Works (52)
Updated: June 3rd, 2024 08:14
2024 journal article
Antioxidant and Anti-Inflammatory Potential of <i>Brassica oleracea</i> Accelerates Third-Degree Burn Healing in Rats
COSMETICS, 11(1).
author keywords: inflammation; oxidative stress; natural compounds; burn wounds
TL;DR:
The ointment based on B. oleracea var.
(via Semantic Scholar)
open access via www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 10, 2024
2024 journal article
Chemopreventive and immunomodulatory effects of phenolic-rich extract of Commiphora leptophloeos against inflammatory bowel disease: Preclinical evidence
JOURNAL OF ETHNOPHARMACOLOGY, 328.
author keywords: Gastrointestinal system; IBD; Inflammatory mediators; Polyphenols; Traditional medicine Southern America
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 28, 2024
2023 journal article
Gel formulated with Bryophyllum pinnatum leaf extract promotes skin wound healing in vivo by increasing VEGF expression: A novel potential active ingredient for pharmaceuticals
FRONTIERS IN PHARMACOLOGY, 13.
author keywords: Crassulaceae; topical gel formulation; wound healing; stability study; analytical marker; phenolic compounds
TL;DR:
The gel formulation containing extract exhibited relevant skin wound healing properties and has the potential to be applied as a novel active ingredient for developing wound healing pharmaceuticals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 20, 2023
2023 article
Phenolic-rich extract of Nopalea cochenillifera attenuates gastric lesions induced in experimental models through inhibiting oxidative stress, modulating inflammatory markers and a cytoprotective effect
Silva, E. C. S., Guerra, G. C. B., Araujo, E. R. D., Schlamb, J., Silva, V. C., Tavares, E. de A., … Zucolotto, S. M. (2023, February 23). FOOD & FUNCTION, Vol. 2.
MeSH headings : Rats; Animals; Plant Extracts / chemistry; Rats, Wistar; Stomach Ulcer / chemically induced; Stomach Ulcer / drug therapy; Stomach Ulcer / pathology; Anti-Ulcer Agents / chemistry; Ethanol / chemistry; Indomethacin / adverse effects; Oxidative Stress; Cactaceae; Models, Theoretical; Gastric Mucosa / metabolism
TL;DR:
The phytochemical profile and gastroprotective activity of phenolic-rich extract of N. cochenillifera shows a cytoprotective effect in the histopathological analysis and stimulated the restoration of the mucus content as observed in the periodic acid-Schiff analysis without modifying the pH, volume or total acidity of the gastric juice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2023
2022 review
Anti-Inflammatory, Antioxidant, and Skin Regenerative Potential of Secondary Metabolites from Plants of the Brassicaceae Family: A Systematic Review of In Vitro and In Vivo Preclinical Evidence (Biological Activities Brassicaceae Skin Diseases)
[Review of ]. ANTIOXIDANTS, 11(7).
author keywords: Brassicaceae; inflammation; murine; epithelial cells; cytokines; inflammatory mediators
TL;DR:
Compounds derived from Brassicaceae present exceptional potential to treat inflammatory skin diseases and accelerate cutaneous wound healing and critical analysis can help to expedite clinical research and to reduce methodological bias, thereby improving the quality of evidence in future research.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 11, 2022
2022 journal article
Brassinosteroids control the inflammation, oxidative stress and cell migration through the control of mitochondrial function on skin regeneration
LIFE SCIENCES, 307.
author keywords: Anti-inflammation; Wound healing; Human dermal fibroblasts; Migration; Gene expression; Mitochondrial function
MeSH headings : Brassinosteroids / metabolism; Brassinosteroids / pharmacology; Cell Movement; Fibroblasts / metabolism; Humans; Inflammation / metabolism; Lipopolysaccharides / pharmacology; Mitochondria / metabolism; Nitric Oxide / metabolism; Oxidative Stress; Plant Growth Regulators / metabolism; Plant Growth Regulators / pharmacology; Reactive Oxygen Species / metabolism; Skin
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 12, 2022
2022 article
Cellular and Molecular Mechanisms of Oxidative Stress in Wound Healing
Goncalves, R. V., Freitas, M. B., & Esposito, D. (2022, June 17). OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, Vol. 2022.
MeSH headings : Oxidative Stress; Wound Healing
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 18, 2022
2022 article
Mechanisms, Biomarkers, and Therapeutics Involved in Inflammatory Disorders and Tissue Repair 2021
Goncalves, R. V., Sarandy, M. M., Esposito, D., & Gouveia Peluzio, M. do C. (2022, March 20). OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, Vol. 2022.
MeSH headings : Biomarkers; Wound Healing
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 30, 2022
2022 journal article
The First Optimization Process from Cultivation to Flavonoid-Rich Extract from Moringa oleifera Lam. Leaves in Brazil
FOODS, 11(10).
author keywords: avonoids; Moringa oleifera; response surface methodology; ultrasound; cultivation; HPLC-ESI-QTRAP-MS/MS
TL;DR:
The results confirmed that it was possible to standardize the flavonoid-rich extract leading to a standardized and reliable raw material extracted from M. oleifera as a final product.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 22, 2022
2020 journal article
Editorial: Cosmeceuticals From Medicinal Plants
Frontiers in Pharmacology.
author keywords: cosmeceutials; medicinal plant; anti-inflammatory; acne (acne vulgaris); skin aging
TL;DR:
This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, as to provide real-time information about the phytochemical properties of manure and its applications in agriculture and animal welfare.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science; OpenAlex)
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(Web of Science)
Source: ORCID
Added: August 4, 2020
2020 journal article
Lily steroidal glycoalkaloid promotes early inflammatory resolution in wounded human fibroblasts
Journal of Ethnopharmacology.
