David Allen Skaar

Works (18)

Updated: December 6th, 2024 15:35

2024 journal article

DNA methylation of imprint control regions associated with Alzheimer’s disease in non-Hispanic Blacks and non-Hispanic Whites

Clinical Epigenetics, 16(1).

By: S. Cevik  n, D. Skaar n , D. Jima n, A. Liu *, T. Østbye *, H. Whitson *, R. Jirtle n, C. Hoyo n , A. Planchart n 

author keywords: Alzheimer's disease; Epigenetics; Imprint control regions; DNA methylation; Computational analysis
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: May 7, 2024

2023 journal article

<i>AHRR</i> Hypomethylation mediates the association between maternal smoking and metabolic profiles in children

HEPATOLOGY COMMUNICATIONS, 7(10).

By: A. Vidal n, S. Chandramouli *, J. Marchesoni n , N. Brown n, Y. Liu n, S. Murphy *, R. Maguire n, Y. Wang n ...

TL;DR: AHRR hypomethylation significantly mediates the association between prenatal tobacco smoke exposure and features of childhood metabolic dysfunction, despite the lack of persistent hypometHylation of AHRR into childhood. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2023

2022 article

Genomic map of candidate human imprint control regions: the imprintome

Jima, D. D., Skaar, D. A., Planchart, A., Motsinger-Reif, A., Cevik, S. E., Park, S. S., … Hoyo, C. (2022, June 25). EPIGENETICS, Vol. 6.

By: D. Jima n, D. Skaar n , A. Planchart n , A. Motsinger-Reif n, S. Cevik  n, S. Park n, M. Cowley n , F. Wright n ...

author keywords: Epigenetics; genomic imprinting; foetal origins; whole genome; methylation; imprint control regions
MeSH headings : Adult; Humans; Genomic Imprinting; DNA Methylation; Chromosome Mapping; Alleles; Genomics
TL;DR: This draft of the human imprintome will allow for the systematic determination of the role of early-acquired imprinting dysregulation in the pathogenesis of human diseases and developmental and behavioural disorders. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 11, 2022

2021 journal article

Association between PEG3 DNA methylation and high-grade cervical intraepithelial neoplasia

INFECTIOUS AGENTS AND CANCER, 16(1).

By: C. Bosire *, A. Vidal*, J. Smith *, D. Jima n, Z. Huang *, D. Skaar n , F. Valea *, R. Bentley * ...

author keywords: Cervical intraepithelial neoplasia; Gene methylation; Imprinted gene; Human papillomavirus
TL;DR: An association between altered DNA methylation at regulatory regions of PEG3 and high grade CIN in high-risk HPV positive cases is suggested in women enrolled at colposcopic evaluation. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 28, 2021

2021 journal article

Epigenetic Dysregulation of KCNK9 Imprinting and Triple-Negative Breast Cancer

CANCERS, 13(23).

By: D. Skaar n , E. Dietze*, J. Alva-Ornelas*, D. Ann *, D. Schones *, T. Hyslop *, C. Sistrunk *, C. Zalles* ...

author keywords: triple negative breast cancer; KCNK9; epigenetics; imprinting
TL;DR: Evidence is provided that hypomethylation of the KNCK9 DMR/TASK3 overexpression may serve as a marker of risk and a target for prevention of TNBC, particularly in African American women. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 10, 2022

2020 journal article

Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort

PEDIATRIC OBESITY, 16(7).

By: R. Maguire n, J. House n , D. Lloyd n, H. Skinner n, T. Allen *, A. Raffi n, D. Skaar n , S. Park n ...

Contributors: R. Maguire n, J. House n , D. Lloyd n, H. Skinner n, T. Allen *, A. Raffi n, D. Skaar n , S. Park n ...

author keywords: cytokines; maternal obesity; childhood obesity
MeSH headings : Black or African American; Body Mass Index; Child; Child, Preschool; Cohort Studies; Cytokines / blood; Female; Humans; Obesity, Maternal / epidemiology; Pediatric Obesity / epidemiology; Pregnancy; White People
TL;DR: Although maternal systemic inflammation is hypothesized to link maternal pre‐pregnancy obesity to offspring metabolic dysfunction, patient empirical data are limited. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 19, 2021

2019 journal article

Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study

EPIGENETICS, 14(4), 325–340.

