Dennis Brown

Yamamoto, K. A., Blackburn, K., Goshe, M. B., Brown, D. T., Migoswski, E., Campanhon, I. B., … Soares, M. R. (2023). Tizoxanide Antiviral Activity on Dengue Virus Replication. VIRUSES-BASEL, 15(3). https://doi.org/10.3390/v15030696

Schuchman, R. M., Vancini, R., Piper, A., Breuer, D., Ribeiro, M., Ferreira, D., … Brown, D. T. (2018). Role of the vacuolar ATPase in the Alphavirus replication cycle. Heliyon, 4(7), e00701. https://doi.org/10.1016/J.HELIYON.2018.E00701

Magliocca, J., Vancini, R., Hernandez, R., & Brown, D. T. (2016). Single-Site Glycoprotein Mutants Inhibit a Late Event in Sindbis Virus Assembly. JOURNAL OF VIROLOGY, 90(18), 8372–8380. https://doi.org/10.1128/jvi.00948-16

Schuchman, R., Vancini, R., Piper, A., Breuer, D., Ribeiro, M., Farreira, D., … Brown, D. (2016). The role of the vacuolar ATPase in alphavirus replication. Molecular Biology of the Cell, 27.

Vancini, R., Hernandez, R., & Brown, D. (2015). [Review of Alphavirus Entry into Host Cells]. Molecular basis of viral infection, 129, 33–62.

Briggs, C. M., Smith, K. M., Piper, A., Huitt, E., Spears, C. J., Quiles, M., … Hernandez, R. (2014). Live Attenuated Tetravalent Dengue Virus Host Range Vaccine Is Immunogenic in African Green Monkeys following a Single Vaccination. JOURNAL OF VIROLOGY, 88(12), 6729–6742. https://doi.org/10.1128/jvi.00541-14

Vancini, R., Wang, G., Ferreira, D., Hernandez, R., & Brown, D. T. (2013). Alphavirus Genome Delivery Occurs Directly at the Plasma Membrane in a Time- and Temperature-Dependent Process. JOURNAL OF VIROLOGY, 87(8), 4352–4359. https://doi.org/10.1128/jvi.03412-12

Piper, A., Ribeiro, M., Smith, K. M., Briggs, C. M., Huitt, E., Nanda, K., … Hernandez, R. (2013). Chikungunya Virus Host Range E2 Transmembrane Deletion Mutants Induce Protective Immunity against Challenge in C57BL/6J Mice. JOURNAL OF VIROLOGY, 87(12), 6748–6757. https://doi.org/10.1128/jvi.03357-12

Vancini, R., Kramer, L. D., Ribeiro, M., Hernandez, R., & Brown, D. (2013). Flavivirus infection from mosquitoes in vitro reveals cell entry at the plasma membrane. VIROLOGY, 435(2), 406–414. https://doi.org/10.1016/j.virol.2012.10.013

He, L., Piper, A., Meilleur, F., Hernandez, R., Heller, W. T., & Brown, D. T. (2012). Conformational Changes in Sindbis Virus Induced by Decreased pH Are Revealed by Small-Angle Neutron Scattering. JOURNAL OF VIROLOGY, 86(4), 1982–1987. https://doi.org/10.1128/jvi.06569-11

Brown, D. T., & Hernandez, R. (2012). Infection of cells by alphaviruses. Viral Molecular Machines, 726, 181–199.

Smith, K. M., Nanda, K., McCarl, V., Spears, C. J., Piper, A., Ribeiro, M., … Hernandez, R. (2012). Testing of Novel Dengue Virus 2 Vaccines in African Green Monkeys: Safety, Immunogenicity, and Efficacy. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 87(4), 743–753. https://doi.org/10.4269/ajtmh.2012.12-0004

Kononchik, J. P., Vancini, R., & Brown, D. T. (2011). Alphavirus adsorption to mosquito cells as viewed by freeze fracture immunolabeling. VIROLOGY, 415(2), 132–140. https://doi.org/10.1016/j.virol.2011.04.011

