Darcy Brittain Adin

Works (24)

Updated: December 11th, 2024 05:01

2024 article

Correlation of serum chloride concentrations with components of the renin-angiotensin-aldosterone system in a dog with congestive heart failure

Banken, C., Harris, A. N., Conway, R., Benjamin, E. J., Shoemaker, R., & Adin, D. (2024, October 31). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 10.

By: C. Banken*, A. Harris* , R. Conway*, E. Benjamin *, R. Shoemaker * & D. Adin*

author keywords: diuretics; electrolytes; hypochloremia; RAAS
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2024

2023 article

Efficacy of a mitral regurgitation severity index to predict long-term outcome in dogs with myxomatous mitral valve disease

Vereb, M., Atkins, C. E., Adin, D., Blondel, T., Coffman, M., Lee, S., … Ward, J. L. (2023, November 1). JOURNAL OF VETERINARY INTERNAL MEDICINE.

By: M. Vereb*, C. Atkins n, D. Adin*, T. Blondel, M. Coffman, S. Lee, E. Guillot, J. Ward *

author keywords: congestive heart failure; echocardiography; prognosis; thoracic radiographs; vertebral heart size; vertebral left atrial size
TL;DR: MRSI was predictive of outcome (onset of CHF and all‐cause death) in MMVD Stage B2, demonstrating utility as a useful prognostic tool. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 20, 2023

2023 journal article

Evaluation of Renin-Angiotensin-Aldosterone System Components and Enzymes in Systemically Hypertensive Cats Receiving Amlodipine

ANIMALS, 13(22).

By: D. Adin*, C. Atkins n, O. Domenig, C. Glahn, T. Defrancesco n  & K. Meurs n 

author keywords: feline; blood pressure; kidney
TL;DR: The findings suggest that the use of concurrent RAAS-suppressant therapy, specifically aldosterone antagonism, in amlodipine-treated SHT cats with chronic kidney disease might be indicated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 18, 2023

2023 journal article

The effect of taurine supplementation on the renin-angiotensin-aldosterone system of dogs with congestive heart failure

SCIENTIFIC REPORTS, 13(1).

By: S. Brethel*, S. Locker*, R. Girens*, P. Rivera *, K. Meurs n  & D. Adin*

TL;DR: Overall, taurine only lowered AA2 in this group of dogs, however, response heterogeneity was noted, with some dogs showing RAAS suppression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023

2021 journal article

A deleterious mutation in the ALMS1 gene in a naturally occurring model of hypertrophic cardiomyopathy in the Sphynx cat

ORPHANET JOURNAL OF RARE DISEASES, 16(1).

By: K. Meurs n , B. Williams n, D. DeProspero n, S. Friedenberg*, D. Malarkey*, J. Ezzell *, B. Keene n, D. Adin n, T. DeFrancesco n , S. Tou n

author keywords: Hypertrophic cardiomyopathy; ALMS1; Feline; Mitogenic; Sphynx
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Cats / genetics; Cell Cycle Proteins / genetics; Exons; Mice; Mutation / genetics
TL;DR: This study demonstrates a novel form of cardiomyopathy associated with ALMS1 in the cat, and suggests that variants in genes involved with cardiac development and cell regulation, like the AL MS1 gene, may deserve further consideration for association with familial hypertrophic cardiopathy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: April 12, 2021

2021 journal article

Absence of known feline MYH7 and MYBPC3 variants in a diverse cohort of cats with hypertrophic cardiomyopathy

ANIMAL GENETICS, 52(4), 542–544.

By: . K. O'Donnell, D. Adin n, C. Atkins n, T. DeFrancesco n , B. Keene n, S. Tou n, K. Meurs n 

author keywords: cardiomyopathy; feline; genetic; HCM; mutation
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Cardiomyopathy, Hypertrophic / veterinary; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cat Diseases / genetics; Cat Diseases / metabolism; Cats; Female; Genetic Variation; Male; Myosin Heavy Chains / genetics; Myosin Heavy Chains / metabolism
TL;DR: The lack of these MYBPC3 and MYH7 variants in this feline HCM population indicates that the clinical utility of genetic testing for these variants may be isolated to the two cat breeds in which these variants have been identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 17, 2021

2021 journal article

Association of diet with clinical outcomes in dogs with dilated cardiomyopathy and congestive heart failure*

JOURNAL OF VETERINARY CARDIOLOGY, 40, 99–109.