author keywords: Steroidal glycoalkaloid; Lilium longiflorum Thunb.; Scratch migration assay; Gene expression; Easter lily; Human dermal fibroblast cells
MeSH headings : Alkaloids / isolation & purification; Alkaloids / pharmacology; Cell Movement / drug effects; Cells, Cultured; Chromatography, Liquid; Fibroblasts / drug effects; Fibroblasts / pathology; Flowers; Gene Expression Regulation / drug effects; Glycosides / isolation & purification; Glycosides / pharmacology; Humans; Inflammation / drug therapy; Inflammation / pathology; Lilium / chemistry; Plant Roots; Wound Healing / drug effects
TL;DR:
It is demonstrated that a glycoalkaloid present in lilies promoted fibroblast migration in vitro and affected inflammatory, remodeling and growth factor gene expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: April 11, 2020
2020 journal article
Phenolic content, anti-inflammatory properties, and dermal wound repair properties of industrially processed and non-processed acai from the Brazilian Amazon
Food & Function, 11(6), 4903–4914.
Contributors: J. Xiong n , F. Matta *, M. Grace n , M. Lila n , N. Ward *, M. Felipe-Sotelo *, n
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Arecaceae; Brazil; Food Industry; Fruit; Humans; Mice; Phytotherapy; Plant Extracts / chemistry; Plant Extracts / pharmacology; Polyphenols / chemistry; RAW 264.7 Cells / drug effects; Wound Healing / drug effects
TL;DR:
The anti-inflammatory effect was diminished but wound healing effect was retained after pulp processing, suggesting the processing technology needs to be improved to maintain biological properties of acai fruit.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: June 5, 2020
2020 journal article
What Is the Impact of Depletion of Immunoregulatory Genes on Wound Healing? A Systematic Review of Preclinical Evidence
Oxidative Medicine and Cellular Longevity, 2020, 1–19.
Ed(s): S. Bekeschus
MeSH headings : Animals; Disease Models, Animal; Gene Expression Regulation; Humans; Immunomodulation / genetics; Skin / metabolism; Wound Healing
TL;DR:
Most gene depletions delayed wound healing, negatively influenced the concentrations of proinflammatory cytokines, and consequently promoted a decrease of inflammatory cell infiltration, angiogenesis, and collagen deposition, compromising the formation of granulation tissue.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: December 9, 2020
2019 journal article
Alaskan Berry Extracts Promote Dermal Wound Repair Through Modulation of Bioenergetics and Integrin Signaling
FRONTIERS IN PHARMACOLOGY, 10(SEP).
Contributors: n , J. Overall n , M. Grace n , S. Komarnytsky n & M. Lila n
author keywords: skin regeneration; wound healing; Alaskan berries; integrins; proanthocyanidins; epicatechins
TL;DR:
Targeting cellular bioenergetics and integrin-mediated cell–ECM signaling with bioactives from Alaskan wild berries shows considerable therapeutic promise to treat chronic skin wounds and inflammatory skin disorders, as well as more generally to support regenerative healing responses and restore function in a variety of tissue and organ settings after injury or aging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 14, 2019
2019 journal article
Changes in the bioactive properties of strawberries caused by the storage in oxygen- and carbon dioxide-enriched atmospheres
FOOD SCIENCE & NUTRITION, 7(8), 2527–2536.
Contributors: F. Velde *, n , J. Overall n , M. Méndez-Galarraga*, M. Grace n , M. Élida Pirovani *, M. Lila n
author keywords: 2; 2-diphenyl-1-picrylhydrazil; cyclooxygenase-2; ferric reducing antioxidant power; human dermal fibroblast migration; interleukin-6; modified atmosphere storage
TL;DR:
Evidence suggests that strawberry storage in 90% O2 + 10% CO2 can be a promissory alternative to offer fruits with enhanced bioactivity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 5, 2019
2019 journal article
Dietary arachidonate in milk replacer triggers dual benefits of PGE2 signaling in LPS-challenged piglet alveolar macrophages
Journal of Animal Science and Biotechnology, 10(1).
Contributors: K. Walter n, X. Lin n, S. Jacobi*, T. Käser n, n & J. Odle n
author keywords: Arachidonic acid; Cyclooxygenase; Eicosanoid; Eicosapentaenoic acid; Inflammation; Lipid mediator class switch; LPS; Lipoxin; Porcine alveolar macrophage
TL;DR:
It is inferred that enriching diets with arachidonic acid may be an effective means to enhance a stronger innate immunologic response to respiratory challenges in neonatal pigs, but further work is needed to examine long-term safety, clinical efficacy and economic viability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: April 20, 2020
2018 journal article
Anti-inflammatory and wound healing properties of polyphenolic extracts from strawberry and blackberry fruits
FOOD RESEARCH INTERNATIONAL, 121, 453–462.