Hunt, S. R., Hernandez, R., & Brown, D. T. (2011). Role of the Vacuolar-ATPase in Sindbis Virus Infection. JOURNAL OF VIROLOGY, 85(3), 1257–1266. https://doi.org/10.1128/jvi.01864-10

Smith, K. M., Nanda, K., Spears, C. J., Ribeiro, M., Vancini, R., Piper, A., … Hernandez, R. (2011). Structural mutants of dengue virus 2 transmembrane domains exhibit host-range phenotype. VIROLOGY JOURNAL, 8. https://doi.org/10.1186/1743-422x-8-289

Hernandez, R., & Brown, D. T. (2010). Growth and Maintenance of Baby Hamster Kidney (BHK) Cells. Current Protocols in Microbiology, 17(1), A.4H.1-A.4H.7. https://doi.org/10.1002/9780471729259.MCA04HS17

Hernandez, R., & Brown, D. T. (2010). Growth and Maintenance of Chick Embryo Fibroblasts (CEF). Current Protocols in Microbiology, 17(1), A.4I.1-A.4I.8. https://doi.org/10.1002/9780471729259.MCA04IS17

Hernandez, R., & Brown, D. T. (2010). Growth and Maintenance of Mosquito Cell Lines. Current Protocols in Microbiology, 17(1), A.4J.1-A.4J.8. https://doi.org/10.1002/9780471729259.MCA04JS17

Mudiganti, U., Hernandez, R., & Brown, D. T. (2010). Insect response to alphavirus infection-Establishment of alphavirus persistence in insect cells involves inhibition of viral polyprotein cleavage. VIRUS RESEARCH, 150(1-2), 73–84. https://doi.org/10.1016/j.virusres.2010.02.016

He, L., Piper, A., Meilleur, F., Myles, D. A. A., Hernandez, R., Brown, D. T., & Heller, W. T. (2010). The Structure of Sindbis Virus Produced from Vertebrate and Invertebrate Hosts as Determined by Small-Angle Neutron Scattering. JOURNAL OF VIROLOGY, 84(10), 5270–5276. https://doi.org/10.1128/jvi.00044-10

Nanda, K., Vancini, R., Ribeiro, M., Brown, D. T., & Hernandez, R. (2009). A high capacity Alphavirus heterologous gene delivery system. VIROLOGY, 390(2), 368–373. https://doi.org/10.1016/j.virol.2009.05.026

Hafer, A., Whittlesey, R., Brown, D. T., & Hernandez, R. (2009). Differential Incorporation of Cholesterol by Sindbis Virus Grown in Mammalian or Insect Cells. JOURNAL OF VIROLOGY, 83(18), 9113–9121. https://doi.org/10.1128/JVI.00755-09

Kononchik, J. R., Jr., Nelson, S., Hernandez, R., & Brown, D. I. (2009). Helical virus particles formed from morphological subunits of a membrane containing icosahedral virus. VIROLOGY, 385(2), 285–293. https://doi.org/10.1016/j.virol.2008.12.015

Smith, K. M., Nanda, K., Slominski, C. J., Hernandez, R., Brown, D. T., & Thomas, M. E. (2008). Construction and characterization of mutant Dengue2 virus vaccine candidates displaying a host-range phenotype. Vaccine.

Hernandez, R., Paredes, A., & Brown, D. T. (2008). Sindbis virus conformational changes induced by a neutralizing anti-E1 monoclonal antibody. JOURNAL OF VIROLOGY, 82(12), 5750–5760. https://doi.org/10.1128/JVI.02673-07

Wang, G. B., Hernandez, R., keith, & Brown, D. T. (2007). Infection of cells by Sindbis virus at low temperature. Virology, 362(2), 461–467. https://doi.org/10.1016/j.virol.2006.12.036

Whitehurst, C. B., Soderblom, E. J., West, M. L., Hernandez, R., Goshe, M. B., & Brown, D. T. (2007). Location and role of free cysteinyl residues in the Sindbis virus E1 and E2 glycoproteins. JOURNAL OF VIROLOGY, 81(12), 6231–6240. https://doi.org/10.1128/JVI.02859-06

