David C Dorman
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Works (107)
Updated: April 3rd, 2024 18:21
2024 review
A Systematic Review and Meta-Analysis of the Efficacy and Safety of Rasagiline or Pramipexole in the Treatment of Early Parkinson's Disease
[Review of ]. PARKINSONS DISEASE, 2024.
downloads.hindawi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: February 12, 2024
2024 article
Pharmacologic interventions for the treatment of equine herpesvirus-1 in domesticated horses: A systematic review
Goehring, L., Dorman, D. C., Osterrieder, K., Burgess, B. A., Dougherty, K., Gross, P., … Lunn, D. P. (2024, February 21). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 2.
author keywords: chemotherapy; equine; equine herpesvirus myeloencephalopathy; herpesvirus-1
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 22, 2024
2024 article
Updated ACVIM consensus statement on equine herpesvirus-1
Lunn, D. P., Burgess, B. A., Dorman, D. C., Goehring, L. S., Gross, P., Osterrieder, K., … Hussey, G. S. (2024, March 18). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 3.
author keywords: abortion; diagnosis; equine; equine herpesvirus myeloencephalopathy; herpesvirus-1; rhinopneumonitis; therapy; vaccination; viremia
TL;DR:
Evidence for successful vaccination against, or effective treatment of EHV-1 infection was limited, and improvements in experimental design and reporting of results are needed in future studies of this important disease.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 22, 2024
2023 review
Phthalates and polycystic ovary syndrome - Systematic literature review
[Review of ]. REPRODUCTIVE TOXICOLOGY, 121.
author keywords: Ovary; Phthalates; Polycystic ovary syndrome (PCOS); Systematic literature review
TL;DR:
Even though studies found no consistent pattern on association with phthalate exposure and PCOS, the results of analyzed studies did not exclude possible effects of phthalates on the female reproductive and metabolic system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(OpenAlex)
Source: Web Of Science
Added: February 12, 2024
2023 article
Relationship between equine herpesvirus-1 viremia and abortion or equine herpesvirus myeloencephalopathy in domesticated horses: A systematic review
Soboll-Hussey, G., Dorman, D. C., Burgess, B. A., Goehring, L., Gross, P., Neinast, C., … Lunn, D. P. (2023, December 9). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 12.
author keywords: abortion; diagnosis; equine; equine herpesvirus myeloencephalopathy; herpesvirus-1; randomized clinical trial; systematic review; viremia
TL;DR:
The results of this study support that viremia is regularly present before EHM or abortion occurs, and no inferences could be made about the relationship between the occurrence of either neurological signs or abortion and the magnitude or duration of viremia.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 18, 2023
2023 review
The Role of Oxidative Stress in Manganese Neurotoxicity: A Literature Review Focused on Contributions Made by Professor Michael Aschner
[Review of ]. BIOMOLECULES, 13(8).
author keywords: manganese; neurotoxicity; oxidative stress; mechanisms; C. elegans
TL;DR:
This literature review focuses on the evidence implicating oxidative stress in the pathogenesis of manganese neurotoxicity and highlights contributions made by Professor Michael Aschner's laboratory in this field of study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 11, 2023
2023 article
Vaccination for the prevention of equine herpesvirus-1 disease in domesticated horses: A systematic review and meta-analysis
Osterrieder, K., Dorman, D. C., Burgess, B. A., Goehring, L. S., Gross, P., Neinast, C., … Lunn, D. P. (2023, November 6). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 11.
author keywords: equine; equine herpesvirus myeloencephalopathy (EHM); equine herpesvirus-1 (EHV-1); vaccination
TL;DR:
It is indicated that commercial and experimental vaccines minimally reduce the incidence of clinical disease associated with EHV-1 infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 20, 2023
2023 article
Viremia and nasal shedding for the diagnosis of equine herpesvirus-1 infection in domesticated horses
Pusterla, N., Dorman, D. C., Burgess, B. A., Goehring, L., Gross, M., Osterrieder, K., … Lunn, D. P. (2023, December 9). JOURNAL OF VETERINARY INTERNAL MEDICINE.
Contributors: N. Pusterla *, n, B. Burgess *, L. Goehring *, M. Gross n, K. Osterrieder *, G. Soboll Hussey *, D. Lunn*
author keywords: abortion; equine; equine herpesvirus myeloencephalopathy; herpesvirus-1; nasal shedding; quantitative polymerase chain reaction (qPCR); rhinopneumonitis; viremia; virus isolation
TL;DR:
Under experimental conditions, blood and nasal secretions have similar sensitivity for the detection of EHV-1 when horses are sampled on multiple consecutive days, but in observational studies detection of EHV-1 in nasal secretions was consistently more successful.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID
Added: December 18, 2023
2022 journal article
The Current State of Veterinary Toxicology Education at AAVMC Member Veterinary Schools
VETERINARY SCIENCES, 9(12).
author keywords: curriculum; veterinary; toxicology; competency-based veterinary education; entrustable professional activities
TL;DR:
The results of this study can assist veterinary schools in evaluating their curricula to better prepare new graduates for the management of toxicology issues they may face in their veterinary careers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(OpenAlex)
Source: Web Of Science
Added: January 17, 2023
2022 article
Why Indoor Chemistry Matters: A National Academies Consensus Report
Habre, R., Dorman, D. C., Abbatt, J., Bahnfleth, W. P., Carter, E., Farmer, D., … Harries, M. E. (2022, August 2). ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol. 56, pp. 10560–10563.
author keywords: air pollution; air quality; indoor environmental quality; chemical exposure; collaborative research; research agenda
MeSH headings : Air Pollutants / analysis; Air Pollution, Indoor / analysis; Consensus; Environmental Monitoring
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 29, 2022
2021 journal article
Effect of Delivery Format on Student Outcomes and Perceptions of a Veterinary Medicine Course: Synchronous Versus Asynchronous Learning
VETERINARY SCIENCES, 8(2).
author keywords: online learning; student perceptions; emergency remote teaching; toxicology
TL;DR:
Results suggest that although some veterinary students perceived the switch in delivery format negatively, the method of delivery did not adversely affect performance in this preclinical course.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
4. Quality Education
(Web of Science)
Source: Web Of Science
Added: March 29, 2021
2021 journal article
Training with Multiple Structurally Related Odorants Fails to Improve Generalization of Ammonium Nitrate Detection in Domesticated Dogs (Canis familiaris)
ANIMALS, 11(1).
author keywords: canine; scent detection; improvised explosive device; categorical formation
TL;DR:
The results suggest the use of authentic explosive materials, without the added complication of including category-learning methods, likely remains a cost-effective and efficient way to train explosive scent detection dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 15, 2021
2019 review
Language Consideration and Methodological Transparency in "Systematic" Reviews of Animal Toxicity Studies
[Review of ]. INTERNATIONAL JOURNAL OF TOXICOLOGY, 38(2), 135–145.
author keywords: toxicology; translation; foreign languages; publications; systematic review methodology; authorship
MeSH headings : Animals; Authorship; Language; Meta-Analysis as Topic; Research Design; Research Support as Topic; Systematic Reviews as Topic; Toxicity Tests
TL;DR:
Neither the study type, grant funding, nor first author country of affiliation was associated with an increased consideration of NEL, and study quality reporting was more common in SRs that considered multiple languages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 22, 2019
2019 journal article
Use of Nasal Pathology in the Derivation of Inhalation Toxicity Values for Hydrogen Sulfide
TOXICOLOGIC PATHOLOGY, 47(8), 1043–1048.