Contributors: F. Velde *, n , M. Grace n , M. Pirovani * & M. Lila n
author keywords: Fragaria ananassa; Rubus fruticosus; Anthocyanins; Proanthocyanidins; Cyclooxygenase-2; Interleukin-6; Skin cell migration
MeSH headings : Animals; Anthocyanins / analysis; Anthocyanins / pharmacology; Anti-Inflammatory Agents / analysis; Anti-Inflammatory Agents / pharmacology; Antioxidants / analysis; Antioxidants / pharmacology; Cell Movement / drug effects; Cell Proliferation / drug effects; Cell Survival / drug effects; Chromatography, High Pressure Liquid; Fragaria / chemistry; Fruit / chemistry; Mice; Phytochemicals / analysis; Phytochemicals / pharmacology; Plant Extracts / analysis; Plant Extracts / pharmacology; Polyphenols / analysis; Polyphenols / pharmacology; Proanthocyanidins / analysis; Proanthocyanidins / pharmacology; RAW 264.7 Cells; Reactive Oxygen Species / metabolism; Rubus / chemistry; Wound Healing / drug effects
TL;DR:
Results obtained in this work highlight the anti-inflammatory properties of berry polyphenolics, especially due to proanthocyanidins, and promising results were obtained about the effects of bberry anthocyanins on wound healing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 24, 2019
2018 journal article
Blueberry polyphenol-protein food ingredients: The impact of spray drying on the in vitro antioxidant activity, anti-inflammatory markers, glucose metabolism and fibroblast migration
Food Chemistry, 280, 187–194.
Contributors: R. Hoskin n, J. Xiong n , n & M. Lila n
author keywords: Berries; By-products; Drying; Inflammation; Phytochemicals
MeSH headings : Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Blueberry Plants / chemistry; Blueberry Plants / metabolism; Cell Line; Cell Movement / drug effects; Cell Survival / drug effects; Cyclooxygenase 2 / metabolism; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Freeze Drying; Glucose / metabolism; Interleukin-1beta / metabolism; Macrophages / cytology; Macrophages / drug effects; Macrophages / metabolism; Mice; Plant Proteins / chemistry; Plant Proteins / pharmacology; Polyphenols / chemistry; Polyphenols / pharmacology; Protein Aggregates; RAW 264.7 Cells; Rats; Reactive Oxygen Species / metabolism
TL;DR:
The data suggests that spray drying is a convenient and cost-effective technique to produce blueberry-polyphenol food ingredients with preserved phytochemicals with biological activities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: January 28, 2019
2018 journal article
Metabolic recovery from heavy exertion following banana compared to sugar beverage or water only ingestion: A randomized, crossover trial
PLoS One, 13(3).
MeSH headings : Adult; Beverages; Bicycling / physiology; Cross-Over Studies; Dietary Carbohydrates / administration & dosage; Drinking Behavior / physiology; Eating / physiology; Exercise / physiology; Female; Humans; Male; Middle Aged; Musa; Physical Exertion / drug effects; Physical Exertion / physiology; Recovery of Function / drug effects; Water / administration & dosage; Young Adult
TL;DR:
CHO ingestion from bananas or a sugar beverage had a comparable influence in attenuating metabolic perturbation and inflammation following 75-km cycling.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2018 journal article
Simultaneous LC-MS quantification of anthocyanins and non-anthocyanin phenolics from blueberries with widely divergent profiles and biological activities
Food Chemistry, 277, 336–346.
Contributors: M. Grace n , J. Xiong n , n , M. Ehlenfeldt * & M. Lila n
author keywords: Pink-fruited; Blueberries; LC-IT-TOF-MS; Quantification; Antioxidant; Anti-inflammatory; PCA
MeSH headings : Animals; Anthocyanins / analysis; Anthocyanins / pharmacology; Anti-Inflammatory Agents / analysis; Anti-Inflammatory Agents / pharmacology; Antioxidants / analysis; Antioxidants / pharmacology; Biological Assay; Blueberry Plants / chemistry; Cell Survival / drug effects; Chromatography, Liquid; Color; Flavonoids / analysis; Flavonoids / pharmacology; Flavonols / analysis; Flavonols / pharmacology; Fruit / chemistry; Hydroxybenzoates / analysis; Hydroxybenzoates / pharmacology; Limit of Detection; Mass Spectrometry; Mice; Nitric Oxide / metabolism; Phenols / analysis; Phenols / pharmacology; Plant Extracts / analysis; Plant Extracts / pharmacology; RAW 264.7 Cells; Reactive Oxygen Species / metabolism; Reproducibility of Results; Resveratrol / analysis; Resveratrol / pharmacology
TL;DR:
A sensitive and straightforward LC-IT-TOF-MS method was validated for the profiling and simultaneous quantification of anthocyanins, flavan-3-ols, flavonols, phenolic acids, and resveratrol in blueberry genotypes with fruit color ranging from deep purple to various shades of pink.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: December 17, 2018
2017 journal article
Berries containing anthocyanins with enhanced methylation profiles are more effective at ameliorating high fat diet-induced metabolic damage
FOOD AND CHEMICAL TOXICOLOGY, 111, 445–453.
author keywords: Bioactive food components; Polyphenols; Obesity; Diabetes; Bioenergetics; Functional food
MeSH headings : Animal Feed; Animals; Anthocyanins / chemistry; Diet; Diet, High-Fat / adverse effects; Energy Metabolism; Fruit / chemistry; Lipid Metabolism; Male; Metabolic Diseases; Methylation; Mice; Mice, Inbred C57BL; Rubus / chemistry
TL;DR:
It is shown that consumption of berries containing anthocyanins with enhanced methylation profiles (malvidin and petunidin) is more effective at reducing high fat diet-induced metabolic damage in the C57BL/6 mouse model of polygenic obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
Dietary long-chain PUFAs enrich porcine alveolar macrophages and alter Prostaglandin E-2 Production Following LPS Challenge
FASEB Journal, 31.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Health modifying regions in the oat (Avena sativa) genome responsible for beneficial effects on immune and gastrointestinal health
FASEB Journal, 31.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Metabolic Effects of Berries with Structurally Diverse Anthocyanins
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(2).
