Chao Wang

Works (16)

Updated: April 23rd, 2025 19:47

2019 article

Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells

Chen, Q., Hu, Q., Dukhovlinova, E., Chen, G., Ahn, S., Wang, C., … Gu, Z. (2019, March 27). Advanced Materials.

By: Q. Chen n, Q. Hu n, E. Dukhovlinova *, G. Chen*, S. Ahn*, C. Wang n, E. Ogunnaike  n, F. Ligler n, G. Dotti*, Z. Gu n

author keywords: CAR T cells; cell therapy; drug delivery; immunotherapy; photothermal therapy
MeSH headings : Animals; Antigens / metabolism; Cell Line, Tumor; Chondroitin Sulfate Proteoglycans / metabolism; Combined Modality Therapy; Female; Heterografts; Humans; Hyperthermia, Induced; Immunotherapy, Adoptive / methods; Indocyanine Green / chemistry; Melanoma / pathology; Melanoma / therapy; Membrane Proteins / metabolism; Mice, SCID; Nanoparticles / chemistry; Photosensitizing Agents / chemistry; Phototherapy / methods; Polylactic Acid-Polyglycolic Acid Copolymer / chemistry; Proteoglycans / metabolism; Skin Neoplasms / pathology; Skin Neoplasms / therapy; T-Lymphocytes / metabolism; T-Lymphocytes / transplantation; Tumor Microenvironment
topics (OpenAlex): CAR-T cell therapy research; Immunotherapy and Immune Responses; Nanowire Synthesis and Applications
TL;DR: It is found that the chondroitin sulfate proteoglycan‐4 (CSPG4)‐specific CAR T cells infused in Nod scid gamma mice engrafted with the human melanoma WM115 cell line have superior antitumor activity after photothermal ablation of the tumor. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: July 22, 2019

2017 article

Bioengineering of Artificial Antigen Presenting Cells and Lymphoid Organs

Wang, C., Sun, W., Ye, Y., Bomba, H. N., & Gu, Z. (2017, January 1). Theranostics.

By: C. Wang n, W. Sun n, Y. Ye n, H. Bomba  n & Z. Gu n

author keywords: artificial immune cells; lymphoid organs
MeSH headings : Animals; Antigen-Presenting Cells / immunology; Artificial Cells / chemistry; Artificial Cells / immunology; Biomimetic Materials / chemistry; Humans; Lymphoid Tissue / cytology; Lymphoid Tissue / immunology
topics (OpenAlex): CAR-T cell therapy research; Immunotherapy and Immune Responses; Monoclonal and Polyclonal Antibodies Research
TL;DR: This review surveys the latest studies on engineering biomimetic materials for immunotherapy, focusing on the perspectives of bioengineering artificial antigen presenting cells and lymphoid organs. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2017 article

Drug Delivery: Thrombin‐Responsive Transcutaneous Patch for Auto‐Anticoagulant Regulation (Adv. Mater. 4/2017)

Zhang, Y., Yu, J., Wang, J., Hanne, N. J., Cui, Z., Qian, C., … Gu, Z. (2017, January 1). Advanced Materials, Vol. 29.

By: Y. Zhang n, J. Yu n, J. Wang  n, N. Hanne  n, Z. Cui n, C. Qian  n, C. Wang n, H. Xin n ...

topics (OpenAlex): Neurological disorders and treatments
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2017 article

Red Blood Cells for Glucose‐Responsive Insulin Delivery

Wang, C., Ye, Y., Sun, W., Yu, J., Wang, J., Lawrence, D. S., … Gu, Z. (2017, March 7). Advanced Materials.

By: C. Wang n, Y. Ye n, W. Sun n, J. Yu n, J. Wang n, D. Lawrence *, J. Buse *, Z. Gu n

MeSH headings : Erythrocytes; Glucose; Insulin
topics (OpenAlex): Erythrocyte Function and Pathophysiology; Pancreatic function and diabetes; Lipid Membrane Structure and Behavior
TL;DR: This work is the first demonstration of utilizing RBC membrane to achieve smart insulin delivery with fast responsiveness and the binding is reversible in the setting of hyperglycemia, resulting in fast release of insulin and subsequent drop of BG level in vivo. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 article

Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook

Wang, C., Ye, Y., Hu, Q., Bellotti, A., & Gu, Z. (2017, May 26). Advanced Materials.