By: A. Walker*, T. DeFrancesco n , J. Bonagura n , B. Keene n, K. Meurs n , S. Tou n, K. Kurtz*, B. Aona* ...

author keywords: Canine; Survival; Grain-free; Echocardiography; Nutritional
MeSH headings : Animals; Dogs; Cardiomyopathy, Dilated / diagnosis; Cardiomyopathy, Dilated / veterinary; Diet / veterinary; Dog Diseases / diagnosis; Echocardiography / veterinary; Edible Grain; Heart Failure / complications; Heart Failure / therapy; Heart Failure / veterinary; Retrospective Studies
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 6, 2022

2021 journal article

Effect of spironolactone and benazepril on furosemide-induced diuresis and renin-angiotensin-aldosterone system activation in normal dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, 35(3), 1245–1254.

By: D. Adin*, C. Atkins n, G. Wallace * & A. Klein n

author keywords: aldosterone antagonist; angiotensin‐ converting enzyme inhibitor; continuous rate infusion; diuretic resistance; neurohormone; urine production
MeSH headings : Aldosterone; Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Benzazepines; Diuresis; Diuretics / pharmacology; Dogs; Furosemide / pharmacology; Male; Renin-Angiotensin System; Spironolactone / pharmacology
TL;DR: The neurohormonal profile during FCRI supports RAAS mediation of diuretic braking in this model, and delayed changes in sCr and serum sodium concentration and incomplete recovery of hydration indicators caused by furosemide hold implications for clinical patients. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: April 5, 2021

2021 journal article

Myxomatous mitral valve disease in Miniature Schnauzers and Yorkshire Terriers: 134 cases (2007-2016)

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 259(12), 1428–1432.

By: D. DeProspero n, . Kerry A. O'Donnell n, T. DeFrancesco n , B. Keene n, S. Tou n, D. Adin n, C. Atkins n, K. Meurs n 

MeSH headings : Animals; Dog Diseases / epidemiology; Dogs; Heart Valve Diseases / veterinary; Humans; Mitral Valve; Mitral Valve Prolapse / epidemiology; Mitral Valve Prolapse / veterinary; Prospective Studies
TL;DR: Features of the disease among Miniature Schnauzers and Yorkshire Terriers were similar, but there were also a few discernable differences between these 2 breeds and from historical findings for dogs with MMVD of other breeds. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 21, 2022

2020 journal article

Correction of serum chloride concentration in dogs with congestive heart failure

JOURNAL OF VETERINARY INTERNAL MEDICINE, 35(1), 51–57.

By: D. Adin*, C. Atkins n, L. Londono * & B. Del Nero*

author keywords: antidiuretic hormone; hypochloremia; sodium
MeSH headings : Animals; Chlorides; Diuretics / therapeutic use; Dog Diseases / drug therapy; Dogs; Heart Failure / drug therapy; Heart Failure / veterinary; Retrospective Studies; Sodium
TL;DR: Serum [Cl- ] increased after mathematical correction in Stage D CHF dogs but not in Stage C and NO-CHF dogs, and hypochloremia persisted, consistent with concurrent loop diuretic effects on electrolytes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: January 4, 2021

2020 journal article

Preliminary Evaluation of a Wearable Sensor System for Heart Rate Assessment in Guide Dog Puppies

IEEE SENSORS JOURNAL, 20(16), 9449–9459.