author keywords: hydrogen sulfide; nasal toxicity; risk assessment; CFD modeling
MeSH headings : Animals; Dose-Response Relationship, Drug; Humans; Hydrogen Sulfide / toxicity; Inhalation Exposure / adverse effects; Nasal Mucosa / drug effects; Nasal Mucosa / pathology; No-Observed-Adverse-Effect Level; Nose / anatomy & histology; Nose / drug effects; Nose / pathology; Toxicity Tests
TL;DR:
Three major areas of focus for this review include a brief description of nasal anatomy, H 2S-induced ONL in rodents, derivation of a chronic inhalation reference concentration for H2S, and the use of CFD models to derive alternative toxicity values for this gas.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 18, 2019
2018 journal article
A pilot study documenting increased thrombin generation following abrupt withdrawal of heparin therapy in healthy dogs
Journal of Veterinary Emergency and Critical Care, 28(6), 518–526.
author keywords: hypercoagulable; rebound; thromboelastography
MeSH headings : Animals; Anticoagulants / administration & dosage; Anticoagulants / pharmacology; Dogs; Heparin / administration & dosage; Heparin / pharmacology; Infusions, Intravenous / veterinary; Male; Pilot Projects; Prospective Studies; Thrombelastography / veterinary; Thrombin / biosynthesis; Thrombin / drug effects
TL;DR:
Results suggest that a transient increase in thrombin generation developed 12 hours after withdrawal of UFH therapy, which is similar to that seen in healthy dogs following abrupt cessation of unfractionated heparin (UFH) therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: November 26, 2018
2018 journal article
Carcinogenicity of some nitrobenzenes and other industrial chemicals
The Lancet Oncology, 19(12), e681–e682.
MeSH headings : Animals; Carcinogenicity Tests; Carcinogens, Environmental / adverse effects; Humans; Nitrobenzenes / adverse effects; Occupational Exposure / adverse effects; Predictive Value of Tests; Risk Assessment
Source: Crossref
Added: July 21, 2019
2018 journal article
Comparing Item Performance on Three- Versus Four-Option Multiple Choice Questions in a Veterinary Toxicology Course
Veterinary Sciences, 5(2), 55.
author keywords: assessment; medical education; veterinary medicine; testing; multiple-choice questions; psychology; toxicology; measurement; item writing; veterinary education
TL;DR:
The findings of this study support earlier research in other medical disciplines and settings that concluded there was no significant change in the psychometric properties of three option MCQs when compared to the traditionalMCQs with four or more options.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(Web of Science)
Sources: Crossref, ORCID
Added: February 11, 2019
2018 article
Neonatal C57BL/6J and parkin mice respond differently following developmental manganese exposure: Result of a high dose pilot study
Foster, M. L., Bartnikas, T. B., Maresca-Fichter, H. C., Mercadante, C., Dash, M., Miller, C., & Dorman, D. C. (2018, January). NEUROTOXICOLOGY, Vol. 64, pp. 291–299.
author keywords: Manganese; Neurotoxicity; Pharmacokinetics; Metabolism
MeSH headings : Animals; Animals, Newborn; Brain / drug effects; Brain / metabolism; Female; Liver / drug effects; Liver / metabolism; Male; Manganese / toxicity; Mice, Inbred C57BL; Mice, Knockout; Motor Activity / drug effects; Pilot Projects; Tissue Distribution; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism
TL;DR:
The results suggest that the Parkin gene defect did not increase the susceptibility of neonatal mice to adverse health effects associated with high‐dose Mn exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 article
Olfactory toxicity in rats following manganese chloride nasal instillation: A pilot study
Foster, M. L., Rao, D. B., Francher, T., Traver, S., & Dorman, D. C. (2018, January). NEUROTOXICOLOGY, Vol. 64, pp. 284–290.
author keywords: Manganese; Olfactory toxicity; Olfactory discrimination; Pharmacokinetics
MeSH headings : Administration, Inhalation; Animals; Chlorides / administration & dosage; Chlorides / metabolism; Chlorides / toxicity; Discrimination, Psychological / drug effects; Male; Manganese Compounds / administration & dosage; Manganese Compounds / metabolism; Odorants; Olfactory Bulb / drug effects; Olfactory Bulb / metabolism; Olfactory Bulb / pathology; Olfactory Mucosa / drug effects; Olfactory Mucosa / metabolism; Olfactory Mucosa / pathology; Pilot Projects; Rats, Inbred F344
TL;DR:
The nasal instillation and OD procedures developed in this study are useful methods to assess manganese – induced olfactory deficits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 review
Polybrominated diphenyl ether (PBDE) neurotoxicity: a systematic review and meta-analysis of animal evidence
[Review of ]. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS, 21(4), 269–289.
author keywords: Developmental neurotoxicity; systematic review; learning and memory
MeSH headings : Animals; Attention / drug effects; Environmental Exposure / analysis; Environmental Pollutants / toxicity; Female; Halogenated Diphenyl Ethers / toxicity; Learning / drug effects; Male; Memory / drug effects; Mice; Rats
TL;DR:
A systematic review and meta-analysis of human studies found an association between prenatal serum polybrominated diphenyl ethers (PBDE) concentrations and a decrease in the IQ of children and identified RoB concerns that might be remedied by better study reporting.
(via Semantic Scholar)
Source: Web Of Science
Added: December 3, 2018
2018 personal communication
Response to Editor: Regarding Foster et al., Neonatal C57BL/6J and parkin mice respond differently following developmental manganese exposure: Result of a high dose pilot study
Dorman, D. C. (2018, December).
author keywords: Manganese; Developmental neurotoxicity; Parkin
MeSH headings : Animals; Manganese; Mice; Mice, Inbred C57BL; Pilot Projects
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 10, 2018
2018 journal article
Student Engagement with Rubrics to Promote Enhanced Written Communication of Health Information
Medical Science Educator, 28(4), 591–596.
TL;DR:
This project explored the impact of rubric design on veterinary student performance on a written assignment in a required toxicology class by randomly assigned students into two groups, each of whom received either a short- or long-form rubric.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: July 21, 2019
2018 review
Systematic reviews and meta-analyses of human and animal evidence of prenatal diethylhexyl phthalate exposure and changes in male anogenital distance
[Review of ]. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS, 21(4), 207–226.
author keywords: Reproductive toxicity; phthalate; anogenital distance; epidemiology
MeSH headings : Animals; Diethylhexyl Phthalate / adverse effects; Environmental Pollutants / adverse effects; Female; Genitalia, Male / anatomy & histology; Genitalia, Male / drug effects; Genitalia, Male / growth & development; Humans; Male; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / pathology
TL;DR:
There is a moderate level of evidence from human investigations and a high level of data from animal studies that in utero exposure to DEHP decreases AGD, and DEHP is presumed to be a reproductive hazard to humans on the basis of effects on AGD.