Heldt, C. L., Hernandez, R., Mudiganti, U., Gurgel, P. V., Brown, D. T., & Carbonell, R. G. (2006). A  colorimetric assay for viral agents that produce cytopathic effects. Journal of Virological Methods, 135(1), 56–65. https://doi.org/10.1016/j.j.viromet.2006.01.022

Heldt, C. L., Hernandez, R., Mudiganti, U., Gurgel, P. V., Brown, D. T., & Carbonell, R. G. (2006). A colorimetric assay for viral agents that produce cytopathic effects. Journal of Virological Methods, 135(1), 56–65. https://doi.org/10.1016/j.jviromet.2006.01.022

West, J., Hernandez, R., Ferreira, D., & Brown, D. T. (2006). Mutations in the endodomain of Sindbis virus glycoprotein E2 define sequences critical for virus assembly. JOURNAL OF VIROLOGY, 80(9), 4458–4468. https://doi.org/10.1128/jvi.80.9.4458-4468.2006

West, J., & Brown, D. T. (2006). Role of a conserved tripeptide in the endodomain of Sindbis virus glycoprotein E2 in virus assembly and function. JOURNAL OF GENERAL VIROLOGY, 87, 657–664. https://doi.org/10.1099/vir.0.81304-0

Mudiganti, U., Hernandez, R., Ferreira, D., & Brown, D. T. (2006). Sindbis virus infection of two model insect cell systems - A comparative study. Virus Research, 122(1-2), 28–34. https://doi.org/10.1016/j.virusres.2006.06.007

Whitehurst, C. B., Willis, J. H., Sinodis, C. N., Hernandez, R., & Brown, D. T. (2006). Single and multiple deletions in the transmembrane domain of the Sindbis virus E2 glycoprotein identify a region critical for normal virus growth. VIROLOGY, 347(1), 199–207. https://doi.org/10.1016/j.virol.2005.11.029

Sharp, J. S., Nelson, S., Brown, D., & Tomer, K. B. (2006). Structural characterization of the E2 glycoprotein from Sindbis by lysine biotinylation and LC-MS/MS. VIROLOGY, 348(1), 216–223. https://doi.org/10.1016/j.virol.2005.12.020

Nelson, S., Hernandez, R., Ferreira, D., & Brown, D. T. (2005). In vivo processing and isolation of furin protease-sensitive alphavirus glycoproteins: a new technique for producing mutations in virus assembly. VIROLOGY, 332(2), 629–639. https://doi.org/10.1016/j.virol.2004.12.013

Hernandez, R., Ferreira, D., Sinodis, C., Litton, K., & Brown, D. T. (2005). Single amino acid insertions at the junction of the Sindbis virus e2 transmembrane domain and endodomain disrupt virus envelopment and alter infectivity. Journal of Virology, 79(12), 7682–7697. https://doi.org/10.1128/JVI.79.7682-7697.2005

Altunay, M., Brown, D., Byrd, G., & Dean, R. (2005). Trust-Based Secure Workflow Path Construction. In B. Benatallah, F. Casati, & P. Traverso (Eds.), Service-Oriented Computing – ICSOC 2007 (pp. 382–395). https://doi.org/10.1007/11596141_29

Paredes, A. M., Ferreira, D., Horton, M., Saad, A., Tsuruta, H., Johnston, R., … Brown, D. T. (2004). Conformational changes in Sindbis virions resulting from exposure to low pH and interactions with cells suggest that cell penetration may occur at the cell surface in the absence of membrane fusion. Virology, 324(2), 373–386. https://doi.org/10.1016/j.virus.2004.03.046

Paredes, A. M., Ferreira, D., Horton, M., Saad, A., Tsuruta, H., Johnston, R., … Brown, D. T. (2004). Conformational changes in Sindbis virions resulting from exposure to low pH and interactions with cells suggest that cell penetration may occur at the cell surface in the absence of membrane fusion. Virology, 324(2), 373–386. https://doi.org/10.1016/j.virol.2004.03.046

Hernandez, R., Nelson, S., Salm, J. R., Brown, D. T., & Alpert, A. J. (2004). Rapid preparative purification of West Nile and Sindbis virus PCR products utilizing a microbore anion-exchange column. Journal of Virological Methods, 120(2), 141–149. https://doi.org/10.1016/j.viromet.2004.04.013