Contributors: J. Overall n , S. Bonney n, M. Wilson n, A. Beermann n, M. Grace n , n , M. Lila n , S. Komarnytsky n
author keywords: berry; gut microbiome; obesity; inflammation; functional food
MeSH headings : Animal Feed; Animals; Anthocyanins / chemistry; Anthocyanins / metabolism; Body Composition; Body Weight; Chromatography, High Pressure Liquid; Dietary Supplements; Feces / chemistry; Fruit / metabolism; Gastrointestinal Microbiome; Glucose / metabolism; Humans; Insulin Resistance; Mice; Molecular Structure; Oxygen Consumption
TL;DR:
Examination of effects of six berries with structurally diverse anthocyanin profiles on development of metabolic risk factors in the C57BL/6 mouse model of polygenic obesity showed a prominent discrepancy between biological activities of delphinidin/malvidin-versus cyanidin-type anthocianins that could be explained by differences in their structure and metabolism in the gut.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
Polyphenols isolated from Acacia mearnsii bark with anti-inflammatory and carbolytic enzyme inhibitory activities
Chinese Journal of Natural Medicines, 15(11), 816–824.
Contributors: J. Xiong n , M. Grace n , n , S. Komarnytsky n , F. Wang * & M. Lila n
author keywords: Acacia mearnsii; Proanthocyanidins; Anti-inflammatory; alpha-Amylase; alpha-Glucosidase
MeSH headings : Acacia / chemistry; Animals; Anti-Inflammatory Agents / isolation & purification; Anti-Inflammatory Agents / pharmacology; Carbohydrate Metabolism / drug effects; Glycoside Hydrolase Inhibitors / pharmacology; Inflammation / metabolism; Interleukin-1beta / metabolism; Lipopolysaccharides; Macrophages / drug effects; Mice; Nitric Oxide / metabolism; Nitric Oxide Synthase Type II / metabolism; Plant Bark / chemistry; Plant Extracts / chemistry; Plant Extracts / pharmacology; Polyphenols / isolation & purification; Polyphenols / pharmacology; Proanthocyanidins / pharmacology; RAW 264.7 Cells; alpha-Amylases / antagonists & inhibitors; alpha-Glucosidases / metabolism
TL;DR:
Polyphenols isolated from Acacia mearnsii bark crude extract and fractions obtained by high-speed counter-current chromatography and evaluated their anti-inflammatory and carbolytic enzymes (α-glucosidase and α-amylase) inhibitory activities showed significant activities against reactive oxygen species, nitric oxide production, and expression of pro-inflammatory genes interleukin-1β.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2017 journal article
Structural constraints and importance of caffeic acid moiety for anti-hyperglycemic effects of caffeoylquinic acids from chicory
MOLECULAR NUTRITION & FOOD RESEARCH, 61(9).
Contributors: K. Jackson n, T. Rathinasabapathy , n & S. Komarnytsky n
author keywords: Blood glucose; Cell bioenergetics; Diabetes; Dietary supplementation; Metabolic syndrome
MeSH headings : Animals; Cell Line, Tumor; Chicory / chemistry; Gluconeogenesis / drug effects; Hypoglycemic Agents / pharmacology; MAP Kinase Signaling System; Pharmacogenetics; Phosphatidylinositol 3-Kinases / physiology; Plant Roots / chemistry; Quinic Acid / analogs & derivatives; Quinic Acid / pharmacology; Rats; Structure-Activity Relationship
TL;DR:
It is concluded that the caffeic acid moiety was important for suppression of hepatic gluconeogenesis and hyperglycemia, ultimately strengthening the link between dietary interventions based on caffeic Acid-containing plant foods and healthy glucose metabolism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
Thiazolopyridines Improve Adipocyte Function by Inhibiting 11 Beta-HSD1 Oxoreductase Activity
Journal of Chemistry, 2017, 1–10.
Contributors: T. Rathinasabapathy , K. Palatini Jackson, Y. Thor n, A. Buru *, n , X. Li n , M. Pichika *, A. Hamzah *, S. Komarnytsky n
TL;DR:
The tetrahydrothiazolopyridine moiety served as an active pharmacophore for inhibiting 11β-HSD1 and offered a novel therapeutic strategy to ameliorate metabolic alterations found in obesity and diabetes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2017 journal article
Wild blueberry polyphenol-protein food ingredients produced by three drying methods: Comparative physico-chemical properties, phytochemical content, and stability during storage
FOOD CHEMISTRY, 235, 76–85.
author keywords: Soy protein isolate; By-products; Spray drying; Phenolics; Shelf life
MeSH headings : Anthocyanins / analysis; Antioxidants; Blueberry Plants / chemistry; Desiccation / methods; Food Handling / methods; Freeze Drying; Phytochemicals; Polyphenols
TL;DR:
Overall, spray drying the blueberry extracts complexed with protein proved to be an environment-friendly strategy to produce stable functional ingredients with multiple applications for the food industry.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2016 journal article
Chemical composition, antioxidant and anti-inflammatory properties of pistachio hull extracts
Food Chemistry, 210, 85–95.