(via Semantic Scholar)
Source: Web Of Science
Added: December 3, 2018
2018 journal article
Toxicity associated with ingestion of a polyacrylic acid hydrogel dog pad
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 30(5), 708–714.
author keywords: Dogs; hydrogel; neurotoxicity; poisoning; sodium polyacrylate
MeSH headings : Acrylic Resins / poisoning; Acrylic Resins / toxicity; Animals; Dog Diseases / chemically induced; Dogs; Eating; Female; Hydrogels / poisoning; Hydrogels / toxicity; Male; North Carolina; Rats; Rats, Sprague-Dawley
TL;DR:
Results from an experimental study in rats support the conclusion that some pet pad hydrogel products can induce acute neurotoxicity in animals under high-dose exposure conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 16, 2018
2017 journal article
Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory testing
Toxicology in Vitro, 41, 245–259.
author keywords: Acute systemic toxicity; Alternatives; LD50; Oral; Dermal Inhalation; 3Rs; In vitro; In silico
MeSH headings : Animal Testing Alternatives; Animals; Government Regulation; High-Throughput Screening Assays; Humans; Research; Toxicity Tests, Acute
TL;DR:
A September 2015 workshop, Alternative Approaches for Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing, reviewed the state of the science of non-animal alternatives for this testing and explored ways to facilitate implementation of alternatives.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2017 journal article
Canine scent detection of canine cancer: a feasibility study
Veterinary Medicine: Research and Reports, Volume 8, 69–76.
author keywords: urinary tract cancer; cancer detection dogs; cancer odor; olfactory memory; multiple sample learning
TL;DR:
The study illustrates the need to consider canine olfactory memory and the use of double-blind methods to avoid erroneous conclusions regarding the ability of dogs to alert on specimens from canine cancer patients and suggests that sample storage, confounding odors, and other factors need to be considered in the design of future studies that evaluate the detection of canine cancers by scent detection dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
Caregiver placebo effect in analgesic clinical trials for cats with naturally occurring degenerative joint disease-associated pain
Veterinary Record, 180(19), 473–473.
MeSH headings : Analgesics / therapeutic use; Animals; Caregivers / psychology; Cat Diseases / drug therapy; Cats; Female; Humans; Joint Diseases / complications; Joint Diseases / veterinary; Male; Optimism; Osteoarthritis / complications; Osteoarthritis / veterinary; Pain / drug therapy; Pain / etiology; Pain / veterinary; Placebo Effect; Treatment Outcome
TL;DR:
The caregiver placebo effect across these clinical trials was remarkably high, making demonstration of efficacy for an analgesic above a placebo difficult, and further work is needed to determine whether a potential placebo-by-proxy effect could benefit cats in clinical settings.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Effect of wearing a Telemetry jacket on behavioral and physiologic parameters of dogs in the open-field test
Journal of the American Association for Laboratory Animal Science, 56(4), 382–389.
Source: NC State University Libraries
Added: August 6, 2018
2017 article
Fifty years of contributions by the American Board of Veterinary Toxicology
Dorman, D. C., Beasley, V. R., & McClellan, R. O. (2017, August 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 251, pp. 268–270.
MeSH headings : Animals; Education, Veterinary; Toxicology; United States; Veterinary Medicine
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Interactions of manganese with iron, zinc, and copper in neonatal C57BL/6J and parkin mice following developmental oral manganese exposure
Data in Brief, 15, 908–915.
author keywords: Copper; Zinc; Iron; Manganese Toxicity; Mouse
TL;DR:
Insight is provided into strain differences in the way Mn interacts with other trace metals in mice by evaluating responses in mice with a Parkin gene defect and a wildtype strain following neonatal Mn exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: July 21, 2019
2017 article
Manganese Neurodegeneration
ENVIRONMENTAL FACTORS IN NEURODEGENERATIVE DISEASES, pp. 157–183.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Metal imaging in the brain
Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics, 349–362.
Source: NC State University Libraries
Added: August 6, 2018
2017 article
Severity scoring of manganese health effects for categorical regression
Mattison, D. R., Milton, B., Krewski, D., Levy, L., Dorman, D. C., Aggett, P. J., … McGough, D. (2017, January). NEUROTOXICOLOGY, Vol. 58, pp. 203–216.
author keywords: Exposure-response assessment; Categorical regression; Database; Manganese toxicity
MeSH headings : Animals; Copper / toxicity; Databases, Factual; Dose-Response Relationship, Drug; Environmental Exposure; Female; Humans; Male; Manganese / toxicity; Manganese Poisoning / etiology; Regression Analysis
TL;DR:
The development of a database on Mn toxicity designed to support the application of categorical regression techniques is documents, providing a comprehensive repository of exposure‐response information with the ability to support categorically regression modeling of oral exposure data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Survey of Diplomates of the American Board of Veterinary Toxicology Regarding Perceptions of the Value of This Certification
INTERNATIONAL JOURNAL OF TOXICOLOGY, 36(5), 380–385.
author keywords: toxicology; specialty board; survey
MeSH headings : Adult; Aged; Aged, 80 and over; Certification; Female; Humans; Male; Middle Aged; Surveys and Questionnaires; Toxicology
TL;DR:
There is concern about the number of DABVTs and the adequacy of training programs to meet this perceived need, and these findings improve the understanding of current attitudes of D ABVTs toward their specialty.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Teaching Tip: Improving Students' Email Communication through an Integrated Writing Assignment in a Third-Year Toxicology Course
Journal of Veterinary Medical Education, 44(2), 280–289.
author keywords: communication; writing; electronic mail; client education
MeSH headings : Curriculum; Education, Veterinary; Electronic Mail; Female; Humans; Male; Students, Medical; Teaching; Toxicology / education; Writing
TL;DR:
It is suggested that additional instruction and practice should emphasize the importance of incorporating examples, metaphors, analogies, and pictures to create texts that are comprehensible and memorable to clients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: June 30, 2019
2017 journal article
Thromboelastographic monitoring of the effect of unfractionated heparin in healthy dogs
JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 27(1), 71–81.
author keywords: anticoagulation monitoring; anti-Xa; canine; RapidTEG; thrombosis
MeSH headings : Animals; Anticoagulants / administration & dosage; Anticoagulants / pharmacology; Blood Coagulation / drug effects; Dogs; Female; Heparin / administration & dosage; Heparin / pharmacology; Injections, Subcutaneous / veterinary; Male; Partial Thromboplastin Time / veterinary; Prospective Studies; Reference Values; Thrombelastography / veterinary
TL;DR:
This study demonstrates that TEG variables derived using robust activation correlate with AXa activity as well as aPTT and have the potential to be used for monitoring UFH therapy in healthy dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Best practice recommendations for prehospital veterinary care of dogs and cats
Journal of Veterinary Emergency and Critical Care, 26(2), 166–233.
author keywords: cat; dog; first response; trauma; VetCOT
MeSH headings : Animals; Cats; Consensus; Databases, Factual; Dogs; Emergency Service, Hospital / standards; Practice Guidelines as Topic; Practice Management, Veterinary / standards; United States; Veterinary Medicine / standards; Wounds and Injuries / therapy; Wounds and Injuries / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2016 journal article
Diphenhydramine exposure in dogs: 621 cases (2008-2013)
Journal of the American Veterinary Medical Association, 249(1), 77–82.