By: C. Wang n, Y. Ye n, Q. Hu n, A. Bellotti  n & Z. Gu n

author keywords: biomaterials; cancer immunotherapy; cell therapy; drug delivery
MeSH headings : Animals; Antigen-Presenting Cells / cytology; Antigen-Presenting Cells / metabolism; Antigens / genetics; Antigens / immunology; Antigens / metabolism; Biocompatible Materials / chemistry; Cell- and Tissue-Based Therapy; Humans; Immunologic Factors / metabolism; Immunologic Factors / therapeutic use; Immunotherapy; Nanostructures / chemistry; Neoplasms / therapy
topics (OpenAlex): CAR-T cell therapy research; Immunotherapy and Immune Responses; Nanoplatforms for cancer theranostics
TL;DR: An overview of the latest studies on engineering biomaterials for the enhancement of anticancer immunity is given, including the perspectives of delivery of immunomodulatory therapeutics, engineering immune cells, and constructing immune‐modulating scaffolds. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 article

Inflammation‐Triggered Cancer Immunotherapy by Programmed Delivery of CpG and Anti‐PD1 Antibody

Wang, C., Sun, W., Wright, G., Wang, A. Z., & Gu, Z. (2016, August 25). Advanced Materials.

By: C. Wang n, W. Sun n, G. Wright n, A. Wang  n & Z. Gu n

MeSH headings : Adjuvants, Immunologic; Animals; Antibodies; CpG Islands; Immunotherapy; Inflammation; Mice; Neoplasms / therapy; Programmed Cell Death 1 Receptor / immunology
topics (OpenAlex): Immunotherapy and Immune Responses; RNA Interference and Gene Delivery; Immune Cell Function and Interaction
TL;DR: Inflammation-triggered combination delivery of anti-PD-1 antibody and CpG oligodeoxynucleotides (CpG ODNs) has been demonstrated to prevent cancer relapse utilizing postsurgical inflammatory response. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 article

Internalized compartments encapsulated nanogels for targeted drug delivery

Yu, J., Zhang, Y., Sun, W., Wang, C., Ranson, D., Ye, Y., … Gu, Z. (2016, January 1). Nanoscale.

By: J. Yu n, Y. Zhang n, W. Sun n, C. Wang n, D. Ranson n, Y. Ye n, Y. Weng *, Z. Gu n

MeSH headings : Doxorubicin / administration & dosage; Drug Delivery Systems; Ferrous Compounds; Hyaluronic Acid; Nanoparticles; Silicon Dioxide
topics (OpenAlex): Nanoparticle-Based Drug Delivery; Nanoplatforms for cancer theranostics; Polymer Surface Interaction Studies
TL;DR: This study illustrates the potential of utilizing an internalized compartments encapsulated formulation for targeted cancer therapy, and offers guidelines for developing a natural particulate-inspired drug delivery system. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 article

Investigation and intervention of autophagy to guide cancer treatment with nanogels

Zhang, X., Liang, X., Gu, J., Chang, D., Zhang, J., Chen, Z., … Gu, Z. (2016, November 14). Nanoscale.

By: X. Zhang n, X. Liang *, J. Gu *, D. Chang*, J. Zhang*, Z. Chen n, Y. Ye n, C. Wang n ...

MeSH headings : Animals; Autophagy; Chloroquine / administration & dosage; Doxorubicin / administration & dosage; Drug Delivery Systems; Endocytosis; Endosomes; Exocytosis; Female; Gels; Humans; MCF-7 Cells; Mice; Mice, SCID; Nanoparticles; Neoplasms, Experimental / drug therapy; Rhodamines; Xenograft Model Antitumor Assays; rab GTP-Binding Proteins / metabolism
topics (OpenAlex): Autophagy in Disease and Therapy; Calcium signaling and nucleotide metabolism; Cellular transport and secretion
TL;DR: Investigation and intervention of the autophagy pathway could provide a new method to improve the therapeutic effect of anticancer nanogels and be sequestered in autophagosomes. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 article

Light‐Activated Hypoxia‐Responsive Nanocarriers for Enhanced Anticancer Therapy

Qian, C., Yu, J., Chen, Y., Hu, Q., Xiao, X., Sun, W., … Gu, Z. (2016, March 7). Advanced Materials.