Contributors: M. Grace n , n , M. Timmers n, J. Xiong n , G. Yousef n, S. Komarnytsky n , M. Lila n
author keywords: Anacardic acids; Triterpene acids; Carotenoids; Tocopherols; Polyphenols; Anti-inflammatory
MeSH headings : Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / isolation & purification; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Antioxidants / isolation & purification; Antioxidants / pharmacology; Cell Line; Dose-Response Relationship, Drug; Macrophages / drug effects; Macrophages / metabolism; Mice; Pistacia; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Plant Extracts / pharmacology; Reactive Oxygen Species / antagonists & inhibitors; Reactive Oxygen Species / metabolism
TL;DR:
The P extract significantly decreased the non-mitochondrial oxidative burst associated with inflammatory response in macrophages and significantly inhibited the release of nitric oxide and reactive oxygen species in lipopolysaccharide-stimulated RAW 264.7 macrophage cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2016 journal article
Formation of whey protein–polyphenol meso-structures as a natural means of creating functional particles
Food & Function, 7(3), 1306–1318.
MeSH headings : Fruit / chemistry; Hydrogen-Ion Concentration; Particle Size; Plant Extracts / chemistry; Polyphenols / chemistry; Ribes / chemistry; Vaccinium macrocarpon / chemistry; Vitis / chemistry; Whey Proteins / chemistry
TL;DR:
Particles improved foam stability, and the anti-inflammatory properties of entrapped polyphenols were maintained in the particles, suggesting highly functional protein-polyphenol particles can be designed to stabilize food structures and simultaneously deliver polyphenol associated with health benefits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018
2016 journal article
In vitro lipolytic, antioxidant and anti-inflammatory activities of roasted pistachio kernel and skin constituents
Food & Function, 7(10), 4285–4298.
Contributors: M. Grace n , n , M. Timmers n, J. Xiong n , G. Yousef n, S. Komarnytsky n , M. Lila n
MeSH headings : Animals; Antioxidants; Cell Survival / drug effects; Cooking; Macrophages / drug effects; Macrophages / metabolism; Mice; Phytochemicals; Pistacia / chemistry; RAW 264.7 Cells; Reactive Oxygen Species; Respiratory Burst; Seeds / chemistry
TL;DR:
The SNP had the strongest effect in decreasing non-mitochondrial oxidative burst associated with inflammatory response in macrophages, and was the most potent to inhibit the expression of COX2.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2016 journal article
Phytochemical Characterization and Anti-inflammatory Properties of Acacia mearnsii Leaves
Natural Product Communications, 11(5), 649–653.
TL;DR:
Results indicate that A. mearnsii leaves, a forest waste product, could be a valuable natural source of anti-inflammatory and functional components related to human health.
(via Semantic Scholar)
Sources: ORCID, NC State University Libraries
Added: July 9, 2020
2016 journal article
Phytochemical characterization and anti-inflammatory properties of Acacia mearnsii leaves
Natural Product Communications, 11(5), 649–653.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Quantitative comparison of phytochemical profile, antioxidant, and anti-inflammatory properties of blackberry fruits adapted to Argentina
JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 47, 82–91.
Contributors: F. Velde *, M. Grace n , n , M. Pirovani * & M. Lila n
author keywords: Bubo fruticosus; Polyphenols content; Vitamin C; Cyanidin-3-O-glucoside; Proanthocyanidins; Reactive oxygen species; Cyclooxygenase-2; Interleukin-6; Food analysis; Food composition
TL;DR:
The potential of blackberries cultivars ‘Black Satin’ and ‘Jumbo’ to contribute to a healthy diet, based on their higher polyphenol content, providing higher antioxidant and anti-inflammatory properties is suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Alaskan seaweeds lower inflammation in RAW 264.7 macrophages and decrease lipid accumulation in 3T3-L1 adipocytes
JOURNAL OF FUNCTIONAL FOODS, 15, 396–407.
Contributors: J. Kellogg n, n , M. Grace n , S. Komarnytsky n & M. Lila n
author keywords: Seaweed; Phlorotannin; Monoglycosyldiacylglycerol; Inflammation; Insulin resistance; Fucus distichus
TL;DR:
Overall, the Alaskan seaweed F. distichus inhibited proinflammatory responses and improved lipid metabolism, suggesting the potential for seaweed phytochemicals to attenuate inflammatory diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Black Currant Anthocyanins Attenuate Weight Gain and Improve Glucose Metabolism in Diet-Induced Obese Mice with Intact, but Not Disrupted, Gut Microbiome
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63(27), 6172–6180.
Contributors: n , T. Damsud n, M. Wilson n, M. Grace n , R. Strauch n, X. Li n , M. Lila n , S. Komarnytsky n
author keywords: gastrointestinal tract; gut microbiome; obesity; inflammation; functional food
MeSH headings : Animals; Anthocyanins / administration & dosage; Anthocyanins / chemistry; Fruit / chemistry; Gastrointestinal Microbiome / drug effects; Glucose / metabolism; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity / drug therapy; Obesity / metabolism; Obesity / microbiology; Obesity / physiopathology; Plant Extracts / administration & dosage; Plant Extracts / chemistry; Ribes / chemistry; Weight Gain / drug effects
TL;DR:
The data clearly demonstrate that gut microbiome and the type of the anthocyanin aglycone moiety can alter the protective effect of Anthocyanins against obesity and associated insulin resistance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Characterization of Phenolic Compounds and Antioxidant and Antiinflammatory Activities from Mamuyo (Styrax ramirezii Greenm.) Fruit
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63(48), 10459–10465.
