Works (41)

Updated: April 5th, 2024 09:41

2024 article

A novel in vitro model of clinical cryoablation to investigate the transition zone for focal tumor ablation

Vrabel, M. R., Fesmire, C. C., Rich, M. J., Kobrin, R. L., Sano, M. B., & Zaharoff, D. A. (2024, March). CRYOBIOLOGY, Vol. 114.

By: M. Vrabel n, C. Fesmire n, M. Rich n, R. Kobrin n, M. Sano n & D. Zaharoff n

author keywords: Cryoablation; Focal ablation; Prostate cancer; Clinical ablation; Immunogenic cell death; Transition zone; Cryosurgery
Source: Web Of Science
Added: March 4, 2024

2024 journal article

Characterization of an Injectable Chitosan Hydrogel for the Tunable, Localized Delivery of Immunotherapeutics

ACS BIOMATERIALS SCIENCE & ENGINEERING, 10(2), 905–920.

By: S. Mantooth n, A. Hancock n, P. Thompson n, P. Varghese n, D. Meritet n, M. Vrabel n, J. Hu n, D. Zaharoff n

author keywords: hydrogel; chitosan; immunotherapy; intratumoral
Sources: Web Of Science, ORCID
Added: March 4, 2024

2023 journal article

Focal Cryo-Immunotherapy with Intratumoral IL-12 Prevents Recurrence of Large Murine Tumors

CANCERS, 15(8).

By: M. Vrabel n, J. Schulman n, F. Gillam n, S. Mantooth n, K. Nguyen n & D. Zaharoff n

author keywords: focal ablation; cryoablation; IL-12; intratumoral; immunotherapy; abscopal response; checkpoint therapy
Source: Web Of Science
Added: May 15, 2023

2023 journal article

Heparin Affinity-Based IL-4 Delivery to Modulate Macrophage Phenotype and Endothelial Cell Activity In Vitro

ACS APPLIED MATERIALS & INTERFACES, 15(23), 27457–27470.

By: F. Zhang n, J. Gluck n, A. Brown n, D. Zaharoff n & M. King n

author keywords: gelatin methacryloyl; heparin; interleukin4; hydrogel; macrophage; endothelial cell; immunomodulation
MeSH headings : Interleukin-4 / pharmacology; Heparin / pharmacology; Heparin / metabolism; Macrophages / metabolism; Phenotype; Hydrogels / pharmacology; Hydrogels / metabolism
Sources: Web Of Science, ORCID
Added: June 26, 2023

2022 article

IDENTIFICATION OF VASOACTIVE INTESTINAL PEPTIDE (VIP)-SPECIFIC SINGLE-CHAIN ANTIBODY FRAGMENTS (SCFVS) VIA YEAST SURFACE DISPLAY

Zaharoff, D., & Nguyen, K. (2022, November). JOURNAL FOR IMMUNOTHERAPY OF CANCER, Vol. 10, pp. A1424–A1425.

By: D. Zaharoff n & K. Nguyen n

Source: Web Of Science
Added: April 24, 2023

2022 journal article

Intranasal Delivery of Thermostable Subunit Vaccine for Cross-Reactive Mucosal and Systemic Antibody Responses Against SARS-CoV-2

FRONTIERS IN IMMUNOLOGY, 13.

By: K. Nguyen n, S. Mantooth n, M. Vrabel n & D. Zaharoff n

author keywords: Intranasal vaccination; COVID-19; mucosal immunity; SARS-CoV-2; Receptor binding domain (RBD); chitosan; CpG
MeSH headings : Animals; Antibody Formation; COVID-19 / prevention & control; COVID-19 Vaccines; Humans; Immunoglobulin G; Mice; SARS-CoV-2; Vaccines, Subunit
Source: Web Of Science
Added: May 31, 2022

2022 journal article

Raman spectroscopy reveals phenotype switches in breast cancer metastasis

THERANOSTICS, 12(12), 5351–5363.

By: S. Paidi, J. Troncoso, M. Harper, Z. Liu, K. Nguyen*, S. Ravindranathan, L. Rebello, D. Lee ...

author keywords: Raman spectroscopy; Cancer metastasis; Random forests; Phenotype switch; TWIST
MeSH headings : Animals; Cell Line, Tumor; Melanoma; Mice; Neoplasm Metastasis; Neoplasms, Second Primary; Phenotype; Skin Neoplasms; Spectrum Analysis, Raman
Source: Web Of Science
Added: August 1, 2022

2021 journal article

Construction of heparan sulfate microarray for investigating the binding of specific saccharide sequences to proteins

GLYCOBIOLOGY, 31(3), 188–199.