By: C. Qian n, J. Yu n, Y. Chen *, Q. Hu n, X. Xiao*, W. Sun n, C. Wang n, P. Feng *, Q. Shen *, Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Cell Hypoxia; Cell Survival / drug effects; Doxorubicin / chemistry; Doxorubicin / pharmacology; Doxorubicin / therapeutic use; Drug Carriers / chemistry; HeLa Cells; Humans; Hydrogen-Ion Concentration; Light; Mice; Mice, Nude; Microscopy, Confocal; Microscopy, Electron, Transmission; Nanoparticles / chemistry; Neoplasms / diagnostic imaging; Neoplasms / drug therapy; Neoplasms / pathology; Optical Imaging; Polyvinyl Alcohol / chemistry; Singlet Oxygen / chemistry; Singlet Oxygen / metabolism; Transplantation, Heterologous
topics (OpenAlex): Nanoplatforms for cancer theranostics; Luminescence and Fluorescent Materials; Photodynamic Therapy Research Studies
TL;DR: A light-activated hypoxia-responsive conjugated polymer-based nanocarrier is developed for efficiently producing singlet oxygen and inducing hypoxide to promote release of its cargoes in tumor cells, leading to enhanced antitumor efficacy. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 article

Local delivery of checkpoints antibodies

Wang, C., Ye, Y., & Gu, Z. (2016, September 26). Human Vaccines & Immunotherapeutics.

By: C. Wang n, Y. Ye n & Z. Gu n

author keywords: biomaterials; cancer immunotherapy; drug delivery; immune checkpoint inhibitors; microneedle
MeSH headings : Antibodies / administration & dosage; Biomedical Research / trends; Humans; Immunologic Factors / administration & dosage; Immunotherapy / methods; Molecular Targeted Therapy / methods; Neoplasms / immunology; Neoplasms / therapy
topics (OpenAlex): Immunotherapy and Immune Responses; Cancer Immunotherapy and Biomarkers; CAR-T cell therapy research
TL;DR: Recent efforts utilizing immunoengineering for local delivery of these immune checkpoint antibodies are introduced in the field of cancer immunotherapy. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery

Advanced Materials, 28(16), 3115–3121.

By: Y. Ye n, J. Yu n, C. Wang n, N. Nguyen n, G. Walker n, J. Buse *, Z. Gu n

MeSH headings : Animals; Blood Glucose / analysis; Blood Glucose / metabolism; Diabetes Mellitus, Experimental / blood; Diabetes Mellitus, Experimental / metabolism; Diabetes Mellitus, Experimental / pathology; Insulin / metabolism; Insulin Secretion; Islets of Langerhans / metabolism; Mice; Needles; Time Factors
topics (OpenAlex): Advancements in Transdermal Drug Delivery; Lipid Membrane Structure and Behavior; Protein Interaction Studies and Fluorescence Analysis
TL;DR: An innovative microneedle (MN)-based cell therapy is developed for glucose-responsive regulation of the insulin secretion from exogenous pancreatic β-cells without implantation that can quickly reduce the blood-sugar levels of chemically induced type-1 diabetic mice. (via Semantic Scholar)
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Sources: Web Of Science, Crossref
Added: August 6, 2018

2016 article

Synergistic Transcutaneous Immunotherapy Enhances Antitumor Immune Responses through Delivery of Checkpoint Inhibitors

Ye, Y., Wang, J., Hu, Q., Hochu, G. M., Xin, H., Wang, C., & Gu, Z. (2016, September 6). ACS Nano.

By: Y. Ye n, J. Wang n, Q. Hu  n, G. Hochu n, H. Xin n, C. Wang n, Z. Gu n

author keywords: drug delivery; immunotherapy; anti-PD1; IDO; microneedle
MeSH headings : Animals; Cell Cycle Checkpoints / drug effects; Drug Delivery Systems; Immunosuppression Therapy; Immunotherapy / methods; Indoleamine-Pyrrole 2,3,-Dioxygenase / therapeutic use; Melanoma / therapy; Programmed Cell Death 1 Receptor / therapeutic use; Skin Neoplasms / therapy; Tumor Microenvironment
topics (OpenAlex): Immunotherapy and Immune Responses; Advancements in Transdermal Drug Delivery; Cancer Immunotherapy and Biomarkers
TL;DR: This synergistic immunotherapy strategy locally targets the immunoinhibitory receptor programmed cell death protein 1 (PD1) and immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO) for the treatment of melanoma through a microneedle-based transcutaneous delivery approach and achieves potent antitumor efficacy. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 article

Transformable DNA nanocarriers for plasma membrane targeted delivery of cytokine

Sun, W., Ji, W., Hu, Q., Yu, J., Wang, C., Qian, C., … Gu, Z. (2016, April 29). Biomaterials.