Contributors: M. Timmers n, J. Guerrero-Medina n, n , M. Grace n , O. Paredes-López *, P. García-Saucedo*, M. Lila n
author keywords: LC-TOF-MS; Styrax ramirezii; antioxidant activity; anti-inflammatory activity; norneolignan
MeSH headings : Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Antioxidants / pharmacology; Cyclooxygenase 2 / immunology; Fruit / chemistry; Humans; Interleukin-1beta / immunology; Nitric Oxide / immunology; Nitric Oxide Synthase Type II / immunology; Nitric Oxide Synthase Type II / metabolism; Phenols / chemistry; Phenols / pharmacology; Plant Extracts / chemistry; Plant Extracts / pharmacology; Reactive Oxygen Species / metabolism; Styrax / chemistry
TL;DR:
Egonol potently inhibited the production of NO and also significantly reduced the release of ROS, suggesting the potential of S. ramirezii Greenm.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Hepatoprotective Activity of Easter Lily (Lilium longiflorum Thunb.) Bulb Extracts
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63(44), 9722–9728.
author keywords: Lilium longiflorum Thunb; Easter lily; steroidal glycoside; hepatoprotective activity; hypoglycemic activity
MeSH headings : Animals; Cholesterol; Diabetes Mellitus, Type 2 / drug therapy; Diabetes Mellitus, Type 2 / metabolism; Female; Flowers / chemistry; Humans; Lilium / chemistry; Liver / drug effects; Liver / metabolism; Mice; Mice, Inbred C57BL; Molecular Structure; Plant Extracts / administration & dosage; Plant Extracts / chemistry; Protective Agents / administration & dosage; Protective Agents / chemistry
TL;DR:
The data suggest that steroidal glycosides 1-5 might play a role in the hepatoprotective activity of the BuOH extracts, while the results of the TC measurements and OGTT study indicate that other constituents present in the CB extract are responsible for its hypocholesterolemic and hypoglycemic activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Method to harness bioactive secondary metabolites from intact Quinoa seeds with implications for chronic disease prevention
Planta Medica, 81(11).
Sources: Crossref, NC State University Libraries
Added: February 21, 2020
2014 journal article
1,25-Dihydroxyvitamin D-3/vitamin D receptor suppresses brown adipocyte differentiation and mitochondrial respiration
EUROPEAN JOURNAL OF NUTRITION, 54(6), 1001–1012.
author keywords: Vitamin D receptor; Brown adipocyte; UCP1; Mitochondrial respiration
MeSH headings : 25-Hydroxyvitamin D3 1-alpha-Hydroxylase / genetics; Adipocytes, Brown / physiology; Adipocytes, Brown / ultrastructure; Animals; Calcitriol / pharmacology; Calcitriol / physiology; Cell Differentiation / physiology; Energy Metabolism; Gene Expression; Ion Channels / genetics; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Mitochondria / metabolism; Mitochondrial Proteins / genetics; Obesity / metabolism; Oxygen Consumption / physiology; PPAR gamma / metabolism; RNA, Messenger / analysis; Receptors, Calcitriol / deficiency; Receptors, Calcitriol / genetics; Receptors, Calcitriol / physiology; Signal Transduction; Uncoupling Protein 1; Vitamin D3 24-Hydroxylase / genetics
TL;DR:
The results demonstrate the suppressive effects of 1,25(OH)2D3/VDR signaling on brown adipocyte differentiation and mitochondrial respiration and the role of the vitamin D system in regulating BAT development and function in obesity warrant further investigation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Activation of pattern recognition receptors in brown adipocytes induces inflammation and suppresses uncoupling protein 1 expression and mitochondrial respiration
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 306(10), C918–C930.
author keywords: brown adipose tissue; brown adipocytes; UCP-1; pattern recognition receptor; inflammation
MeSH headings : Adipocytes / drug effects; Adipocytes / metabolism; Adipocytes / pathology; Adipose Tissue, Brown / drug effects; Adipose Tissue, Brown / metabolism; Adipose Tissue, Brown / pathology; Animals; Cell Line; Cytokines / genetics; Cytokines / metabolism; Diet, High-Fat; Electron Transport / drug effects; Gene Expression Regulation; Inflammation / genetics; Inflammation / metabolism; Inflammation / pathology; Ion Channels / genetics; Ion Channels / metabolism; Isoproterenol / pharmacology; Male; Mice; Mitochondria / drug effects; Mitochondria / metabolism; Mitochondrial Proteins / genetics; Mitochondrial Proteins / metabolism; Mitogen-Activated Protein Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; NF-kappa B / genetics; NF-kappa B / metabolism; Nod1 Signaling Adaptor Protein / genetics; Nod1 Signaling Adaptor Protein / metabolism; Nod2 Signaling Adaptor Protein / genetics; Nod2 Signaling Adaptor Protein / metabolism; Obesity / genetics; Obesity / metabolism; Obesity / pathology; Promoter Regions, Genetic; RNA, Messenger / genetics; RNA, Messenger / metabolism; Signal Transduction; Toll-Like Receptor 2 / genetics; Toll-Like Receptor 2 / metabolism; Toll-Like Receptor 4 / genetics; Toll-Like Receptor 4 / metabolism; Uncoupling Protein 1
TL;DR:
The role of selected PRR activation in inducing inflammation and downregulation of UCP-1 expression and mitochondrial respiration in brown adipocytes is demonstrated and novel targets in BAT are uncovered for obesity treatment and prevention.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Bioactive Capacity, Sensory Properties, and Nutritional Analysis of a Shelf Stable Protein-rich Functional Ingredient with Concentrated Fruit and Vegetable Phytoactives
PLANT FOODS FOR HUMAN NUTRITION, 69(4), 372–378.
