Works (8)
Updated: August 11th, 2023 21:15
2012 journal article
Long-Term Efficacy Following Readministration of an Adeno-Associated Virus Vector in Dogs with Glycogen Storage Disease Type Ia
HUMAN GENE THERAPY, 23(4), 407–418.
MeSH headings : Animals; Dependovirus / genetics; Dogs; Genetic Therapy; Genetic Vectors; Glucose-6-Phosphatase / genetics; Glucose-6-Phosphatase / metabolism; Glycogen Storage Disease Type I / genetics; Glycogen Storage Disease Type I / metabolism; Glycogen Storage Disease Type I / therapy; Hypoglycemia / genetics; Hypoglycemia / metabolism; Hypoglycemia / therapy; Liver / metabolism
TL;DR:
Preclinical data support the further translation of AAV vector-mediated gene therapy in GSD-Ia and support the demonstrated risk for recurrent hypoglycemia and mortality from waning efficacy of the AAV2/9 vector.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Rescue administration of a helper-dependent adenovirus vector with long-term efficacy in dogs with glycogen storage disease type Ia
GENE THERAPY, 19(4), 443–452.
author keywords: glycogen storage disease; von Gierke disease; glucose-6-phosphatase; adenovirus vector; renal dysfunction
MeSH headings : Adenoviridae / genetics; Animals; Body Weight; Dog Diseases / therapy; Dogs; Genetic Therapy / adverse effects; Genetic Therapy / methods; Genetic Vectors; Glucose-6-Phosphatase / genetics; Glycogen Storage Disease Type I / therapy; Glycogen Storage Disease Type I / veterinary; Hypoglycemia / complications; Hypoglycemia / prevention & control
TL;DR:
Administration of a serotype 2 HDAd vector prolonged survival in one GSD-Ia dog to 12 years of age and 36 months of age in the other, but the persistence of long-term complications limited HDAd vectors in the canine model for GSD -Ia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Gene Therapy for Inherited Metabolic Disorders in Companion Animals
ILAR JOURNAL, 50(2), 122–127.
author keywords: amino acid metabolism; large animal model; gene therapy; glycogen storage disease; inborn errors of metabolism; inherited metabolic disorders; mitochondrial disorder; organic acidemia
MeSH headings : Animals; Cats; Disease Models, Animal; Dogs; Genetic Therapy / methods; Metabolism, Inborn Errors / genetics; Metabolism, Inborn Errors / therapy
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
AAV vector-mediated reversal of hypoglycemia in canine and murine glycogen storage disease type Ia
MOLECULAR THERAPY, 16(4), 665–672.
MeSH headings : Animals; Dependovirus / genetics; Disease Models, Animal; Dogs; Genetic Therapy; Genetic Vectors; Glucose-6-Phosphatase / biosynthesis; Glucose-6-Phosphatase / genetics; Glycogen Storage Disease Type I / enzymology; Glycogen Storage Disease Type I / therapy; Humans; Hypoglycemia / enzymology; Hypoglycemia / therapy; Liver Glycogen / metabolism; Mice; Mice, Knockout
TL;DR:
The AAV2/8 vector uniquely prevented hypoglycemia during fasting and fully corrected liver G6Pase deficiency in GSD-Ia mice and dogs, and support the further preclinical development of AAV vector-mediated gene therapy for GSD -Ia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Pharmacokinetics of carbetocin, a long-acting oxytocin analogue, following intravenous administration in horses
EQUINE VETERINARY JOURNAL, 40(7), 658–661.
author keywords: horse; oxytocin; pharmacokinetics; carbetocin
MeSH headings : Animals; Area Under Curve; Female; Half-Life; Heart Rate / drug effects; Horse Diseases / blood; Horse Diseases / drug therapy; Horses / blood; Injections, Intravenous / veterinary; Oxytocin / adverse effects; Oxytocin / analogs & derivatives; Oxytocin / pharmacokinetics; Oxytocin / therapeutic use; Pain / chemically induced; Pain / epidemiology; Pain / veterinary; Radioimmunoassay / veterinary; Respiration / drug effects
TL;DR:
The half-life of carbetocin is greater than that previously reported for oxytocin (6.8 min) and is an attractive alternative to Oxytocin therapy in broodmare management.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Simplified hypoosmotic swelling testing (HOST) of fresh and frozen-thawed canine spermatozoa
ANIMAL REPRODUCTION SCIENCE, 104(2-4), 450–455.
author keywords: canine; sperm; sperm membrane; hypoosmotic swelling test
MeSH headings : Animals; Cell Membrane / physiology; Cryopreservation / veterinary; Dogs / physiology; Male; Osmotic Pressure; Semen Preservation / veterinary; Sperm Motility / physiology; Spermatozoa / physiology; Statistics, Nonparametric
TL;DR:
Based on the results of this study, it is recommended to decrease the incubation time of the HOST for canine spermatozoa to as short a period as 1 min, to encourage the application of this relatively simple and inexpensive test of canine sperm membrane function in a clinical setting.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Bilateral occurrence of granulosa-theca cell tumors in an Arabian mare
Canadian Veterinary Journal, 48(5), 502–505.
Source: NC State University Libraries
Added: August 6, 2018
2003 journal article
Concentrations of nitric oxide in equine preovulatory follicles before and after administration of human chorionic gonadotropin
THERIOGENOLOGY, 60(5), 819–827.
author keywords: follicular fluid; nitric oxide; mare; hCG
MeSH headings : Animals; Chorionic Gonadotropin / administration & dosage; Enzyme Inhibitors / pharmacology; Estradiol / analysis; Female; Follicular Fluid / chemistry; Guanidines / pharmacology; Horses / metabolism; Kinetics; NG-Nitroarginine Methyl Ester / pharmacology; Nitric Oxide / analysis; Nitric Oxide Synthase / antagonists & inhibitors; Ovulation; Progesterone / analysis
TL;DR:
Increased intrafollicular concentrations of NO in control, hCG-stimulated mares provide evidence for the presence of an NO-generating system in the equine preovulatory follicle that is likely upregulated following administration of hCG.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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