Hernandez, R., Nelson, S., Salm, J. R., Brown, D. T., & Alpert, A. J. (2004). Rapid preparative purification of West Nile and Sindbis virus PCR products utilizing a microbore anion-exchange column. Journal of Virological Methods, 120(2), 141–149. https://doi.org/10.1016/j.jviromet.2004.04.013

Hernandez, R., Sinodis, C., Horton, M., Ferreira, D., Yang, C. N., & Brown, D. T. (2003). Deletions in the transmembrane domain of a Sindbis virus glycoprotein alter virus infectivity, stability, and host range. JOURNAL OF VIROLOGY, 77(23), 12710–12719. https://doi.org/10.1128/JVI.77.23.12710-12719.2003

Ferreira, D., Hernandez, R., Horton, M., & Brown, D. T. (2003). Morphological variants of Sindbis virus produced by a mutation in the capsid protein. VIROLOGY, 307(1), 54–66. https://doi.org/10.1016/S0042-6822(02)00034-X

Hernandez, R., Luo, T. C., & Brown, D. T. (2001). Exposure to low pH is not required for penetration of mosquito cells by Sindbis virus. JOURNAL OF VIROLOGY, 75(4), 2010–2013. https://doi.org/10.1128/jvi.75.4.2010-2013.2001

Thomas, M. R., Brown, D., Franzen, S., & Boxer, S. G. (2001). FTIR and resonance Raman studies of nitric oxide binding to H93G cavity mutants of myoglobin. BIOCHEMISTRY, 40(49), 15047–15056. https://doi.org/10.1021/bi011440l

Pletnev, S. V., Zhang, W., Mukhopadhyay, S., Fisher, B. R., Hernandez, R., Brown, D. T., … Kuhn, R. J. (2001). Locations of carbohydrate sites on alphavirus glycoproteins show that E1 forms an icosahedral scaffold. CELL, 105(1), 127–136. https://doi.org/10.1016/S0092-8674(01)00302-6

Hernandez, R., Lee, H., Nelson, C., & Brown, D. T. (2000). A single deletion in the membrane-proximal region of the Sindbis virus glycoprotein E2 endodomain blocks virus assembly. JOURNAL OF VIROLOGY, 74(9), 4220–4228. https://doi.org/10.1128/JVI.74.9.4220-4228.2000

Phinney, B. S., & Brown, D. T. (2000). Sindbis virus glycoprotein E1 is divided into two discrete domains at amino acid 129 by disulfide bridge connections. JOURNAL OF VIROLOGY, 74(19), 9313–9316. https://doi.org/10.1128/JVI.74.19.9313-9316.2000

Phinney, B. S., Blackburn, K., & Brown, D. T. (2000). The surface conformation of sindbis virus glycoproteins E1 and E2 at neutral and low pH, as determined by mass spectrometry-based mapping. JOURNAL OF VIROLOGY, 74(12), 5667–5678. https://doi.org/10.1128/JVI.74.12.5667-5678.2000

Karpf, A. R., & Brown, D. T. (1998). Comparison of Sindbis virus-induced pathology in mosquito and vertebrate cell cultures. VIROLOGY, 240(2), 193–201. https://doi.org/10.1006/viro.1997.8914

Chan, E. K., Lu, Q., Bell, B., Motamedi, M., Frederickson, C., Brown, D. T., … Welch, A. J. (1998). Laser assisted soldering: Microdroplet accumulation with a microjet device. Lasers in Surgery and Medicine, 23(4), 213–220. https://doi.org/10.1002/(sici)1096-9101(1998)23:4<213::aid-lsm4>3.0.co;2-8

Karpf, A. R., Lenches, E., Strauss, E. G., Strauss, J. H., & Brown, D. T. (1997). Superinfection exclusion of alphaviruses in three mosquito cell lines persistently infected with sindbis virus. Journal of Virology, 71(9), 7119–7123.

Carleton, M., & Brown, D. T. (1997). The formation of intramolecular disulfide bridges is required for induction of the Sindbis virus mutant TS23 phenotype. Journal of Virology, 71(10), 7696–7703.