Contributors: M. Grace n , G. Yousef n, n , I. Raskin * & M. Lila n
author keywords: Muscadine; Kale; Protein isolate; Inflammatory biomarkers
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Anti-Inflammatory Agents / therapeutic use; Brassica / chemistry; Cannabis; Carotenoids / pharmacology; Carotenoids / therapeutic use; Chemokine CCL2 / metabolism; Diet; Dietary Proteins / analysis; Fruit / chemistry; Functional Food / analysis; Glucosinolates / pharmacokinetics; Glucosinolates / pharmacology; Humans; Inflammation / drug therapy; Inflammation / metabolism; Interleukin-6 / metabolism; Mice; Nutritive Value; Plant Preparations / pharmacology; Plant Preparations / therapeutic use; Polyphenols / pharmacology; Polyphenols / therapeutic use; Soybean Proteins; Taste; Vegetables / chemistry; Vitis / chemistry
TL;DR:
Proximate analyses determined that fortification of the soy protein isolate with muscadine or kale bioactives resulted in elevated dietary fibers, total carbohydrates, and free sugars, but did not increase calories/100 g dry matrix compared to unfortified SPI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Compounds leached from quinoa seeds inhibit matrix metalloproteinase activity and intracellular reactive oxygen species
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, 37(2), 212–221.
author keywords: ageing; cell culture; chemical analysis; oxidative damage; phytochemistry; phytoecdysteroid
MeSH headings : Cells, Cultured; Chenopodium quinoa / embryology; Chromatography, Liquid; Humans; Mass Spectrometry; Matrix Metalloproteinase 1 / drug effects; Matrix Metalloproteinase 1 / genetics; Monophenol Monooxygenase / antagonists & inhibitors; Protease Inhibitors / pharmacology; Reactive Oxygen Species / metabolism; Seeds / chemistry
TL;DR:
This work aimed to determine the effect of QL and its chemically distinct fractions on five biochemical endpoints relevant to skin care applications: cell viability, matrix metalloproteinase (MMP) mRNA expression, MMP enzymatic activity, tyrosinase enzymatics activity and intracellular reactive oxygen species (ROS) production.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Cytotoxic Effects of Ellagitannins Isolated from Walnuts in Human Cancer Cells
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 66(8), 1304–1314.
MeSH headings : 3T3 Cells; Animals; Apoptosis / drug effects; Cell Line, Tumor; Cyclin B1 / metabolism; Cytochromes c / metabolism; Diet; HeLa Cells; Humans; Hydrogen-Ion Concentration; Hydrolyzable Tannins / pharmacology; Juglans / chemistry; MCF-7 Cells; Mice; Mice, Nude; Mitochondria / drug effects; Nuts / chemistry; Plant Extracts / pharmacology
TL;DR:
The results suggest impairment of mitochondrial function and apoptosis as relevant mechanism of anticancer effects of the walnut extract as well as antimitogenic effects of walnuts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Inhibitory Effects of Wild Blueberry Anthocyanins and Other Flavonoids on Biomarkers of Acute and Chronic Inflammation in Vitro
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62(29), 7022–7028.
Contributors: n , A. Chen n, M. Grace n , S. Komarnytsky n & M. Lila n
author keywords: Vaccinium angustifolium; lowbush blueberry; polyphenols; proanthocyanidins; chlorogenic acid
MeSH headings : Acute Disease; Animals; Anthocyanins / pharmacology; Base Sequence; Biomarkers / metabolism; Blueberry Plants / chemistry; Cell Line; Chromatography, High Pressure Liquid; Chronic Disease; DNA Primers; In Vitro Techniques; Inflammation / metabolism; Macrophages / drug effects; Macrophages / metabolism; Mice; Polymerase Chain Reaction
TL;DR:
Among major polyphenols found in the wild blueberries, malvidin-3-glucoside was significantly more effective than epicatechin or chlorogenic acid in reducing the expression of pro-inflammatory genes in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 journal article
Comparative Analysis of Phenolic Content and Profile, Antioxidant Capacity, and Anti-inflammatory Bioactivity in Wild Alaskan and Commercial Vaccinium Berries
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62(18), 4007–4017.
Contributors: M. Grace n , n , K. Dunlap * & M. Lila n
author keywords: Vaccinium vitis-idaea; V. uliginosum; V. macrocarpon; V. angustifolium; phenolics; antioxidant; anti-inflammatory
MeSH headings : Alaska; Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Antioxidants / pharmacology; Chromatography, High Pressure Liquid; Fruit / chemistry; Macrophages / drug effects; Macrophages / immunology; Mass Spectrometry; Mice; Phenols / chemistry; Plant Extracts / chemistry; Plant Extracts / pharmacology; Vaccinium / chemistry
TL;DR:
A polyphenol-rich fraction from lowbush cranberry exhibited dose-dependent inhibition of LPS-elicited induction of IL-1β in RAW 2647 cells, indicative of strong anti-inflammatory activity, corroborate the historic use of wild Alaskan berries as medicinally important foods in Alaska Native communities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 journal article
Effects of Pregnane Glycosides on Food Intake Depend on Stimulation of the Melanocortin Pathway and BDNF in an Animal Model
Journal of Agricultural and Food Chemistry, 61(8), 1841–1849.
