Doug Snider

College of Veterinary Medicine

Works (2)

Updated: September 26th, 2023 05:01

2022 journal article

Immunologic and pathologic characterization of a novel swine biomedical research model for eosinophilic esophagitis

FRONTIERS IN ALLERGY, 3.

By: L. Cortes n, D. Brodsky n, C. Chen, T. Pridgen n, J. Odle n , D. Snider n, G. Cruse n , A. Putikova* ...

author keywords: pig; food allergy; animal model; immunology; gastrointestinal; eosinophilic esophagitis
TL;DR: Swine is established as a relevant large animal model for translational biomedical research in EoE with the potential to facilitate development of therapeutics and it is demonstrated that the sensitization and oral challenge protocol not only induces the underlying immune markers but also the micro- and macro-pathological hallmarks of human EiE. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: September 25, 2023

2021 journal article

Targeting KIT by frameshifting mRNA transcripts as a therapeutic strategy for aggressive mast cell neoplasms

MOLECULAR THERAPY, 30(1), 295–310.

By: D. Snider n, G. Arthur n, G. Falduto *, A. Olivera *, L. Ehrhardt-Humbert n, E. Smith n, C. Smith n, D. Metcalfe *, G. Cruse n 

Contributors: D. Snider n, G. Arthur n, G. Falduto *, A. Olivera *, L. Ehrhardt-Humbert n, E. Smith n, C. Smith n, D. Metcalfe *, G. Cruse n 

MeSH headings : Humans; Mast Cells / metabolism; Mast Cells / pathology; Mastocytosis / genetics; Mastocytosis / pathology; Mastocytosis / therapy; Proto-Oncogene Proteins c-kit / genetics; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptor Protein-Tyrosine Kinases / metabolism
TL;DR: It is proposed that the innovative approach, which employs well-tolerated, chemically stable oligonucleotides to target KIT expression through unconventional pathways, has potential as a KIT-targeted therapeutic alone, or in combination with agents thattarget KIT signaling, in the treatment of K IT-associated malignancies. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 7, 2022

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