@article{robichaud_dixon_potturi_cassidy_edwards_sohn_dow_muddiman_2011, title={Design, modeling, fabrication, and evaluation of the air amplifier for improved detection of biomolecules by electrospray ionization mass spectrometry}, volume={300}, ISSN={["1873-2798"]}, DOI={10.1016/j.ijms.2010.04.006}, abstractNote={Through a multi-disciplinary approach, the air amplifier is being evolved as a highly engineered device to improve detection limits of biomolecules when using electrospray ionization. Several key aspects have driven the modifications to the device through experimentation and simulations. We have developed a computer simulation that accurately portrays actual conditions and the results from these simulations are corroborated by the experimental data. These computer simulations can be used to predict outcomes from future designs resulting in a design process that is efficient in terms of financial cost and time. We have fabricated a new device with annular gap control over a range of 50 to 70 μm using piezoelectric actuators. This has enabled us to obtain better aerodynamic performance when compared to the previous design (2× more vacuum) and also more reproducible results. This is allowing us to study a broader experimental space than the previous design which is critical in guiding future directions. This work also presents and explains the principles behind a fractional factorial design of experiments methodology for testing a large number of experimental parameters in an orderly and efficient manner to understand and optimize the critical parameters that lead to obtain improved detection limits while minimizing the number of experiments performed. Preliminary results showed that several folds of improvements could be obtained for certain condition of operations (up to 34 folds).}, number={2-3}, journal={INTERNATIONAL JOURNAL OF MASS SPECTROMETRY}, author={Robichaud, Guillaume and Dixon, R. Brent and Potturi, Amarnatha S. and Cassidy, Dan and Edwards, Jack R. and Sohn, Alex and Dow, Thomas A. and Muddiman, David C.}, year={2011}, month={Mar}, pages={99–107} }
 @article{cassidy_edwards_tian_2009, title={An investigation of interface-sharpening schemes for multi-phase mixture flows}, volume={228}, ISSN={["1090-2716"]}, DOI={10.1016/j.jcp.2009.02.028}, abstractNote={This work evaluates several approaches for sharp phase interface-capturing in computations of multi-phase mixture flows. Attention is focused on algebraic interface-capturing strategies that fit directly within a finite-volume MUSCL-type framework, in which dimension-by-dimension reconstruction of interface states based on extrapolated fluid properties is the norm. In this scope, linear, sine-wave, and tangent hyperbola volume-fraction reconstructions are examined for a range of problems, including advection of a volume-fraction discontinuity, the Rayleigh–Taylor instability, a dam-break problem, an axisymmetric jet instability, the Rayleigh instability, and flow within an aerated-liquid injector. An implicit dual-time stepping approach, applied directly to a preconditioned form of the governing equations, is used for time-advancement. The results show that the sharpening strategies are successful in providing two-to-three-cell capturing of volume-fraction discontinuities.}, number={16}, journal={JOURNAL OF COMPUTATIONAL PHYSICS}, author={Cassidy, Daniel A. and Edwards, Jack R. and Tian, Ming}, year={2009}, month={Sep}, pages={5628–5649} }