Contributors: S. Komarnytsky n , n , T. Rathinasabapathy , A. Poulev * & I. Raskin *
author keywords: appetite; satiety; body weight; milkweed; Asclepias
MeSH headings : Animals; Appetite / drug effects; Asclepias / chemistry; Brain-Derived Neurotrophic Factor / genetics; Brain-Derived Neurotrophic Factor / metabolism; Cell Line, Tumor; Eating / drug effects; Female; Glycosides / administration & dosage; Humans; Male; Melanocortins / metabolism; Models, Animal; Plant Extracts / administration & dosage; Pregnanes / administration & dosage; Rats; Rats, Wistar
TL;DR:
The results support the multimodal effects of pregnane glycosides on feeding regulation, which depends on the activity of the melanocortin signaling pathway and BDNF.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
Steroidal glycosides from the bulbs of Easter lily (Lilium longiflorum Thunb.) promote dermal fibroblast migration in vitro
JOURNAL OF ETHNOPHARMACOLOGY, 148(2), 433–440.
author keywords: Lilium longiflorum Thunb.; Steroidal glycoside; Furostanol saponin; Transforming growth factor beta; Nitric oxide; Wound healing
MeSH headings : 3T3 Cells; Animals; Carbohydrate Sequence; Cell Movement / drug effects; Cell Proliferation / drug effects; Cells, Cultured; Dermis / cytology; Dermis / drug effects; Dermis / metabolism; Ethnopharmacology / methods; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Glycosides / chemistry; Glycosides / pharmacology; Human Umbilical Vein Endothelial Cells; Humans; Lilium / chemistry; Mice; Molecular Sequence Data; Nitric Oxide / metabolism; Plant Extracts / chemistry; Plant Extracts / pharmacology; Plant Roots / chemistry; Skin / cytology; Skin / drug effects; Skin / metabolism; Steroids / chemistry; Steroids / pharmacology; Transforming Growth Factor beta / metabolism; Wound Healing / drug effects
TL;DR:
This is the first evidence that steroidal glycosides from Lilium longiflorum may potentially play a role in the wound healing process and may provide a scientific basis for the historical use of lily bulbs for this purpose.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
Modulation of muscle mass and myogenic stem cells with natural products
Planta Medica, 78(11).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: February 5, 2020
2012 conference paper
Modulation of muscle mass and myogenic stem cells with natural products
Planta Medica, 78(11), 1096–1096.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Pregnane glycosides interfere with steroidogenic enzymes to down-regulate corticosteroid production in human adrenocortical H295R cells
JOURNAL OF CELLULAR PHYSIOLOGY, 228(5), 1120–1126.
MeSH headings : 3-Hydroxysteroid Dehydrogenases / antagonists & inhibitors; 3-Hydroxysteroid Dehydrogenases / biosynthesis; Adrenal Cortex Hormones / metabolism; Androstenedione / analogs & derivatives; Animals; Cell Line, Tumor; Cholesterol Side-Chain Cleavage Enzyme / antagonists & inhibitors; Cholesterol Side-Chain Cleavage Enzyme / biosynthesis; Corticosterone / biosynthesis; Corticosterone / metabolism; Cortisone / metabolism; Glycosides / administration & dosage; Humans; Pregnanes / administration & dosage; Progesterone / analogs & derivatives; Progesterone / biosynthesis; Steroid 11-beta-Hydroxylase / antagonists & inhibitors; Steroid 11-beta-Hydroxylase / biosynthesis; Steroid 17-alpha-Hydroxylase / antagonists & inhibitors; Steroid 17-alpha-Hydroxylase / biosynthesis; Structure-Activity Relationship
TL;DR:
Data suggest that pregnane glycosides specifically suppress steroidogenesis through strong inhibition of 11β‐hydroxylase and steroid 17‐alpha‐monooxygenase, and weak inhibition of cytochrome P450 side chain cleavage enzyme and 21β‐ dehydrogenase/isomerase, but not 3 β‐hydroxysteroid dehydrogenases/isomersase.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2011 journal article
Akt-Dependent Anabolic Activity of Natural and Synthetic Brassinosteroids in Rat Skeletal Muscle Cells
Journal of Medicinal Chemistry, 54(12), 4057–4066.
Contributors: * , T. Rathinasabapathy , A. Poulev *, S. Komarnytsky* & I. Raskin *
MeSH headings : Anabolic Agents / chemical synthesis; Anabolic Agents / chemistry; Anabolic Agents / pharmacology; Animals; Cell Line; Cell Survival / drug effects; Cholestanones / chemical synthesis; Cholestanones / chemistry; Cholestanones / pharmacology; Mice; Muscle, Skeletal / cytology; Muscle, Skeletal / drug effects; Phosphorylation; Proto-Oncogene Proteins c-akt / metabolism; Rats; Stereoisomerism; Structure-Activity Relationship
TL;DR:
Presence of the 6-keto group in the B ring and stereochemistry of 22α,23α-vicinal hydroxyl groups in the side chain were critical for the anabolic activity, possibly due to higher cytotoxicity of the 22β,23β-hydroxylated brassinosteroids.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Crossref, NC State University Libraries, Web Of Science, ORCID
Added: August 6, 2018
Employment
Updated: November 2nd, 2021 16:49
2016 - present
North Carolina State University North Carolina Agricultural Research Service Raleigh, NC, US
Assistant Professor
Animal Science - Plants for Human Health Institute
Education
Updated: November 2nd, 2021 16:52
2010 - 2012
Rutgers The State University of New Jersey New Brunswick, NJ, US
MBS Drug Discovery & Development
Business School
2007 - 2012
Rutgers University - Douglass Campus New Brunswick, NJ, US
PhD Cell Molecular Biology
Plant Pathology & Biology
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