Dennis Kien Balaong Pacardo

Works (7)

Updated: July 5th, 2023 15:43

2015 journal article

A dual wavelength-activatable gold nanorod complex for synergistic cancer treatment

NANOSCALE, 7(28), 12096–12103.

By: D. Pacardo n, B. Neupane n, S. Rikard  n, Y. Lu n, R. Mo n, S. Mishra n, J. Tracy n , G. Wang n, F. Ligler n, Z. Gu n

Contributors: D. Pacardo n, B. Neupane n, S. Rikard  n, Y. Lu n, R. Mo n, S. Mishra n, J. Tracy n , G. Wang n, F. Ligler n, Z. Gu n

MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Drug Screening Assays, Antitumor; Gold / chemistry; Gold / pharmacology; HeLa Cells; Humans; Infrared Rays; Nanotubes / chemistry; Neoplasms / drug therapy; Photochemotherapy
TL;DR: This multifunctional AuNR-based system represents a novel theranostic strategy for spatiotemporal delivery of anticancer therapeutics and demonstrates enhanced anticancer efficacy through the synergistic combination of promoted drug release upon ultraviolet (UV) light irradiation and photothermal therapy upon infrared (IR) irradiation. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 review

Programmable nanomedicine: synergistic and sequential drug delivery systems

[Review of ]. NANOSCALE, 7(8), 3381–3391.

By: D. Pacardo n, F. Ligler n & Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Cell Line, Tumor; DNA / chemistry; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Drug Resistance, Neoplasm; Humans; Microscopy, Electron, Transmission; Nanomedicine / methods; Nanoparticles / chemistry; Neoplasms / drug therapy; Neoplasms / pathology
TL;DR: This minireview discusses the current advances in programmable nanocarriers for cancer therapy with particular emphasis on synergistic and sequential drug delivery systems. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Transformable liquid-metal nanomedicine

NATURE COMMUNICATIONS, 6(1).

By: Y. Lu n, Q. Hu n, Y. Lin n, D. Pacardo n, C. Wang n, W. Sun n, F. Ligler n, M. Dickey n , Z. Gu*

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / chemistry; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Drug Carriers / chemistry; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Female; Gallium / chemistry; Humans; Indium / chemistry; Metal Nanoparticles / chemistry; Mice; Mice, Inbred BALB C; Nanomedicine / instrumentation; Nanomedicine / methods; Neoplasms / drug therapy
TL;DR: A transformable liquid-metal nanomedicine, based on a core–shell nanosphere composed of a liquid-phase eutectic gallium-indium core and a thiolated polymeric shell, providing a new strategy for engineering theranostic agents with low toxicity. (via Semantic Scholar)
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Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

A temperature microsensor for measuring laser-induced heating in gold nanorods

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 407(3), 719–725.

By: D. Pacardo n, B. Neupane n, G. Wang n, Z. Gu n, G. Walker n & F. Ligler n

author keywords: Microsensor; Gold nanorods; Temperature; Nanoparticles; Microfluidics
MeSH headings : Chemistry Techniques, Analytical / instrumentation; Chemistry Techniques, Analytical / methods; Equipment Design; Gold; Heating; Hot Temperature; Lasers; Microtechnology; Nanotubes / analysis
TL;DR: The results demonstrate the suitability of this simple temperature microsensor for determining laser-induced heating profiles of metallic nanomaterials; such measurements will be essential for optimizing therapeutic and catalytic applications. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2014 journal article

Facile Fabrication of Color Tunable Film and Fiber Nanocomposites via Thiol Click Chemistry

MACROMOLECULES, 47(2), 695–704.

By: D. Boyd *, J. Naciri*, J. Fontana *, D. Pacardo n, A. Shields*, J. Verbarg*, C. Spillmann *, F. Ligler n

Source: Web Of Science
Added: August 6, 2018

2014 journal article

Self-folded redox/acid dual-responsive nanocarriers for anticancer drug delivery

CHEMICAL COMMUNICATIONS, 50(95), 15105–15108.

By: Y. Lu n, R. Mo n, W. Tai n, W. Sun n, D. Pacardo n, C. Qian  n, Q. Shen *, F. Ligler n, Z. Gu n

MeSH headings : Antineoplastic Agents / administration & dosage; Antineoplastic Agents / chemistry; Cell Survival / drug effects; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Drug Carriers / administration & dosage; Drug Carriers / chemistry; Folic Acid / administration & dosage; Folic Acid / chemistry; Glutathione / chemistry; HeLa Cells; Humans; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Oxidation-Reduction; Peptides / chemistry; Polyethylene Glycols / chemistry
TL;DR: Self-folded redox/acid dual-responsive nanocarriers developed for physiologically triggered delivery of anticancer drugs suggest their potential as a promising formulation for tumor-targeted chemotherapy. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Small-Molecule Detection in Thiol-Yne Nanocomposites via Surface-Enhanced Raman Spectroscopy

ANALYTICAL CHEMISTRY, 86(24), 12315–12320.

By: D. Boyd *, F. Bezares *, D. Pacardo n, M. Ukaegbu *, C. Hosten* & F. Ligler n

MeSH headings : Nanocomposites; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman / methods; Sulfhydryl Compounds / chemistry; Surface Properties
TL;DR: Thiol-yne nanocomposite films and fibers fabricated using exposure to long-wave ultraviolet light after the inclusion of gold nanoparticles functionalized with thiophenol indicated that thiol-ynes may be useful as durable film or fiber SERS probes. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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