MeSH headings : Animals; Anti-Allergic Agents / poisoning; Diphenhydramine / poisoning; Dog Diseases / epidemiology; Dog Diseases / pathology; Dog Diseases / prevention & control; Dogs; Female; Illinois / epidemiology; Male; Poison Control Centers / statistics & numerical data; Poisoning / epidemiology; Poisoning / veterinary; Retrospective Studies; Severity of Illness Index
TL;DR:
Results indicated that dogs exposed to diphenhydramine developed clinical signs of toxicosis fairly infrequently, and those clinical signs were generally mild and primarily affected the neurologic and cardiovascular systems.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure
Data in Brief, 6, 989–997.
author keywords: Inhalation; Iron; Manganese; Monkey
TL;DR:
Liver manganese and iron levels were linearly correlated although only the intermediate mangansese exposure level (0.3 mg Mn/m3) led to a statistically significant increase in liver iron levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: July 21, 2019
2016 journal article
The effect of high dose oral manganese exposure on copper, iron and zinc levels in rats
BIOMETALS, 29(3), 417–422.
author keywords: Manganese; Copper; Iron; Zinc; Exposure
MeSH headings : Administration, Oral; Animals; Copper / metabolism; Diet; Homeostasis / drug effects; Iron / metabolism; Male; Manganese / administration & dosage; Manganese / analysis; Manganese / toxicity; Rats; Rats, Inbred F344; Zinc / metabolism
TL;DR:
While manganese exposure affected levels of all metals, particularly in the frontal cortex and liver, copper levels were most prominently affected and suggests an under-appreciated effect of manganae exposure on copper homeostasis which may contribute to the understanding of the pathophysiology of mangansese toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
A comparison of pet and purpose-bred research dog (Canis familiaris) performance on human-guided object-choice tasks
BEHAVIOURAL PROCESSES, 110, 60–67.
author keywords: Domestic dog; Object-choice task; Social cognition; Purpose-bred dog
MeSH headings : Animals; Behavior, Animal / physiology; Choice Behavior / physiology; Cues; Dogs / physiology; Gestures; Human-Animal Bond; Humans; Male
TL;DR:
It is found that while pet dogs followed the momentary distal point above chance levels, research dogs did not, and the results indicate that ontogenetic experiences may influence a domestic dog's ability to use human gestures, highlighting the importance of testing different sub-populations of domestic dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
A test for the evaluation of emotional reactivity in Labrador retrievers used for explosives detection
JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH, 10(2), 94–102.
author keywords: emotional reactivity test; anxiety scores; selection criteria; behavioral screening; explosives detection dog
TL;DR:
It is concluded that the ERT is a useful pre-training screening test that can be used to identify dogs with a low threshold of emotional reactivity for rejection, anddogs with a high threshold of emotions for entry into the IDD training program.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 article
Answering the Call for Improved Chemical Alternatives Assessments (CAA)
Tickner, J. A., Dorman, D. C., & Sheton-Davenport, M. (2015, February 17). ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol. 49, pp. 1995–1996.
MeSH headings : Chemical Industry; Green Chemistry Technology / methods; Green Chemistry Technology / standards; Humans; Research; Risk Assessment
TL;DR:
It is critical that CAA processes be flexible so they can be adapted to varied decision contexts and avoid “paralysis by analysis”, and that emerging developments in toxicity testing be able to support the evaluation, comparison and design of safer chemicals and materials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 chapter
Extrapyramidal system neurotoxicity
In Handbook of Clinical Neurology (pp. 207–223).
MeSH headings : Animals; Basal Ganglia Diseases / etiology; Disease Models, Animal; Humans; Neurotoxicity Syndromes / complications
TL;DR:
The central focus of the chapter is on animal models, especially the concordance between clinical signs, neurochemical changes, and neuropathology between animals and people.
(via Semantic Scholar)
Source: Crossref
Added: July 21, 2019
2015 journal article
Feasibility of flotation concentration of fungal spores as a method to identify toxigenic mushrooms
Veterinary Medicine: Research and Reports, 6, 1–9.
Source: NC State University Libraries
Added: July 28, 2019
2015 journal article
Olfactory discrimination and generalization of ammonium nitrate and structurally related odorants in Labrador retrievers
Animal Cognition, 18(6), 1255–1265.
MeSH headings : Aluminum; Ammonium Compounds; Animals; Discrimination Learning; Discrimination, Psychological; Dogs; Explosive Agents; Fertilizers; Iraq; Nitrates; Odorants; Smell / physiology; Soil
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Olfactory transport of manganese: Implications for neurotoxicity
Manganese in Health and Disease, 22, 119–132.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Pharmacokinetic Evaluation of the Equivalency of Gavage, Dietary, and Drinking Water Exposure to Manganese in F344 Rats
TOXICOLOGICAL SCIENCES, 145(2), 244–251.
author keywords: manganese; pharmacokinetics; oral exposure; dose rate
MeSH headings : Administration, Oral; Animals; Body Burden; Chlorides / administration & dosage; Chlorides / pharmacokinetics; Chlorides / toxicity; Diet; Food Contamination; Male; Manganese Compounds / administration & dosage; Manganese Compounds / pharmacokinetics; Manganese Poisoning / etiology; Rats, Inbred F344; Risk Assessment; Tissue Distribution; Water Pollutants, Chemical / administration & dosage; Water Pollutants, Chemical / pharmacokinetics; Water Pollutants, Chemical / toxicity
TL;DR:
Increased femur, striatum, cerebellum, frontal cortex, and olfactory bulb manganese concentrations were also seen following gavage suggesting that dose rate is an important factor in the pharmacokinetics of oral mangansese.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
The use of an open-field model to assess sound-induced fear and anxiety-associated behaviors in Labrador retrievers
JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH, 10(4), 338–345.
author keywords: military working dogs; open-field test; fear; anxiety; thunderstorm; gunfire
TL;DR:
In general, candidate IED-detection Labrador retrievers responded to sound stimuli and recovered quickly, although dogs stratified in their response to sound stimulus, suggesting that dogs habituated to the open field arena.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Acquisition of a visual discrimination and reversal learning task by Labrador retrievers
ANIMAL COGNITION, 17(3), 787–792.
author keywords: Dog; Canine; Cognition; Visual discrimination
MeSH headings : Animals; Cognition; Discrimination Learning; Discrimination, Psychological; Dogs / psychology; Female; Male; Neuropsychological Tests; Pattern Recognition, Visual; Reversal Learning; Visual Perception
TL;DR:
The present study confirmed that the modified TGTA system is suitable for cognitive evaluations in Labrador retriever MWDs and can be used to further explore effects of sex, phenotype, age, and other factors in relation to canine cognition and learning, and may provide an additional screening tool for MWD selection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Evaluation of a point-of-care anticoagulant rodenticide test for dogs
Journal of Veterinary Emergency and Critical Care, 24(2), 168–173.
