycemia / prevention & control
TL;DR: Administration of a serotype 2 HDAd vector prolonged survival in one GSD-Ia dog to 12 years of age and 36 months of age in the other, but the persistence of long-term complications limited HDAd vectors in the canine model for GSD -Ia. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Gene Therapy for Inherited Metabolic Disorders in Companion Animals

ILAR JOURNAL, 50(2), 122–127.

By: D. Koeberl *, C. Pinto*, T. Brown n & Y. Chen*

author keywords: amino acid metabolism; large animal model; gene therapy; glycogen storage disease; inborn errors of metabolism; inherited metabolic disorders; mitochondrial disorder; organic acidemia
MeSH headings : Animals; Cats; Disease Models, Animal; Dogs; Genetic Therapy / methods; Metabolism, Inborn Errors / genetics; Metabolism, Inborn Errors / therapy
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Source: Web Of Science
Added: August 6, 2018

2008 journal article

AAV vector-mediated reversal of hypoglycemia in canine and murine glycogen storage disease type Ia

MOLECULAR THERAPY, 16(4), 665–672.

By: D. Koeberl *, C. Pinto n, B. Sun *, S. Li *, D. Kozink n, D. Benjamin *, A. Demaster n, M. Kruse n ...

MeSH headings : Animals; Dependovirus / genetics; Disease Models, Animal; Dogs; Genetic Therapy; Genetic Vectors; Glucose-6-Phosphatase / biosynthesis; Glucose-6-Phosphatase / genetics; Glycogen Storage Disease Type I / enzymology; Glycogen Storage Disease Type I / therapy; Humans; Hypoglycemia / enzymology; Hypoglycemia / therapy; Liver Glycogen / metabolism; Mice; Mice, Knockout
TL;DR: The AAV2/8 vector uniquely prevented hypoglycemia during fasting and fully corrected liver G6Pase deficiency in GSD-Ia mice and dogs, and support the further preclinical development of AAV vector-mediated gene therapy for GSD -Ia. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 journal article

Pharmacokinetics of carbetocin, a long-acting oxytocin analogue, following intravenous administration in horses

EQUINE VETERINARY JOURNAL, 40(7), 658–661.

By: A. Schramme n, C. Pinto  n, J. Davis  n, C. Whisnant n & M. Whitacre n

author keywords: horse; oxytocin; pharmacokinetics; carbetocin
MeSH headings : Animals; Area Under Curve; Female; Half-Life; Heart Rate / drug effects; Horse Diseases / blood; Horse Diseases / drug therapy; Horses / blood; Injections, Intravenous / veterinary; Oxytocin / adverse effects; Oxytocin / analogs & derivatives; Oxytocin / pharmacokinetics; Oxytocin / therapeutic use; Pain / chemically induced; Pain / epidemiology; Pain / veterinary; Radioimmunoassay / veterinary; Respiration / drug effects
TL;DR: The half-life of carbetocin is greater than that previously reported for oxytocin (6.8 min) and is an attractive alternative to Oxytocin therapy in broodmare management. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Bilateral occurrence of granulosa-theca cell tumors in an Arabian mare

Canadian Veterinary Journal, 48(5), 502–505.

By: L. Frederico, M. Gerard, C. Pinto & C. Gradil

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Simplified hypoosmotic swelling testing (HOST) of fresh and frozen-thawed canine spermatozoa

ANIMAL REPRODUCTION SCIENCE, 104(2-4), 450–455.

By: C. Pinto  n & D. Kozink n

author keywords: canine; sperm; sperm membrane; hypoosmotic swelling test
MeSH headings : Animals; Cell Membrane / physiology; Cryopreservation / veterinary; Dogs / physiology; Male; Osmotic Pressure; Semen Preservation / veterinary; Sperm Motility / physiology; Spermatozoa / physiology; Statistics, Nonparametric
TL;DR: Based on the results of this study, it is recommended to decrease the incubation time of the HOST for canine spermatozoa to as short a period as 1 min, to encourage the application of this relatively simple and inexpensive test of canine sperm membrane function in a clinical setting. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2003 journal article

Concentrations of nitric oxide in equine preovulatory follicles before and after administration of human chorionic gonadotropin

THERIOGENOLOGY, 60(5), 819–827.

By: C. Pinto *, D. Paccamonti *, B. Eilts*, C. Venugopal*, C. Short*, L. Gentry*, D. Thompson *, R. Godke*

author keywords: follicular fluid; nitric oxide; mare; hCG
MeSH headings : Animals; Chorionic Gonadotropin / administration & dosage; Enzyme Inhibitors / pharmacology; Estradiol / analysis; Female; Follicular Fluid / chemistry; Guanidines / pharmacology; Horses / metabolism; Kinetics; NG-Nitroarginine Methyl Ester / pharmacology; Nitric Oxide / analysis; Nitric Oxide Synthase / antagonists & inhibitors; Ovulation; Progesterone / analysis
TL;DR: Increased intrafollicular concentrations of NO in control, hCG-stimulated mares provide evidence for the presence of an NO-generating system in the equine preovulatory follicle that is likely upregulated following administration of hCG. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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