By: M. Horton*, G. Su*, L. Yi*, Z. Wang*, Y. Xu*, V. Pagadala, F. Zhang*, D. Zaharoff n ...

author keywords: carbohydrates; chemoenzymatic synthesis; heparan sulfate; microarray; oligosaccharides
MeSH headings : Antithrombin III / chemistry; Binding Sites; Carbohydrate Conformation; Carbohydrate Sequence; Fibroblast Growth Factor 2 / chemistry; Heparitin Sulfate / chemistry; Humans; Microarray Analysis
Source: Web Of Science
Added: May 24, 2021

2021 article

INJECTABLE CHITOSAN HYDROGEL FOR LOCALIZED DELIVERY OF IMMUNE CHECKPOINT INHIBITORS

Mantooth, S., Zaharoff, D., & Mantooth, S. (2021, November). JOURNAL FOR IMMUNOTHERAPY OF CANCER, Vol. 9, pp. A281–A281.

By: S. Mantooth n, D. Zaharoff n & S. Mantooth n

Source: Web Of Science
Added: April 18, 2022

2021 article

ONCO-IMMUNOLOGICAL MECHANISMS OF FOCAL ABLATION AND LOCALIZED IL-12 IMMUNOTHERAPY

Vrabel, M., Zaharoff, D., & Mantooth, S. (2021, November). JOURNAL FOR IMMUNOTHERAPY OF CANCER, Vol. 9, pp. A650–A650.

By: M. Vrabel n, D. Zaharoff n & S. Mantooth n

Source: Web Of Science
Added: April 18, 2022

2021 journal article

Safety and Pharmacokinetics of Intravesical Chitosan/Interleukin-12 Immunotherapy in Murine Bladders

BLADDER CANCER, 7(4), 427–437.

By: K. Nguyen n, E. Wagner n, M. Vrabel n, S. Mantooth n, D. Meritet n & D. Zaharoff n

author keywords: Bladder cancer; Interleukin-12; immunotherapy; chitosan; intravesical
Source: Web Of Science
Added: January 10, 2022

2020 article

INTRATUMORAL INTERLEUKIN-12 ADMINISTERED AFTER CRYOABLATION DOES NOT IMPROVE SURVIVAL IN MULTIPLE BILATERAL MURINE MODELS

Vrabel, M., Schulman, J., & Zaharoff, D. (2020, November). JOURNAL FOR IMMUNOTHERAPY OF CANCER, Vol. 8, pp. A277–A278.

By: M. Vrabel n, J. Schulman n & D. Zaharoff n

Source: Web Of Science
Added: March 1, 2021

2019 journal article

Analyzing the effects of instillation volume on intravesical delivery using biphasic solute transport in a deformable geometry

MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA, 36(2), 139–156.

By: S. Smith n, B. Griffith* & D. Zaharoff n

author keywords: bladder cancer; cystitis; intravesical delivery; FEBio
MeSH headings : Administration, Intravesical; Humans; Models, Theoretical; Urinary Bladder Diseases / drug therapy
Source: Web Of Science
Added: November 18, 2019

2019 journal article

Design of a thrombin resistant human acidic fibroblast growth factor (hFGF1) variant that exhibits enhanced cell proliferation activity

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 518(2), 191–196.

By: R. Kerr*, S. Agrawal*, S. Maity*, B. Koppolu n, S. Jayanthi*, G. Kumar*, R. Gundampati*, D. McNabb*, D. Zaharoff n, T. Kumar*

author keywords: Fibroblast growth factor; Cell signaling; Stability; Heparin; Binding affinity; Cell proliferation
MeSH headings : Animals; Cell Proliferation; Fibroblast Growth Factor 1 / chemistry; Fibroblast Growth Factor 1 / genetics; Fibroblast Growth Factor 1 / metabolism; Humans; Mice; Models, Molecular; Mutagenesis, Site-Directed; NIH 3T3 Cells; Point Mutation; Protein Conformation; Thrombin / metabolism
Source: Web Of Science
Added: January 21, 2020

2019 journal article

Flow-Encoded Oxygen Control to Track the Time-Dependence of Molecular Changes Induced by Static or Cycling Hypoxia

ANALYTICAL CHEMISTRY, 91(23), 15032–15039.