author keywords: bedside; canine; poisoning; rodenticide; toxicology
MeSH headings : Animals; Anticoagulants / blood; Anticoagulants / chemistry; Dogs / blood; Molecular Structure; Point-of-Care Systems; Rodenticides / blood; Rodenticides / chemistry
TL;DR:
The point-of-care test kit was able to detect a single anticoagulant rodenticide (warfarin) at concentrations below the manufacturer's recommended limit of detection, but was unable to detect any other antICOagulants rodenticide.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, Web Of Science
Added: August 6, 2018
2014 journal article
Explosives detection by military working dogs: Olfactory generalization from components to mixtures
APPLIED ANIMAL BEHAVIOUR SCIENCE, 151, 84–93.
author keywords: Dog; Olfactory; Explosives; Odor mixtures
TL;DR:
It was found that the majority of dogs (87%) trained with pure PC alone did not correctly signal the presence of one or more of four PC-based explosive mixtures.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Assessment of geographical variation in the respiratory toxicity of desert dust particles
INHALATION TOXICOLOGY, 25(7), 405–416.
author keywords: Cytotoxicity; dust inhalation; in vitro; in vivo; particle toxicity; pulmonary toxicity; rat
MeSH headings : Administration, Inhalation; Afghanistan; Animals; Arsenic / analysis; Arsenic / toxicity; Bronchoalveolar Lavage Fluid / chemistry; Bronchoalveolar Lavage Fluid / cytology; Cell Count; Cell Line; Cell Survival / drug effects; Cytokines / metabolism; Dust / analysis; Endotoxins / analysis; Endotoxins / toxicity; Geography; Iraq; L-Lactate Dehydrogenase / metabolism; Lung / drug effects; Lung / metabolism; Lung / pathology; Male; Metals / analysis; Metals / toxicity; Rats; Silicon Dioxide / analysis; Silicon Dioxide / toxicity; United States
TL;DR:
The in vitro cytotoxicity assay results were partially predictive of in vivo responses and could be used to prioritize future particle inhalation studies or guide epidemiological study design.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Inhalation dosimetry of hexamethylene diisocyanate vapor in the rat and human respiratory tracts
INHALATION TOXICOLOGY, 25(3), 168–177.
author keywords: Computational fluid dynamics; dosimetry; hexamethylene diisocyanate; inhalation; lung; nose
MeSH headings : Air Pollutants, Occupational / pharmacokinetics; Air Pollutants, Occupational / toxicity; Animals; Cyanates / pharmacokinetics; Cyanates / toxicity; Dose-Response Relationship, Drug; Humans; Inhalation Exposure; Isocyanates; Lung / drug effects; Lung / metabolism; Lung / pathology; Male; Models, Biological; Rats; Rats, Inbred F344; Respiratory Mucosa / drug effects; Respiratory Mucosa / metabolism; Species Specificity; Volatilization
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Subject Matter Expert and Public Evaluations of a Veterinary Toxicology Course Brochure-Writing Assignment
JOURNAL OF VETERINARY MEDICAL EDUCATION, 40(1), 19–28.
author keywords: communication; brochure; rubrics; toxicology; activity; educational
MeSH headings : Comprehension; Education, Veterinary; Health Communication; North Carolina; Pamphlets; Schools, Veterinary; Students, Health Occupations; Toxicology / education; Writing
TL;DR:
How patient-centered written communication has been integrated into the training of veterinary students using toxicology-related preventive materials is described and revised, resulting in revision of the grading rubric, increased use of brochure examples, and additional instruction in readability assessment and brochure development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Application of a Multi-Route Physiologically Based Pharmacokinetic Model for Manganese to Evaluate Dose-Dependent Neurological Effects in Monkeys
TOXICOLOGICAL SCIENCES, 129(2), 432–446.
author keywords: manganese; neurotoxicity; dose response; physiologically based pharmacokinetic modeling
MeSH headings : Animals; Cebus; Dose-Response Relationship, Drug; Manganese / pharmacokinetics; Models, Biological; Risk Assessment
TL;DR:
A physiologically based pharmacokinetic model that accurately accounts for the dose dependencies of Mn distribution was used to estimate increases in brain Mn concentrations in monkeys following Mn exposure and provides strong evidence of a dose-dependent transition in the mode of action for the neurological effects of Mn that needs to be considered in risk assessments for this essential metal.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Biological responses in rats exposed to cigarette smoke and Middle East sand (dust)
INHALATION TOXICOLOGY, 24(2), 109–124.
author keywords: Particle toxicity; nanoparticles; rat; in vivo; in vitro; pulmonary toxicity; cytotoxicity; dust inhalation
MeSH headings : Administration, Inhalation; Air Pollutants / toxicity; Animals; Behavior, Animal / drug effects; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid / chemistry; Bronchoalveolar Lavage Fluid / cytology; Dust / analysis; Gene Expression / drug effects; Hand Strength; Iraq; Larynx / drug effects; Larynx / pathology; Lung / drug effects; Lung / pathology; Lung / physiology; Male; Metals / analysis; Metals / toxicity; Motor Activity / drug effects; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Respiratory Function Tests; Respiratory Mucosa / drug effects; Respiratory Mucosa / pathology; Silicon Dioxide / analysis; Silicon Dioxide / toxicity; Tobacco Smoke Pollution / adverse effects; Trachea / drug effects; Trachea / pathology
TL;DR:
The studies show that the respiratory toxicity of IS is qualitatively similar to or less than that seen following short-term silica exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Neurological impacts from inhalation of pollutants and the nose-brain connection
NeuroToxicology, 33(4), 838–841.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Neurological impacts from inhalation of pollutants and the nose–brain connection
NeuroToxicology, 33(4), 838–841.
author keywords: Air pollution; Neurotoxicity; Olfactory tract
MeSH headings : Air Pollutants / adverse effects; Animals; Body Burden; Environmental Monitoring; Humans; Inhalation Exposure / adverse effects; Nervous System / drug effects; Nervous System / physiopathology; Neurotoxicity Syndromes / etiology; Neurotoxicity Syndromes / physiopathology; Nose / drug effects; Nose / physiopathology; Olfactory Pathways / drug effects; Olfactory Pathways / physiopathology; Risk Assessment; Risk Factors
TL;DR:
The key available literature on nanoparticle uptake and transport through the olfactory pathway, the experimental data from animal and in vitro studies, and human epidemiological observations are reviewed to provide an increased understanding of the neurotoxicity associated with air pollution exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Source: Crossref
Added: August 28, 2020
2012 journal article
The outdoor air pollution and brain health workshop
NeuroToxicology, 33(5), 972–984.
author keywords: Air pollution; Brain; Particulate matter; Ozone; Central nervous system; Susceptibility; Epidemiology; Neuroinflammation; Neurotoxicity; Behavior
MeSH headings : Air Pollutants / poisoning; Air Pollution / adverse effects; Brain / pathology; Cardiovascular Diseases / chemically induced; Cardiovascular Diseases / pathology; Disease Susceptibility; Encephalitis / etiology; Encephalitis / pathology; Humans; Lung Diseases / chemically induced; Lung Diseases / pathology; Neurotoxicity Syndromes / epidemiology; Neurotoxicity Syndromes / etiology; Neurotoxicity Syndromes / pathology
TL;DR:
Recent findings that have established the effects of inhaled air pollutants in the brain, explore the potential mechanisms driving these phenomena, and discuss the recommended research priorities/approaches that were identified by the panel.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Crossref
Added: February 24, 2020
2012 review
The outdoor air pollution and brain health workshop
[Review of]. NeuroToxicology, 33(5), 972–984.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Analysis of Manganese Tracer Kinetics and Target Tissue Dosimetry in Monkeys and Humans with Multi-Route Physiologically Based Pharmacokinetic Models
TOXICOLOGICAL SCIENCES, 120(2), 481–498.
