Clyde S. Manuel

Works (7)

Updated: July 5th, 2023 15:40

2022 journal article

Comparative Assessment of the Efficacy of Commercial Hand Sanitizers Against Human Norovirus Evaluated by an in vivo Fingerpad Method

FRONTIERS IN MICROBIOLOGY, 13.

By: B. Escudero-Abarca n, R. Goulter n, C. Manuel*, R. Leslie *, K. Green*, J. Arbogast *, L. Jaykus n

author keywords: human norovirus; hand sanitizer; hand hygiene; fingerpad method; alcohol
TL;DR: There remains a need for more hand sanitizer formulations having greater activity against hNoV, a virus that is comparatively recalcitrant relative to other pathogens of concern in community, healthcare, and food preparation environments. (via Semantic Scholar)
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Added: May 16, 2022

2022 article

Efficacy of an alcohol-based surface disinfectant formulation against human norovirus

Escudero-Abarca, B. I., Goulter, R. M., Bradshaw, J., Faircloth, J., Leslie, R. A., Manuel, C. S., … Jaykus, L.-A. (2022, February 19). JOURNAL OF APPLIED MICROBIOLOGY.

By: B. Escudero-Abarca n, R. Goulter n, J. Bradshaw n, J. Faircloth n, R. Leslie *, C. Manuel*, J. Arbogast *, L. Jaykus n

author keywords: food safety; food virology; human intestinal enteroids; human norovirus; surface disinfection; surface sanitizing; Tulane virus
MeSH headings : Disinfectants / pharmacology; Disinfection / methods; Ethanol; Humans; Norovirus / genetics; Sodium Hypochlorite / pharmacology; Soil; Stainless Steel
TL;DR: To evaluate the anti‐noroviral efficacy of PURELL® surface sanitizer and disinfectant spray (PSS, an alcohol‐based formulation) using human norovirus GII.4 Sydney and its cultivable surrogate, Tulane virus (TuV, infectivity assay), compared to sodium hypochlorite (NaOCl) solutions. (via Semantic Scholar)
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Added: March 14, 2022

2021 journal article

Comparison of a one-step real-time RT-PCR and a nested real-time RT-PCR for a genogroup II norovirus reveals differences in sensitivity depending upon assay design and visualization

PLOS ONE, 16(4).

By: C. Manuel n, C. Suther *, M. Moore n & L. Jaykus n

MeSH headings : Caliciviridae Infections / diagnosis; Caliciviridae Infections / genetics; Caliciviridae Infections / metabolism; Feces / virology; Female; Genome, Viral; Humans; Male; Norovirus / genetics; RNA, Viral / genetics; RNA, Viral / metabolism; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction
TL;DR: A controlled comparison of two published NoV detection assays shows the complexities in designing and interpreting molecular techniques having a sufficient detection limit to detect low levels of viruses that might be anticipated in contaminated food and environmental samples. (via Semantic Scholar)
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Added: June 10, 2021

2017 journal article

Virucidal Activity of Fogged Chlorine Dioxide-and Hydrogen Peroxide-Based Disinfectants against Human Norovirus and Its Surrogate, Feline Calicivirus, on Hard-to-Reach Surfaces

FRONTIERS IN MICROBIOLOGY, 8.

By: N. Montazeri  n, C. Manuel n, E. Moorman n, J. Khatiwada *, L. Williams * & L. Jaykus n

author keywords: hydrogen peroxide; chlorine dioxide; fogged disinfectant; norovirus inactivation; surface disinfection; public health
TL;DR: Hydrogen peroxide delivered by fog showed promising virucidal activity against FCV by meeting the United States EPA 4-log10 reduction criteria for an anti-noroviral disinfectant; however, fogged chlorine dioxide-surfactant-based product did not achieve a 4- log10 inactivation. (via Semantic Scholar)
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Added: August 6, 2018

2016 journal article

Efficacy of a disinfectant containing silver dihydrogen citrate against GI.6 and GII.4 human norovirus

JOURNAL OF APPLIED MICROBIOLOGY, 122(1), 78–86.

By: C. Manuel n, M. Moore n & L. Jaykus n

author keywords: antimicrobials; disinfection; environmental; food safety; norovirus; viruses
MeSH headings : Capsid Proteins / genetics; Citrates / pharmacology; Disinfectants / pharmacology; Humans; Norovirus / drug effects; Norovirus / genetics; Real-Time Polymerase Chain Reaction; Silver Compounds / pharmacology
TL;DR: This study tested the efficacy of an antimicrobial product containing a blend of silver ions and citric acid (silver dihydrogen citrate; SDC) against GI. (via Semantic Scholar)
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Added: August 6, 2018

2016 journal article

Listeria monocytogenes Isolates Carrying Virulence-Attenuating Mutations in Internalin A Are Commonly Isolated from Ready-to-Eat Food Processing Plant and Retail Environments

JOURNAL OF FOOD PROTECTION, 79(10), 1733–1740.

By: A. Van Stelten*, A. Roberts*, C. Manuel n & K. Nightingale *

author keywords: inlA; Listeria monocytogenes; Mutations; Premature stop codon; Single nucleotide polymorphism; Virulence attenuating
MeSH headings : Bacterial Proteins / genetics; Food Handling; Food Microbiology; Humans; Listeria monocytogenes / genetics; Listeriosis; Mutation; Virulence
TL;DR: A significant proportion of L. monocytogenes isolated from RTE food production and handling environments have reduced virulence, which will be useful in the revision of current and the development of future risk assessments that incorporate strain-specific virulence parameters. (via Semantic Scholar)
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Added: August 6, 2018

2015 journal article

Destruction of the Capsid and Genome of GII.4 Human Norovirus Occurs during Exposure to Metal Alloys Containing Copper

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 81(15), 4940–4946.

By: C. Manuel n, M. Moore n & L. Jaykus n

MeSH headings : Alloys / toxicity; Blotting, Western; Capsid / drug effects; Copper / toxicity; Feces / virology; Genome, Viral / drug effects; Humans; Microscopy, Electron, Transmission; Norovirus / drug effects; Norovirus / physiology; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Virus Attachment / drug effects
TL;DR: It is suggested that copper surfaces destroy HuNoV and may be useful in preventing environmental transmission of the virus in at-risk settings. (via Semantic Scholar)
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Added: August 6, 2018

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