Works (36)

2022 journal article

Intranasal Delivery of Thermostable Subunit Vaccine for Cross-Reactive Mucosal and Systemic Antibody Responses Against SARS-CoV-2

FRONTIERS IN IMMUNOLOGY, 13.

By: K. Nguyen, S. Mantooth, M. Vrabel n & D. Zaharoff

author keywords: Intranasal vaccination; COVID-19; mucosal immunity; SARS-CoV-2; Receptor binding domain (RBD); chitosan; CpG
Source: Web Of Science
Added: May 31, 2022

2022 journal article

Raman spectroscopy reveals phenotype switches in breast cancer metastasis

THERANOSTICS, 12(12), 5351–5363.

By: S. Paidi, J. Troncoso, M. Harper, Z. Liu, K. Nguyen, S. Ravindranathan, L. Rebello, D. Lee ...

author keywords: Raman spectroscopy; Cancer metastasis; Random forests; Phenotype switch; TWIST
Source: Web Of Science
Added: August 1, 2022

2021 journal article

Construction of heparan sulfate microarray for investigating the binding of specific saccharide sequences to proteins

GLYCOBIOLOGY, 31(3), 188–199.

By: M. Horton*, G. Su*, L. Yi*, Z. Wang*, Y. Xu*, V. Pagadala*, F. Zhang*, D. Zaharoff ...

author keywords: carbohydrates; chemoenzymatic synthesis; heparan sulfate; microarray; oligosaccharides
Source: Web Of Science
Added: May 24, 2021

2021 article

INJECTABLE CHITOSAN HYDROGEL FOR LOCALIZED DELIVERY OF IMMUNE CHECKPOINT INHIBITORS

Mantooth, S., Zaharoff, D., & Mantooth, S. (2021, November). JOURNAL FOR IMMUNOTHERAPY OF CANCER, Vol. 9, pp. A281–A281.

By: S. Mantooth, D. Zaharoff & S. Mantooth

Source: Web Of Science
Added: April 18, 2022

2021 article

ONCO-IMMUNOLOGICAL MECHANISMS OF FOCAL ABLATION AND LOCALIZED IL-12 IMMUNOTHERAPY

Vrabel, M., Zaharoff, D., & Mantooth, S. (2021, November). JOURNAL FOR IMMUNOTHERAPY OF CANCER, Vol. 9, pp. A650–A650.

By: M. Vrabel n, D. Zaharoff & S. Mantooth

Source: Web Of Science
Added: April 18, 2022

2021 journal article

Safety and Pharmacokinetics of Intravesical Chitosan/Interleukin-12 Immunotherapy in Murine Bladders

BLADDER CANCER, 7(4), 427–437.

By: K. Nguyen, E. Wagner n, M. Vrabel n, S. Mantooth, D. Meritet & D. Zaharoff

author keywords: Bladder cancer; Interleukin-12; immunotherapy; chitosan; intravesical
Source: Web Of Science
Added: January 10, 2022

2020 article

INTRATUMORAL INTERLEUKIN-12 ADMINISTERED AFTER CRYOABLATION DOES NOT IMPROVE SURVIVAL IN MULTIPLE BILATERAL MURINE MODELS

Vrabel, M., Schulman, J., & Zaharoff, D. (2020, November). JOURNAL FOR IMMUNOTHERAPY OF CANCER, Vol. 8, pp. A277–A278.

By: M. Vrabel n, J. Schulman & D. Zaharoff

Source: Web Of Science
Added: March 1, 2021

2019 journal article

Analyzing the effects of instillation volume on intravesical delivery using biphasic solute transport in a deformable geometry

MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA, 36(2), 139–156.

By: S. Smith, B. Griffith & D. Zaharoff

author keywords: bladder cancer; cystitis; intravesical delivery; FEBio
Source: Web Of Science
Added: November 18, 2019

2019 journal article

Design of a thrombin resistant human acidic fibroblast growth factor (hFGF1) variant that exhibits enhanced cell proliferation activity

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 518(2), 191–196.