By: M. Foster n , R. Brugarolas n, K. Walker n, S. Mealin n, Z. Cleghern n, S. Yuschak n, J. Clark n, D. Adin n ...

author keywords: ECG; heart rate variability; electrodes; machine learning; 3D printing; wearable
TL;DR: A novel wireless heart rate sensing system for puppies in training as guide dogs that includes a harness with on-board electrocardiography front-end circuit, inertial measurement unit and a micro-computer with wireless capability is developed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 10, 2020

2020 journal article

Renin-angiotensin aldosterone profile before and after angiotensin-converting enzyme-inhibitor administration in dogs with angiotensin-converting enzyme gene polymorphism

JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(2), 600–606.

By: D. Adin*, C. Atkins n, O. Domenig, T. DeFrancesco n , B. Keene n, S. Tou n, J. Stern* , K. Meurs n 

author keywords: ACE-inhibitor; enalapril; genotype; pharmacogenetic; pharmacogenomic
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Genetic Predisposition to Disease; Genotype; Humans; Mitral Valve Prolapse / enzymology; Mitral Valve Prolapse / genetics; Peptidyl-Dipeptidase A / genetics; Peptidyl-Dipeptidase A / metabolism; Polymorphism, Genetic; Renin-Angiotensin System / physiology; Retrospective Studies
TL;DR: The results support the use of aldosterone receptor antagonists with ACE‐inhibitors when RAAS inhibition is indicated for dogs, especially those positive for the ACE gene polymorphism, which did not alter baseline RAAS activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 16, 2020

2019 journal article

A missense variant in the titin gene in Doberman pinscher dogs with familial dilated cardiomyopathy and sudden cardiac death

Human Genetics, 138(5), 515–524.

By: K. Meurs n , S. Friedenberg*, J. Kolb *, C. Saripalli*, P. Tonino *, K. Woodruff n, N. Olby n , B. Keene n ...

MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / veterinary; Connectin / genetics; Death, Sudden, Cardiac / etiology; Death, Sudden, Cardiac / veterinary; Disease Models, Animal; Dogs; Female; Genetic Predisposition to Disease / genetics; Male; Mutation, Missense / genetics; Protein Kinases / genetics; Whole Genome Sequencing
TL;DR: The dog provides a large animal model of familial dilated cardiomyopathy and is an excellent model to improve the understanding of the genotypic phenotypic relationships, penetrance, expression and the pathophysiology of variants in the titin gene. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 17, 2019

2019 journal article

Cardiac Leiomyosarcoma in a Cat Presenting for Bilateral Renal Neoplasia

JOURNAL OF COMPARATIVE PATHOLOGY, 168, 19–24.

By: M. Schreeg n, B. Evans n, J. Allen n, M. Lewis n , E. Luckring n, M. Evola n, D. Richard, K. Piner* ...

author keywords: cardiac neoplasia; cat; immunohistochemistry; leiomyosarcoma
MeSH headings : Animals; Cat Diseases / pathology; Cats; Female; Heart Neoplasms / veterinary; Kidney Neoplasms / veterinary; Leiomyosarcoma / veterinary
TL;DR: A 10-year-old neutered female domestic longhair cat was presented to a tertiary care veterinary hospital for evaluation of a right renal mass that was identified incidentally on abdominal radiographs as a sarcoma based on fine needle aspiration cytology, and diagnosed with cardiac leiomyosarcoma with pulmonary and bilateral renal metastasis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 4, 2019

2019 journal article

Cross-Sectional Assessment of the Emotional Intelligence of Fourth-Year Veterinary Students and Veterinary House Officers in a Teaching Hospital

JOURNAL OF VETERINARY MEDICAL EDUCATION, 47(2), 193–201.

By: D. Adin*, K. Royal*  & C. Adin*

author keywords: emotions; expression; empathy; stress; resident; training
MeSH headings : Cross-Sectional Studies; Education, Veterinary; Emotional Intelligence; Hospitals, Teaching / statistics & numerical data; Humans; Students / psychology; Students / statistics & numerical data
TL;DR: B baseline EI scores of 4th-year veterinary students, interns, and residents at a teaching hospital were similar to, but uniformly lower than, those of other professionals and did not increase with training level. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: April 14, 2020

2018 article

ECG of the Month

McManamey, A. K., Adin, D. B., Elfenbeien, J. R., & Manship, A. J. (2018, September 15). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 253, pp. 714–717.