By: M. Yao n, Z. Rabbani n, T. Sattler n, K. Nguyen n, D. Zaharoff n, G. Walker n, M. Gamcsik n

MeSH headings : Aldehyde Dehydrogenase / metabolism; Caco-2 Cells; Cell Hypoxia; Cell Line, Tumor; Glucose / pharmacokinetics; Humans; Hypoxia-Inducible Factor 1, alpha Subunit / drug effects; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Oxygen / metabolism; Oxygen / pharmacology; Pancreatic Neoplasms / pathology; Time Factors
Source: Web Of Science
Added: December 30, 2019

2019 journal article

Molecular mechanisms of heparin-induced modulation of human interleukin 12 bioactivity

Journal of Biological Chemistry, 294(12), 4412–4424.

By: K. Nguyen n, F. Gillam n, J. Hopkins n, S. Jayanthi*, R. Gundampati*, G. Su*, J. Bear*, G. Pilkington* ...

author keywords: heparin; interleukin; glycosaminoglycan; cytokine; immunology; heparan sulfate; heparin-binding cytokine; IL-12
MeSH headings : Animals; Biophysical Phenomena; Calorimetry; Cytokines / biosynthesis; Dose-Response Relationship, Drug; Female; Flow Cytometry; HEK293 Cells; Heparin / chemistry; Heparin / pharmacology; Heparitin Sulfate / metabolism; Humans; Interleukin-12 / metabolism; Interleukin-12 / pharmacology; Mice; Mice, Inbred C57BL; Protein Binding; Receptors, Interleukin-2 / metabolism; Recombinant Proteins / metabolism; Recombinant Proteins / pharmacology; Signal Transduction / drug effects; T-Lymphocytes / drug effects; T-Lymphocytes / metabolism
Source: Crossref
Added: February 24, 2020

2019 journal article

ULTRASOUND-STIMULATED PHASE-CHANGE CONTRAST AGENTS FOR TRANSEPITHELIAL DELIVERY OF MACROMOLECULES, TOWARD GASTROINTESTINAL DRUG DELIVERY

ULTRASOUND IN MEDICINE AND BIOLOGY, 45(7), 1762–1776.

co-author countries: France 🇫🇷
author keywords: Ultrasound; Transepithelial delivery; Acoustic droplet vaporization; Phase-change contrast agents; Nanodroplet
MeSH headings : Cells, Cultured; Contrast Media; Dextrans / administration & dosage; Drug Delivery Systems / methods; Fluorescein-5-isothiocyanate / administration & dosage; Fluorescein-5-isothiocyanate / analogs & derivatives; Gastrointestinal Agents / administration & dosage; Humans; Image Enhancement / methods; In Vitro Techniques; Ultrasonography / methods
Source: Web Of Science
Added: June 24, 2019

2018 journal article

Effect of extension of the heparin binding pocket on the structure, stability, and cell proliferation activity of the human acidic fibroblast growth factor

Biochemistry and Biophysics Reports, 13, 45–57.

By: J. Davis*, R. Gundampati*, S. Jayanthi*, J. Anderson*, A. Pickhardt*, B. Koppolu n, D. Zaharoff n, T. Kumar*

author keywords: Fibroblast growth factor; Heparin binding; Stability; Cell proliferation
Source: Crossref
Added: February 24, 2020

2018 journal article

Probing the role of proline-135 on the structure, stability, and cell proliferation activity of human acidic fibroblast growth factor

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 654, 115–125.

By: J. Davis*, A. Alghanmi*, R. Gundampati*, S. Jayanthi*, E. Fields*, M. Armstrong*, V. Weidling*, V. Shah* ...

author keywords: Fibroblast growth factor; Heparin binding; Charge-reversal; Bioactivity; Stability
MeSH headings : Cell Proliferation / physiology; Fibroblast Growth Factor 1 / chemistry; Fibroblast Growth Factor 1 / genetics; Fibroblast Growth Factor 1 / physiology; Heparin / metabolism; Humans; Mutagenesis, Site-Directed; Proline / physiology; Protein Binding; Protein Stability; Protein Structure, Tertiary; Proton Magnetic Resonance Spectroscopy; Receptors, Fibroblast Growth Factor / metabolism
Source: Web Of Science
Added: October 19, 2018

2018 journal article

Tumor-derived granulocyte colony-stimulating factor diminishes efficacy of breast tumor cell vaccines

BREAST CANCER RESEARCH, 20.