By: R. Kerr*, S. Agrawal*, S. Maity*, B. Koppolu n, S. Jayanthi*, G. Kumar*, R. Gundampati*, D. McNabb*, D. Zaharoff, T. Kumar*

author keywords: Fibroblast growth factor; Cell signaling; Stability; Heparin; Binding affinity; Cell proliferation
Source: Web Of Science
Added: January 21, 2020

2019 journal article

Flow-Encoded Oxygen Control to Track the Time-Dependence of Molecular Changes Induced by Static or Cycling Hypoxia

ANALYTICAL CHEMISTRY, 91(23), 15032–15039.

By: M. Yao, Z. Rabbani, T. Sattler, K. Nguyen*, D. Zaharoff, G. Walker, M. Gamcsik

Source: Web Of Science
Added: December 30, 2019

2019 journal article

Molecular mechanisms of heparin-induced modulation of human interleukin 12 bioactivity

Journal of Biological Chemistry, 294(12), 4412–4424.

By: K. Nguyen n, F. Gillam n, J. Hopkins n, S. Jayanthi*, R. Gundampati*, G. Su*, J. Bear*, G. Pilkington* ...

author keywords: heparin; interleukin; glycosaminoglycan; cytokine; immunology; heparan sulfate; heparin-binding cytokine; IL-12
Source: Crossref
Added: February 24, 2020

2019 journal article

ULTRASOUND-STIMULATED PHASE-CHANGE CONTRAST AGENTS FOR TRANSEPITHELIAL DELIVERY OF MACROMOLECULES, TOWARD GASTROINTESTINAL DRUG DELIVERY

ULTRASOUND IN MEDICINE AND BIOLOGY, 45(7), 1762–1776.

By: S. Fix*, B. Koppolu, A. Novell*, J. Hopkins, T. Kierski n, D. Zaharoff, P. Dayton, V. Papadopoulou n

author keywords: Ultrasound; Transepithelial delivery; Acoustic droplet vaporization; Phase-change contrast agents; Nanodroplet
Source: Web Of Science
Added: June 24, 2019

2018 journal article

Effect of extension of the heparin binding pocket on the structure, stability, and cell proliferation activity of the human acidic fibroblast growth factor

Biochemistry and Biophysics Reports, 13, 45–57.

By: J. Davis*, R. Gundampati*, S. Jayanthi*, J. Anderson*, A. Pickhardt*, B. Koppolu n, D. Zaharoff, T. Kumar*

author keywords: Fibroblast growth factor; Heparin binding; Stability; Cell proliferation
Source: Crossref
Added: February 24, 2020

2018 journal article

Probing the role of proline-135 on the structure, stability, and cell proliferation activity of human acidic fibroblast growth factor

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 654, 115–125.

By: J. Davis*, A. Alghanmi*, R. Gundampati*, S. Jayanthi*, E. Fields*, M. Armstrong*, V. Weidling*, V. Shah* ...

author keywords: Fibroblast growth factor; Heparin binding; Charge-reversal; Bioactivity; Stability
Source: Web Of Science
Added: October 19, 2018

2018 journal article

Tumor-derived granulocyte colony-stimulating factor diminishes efficacy of breast tumor cell vaccines

BREAST CANCER RESEARCH, 20.

By: S. Ravindranathan*, K. Nguyen*, S. Kurtz*, H. Frazier*, S. Smith, B. Koppolu n, N. Rajaram*, D. Zaharoff

author keywords: Breast cancer vaccine; Autologous tumor cell vaccine; MDSCs; Breast cancer immunogenicity
Source: Web Of Science
Added: November 12, 2018

2017 journal article

Immunological mechanisms of intravesical chitosan/interleukin-12 immunotherapy against murine bladder cancer

ONCOIMMUNOLOGY, 6(1).