By: A. McManamey*, D. Adin*, J. Elfenbeien & A. Manship

MeSH headings : Animals; Diagnosis, Differential; Electrocardiography / veterinary; Horse Diseases / diagnosis; Horse Diseases / physiopathology; Horses; Humans; Male; Tachycardia, Supraventricular / diagnosis; Tachycardia, Supraventricular / veterinary
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 19, 2018

2018 journal article

Echocardiographic phenotype of canine dilated cardiomyopathy differs based on diet type

JOURNAL OF VETERINARY CARDIOLOGY, 21, 1–9.

By: D. Adin n, T. DeFrancesco n , B. Keene n, S. Tou n, K. Meurs n , C. Atkins n, B. Aona n, K. Kurtz n ...

author keywords: Nutritional; Heart failure; Dog; Taurine
MeSH headings : Animals; Cardiomyopathy, Dilated / diagnostic imaging; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / veterinary; Diet / adverse effects; Diet / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Echocardiography / veterinary; Edible Grain / adverse effects; Female; Male; Phenotype
TL;DR: Dietary-associated DCM occurs with some GF diets and can improve with nutritional management, including diet change, and the role of taurine supplementation, even without deficiency, is uncertain. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 2, 2019

2018 journal article

Myxomatous mitral valve disease in the miniature poodle: A retrospective study

VETERINARY JOURNAL, 244, 94–97.

By: K. Meurs n , D. Adin n, . K. O'Donnell, B. Keene n, C. Atkins n, T. DeFrancesco n , S. Tou n

author keywords: Canine; Genetic; Miniature poodle; Mitral valve; Myxomatous valve
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / epidemiology; Dog Diseases / genetics; Dogs; Female; Male; Mitral Valve Prolapse / diagnostic imaging; Mitral Valve Prolapse / epidemiology; Mitral Valve Prolapse / genetics; Mitral Valve Prolapse / veterinary; North Carolina / epidemiology; Pedigree; Records; Retrospective Studies; Severity of Illness Index
TL;DR: In the miniature poodles reported here, MMVD appears to be a fairly late onset disease and often is a mild phenotype. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 2, 2019

2018 journal article

Pharmacodynamic assessment of diuretic efficacy and braking in a furosemide continuous infusion model

JOURNAL OF VETERINARY CARDIOLOGY, 20(2), 92–101.

By: D. Adin n, C. Atkins n & M. Papich n 

author keywords: Lasix; Urine; Natriuresis; Aldosterone
MeSH headings : Aldosterone / urine; Animals; Diuretics / administration & dosage; Diuretics / blood; Diuretics / pharmacology; Diuretics / urine; Dogs; Electrolytes / urine; Furosemide / administration & dosage; Furosemide / blood; Furosemide / pharmacology; Furosemide / urine; Infusions, Intravenous; Male; Renin-Angiotensin System / drug effects
TL;DR: The decrease in uNa:uK over time during the infusion is consistent with mineralocorticoid modification of urinary electrolyte excretion, supporting renin-angiotensin-aldosterone activation as a cause of diuretic braking in this model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2018 journal article

Simultaneous Monitoring of Canine Heart Rate and Respiratory Patterns During Scent Detection Tasks

IEEE SENSORS JOURNAL, 19(4), 1454–1462.

By: R. Brugarolas n, S. Yuschak n, D. Adin n, D. Roberts n, B. Sherman n & A. Bozkurt n

author keywords: Sniffing; tachogram; PSD; wearable; ECG
TL;DR: These contributions pave the way for a novel real-time cybernetic olfactory detection monitoring system to provide decision support for handlers in the field in addition to enabling future computer-sniffing dog interfaces. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 18, 2019

2017 journal article

Angiotensin-converting enzyme activity and inhibition in dogs with cardiac disease and an angiotensin-converting enzyme polymorphism

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 18(4).