By: W. Sun n, W. Ji  n, Q. Hu n, J. Yu n, C. Wang n, C. Qian n, G. Hochu n, Z. Gu n

author keywords: Cancer; Protein delivery; DNA structures; Cytokine; Nanomedicine
MeSH headings : Cell Death / drug effects; Cell Line, Tumor; Cell Membrane / metabolism; Cytokines / administration & dosage; DNA / metabolism; Drug Carriers / chemistry; Drug Delivery Systems; Humans; Hydrodynamics; Liposomes; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Nickel / chemistry; Particle Size; Phosphatidylcholines / chemistry; Phospholipases A2 / metabolism; TNF-Related Apoptosis-Inducing Ligand / pharmacology
topics (OpenAlex): RNA Interference and Gene Delivery; Advanced biosensing and bioanalysis techniques; Dendrimers and Hyperbranched Polymers
TL;DR: A tumor microenvironment-responsive and transformable nanocarrier for cell membrane targeted delivery of cytokine using a phospholipase A2 degradable liposome as a shell and complementary DNA nanostructures decorated with cytokines as the cores is reported. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 article

Anticancer Platelet‐Mimicking Nanovehicles

Hu, Q., Sun, W., Qian, C., Wang, C., Bomba, H. N., & Gu, Z. (2015, September 29). Advanced Materials.

By: Q. Hu n, W. Sun n, C. Qian n, C. Wang n, H. Bomba n & Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / metabolism; Antineoplastic Agents / pharmacology; Biomimetic Materials / chemistry; Blood Platelets / cytology; Cell Line, Tumor; Cell Membrane / chemistry; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers / chemistry; Humans; Intracellular Space / metabolism; Mice; Nanomedicine / methods; Nanostructures / chemistry; TNF-Related Apoptosis-Inducing Ligand / chemistry; TNF-Related Apoptosis-Inducing Ligand / metabolism
topics (OpenAlex): Extracellular vesicles in disease; Nanoparticle-Based Drug Delivery; Nanoplatforms for cancer theranostics
TL;DR: A core-shell nanovehicle coated with a platelet membrane (PM) is developed for targeted and site-specific delivery of an extracellularly active drug and an intracellular functional small-molecular drug, leading to enhanced antitumor efficacy. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 article

Recent advances of cocktail chemotherapy by combination drug delivery systems

Hu, Q., Sun, W., Wang, C., & Gu, Z. (2015, November 6). Advanced Drug Delivery Reviews.

By: Q. Hu n, W. Sun n, C. Wang n & Z. Gu n

author keywords: Chemotherapy; Combination; Cancer; Nanocarriers; Drug delivery
MeSH headings : Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Drug Delivery Systems; Humans; Nanoparticles / administration & dosage; Nanoparticles / therapeutic use; Neoplasms / drug therapy
topics (OpenAlex): Nanoparticle-Based Drug Delivery; Graphene and Nanomaterials Applications; Advanced biosensing and bioanalysis techniques
TL;DR: This review surveys the most recent advances in combination delivery of multiple small molecule chemotherapeutics using nanocarriers and highlights the sequential and site-specific co-delivery strategies, which provide new guidelines for development of programmable combination drug delivery systems. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 article

Transformable liquid-metal nanomedicine

Lu, Y., Hu, Q., Lin, Y., Pacardo, D. B., Wang, C., Sun, W., … Gu, Z. (2015, December 2). Nature Communications, Vol. 6.

By: Y. Lu n, Q. Hu n, Y. Lin n, D. Pacardo n, C. Wang n, W. Sun n, F. Ligler n, M. Dickey n , Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / chemistry; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Drug Carriers / chemistry; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Female; Gallium / chemistry; Humans; Indium / chemistry; Metal Nanoparticles / chemistry; Mice; Mice, Inbred BALB C; Nanomedicine / instrumentation; Nanomedicine / methods; Neoplasms / drug therapy
topics (OpenAlex): Nanoparticle-Based Drug Delivery; Nanoplatforms for cancer theranostics; Nanowire Synthesis and Applications
TL;DR: A transformable liquid-metal nanomedicine, based on a core–shell nanosphere composed of a liquid-phase eutectic gallium-indium core and a thiolated polymeric shell, providing a new strategy for engineering theranostic agents with low toxicity. (via Semantic Scholar)
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Sources: Web Of Science, ORCID
Added: August 6, 2018

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