By: S. Ravindranathan*, K. Nguyen*, S. Kurtz*, H. Frazier*, S. Smith*, B. Koppolu*, N. Rajaram*, D. Zaharoff*

author keywords: Breast cancer vaccine; Autologous tumor cell vaccine; MDSCs; Breast cancer immunogenicity
MeSH headings : Animals; Breast / pathology; Breast Neoplasms / immunology; Breast Neoplasms / pathology; Breast Neoplasms / therapy; CRISPR-Cas Systems; Cancer Vaccines / administration & dosage; Cancer Vaccines / immunology; Cell Line, Tumor / immunology; Cell Line, Tumor / radiation effects; Cell Line, Tumor / transplantation; Disease Models, Animal; Female; Gene Deletion; Granulocyte Colony-Stimulating Factor / genetics; Granulocyte Colony-Stimulating Factor / immunology; Humans; Immunogenicity, Vaccine; Mice; Mice, Inbred BALB C; Neoplasm Recurrence, Local / immunology; Neoplasm Recurrence, Local / prevention & control; Treatment Outcome
Source: Web Of Science
Added: November 12, 2018

2017 journal article

Immunological mechanisms of intravesical chitosan/interleukin-12 immunotherapy against murine bladder cancer

ONCOIMMUNOLOGY, 6(1).

By: S. Smith n, J. Baltz*, B. Koppolu n, S. Ravindranathan*, K. Nguyen* & D. Zaharoff n

author keywords: BCG; bladder cancer; chitosan; immunotherapy; interleukin-12; intratumoral; intravesical; MDSC; TILS; TReg
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Modulation of Interleukin-12 activity in the presence of heparin

SCIENTIFIC REPORTS, 7.

By: S. Jayanthi*, B. Koppolu*, K. Nguyen*, S. Smith*, B. Felber*, T. Kumar*, D. Zaharoff n

MeSH headings : Biophysical Phenomena; Cell Line; Chromatography, Gel; Flow Cytometry; Heparin / metabolism; Heparitin Sulfate / metabolism; Humans; Immunologic Factors / metabolism; Interleukin-12 / chemistry; Interleukin-12 / metabolism; Interleukin-12 Subunit p35; Protein Binding; Protein Conformation / drug effects; Protein Multimerization / drug effects; Scattering, Small Angle
Source: Web Of Science
Added: August 6, 2018

2017 article

Strategic Directions in Immunoresponsive Biomaterials in Tissue Engineering INTRODUCTION

Zaharoff, D. A., & Jewell, C. M. (2017, October). TISSUE ENGINEERING PART A, Vol. 23, pp. 1042–1043.

By: D. Zaharoff n & C. Jewell*

MeSH headings : Biocompatible Materials / adverse effects; Biocompatible Materials / chemistry; Cell Survival / drug effects; Humans; Regenerative Medicine / methods; Tissue Engineering / methods
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Corrigendum to ‘Controlling chitosan-based encapsulation for protein and vaccine delivery’ [Biomaterials 35 (2014) 4382–4389]

Biomaterials, 73, 308.

By: B. Koppolu*, S. Smith*, S. Ravindranathan*, S. Jayanthi*, T. Suresh Kumar* & D. Zaharoff*

Source: Crossref
Added: August 28, 2020

2015 journal article

Intravesical chitosan/interleukin-12 immunotherapy induces tumor-specific systemic immunity against murine bladder cancer

Cancer Immunology, Immunotherapy, 64(6), 689–696.

By: S. Smith*, B. Koppolu*, S. Ravindranathan*, S. Kurtz*, L. Yang*, M. Katz*, D. Zaharoff*

author keywords: Intravesical immunotherapy; Bladder cancer; Interleukin-12; Chitosan
MeSH headings : Administration, Intravesical; Animals; Cell Line, Tumor; Chitosan / administration & dosage; Chitosan / immunology; Dose-Response Relationship, Immunologic; Female; Immunotherapy / methods; Interleukin-12 / administration & dosage; Interleukin-12 / immunology; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Random Allocation; Urinary Bladder Neoplasms / drug therapy; Urinary Bladder Neoplasms / immunology
Source: Crossref
Added: February 24, 2020

2014 journal article

Controlling chitosan-based encapsulation for protein and vaccine delivery

Biomaterials, 35(14), 4382–4389.