By: C. Martin *, D. Jima n, G. Sharp *, L. McCullough *, S. Park n, K. Gowdy *, D. Skaar n , M. Cowley n  ...

author keywords: DNA methylation; epigenome-wide association study; maternal obesity; offspring body mass index; offspring blood pressure; cardiometabolic health; ALSPAC; NEST
MeSH headings : Adult; Blood Pressure; Cardiovascular Diseases / epidemiology; Cardiovascular Diseases / genetics; Child; Child, Preschool; DNA Methylation; Epigenesis, Genetic; Epigenomics; Female; Genome-Wide Association Study; Humans; Infant, Newborn / blood; Infant, Newborn / growth & development; Male; Membrane Transport Proteins / genetics; Metabolic Syndrome / epidemiology; Metabolic Syndrome / genetics; Obesity / epidemiology; Obesity / genetics
TL;DR: Findings suggest sex-specific effects at CpG sites of the TAPBP gene were associated with BMI z-score and systolic BP percentile in female and syStolic and diastolicBP percentile in male offspring, which, if causal, may explain observed sex- specific effects of maternal obesity. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 29, 2019

2018 journal article

DNA methylation of imprinted gene control regions in the regression of low-grade cervical lesions

INTERNATIONAL JOURNAL OF CANCER, 143(3), 552–560.

By: A. Gomih *, J. Smith *, K. North *, M. Hudgens *, W. Brewster *, Z. Huang *, D. Skaar n , F. Valea * ...

author keywords: methylation; imprinted genes; cervical cancer; neoplasia; epigenetics; HPV
MeSH headings : Adult; Aged; Biopsy; CpG Islands; DNA Methylation; Disease Progression; Epigenesis, Genetic; Female; Genomic Imprinting; Humans; Middle Aged; Neoplasm Grading; Neoplasm Staging; Regulatory Sequences, Nucleic Acid; Uterine Cervical Neoplasms / epidemiology; Uterine Cervical Neoplasms / etiology; Uterine Cervical Neoplasms / genetics; Uterine Cervical Neoplasms / pathology; Young Adult
TL;DR: Altered methylation of imprinted IGF2AS and PEG10 DMRs may play a role in the natural history of CIN1, and further research on imprinted gene DMR methylation is warranted to determine its efficacy as a biomarker for cervical cancer screening. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 article

EPIGENOMICS AND HUMAN OBESITY

EPIGENETICS IN HUMAN DISEASE, 2ND EDITION, Vol. 6, pp. 409–426.

By: C. Hoyo n , D. Skaar n , S. Park n & P. Sorrow n

TL;DR: This chapter summarizes human data on CpG methylation, the most studied epigenetic mechanism in humans, in the context of causal inference, in adults and children, and concludes with a call for sex- and ethnic-specific data, together with data demonstrating that obesity-associated DNA methylation marks identified precede obesity. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: April 22, 2019

2018 journal article

Effects of cadmium exposure on DNA methylation at imprinting control regions and genome-wide in mothers and newborn children

Environmental Health Perspectives, 126(3).

By: M. Cowley , D. Skaar , D. Jima, R. Maguire, K. Hudson, S. Park, P. Sorrow, C. Hoyo 

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

An Extended n-h bond, driven by a conserved second-order interaction, orients the flavin n5 orbital in cholesterol oxidase

Scientific Reports, 7.

By: E. Golden, L. Yu, F. Meilleur, M. Blakeley, A. Duff, A. Karton, A. Vrielink

Source: NC State University Libraries
Added: August 6, 2018

2016 article

Effects of Environmentally Acquired Heavy Metals and Nutrients on the Epigenome and Phenotype

TRANSLATIONAL TOXICOLOGY: DEFINING A NEW THERAPEUTIC DISCIPLINE, pp. 139–169.

By: D. Skaar n , S. Murphy * & C. Hoyo n 

author keywords: Cadmium; Lead; Arsenic; Mercury; Epigenetics; DNA methylation; Cancer; Neurodevelopment
TL;DR: The extent to which heavy-metal-associated epigenetic alterations alter susceptibility to common chronic diseases and how they might be mitigated by some nutrients is discussed, albeit within narrow margins. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 article

Environmentally Induced Alterations in the Epigenome Affecting Obesity and Cancer in Minority Populations

EPIGENETICS, ENERGY BALANCE, AND CANCER, pp. 109–146.