By: K. Meurs n , J. Stern n , C. Atkins n, D. Adin n, B. Aona n, J. Condit n, T. DeFrancesco n , Y. Reina-Doreste n ...

author keywords: Polymorphism; canine; angiotensin-converting enzyme; enalapril
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / therapeutic use; Animals; Breeding; Dogs; Genotype; Heart Diseases / drug therapy; Heart Diseases / enzymology; Heart Diseases / genetics; Peptidyl-Dipeptidase A / genetics; Polymorphism, Genetic
TL;DR: It is possible that the genetic status and ACE activity of dogs may impact the response of dogs with this variant to an ACE inhibitor, and an ACE polymorphism is associated with lower levels of ACE activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Evaluation of genes associated with human myxomatous mitral valve disease in dogs with familial myxomatous mitral valve degeneration

VETERINARY JOURNAL, 232, 16–19.

By: K. Meurs n , S. Friedenberg *, B. Williams n, B. Keene n, C. Atkins n, D. Adin n, B. Aona n, T. DeFrancesco n  ...

author keywords: Canine; Cavalier King Charles spaniel; Dachshund; Genetic; Mitral valve; Myxomatous valve
MeSH headings : Animals; DNA / blood; Dog Diseases / genetics; Dogs; Heart Valve Diseases / genetics; Heart Valve Diseases / veterinary; Humans; Mitral Valve; Mitral Valve Prolapse / genetics; Mutation; Species Specificity; Whole Genome Sequencing / veterinary
TL;DR: Although mitral valve disease in the CKCS and Dachshund is a familial disease, it was hypothesized that a genetic mutation associated with the development of the human form of MMVD was associated withthe development of canine MMVD and this work identified genetic cause in the genes responsible for the human disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Long-term Stability of a Compounded Suspension of Torsemide (5 mg/mL) for Oral Administration

JOURNAL OF VETERINARY INTERNAL MEDICINE, 31(6), 1822–1826.

By: D. Adin n, P. Johnson *, C. Kim*, T. Nguyenba & S. Rosen n

author keywords: Heart failure; Loop diuretic
MeSH headings : Administration, Oral; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Compounding / veterinary; Drug Stability; Drug Storage; Furosemide / administration & dosage; Pharmaceutical Solutions; Pharmaceutical Vehicles / chemistry; Refrigeration; Sulfonamides / administration & dosage; Sulfonamides / chemistry; Suspensions; Temperature; Torsemide
TL;DR: The results support the assignment of a 90‐day BUD for torsemide 5 mg/mL suspension for oral administration compounded in OraPlus:Sweet 1:1 buffered to a pH of 8.3 and indicate availability of a validated and stable compounded formulation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Furosemide continuous rate infusion diluted with 5% dextrose in water or hypertonic saline in normal adult dogs: a pilot study

JOURNAL OF VETERINARY CARDIOLOGY, 19(1), 44–56.

By: D. Adin n, C. Atkins n, M. Papich n , T. DeFrancesco n , E. Griffiths n, M. Penteado*, K. Kurtz n, A. Klein n

author keywords: Lasix; Diuretic; Sodium; Salt
MeSH headings : Animals; Cross-Over Studies; Diuretics / administration & dosage; Diuretics / adverse effects; Diuretics / pharmacokinetics; Dogs; Furosemide / administration & dosage; Furosemide / adverse effects; Furosemide / pharmacokinetics; Glucose / administration & dosage; Infusions, Intravenous / veterinary; Male; Pilot Projects; Saline Solution, Hypertonic / administration & dosage; Single-Blind Method; Water
TL;DR: Diuresis was similar for both furosemide CRI methods; however, the H-SAL method induced less renin-angiotensin-aldosterone system activation than the DEX method, suggesting that dilution of a furo Semine CRI with 2.4% hypertonic saline may be well tolerated in heart failure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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