By: B. Koppolu*, S. Smith*, S. Ravindranathan*, S. Jayanthi*, T. Suresh Kumar* & D. Zaharoff*

author keywords: Chitosan particles; Protein encapsulation; Vaccine delivery; Precipitation-coacervation; Microencapsulation; Nanoencapsulation
MeSH headings : Calorimetry; Chemical Precipitation; Chitosan / chemistry; Drug Delivery Systems; Fluorescein-5-isothiocyanate / administration & dosage; Fluorescein-5-isothiocyanate / analogs & derivatives; Fluorescein-5-isothiocyanate / chemistry; Immobilized Proteins / chemistry; Molecular Weight; Osmolar Concentration; Particle Size; Protein Binding; Serum Albumin, Bovine / administration & dosage; Serum Albumin, Bovine / chemistry; Solutions; Sonication; Sulfates / chemistry; Thermodynamics; Vaccines / administration & dosage; Water / chemistry
Source: Crossref
Added: August 28, 2020

2014 journal article

Efficient production and purification of recombinant human interleukin-12 (IL-12) overexpressed in mammalian cells without affinity tag

Protein Expression and Purification, 102, 76–84.

By: S. Jayanthi*, B. Koppolu*, S. Smith*, R. Jalah*, J. Bear*, M. Rosati*, G. Pavlakis*, B. Felber*, D. Zaharoff*, T. Kumar*

author keywords: Interleukin-12; Heparin Sepharose; HEK293; Cytokine; Purification; Bioactivity
MeSH headings : Amino Acid Sequence; Binding Sites; Blotting, Western; Chromatography, Affinity; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; HEK293 Cells / metabolism; Heparin / metabolism; Humans; Interleukin-12 / chemistry; Interleukin-12 / genetics; Interleukin-12 / isolation & purification; Interleukin-12 / metabolism; Models, Molecular; Molecular Sequence Data; Protein Conformation; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Recombinant Proteins / isolation & purification; Recombinant Proteins / metabolism; Up-Regulation
Source: Crossref
Added: August 28, 2020

2013 journal article

583 INTRAVESICAL IMMUNOTHERAPY WITH CHITOSAN AND INTERLEUKIN-12 INDUCES SYSTEMIC TUMOR-SPECIFIC IMMUNITY

Journal of Urology, 189(4S).

By: S. Smith*, L. Yang*, J. Vo* & D. Zaharoff*

Source: Crossref
Added: August 28, 2020

2013 journal article

Nanotheranostics of Circulating Tumor Cells, Infections and Other Pathological Features in Vivo

Molecular Pharmaceutics, 10(3), 813–830.

By: J. Kim*, E. Galanzha*, D. Zaharoff*, R. Griffin* & V. Zharov*

author keywords: metastasis; circulating tumor cells (CTCs); circulating endothelial cells (CECs); circulating cancer stem cells (CCSCs); circulating microparticles and exosomes; circulating pathogens; viruses and parasites; blood clots; blood and lymph flow; contrast nanoagents; positive and negative photoacoustic contrasts; micro- and nanobubbles; multimodal; multicolor; nanotechnology; multifunctional real-time nanotheranostics; nanomedicine
MeSH headings : Humans; Molecular Imaging / methods; Nanotechnology / methods; Neoplastic Cells, Circulating / pathology; Photoacoustic Techniques
Source: Crossref
Added: October 29, 2020

2013 journal article

Role of chitosan co-formulation in enhancing interleukin-12 delivery and antitumor activity

Biomaterials, 34(15), 3828–3836.

By: L. Yang* & D. Zaharoff*

author keywords: Chitosan; Paracrine delivery; Interleukin-12; Intratumoral; Immunotherapy
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacology; Cell Line, Tumor; Cell Proliferation / drug effects; Chemistry, Pharmaceutical; Chitosan / chemistry; Dose-Response Relationship, Drug; Drug Delivery Systems; Female; Humans; Injections; Interleukin-12 / administration & dosage; Interleukin-12 / pharmacology; Leukocytes / cytology; Leukocytes / drug effects; Mice; Mice, Inbred C57BL; Phenotype
Source: Crossref
Added: August 28, 2020

2013 journal article

The effect of antigen encapsulation in chitosan particles on uptake, activation and presentation by antigen presenting cells

Biomaterials, 34(9), 2359–2369.