author keywords: manganese; PBPK; inhalation exposure; risk assessment; neurotoxicity; pharmacokinetics
MeSH headings : Administration, Oral; Adult; Animals; Humans; Inhalation Exposure; Injections; Macaca mulatta; Manganese Compounds / pharmacokinetics; Metabolic Clearance Rate; Models, Biological; Organ Specificity; Physiology; Radioisotopes; Species Specificity; Time Factors; Tissue Distribution
TL;DR:
The use of this human Mn PBPK model can become a key component of future human health risk assessment, allowing the consideration of various exposure routes, natural tissue background levels, and homeostatic controls to explore exposure conditions that lead to increased target tissue levels resulting from Mn overexposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Physiologically Based Pharmacokinetic Modeling of Fetal and Neonatal Manganese Exposure in Humans: Describing Manganese Homeostasis during Development
TOXICOLOGICAL SCIENCES, 122(2), 297–316.
author keywords: manganese; potentially susceptible subpopulation; environmental exposure to Mn; formula; fetus; neonate
MeSH headings : Adult; Animals; Child, Preschool; Female; Fetus / drug effects; Fetus / metabolism; Homeostasis; Humans; Infant; Inhalation Exposure; Lactation; Male; Manganese / blood; Manganese / pharmacokinetics; Manganese / toxicity; Maternal Exposure; Milk, Human / chemistry; Models, Biological; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Tissue Distribution
TL;DR:
A physiologically based pharmacokinetic model for Mn during human gestation and lactation was developed to predict Mn in fetal and neonatal brain using a parallelogram approach based upon extrapolation across life stages in rats and cross-species extrapolation to humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 article
Multi-Dose-Route, Multi-Species Pharmacokinetic Models for Manganese and Their Use in Risk Assessment
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, Vol. 73, pp. 217–234.
MeSH headings : Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Haplorhini; Humans; Manganese / adverse effects; Manganese / pharmacokinetics; Models, Biological; Nutritional Requirements; Rats; Risk Assessment; Tissue Distribution
TL;DR:
This study reviews the development of the Mn PBPK models, reassesses the previously identified data needs, and details potential uses of these models in risk assessment of Mn.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Pharmacokinetics of radiolabeled tungsten (W-188) in male Sprague-Dawley rats following acute sodium tungstate inhalation
INHALATION TOXICOLOGY, 22(1), 69–76.
author keywords: Inhalation; kinetics; tungsten
MeSH headings : Administration, Inhalation; Aerosols; Animals; Inhalation Exposure; Male; Metabolic Clearance Rate; Models, Biological; Radioisotopes; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tungsten Compounds / pharmacokinetics
TL;DR:
Evaluated the pharmacokinetics of inhaled tungstate (WO4) in rats found the kidney, adrenal, spleen, femur, lymph nodes, and brain continued to accumulate small amounts of tungsten as reflected by tissue:blood activity ratios that increased throughout the 21-day period.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Acute sodium tungstate inhalation is associated with minimal olfactory transport of tungsten (W-188) to the rat brain
NEUROTOXICOLOGY, 30(3), 445–450.
author keywords: Inhalation; Olfactory transport; Brain; Tungsten; Single-dose; Rat
MeSH headings : Administration, Inhalation; Aerosols; Animals; Corpus Striatum / metabolism; Male; Olfactory Pathways / metabolism; Pituitary Gland / metabolism; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tungsten Compounds / administration & dosage; Tungsten Compounds / blood; Tungsten Compounds / pharmacokinetics
TL;DR:
The data suggest that olfactory transport plays a minimal role in delivering tungsten to the rat brain, i.e., approximately 1-3% of the amount ofTungsten seen in the olf factory epithelium suggesting that o aroma transport plays an important role in transporting metals to the CNS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Evaluating Placental Transfer and Tissue Concentrations of Manganese in the Pregnant Rat and Fetuses after Inhalation Exposures with a PBPK Model
TOXICOLOGICAL SCIENCES, 112(1), 44–58.
author keywords: manganese; inhalation exposure; gestation; placental transfer; homeostasis during gestation; PBPK
MeSH headings : Animals; Female; Fetus / metabolism; Homeostasis; Inhalation Exposure; Manganese / administration & dosage; Manganese / pharmacokinetics; Maternal-Fetal Exchange; Placenta / metabolism; Pregnancy; Rats; Rats, Wistar; Tissue Distribution
TL;DR:
A PBPK model, based on a published description of manganese (Mn) kinetics in adult rats, has been developed to describe Mn uptake and tissue distribution in the pregnant dam and fetus during dietary and inhalation exposures, and incorporated key physiological processes controlling Mn pharmacokinetics during pregnancy and fetal development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Lactational Transfer of Manganese in Rats: Predicting Manganese Tissue Concentration in the Dam and Pups from Inhalation Exposure with a Pharmacokinetic Model
TOXICOLOGICAL SCIENCES, 112(1), 23–43.
author keywords: manganese; inhalation exposure; postnatal period; enhanced biliary excretion; homeostasis during lactation; PBPK
MeSH headings : Animals; Animals, Newborn; Female; Inhalation Exposure; Lactation; Manganese / administration & dosage; Manganese / pharmacokinetics; Milk / chemistry; Models, Biological; Pregnancy; Rats; Tissue Distribution
TL;DR:
The successful description of Mn kinetics across these life stages suggests that the present model can help describe the relationship between dose of exposure and target tissue Mn concentrations across different developmental stages and its potential risks and assess whether infants and children should be regarded as susceptible populations for Mn inhalation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Manganese Tissue Dosimetry in Rats and Monkeys: Accounting for Dietary and Inhaled Mn with Physiologically based Pharmacokinetic Modeling
TOXICOLOGICAL SCIENCES, 108(1), 22–34.
author keywords: manganese; nonhuman primates; dose-dependent regulation; saturable tissue binding; asymmetrical diffusional flux; biliary induction; inhalation exposures; PBPK
MeSH headings : Administration, Inhalation; Administration, Oral; Animals; Brain Chemistry; Calibration; Computer Simulation; Disease Models, Animal; Dose-Response Relationship, Drug; Inhalation Exposure / analysis; Liver / chemistry; Macaca mulatta; Manganese / administration & dosage; Manganese / pharmacokinetics; Models, Biological; Rats; Sensitivity and Specificity
TL;DR:
A physiologically based pharmacokinetic model for Mn in rats and scale the model to describe Mn tissue accumulation in nonhuman primates exposed to Mn by inhalation and diet are complete and consistent with the available experimental kinetic data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 review
Provisional Advisory Levels (PALs) for acrylonitrile
[Review of ]. INHALATION TOXICOLOGY, 21, 17–55.