By: S. Smith, J. Baltz*, B. Koppolu, S. Ravindranathan*, K. Nguyen* & D. Zaharoff

author keywords: BCG; bladder cancer; chitosan; immunotherapy; interleukin-12; intratumoral; intravesical; MDSC; TILS; TReg
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Modulation of Interleukin-12 activity in the presence of heparin

SCIENTIFIC REPORTS, 7.

By: S. Jayanthi*, B. Koppolu, K. Nguyen*, S. Smith, B. Felber*, T. Kumar*, D. Zaharoff

Source: Web Of Science
Added: August 6, 2018

2017 article

Strategic Directions in Immunoresponsive Biomaterials in Tissue Engineering INTRODUCTION

Zaharoff, D. A., & Jewell, C. M. (2017, October). TISSUE ENGINEERING PART A, Vol. 23, pp. 1042–1043.

By: D. Zaharoff & C. Jewell*

Source: Web Of Science
Added: August 6, 2018

2015 journal article

Corrigendum to ‘Controlling chitosan-based encapsulation for protein and vaccine delivery’ [Biomaterials 35 (2014) 4382–4389]

Biomaterials, 73, 308.

Source: Crossref
Added: August 28, 2020

2015 journal article

Intravesical chitosan/interleukin-12 immunotherapy induces tumor-specific systemic immunity against murine bladder cancer

Cancer Immunology, Immunotherapy, 64(6), 689–696.

author keywords: Intravesical immunotherapy; Bladder cancer; Interleukin-12; Chitosan
Source: Crossref
Added: February 24, 2020

2014 journal article

Controlling chitosan-based encapsulation for protein and vaccine delivery

Biomaterials, 35(14), 4382–4389.

author keywords: Chitosan particles; Protein encapsulation; Vaccine delivery; Precipitation-coacervation; Microencapsulation; Nanoencapsulation
Source: Crossref
Added: August 28, 2020

2014 journal article

Efficient production and purification of recombinant human interleukin-12 (IL-12) overexpressed in mammalian cells without affinity tag

Protein Expression and Purification, 102, 76–84.

author keywords: Interleukin-12; Heparin Sepharose; HEK293; Cytokine; Purification; Bioactivity
Source: Crossref
Added: August 28, 2020

2013 journal article

583 INTRAVESICAL IMMUNOTHERAPY WITH CHITOSAN AND INTERLEUKIN-12 INDUCES SYSTEMIC TUMOR-SPECIFIC IMMUNITY

Journal of Urology, 189(4S).

By: S. Smith*, L. Yang*, J. Vo* & D. Zaharoff

Source: Crossref
Added: August 28, 2020

2013 journal article

Nanotheranostics of Circulating Tumor Cells, Infections and Other Pathological Features in Vivo

Molecular Pharmaceutics, 10(3), 813–830.

author keywords: metastasis; circulating tumor cells (CTCs); circulating endothelial cells (CECs); circulating cancer stem cells (CCSCs); circulating microparticles and exosomes; circulating pathogens; viruses and parasites; blood clots; blood and lymph flow; contrast nanoagents; positive and negative photoacoustic contrasts; micro- and nanobubbles; multimodal; multicolor; nanotechnology; multifunctional real-time nanotheranostics; nanomedicine
Source: Crossref
Added: October 29, 2020

2013 journal article

Role of chitosan co-formulation in enhancing interleukin-12 delivery and antitumor activity

Biomaterials, 34(15), 3828–3836.

By: L. Yang* & D. Zaharoff

author keywords: Chitosan; Paracrine delivery; Interleukin-12; Intratumoral; Immunotherapy
Source: Crossref
Added: August 28, 2020

2013 journal article

The effect of antigen encapsulation in chitosan particles on uptake, activation and presentation by antigen presenting cells

Biomaterials, 34(9), 2359–2369.

By: B. Koppolu* & D. Zaharoff

author keywords: Chitosan particles; Antigen delivery; Antigen presentation; Adjuvant; Co-stimulation
Source: Crossref
Added: August 28, 2020

2011 journal article

In vivo efficacy of a chitosan/IL-12 adjuvant system for protein-based vaccines

Biomaterials, 32(3), 926–932.