By: B. Koppolu* & D. Zaharoff*

author keywords: Chitosan particles; Antigen delivery; Antigen presentation; Adjuvant; Co-stimulation
MeSH headings : Animals; Antigen Presentation; Antigen-Presenting Cells / metabolism; Antigens / chemistry; Biocompatible Materials / chemistry; Cell Line; Cell Proliferation; Chitosan / chemistry; Dendritic Cells / cytology; Dendritic Cells / immunology; Dendritic Cells / metabolism; Macrophages / cytology; Macrophages / immunology; Macrophages / metabolism; Mice; Ovalbumin / chemistry; Particle Size; Serum Albumin / chemistry
Source: Crossref
Added: August 28, 2020

2011 journal article

In vivo efficacy of a chitosan/IL-12 adjuvant system for protein-based vaccines

Biomaterials, 32(3), 926–932.

By: M. Heffernan*, D. Zaharoff*, J. Fallon*, J. Schlom* & J. Greiner*

author keywords: Chitosan; Drug delivery; Immunostimulation; Interleukin 12; Polysaccharide; Vaccine
MeSH headings : Adjuvants, Immunologic / metabolism; Animals; CD4-Positive T-Lymphocytes / metabolism; Chitosan / immunology; Enzyme-Linked Immunosorbent Assay; Interferon-gamma / metabolism; Interleukin-12 / immunology; Mice; Mice, Inbred C57BL; Proteins / immunology; Vaccines / immunology
Source: Crossref
Added: August 28, 2020

2008 journal article

Exercise enhances vaccine-induced antigen-specific T cell responses

Vaccine, 26(42), 5407–5415.

By: C. Rogers*, D. Zaharoff*, K. Hance*, S. Perkins*, S. Hursting*, J. Schlom*, J. Greiner*

author keywords: adaptive immunity; cytokines; cell proliferation
MeSH headings : Animals; Body Composition; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / metabolism; Cell Proliferation; Cytokines / biosynthesis; Cytokines / immunology; Female; Lymphocyte Activation / immunology; Mice; Mice, Inbred C57BL; Motor Activity; Ovalbumin / immunology; Substrate Specificity; Vaccination
Source: Crossref
Added: August 28, 2020

2007 journal article

Chitosan solution enhances both humoral and cell-mediated immune responses to subcutaneous vaccination

Vaccine, 25(11), 2085–2094.

By: D. Zaharoff*, C. Rogers*, K. Hance*, J. Schlom* & J. Greiner*

author keywords: adjuvant; depot; vaccination
MeSH headings : Adjuvants, Immunologic; Aluminum Hydroxide / immunology; Animals; Antibodies / blood; CD4-Positive T-Lymphocytes / immunology; Chitosan / immunology; Chitosan / pharmacokinetics; Enzyme-Linked Immunosorbent Assay; Female; Freund's Adjuvant; Histocytochemistry; Hypersensitivity, Delayed; Injections, Subcutaneous; Lipids; Lymph Nodes / cytology; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Models, Animal; Skin / pathology; Vaccination; Vaccines / administration & dosage; Vaccines / immunology; beta-Galactosidase / immunology
Source: Crossref
Added: August 28, 2020

2007 journal article

Chitosan solution enhances the immunoadjuvant properties of GM-CSF

Vaccine, 25(52), 8673–8686.

By: D. Zaharoff*, C. Rogers*, K. Hance*, J. Schlom* & J. Greiner*

author keywords: chitosan; immunoadjuvant; GM-CSF; controlled release; cytokine
MeSH headings : Adjuvants, Immunologic / administration & dosage; Animals; Antigen Presentation / immunology; CD4-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; Cell Proliferation; Chitosan / immunology; Cytotoxicity Tests, Immunologic; Delayed-Action Preparations / administration & dosage; Dendritic Cells / immunology; Female; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor / administration & dosage; Granulocyte-Macrophage Colony-Stimulating Factor / immunology; Histocompatibility Antigens Class II / genetics; Injections, Subcutaneous; Lymph Nodes / immunology; Lymphocyte Subsets / immunology; Mice; T-Lymphocytes, Cytotoxic / immunology
Source: Crossref
Added: August 28, 2020

2007 journal article

Electric field-mediated transport of plasmid DNA in tumor interstitium in vivo

Bioelectrochemistry, 71(2), 233–242.