author keywords: PALs; acrylonitrile; emergency response; inhalation; drinking water
MeSH headings : Acrylonitrile / adverse effects; Acrylonitrile / chemistry; Acrylonitrile / standards; Animals; Consultants; Environmental Exposure / adverse effects; Environmental Exposure / standards; Humans; Inhalation Exposure / adverse effects; Inhalation Exposure / standards; Occupational Exposure / adverse effects; Occupational Exposure / standards
TL;DR:
This study characterize the key physical processes related to formation and growth of nanoparticles and two of the main protection techniques are ventilation and filtration, which are widely used in practical applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Provisional Advisory Levels (PALs) for hydrogen sulfide (H2S)
INHALATION TOXICOLOGY, 21, 56–72.
author keywords: PALs; hydrogen sulfide; emergency planning; inhalation; drinking water
MeSH headings : Animals; Consultants; Environmental Exposure / adverse effects; Environmental Exposure / standards; Humans; Hydrogen Sulfide / adverse effects; Hydrogen Sulfide / chemistry; Hydrogen Sulfide / standards; Inhalation Exposure / standards; Occupational Exposure / adverse effects; Occupational Exposure / standards
TL;DR:
Application of Provisional Advisory Levels (PALs) protocols was performed for hydrogen sulfide (H2S) as experimental data permitted, and no reliable data were found on oral exposure, making it impractical to estimate PALs for drinking water.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Reproductive Toxicity and Pharmacokinetics of di-n-butyl Phthalate (DBP) Following Dietary Exposure of Pregnant Rats
BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY, 86(4), 345–354.
author keywords: anti-androgen; endocrine disruptor; phthalate
MeSH headings : Administration, Oral; Amniotic Fluid / chemistry; Androgen Antagonists / administration & dosage; Androgen Antagonists / pharmacokinetics; Androgen Antagonists / toxicity; Animals; Biotransformation; Body Weight / drug effects; Dibutyl Phthalate / administration & dosage; Dibutyl Phthalate / pharmacokinetics; Dibutyl Phthalate / toxicity; Dose-Response Relationship, Drug; Female; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation, Developmental / drug effects; Genitalia, Male / drug effects; Genitalia, Male / embryology; Genitalia, Male / pathology; Gestational Age; Glucuronides / analysis; Glucuronides / blood; Glucuronides / pharmacokinetics; Glucuronides / urine; Male; Phthalic Acids / analysis; Phthalic Acids / blood; Phthalic Acids / urine; Pregnancy; Random Allocation; Rats; Rats, Sprague-Dawley; Scavenger Receptors, Class B / drug effects; Steroids / biosynthesis; Testis / drug effects; Testis / embryology; Testis / metabolism; Testis / pathology; Testosterone / biosynthesis
TL;DR:
It is indicated that approximately equal doses of oral DBP exposure of pregnant rats, from diet or gavage, result in similar responses in male offspring.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 review
"Current Pathology Techniques" Symposium Review: Advances and Issues in Neuropathology
[Review of ]. TOXICOLOGIC PATHOLOGY, 36(6), 871–889.
author keywords: neuropathology; neurotoxicity; review
TL;DR:
This mini-review has been designed to communicate the principal technical advances and current issues of importance in neuropathology research today in the context of traditional neuropathological practices.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Application of Physiological Computational Fluid Dynamics Models to Predict Interspecies Nasal Dosimetry of Inhaled Acrolein
Inhalation Toxicology, 20(3), 227–243.
MeSH headings : Acrolein / pharmacokinetics; Acrolein / toxicity; Air Pollutants / pharmacokinetics; Air Pollutants / toxicity; Animals; Computer Simulation; Dose-Response Relationship, Drug; Humans; Inhalation Exposure; Models, Biological; Nasal Cavity / drug effects; Nasal Cavity / metabolism; Nasal Cavity / pathology; Nasal Mucosa / drug effects; Nasal Mucosa / metabolism; Nasal Mucosa / pathology; Rats
TL;DR:
In this study, anatomically accurate three-dimensional computational fluid dynamics (CFD) models were used to simulate steady-state inspiratory airflow and to quantitatively predict acrolein tissue dose in rat and human nasal passages to estimate a tissue dose-based no-observed-adverse-effect level (NOAEL) for inhaled ac rolein.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2008 journal article
Derivation of an inhalation reference concentration based upon olfactory neuronal loss in male rats following subchronic acetaldehyde inhalation
INHALATION TOXICOLOGY, 20(3), 245–256.
MeSH headings : Acetaldehyde / toxicity; Air Pollutants / toxicity; Animals; Benchmarking; Cell Proliferation / drug effects; Cross-Linking Reagents / toxicity; DNA / chemistry; DNA / drug effects; Dose-Response Relationship, Drug; Inhalation Exposure; Male; Metaplasia / chemically induced; Metaplasia / pathology; Nasal Cavity / drug effects; Nasal Cavity / metabolism; Nasal Cavity / pathology; Neurons, Afferent / drug effects; Neurons, Afferent / pathology; No-Observed-Adverse-Effect Level; Olfactory Mucosa / drug effects; Olfactory Mucosa / pathology; Olfactory Pathways / drug effects; Olfactory Pathways / pathology; Protein Binding / drug effects; Proteins / chemistry; Proteins / drug effects; Rats; Rats, Inbred F344; Rhinitis / chemically induced; Rhinitis / pathology
TL;DR:
The severity of the ONL demonstrated dose-and temporal-dependent behaviors, with minimal effects noted at 150–500 ppm acetaldehyde and moderately severe lesions seen in the highest exposure group, with increased lesion severity and extent as the exposure duration increased.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Duration of airborne-manganese exposure in rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity
NeuroToxicology, 29(3), 377–385.
author keywords: brain; monkey; air borne; manganese; glutathione; glutamate
MeSH headings : Amino Acid Transport System X-AG / metabolism; Animals; Biomarkers; Blotting, Northern; Blotting, Western; Brain / metabolism; Excitatory Amino Acid Transporter 2 / metabolism; Glutamate-Ammonia Ligase / metabolism; Glutathione / metabolism; Inhalation Exposure / adverse effects; Macaca mulatta; Male; Manganese / analysis; Manganese / pharmacokinetics; Manganese Poisoning / metabolism; Manganese Poisoning / pathology; Metallothionein / metabolism; Nerve Tissue Proteins / biosynthesis; Nerve Tissue Proteins / genetics; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Tyrosine 3-Monooxygenase / metabolism
TL;DR:
The nonhuman primate brain responds to airborne Mn in a heterogeneous manner and most alterations in these biomarkers of neurotoxicity are reversible upon cessation of Mn exposure.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2008 journal article
Gene Expression Changes Following Acute Hydrogen Sulfide (H2S)-induced Nasal Respiratory Epithelial Injury
TOXICOLOGIC PATHOLOGY, 36(4), 560–567.
author keywords: gene expression; nasal respiratory epithelium; LCM; rat; H2S; inhalation; DNA microarray
MeSH headings : Air Pollutants / toxicity; Animals; Cluster Analysis; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Epithelial Cells / pathology; Gene Expression / drug effects; Gene Expression Profiling; Hydrogen Sulfide / toxicity; Inhalation Exposure / adverse effects; Male; Microdissection; Nasal Mucosa / drug effects; Nasal Mucosa / metabolism; Nasal Mucosa / pathology; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
Gene ontology enrichment analysis showed that H2S exposure altered gene expression associated with a variety of biological processes, including cell cycle regulation, protein kinase regulation, and cytoskeletal organization and biogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Genotoxicity of intermittent co-exposure to benzene and toluene in male CD-1 mice
Chemico-Biological Interactions, 173(3), 166–178.