By: M. Heffernan*, D. Zaharoff, J. Fallon*, J. Schlom* & J. Greiner*

author keywords: Chitosan; Drug delivery; Immunostimulation; Interleukin 12; Polysaccharide; Vaccine
Source: Crossref
Added: August 28, 2020

2008 journal article

Exercise enhances vaccine-induced antigen-specific T cell responses

Vaccine, 26(42), 5407–5415.

By: C. Rogers*, D. Zaharoff, K. Hance*, S. Perkins*, S. Hursting*, J. Schlom*, J. Greiner*

author keywords: adaptive immunity; cytokines; cell proliferation
Source: Crossref
Added: August 28, 2020

2007 journal article

Chitosan solution enhances both humoral and cell-mediated immune responses to subcutaneous vaccination

Vaccine, 25(11), 2085–2094.

By: D. Zaharoff, C. Rogers*, K. Hance*, J. Schlom* & J. Greiner*

author keywords: adjuvant; depot; vaccination
Source: Crossref
Added: August 28, 2020

2007 journal article

Chitosan solution enhances the immunoadjuvant properties of GM-CSF

Vaccine, 25(52), 8673–8686.

By: D. Zaharoff, C. Rogers*, K. Hance*, J. Schlom* & J. Greiner*

author keywords: chitosan; immunoadjuvant; GM-CSF; controlled release; cytokine
Source: Crossref
Added: August 28, 2020

2007 journal article

Electric field-mediated transport of plasmid DNA in tumor interstitium in vivo

Bioelectrochemistry, 71(2), 233–242.

By: J. Henshaw*, D. Zaharoff, B. Mossop* & F. Yuan*

author keywords: in vivo DNA electrophoresis; interstitial transport; non-viral gene therapy; DNA electrotransfer; electric field-mediated gene delivery
Source: Crossref
Added: August 28, 2020

2006 journal article

A single molecule detection method for understanding mechanisms of electric field-mediated interstitial transport of genes

Bioelectrochemistry, 69(2), 248–253.

By: J. Henshaw*, D. Zaharoff, B. Mossop* & F. Yuan*

author keywords: single molecule detection; DNA electromobility; interstitial transport; electric field-mediated gene delivery; non-viral gene delivery
Source: Crossref
Added: August 28, 2020

2006 journal article

Electric Fields in Tumors Exposed to External Voltage Sources: Implication for Electric Field-Mediated Drug and Gene Delivery

Annals of Biomedical Engineering, 34(10), 1564–1572.

By: B. Mossop*, R. Barr*, J. Henshaw*, D. Zaharoff & F. Yuan*

author keywords: drug and gene delivery; electroporation; electrogenetherapy; electrochemotherapy
Source: Crossref
Added: August 28, 2020

2006 journal article

Electric field-mediated enhancement of in vivo transport of plasmid DNA in tumor interstitium

Journal of Biomechanics, 39, S377.

By: J. Henshaw, D. Zaharoff, B. Mossop & F. Yuan

Source: Crossref
Added: August 28, 2020

2006 journal article

Nonlinear Dependence of Hydraulic Conductivity on Tissue Deformation During Intratumoral Infusion

Annals of Biomedical Engineering, 34(7), 1173–1181.

By: S. McGuire*, D. Zaharoff & F. Yuan*

author keywords: collagen concentration; hydraulic conductivity; intratumoral infusion; drug and gene delivery
Source: Crossref
Added: August 28, 2020

2004 journal article

Effects of pulse strength and pulse duration on in vitro DNA electromobility

Bioelectrochemistry, 62(1), 37–45.

By: D. Zaharoff & F. Yuan*

author keywords: interstitial transport; plasmid electromobility; electric field-mediated gene delivery; non-viral gene delivery
Source: Crossref
Added: August 28, 2020