By: J. Henshaw*, D. Zaharoff*, B. Mossop* & F. Yuan*

author keywords: in vivo DNA electrophoresis; interstitial transport; non-viral gene therapy; DNA electrotransfer; electric field-mediated gene delivery
MeSH headings : Animals; Azo Compounds; Biological Transport, Active; Cell Line, Tumor; Collagen; DNA, Neoplasm / genetics; DNA, Neoplasm / metabolism; Electrodes; Electrophoresis; Eosine Yellowish-(YS); Fluorescent Dyes; Mammary Neoplasms, Experimental / genetics; Mammary Neoplasms, Experimental / metabolism; Melanoma, Experimental / genetics; Melanoma, Experimental / metabolism; Methyl Green; Mice; Microscopy, Confocal; Plasmids / genetics; Plasmids / metabolism; Rhodamines
Source: Crossref
Added: August 28, 2020

2006 journal article

A single molecule detection method for understanding mechanisms of electric field-mediated interstitial transport of genes

Bioelectrochemistry, 69(2), 248–253.

By: J. Henshaw*, D. Zaharoff*, B. Mossop* & F. Yuan*

author keywords: single molecule detection; DNA electromobility; interstitial transport; electric field-mediated gene delivery; non-viral gene delivery
MeSH headings : DNA / chemistry; DNA / radiation effects; Dose-Response Relationship, Radiation; Electromagnetic Fields; Electroporation / methods; Molecular Probe Techniques; Motion; Radiation Dosage; Stress, Mechanical; Transfection / methods
Source: Crossref
Added: August 28, 2020

2006 journal article

Electric Fields in Tumors Exposed to External Voltage Sources: Implication for Electric Field-Mediated Drug and Gene Delivery

Annals of Biomedical Engineering, 34(10), 1564–1572.

By: B. Mossop*, R. Barr*, J. Henshaw*, D. Zaharoff* & F. Yuan*

author keywords: drug and gene delivery; electroporation; electrogenetherapy; electrochemotherapy
MeSH headings : Animals; Biomedical Engineering; Cell Line, Tumor; Drug Delivery Systems; Electric Impedance; Electric Stimulation; Electrochemotherapy; Electroporation; Female; Genetic Therapy; In Vitro Techniques; Mammary Neoplasms, Experimental / physiopathology; Mammary Neoplasms, Experimental / therapy; Melanoma, Experimental / physiopathology; Melanoma, Experimental / therapy; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phantoms, Imaging
Source: Crossref
Added: August 28, 2020

2006 journal article

Electric field-mediated enhancement of in vivo transport of plasmid DNA in tumor interstitium

Journal of Biomechanics, 39, S377.

By: J. Henshaw, D. Zaharoff*, B. Mossop & F. Yuan

Source: Crossref
Added: August 28, 2020

2006 journal article

Nonlinear Dependence of Hydraulic Conductivity on Tissue Deformation During Intratumoral Infusion

Annals of Biomedical Engineering, 34(7), 1173–1181.

By: S. McGuire*, D. Zaharoff* & F. Yuan*

author keywords: collagen concentration; hydraulic conductivity; intratumoral infusion; drug and gene delivery
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Biological Transport; Cell Line, Tumor; Collagen / metabolism; Elasticity; Gene Transfer Techniques; Genetic Therapy; Humans; Infusions, Parenteral / methods; Mice; Models, Biological; Neoplasm Transplantation; Neoplasms, Experimental / metabolism; Neoplasms, Experimental / therapy
Source: Crossref
Added: August 28, 2020

2004 journal article

Effects of pulse strength and pulse duration on in vitro DNA electromobility

Bioelectrochemistry, 62(1), 37–45.

By: D. Zaharoff* & F. Yuan*

author keywords: interstitial transport; plasmid electromobility; electric field-mediated gene delivery; non-viral gene delivery
MeSH headings : DNA / chemistry; Electrochemistry; Electrophoresis, Gel, Pulsed-Field / methods; Fluorescence; Gels / chemistry; Gene Transfer Techniques; In Vitro Techniques; Ions / chemistry; Plasmids / chemistry; Plasmids / genetics
Source: Crossref
Added: August 28, 2020

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