By: D. Skaar n , R. Jirtle n & C. Hoyo n 

author keywords: Obesity; Obesogen; Prostate cancer; Adenocarcinoma; Disparity; Epigenetic
TL;DR: Evidence for the influence of environmental exposures on obesity and how epigenetic alterations may contribute to cancers that disproportionately affect minority populations exhibit disparities in incidence and mortality are summarized in this chapter. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

IL-10, IL-15, IL-17, and GMCSF levels in cervical cancer tissue of Tanzanian women infected with HPV16/18 vs. non-HPV16/18 genotypes

Infectious Agents and Cancer, 10.

By: A. Vidal, D. Skaar , R. Maguire, S. Dodor, L. Musselwhite, J. Bartlett, O. Oneko, J. Obure ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood

ENVIRONMENTAL HEALTH PERSPECTIVES, 124(5), 666–673.

By: Y. Li *, C. Xie *, S. Murphy *, D. Skaar n , M. Nye*, A. Vidal*, K. Cecil *, K. Dietrich* ...

MeSH headings : Cell Cycle Proteins / metabolism; Child Development / physiology; Child, Preschool; DNA Methylation; Environmental Exposure / statistics & numerical data; Environmental Pollutants / blood; Female; Humans; Infant; Infant, Newborn; Insulin-Like Growth Factor II / metabolism; Lead / blood; Male; Transcription Factors / metabolism; Tumor Suppressor Proteins / metabolism
TL;DR: Evidence is provided that early childhood lead exposure results in sex-dependent and gene-specific DNA methylation differences in the DMRs of PEG3, IGF2/H19, and PLAGL1/HYMAI in adulthood. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Maternal cadmium, iron and zinc levels, DNA methylation and birth weight

BMC Pharmacology & Toxicology, 16.

By: A. Vidal, V. Semenova, T. Darrah, A. Vengosh, Z. Huang, K. King, M. Nye, R. Fry ...

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Identification of chromosome 7 inversion breakpoints in an autistic family narrows candidate region for autism susceptibility

Autism Research, 2(5), 258–266.

By: H. Cukier *, D. Skaar* , M. Rayner-Evans*, I. Konidari *, P. Whitehead*, J. Jaworski*, M. Cuccaro *, M. Pericak-Vance *, J. Gilbert*

author keywords: molecular genetics; paracentric inversion; fluorescent in situ hybridization (FISH); genome-wide association study (GWAS)
MeSH headings : Autistic Disorder / genetics; Child; Child, Preschool; Chromosome Inversion / genetics; Chromosomes, Human, Pair 7 / genetics; Comparative Genomic Hybridization / methods; DNA Copy Number Variations / genetics; Family; Female; Follow-Up Studies; Genetic Markers / genetics; Genetic Predisposition to Disease / genetics; Humans; In Situ Hybridization, Fluorescence / methods; Male; Oligonucleotide Array Sequence Analysis / methods; Polymorphism, Single Nucleotide / genetics
TL;DR: The chromosomal abnormality in this family strengthens the case for an autism susceptibility gene in the chromosome 7q22‐31 region and targets a candidate region for further investigation. (via Semantic Scholar)
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4. Quality Education (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2004 journal article

Analysis of the RELN gene as a genetic risk factor for autism

Molecular Psychiatry, 10(6), 563–571.

By: D. Skaar* , Y. Shao*, J. Haines*, J. Stenger*, J. Jaworski*, E. Martin *, G. DeLong*, J. Moore * ...

author keywords: autism; candidate gene; chromosome 7q; RELN; association
MeSH headings : 5' Untranslated Regions / genetics; Autistic Disorder / genetics; Cell Adhesion Molecules, Neuronal / genetics; Chromosomes, Human, Pair 7 / genetics; Extracellular Matrix Proteins / genetics; Female; Genetic Predisposition to Disease / genetics; Genotype; Humans; Infant; Linkage Disequilibrium; Male; Nerve Tissue Proteins / genetics; Pedigree; Polymorphism, Single Nucleotide / genetics; Reelin Protein; Serine Endopeptidases / genetics; White People / genetics
TL;DR: Combined analyses show the potential of RELN as an important contributor to genetic risk in autism and test for association of single-locus markers and multilocus haplotypes with autism. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 2, 2020

Employment

Updated: November 27th, 2021 21:15

North Carolina State University Raleigh, North Carolina, US
Associate Research Professor Biological Sciences

Education

Updated: September 28th, 2015 09:30

1994 - 2002

Duke University Graduate School Durham, NC, US
Ph.D. Biochemistry

1990 - 1994

New Mexico Institute of Mining and Technology Socorro, New Mexico, US
BS Biology

1990 - 1994

New Mexico Institute of Mining and Technology Socorro, NM, US
BS Mathematics

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