MeSH headings : Animals; Atmosphere Exposure Chambers; Benzene / toxicity; Benzene Derivatives / urine; Body Weight / drug effects; Bone Marrow Cells / drug effects; DNA / chemistry; DNA / drug effects; Drug Administration Schedule; Glutathione / blood; Glutathione / metabolism; Inhalation Exposure; Liver / drug effects; Liver / metabolism; Male; Mice; Micronuclei, Chromosome-Defective / chemically induced; Molecular Structure; Mutagenicity Tests; Time Factors; Toluene / toxicity
TL;DR:
The higher frequency of micronucleated PCE following benzene and toLUene co-exposure when compared with mice exposed to benzene or toluene alone suggests that, at the doses used in this study, toluenes can enhance benzene-induced clastogenic or aneugenic bone marrow injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
Metabolomic analyses of body fluids after subchronic manganese inhalation in rhesus monkeys
TOXICOLOGICAL SCIENCES, 106(1), 46–54.
author keywords: metabolomics; metal; neurotoxicity
MeSH headings : Air Pollutants / blood; Air Pollutants / toxicity; Air Pollutants / urine; Animals; Biomarkers / blood; Biomarkers / urine; Chromatography, Liquid; Cluster Analysis; Environmental Monitoring; Globus Pallidus / drug effects; Globus Pallidus / metabolism; Inhalation Exposure; Macaca mulatta; Male; Manganese Compounds / blood; Manganese Compounds / urine; Metabolomics / methods; Principal Component Analysis; Sulfates / blood; Sulfates / toxicity; Sulfates / urine; Tandem Mass Spectrometry
TL;DR:
Biochemical changes identified in manganese-exposed monkeys included endpoints relate to oxidative stress and neurotransmission (aminobutyrate, glutamine, phenylalanine), and 27 metabolites with statistically significant expression differences were structurally confirmed by MS-MS methods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Nasal uptake of inhaled acrolein in rats
INHALATION TOXICOLOGY, 20(3), 217–225.
MeSH headings : Acrolein / pharmacokinetics; Air Pollutants / pharmacokinetics; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Glutathione / metabolism; Inhalation Exposure; Lung / metabolism; Male; Nasal Cavity / metabolism; Rats; Rats, Inbred F344; Respiratory Mucosa / metabolism
TL;DR:
Acrolein UE in naive animals was dependent on the concentration of inspired acrolein, airflow rate, and duration of exposure, with increased UE occurring with lower ac rolein exposure concentrations, and a statistically significant decline in UE occurred during the exposures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Pharmacokinetic Modeling of Manganese in the Rat IV: Assessing Factors that Contribute to Brain Accumulation During Inhalation Exposure
Journal of Toxicology and Environmental Health, Part A, 71(7), 413–426.
MeSH headings : Administration, Oral; Air Pollutants / pharmacokinetics; Animals; Brain / drug effects; Brain Chemistry; Disease Models, Animal; Dust; Environmental Exposure / adverse effects; Inhalation Exposure / adverse effects; Liver / drug effects; Manganese / administration & dosage; Manganese / pharmacokinetics; Models, Biological; Rats; Risk Assessment
TL;DR:
Multi-dose-route PBPK models for Mn based on this alternative model structure can be readily scaled to evaluate tissue Mn kinetics in other species and for human populations, and will be useful in tissue-dose based risk assessment with manganese.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2008 journal article
Respiratory tract responses in male rats following subchronic acrolein inhalation
INHALATION TOXICOLOGY, 20(3), 205–216.
MeSH headings : Acrolein / toxicity; Air Pollutants / toxicity; Animals; Body Weight / drug effects; Dose-Response Relationship, Drug; Inhalation Exposure; Male; Metaplasia / chemically induced; Metaplasia / pathology; Nasal Mucosa / drug effects; Nasal Mucosa / pathology; Neurons, Afferent / drug effects; Neurons, Afferent / pathology; Olfactory Pathways / drug effects; Olfactory Pathways / pathology; Rats; Rats, Inbred F344; Respiratory System / drug effects; Respiratory System / pathology; Rhinitis / chemically induced; Rhinitis / pathology; Turbinates / drug effects; Turbinates / pathology
TL;DR:
Acrolein exposure was associated with inflammation, hyperplasia, and squamous metaplasia of the respiratory epithelium, and the lateral wall was amongst the most sensitive locations for these responses and increased respiratory epithelial cell proliferation occurred following 4 to 30 days of exposure to ≥ 0.6 ppm acrolein.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Basal Gene Expression in Male and Female Sprague-Dawley Rat Nasal Respiratory and Olfactory Epithelium
Inhalation Toxicology, 19(11), 941–949.
MeSH headings : Animals; Female; Gene Expression Profiling / methods; Gene Expression Regulation / physiology; Male; Nasal Mucosa / metabolism; Nasal Mucosa / physiology; Nasal Mucosa / ultrastructure; Olfactory Mucosa / metabolism; Olfactory Mucosa / physiology; Olfactory Mucosa / ultrastructure; Rats; Rats, Sprague-Dawley; Xenobiotics / metabolism
TL;DR:
To better understand and predict gender differences in response of the nasal epithelium to inhaled xenobiotics, gene expression profiles from naive male and female Sprague-Dawley rats were constructed and surprisingly, there were few gender Differences in gene expression.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2007 journal article
Basal ganglia neurotransmitter concentrations in rhesus monkeys following subchronic manganese sulfate inhalation
American Journal of Industrial Medicine, 50(10), 772–778.
author keywords: parkinsonism; neurochemistry; inhalation; macaca mulatta; manganese
MeSH headings : 3,4-Dihydroxyphenylacetic Acid / metabolism; Animals; Basal Ganglia / drug effects; Basal Ganglia / metabolism; Disease Models, Animal; Dopamine / metabolism; Glutamic Acid / metabolism; Hydroxyindoleacetic Acid / metabolism; Inhalation; Macaca mulatta; Manganese Compounds / analysis; Neurotransmitter Agents / analysis; Neurotransmitter Agents / metabolism; Norepinephrine / metabolism; Parkinsonian Disorders / physiopathology; Serotonin / metabolism; Sulfates / analysis; Sulfates / toxicity; gamma-Aminobutyric Acid / metabolism
TL;DR:
Despite the presence of increased tissue manganese concentrations, high-dose exposure to MnSO4 was associated with relatively few changes in basal ganglial neurotransmitter concentrations.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2007 journal article
Inhibition and recovery of maternal and foetal cholinesterase enzymes following fenitrothion administration in CD rats
Xenobiotica, 37(1), 19–29.
author keywords: toxicology; pharmacokinetics; fenitrothion; neurotoxicity; esterases; rodent
MeSH headings : Animals; Brain / drug effects; Brain / enzymology; Cholinesterase Inhibitors / administration & dosage; Cholinesterase Inhibitors / blood; Cholinesterase Inhibitors / pharmacokinetics; Cholinesterase Inhibitors / pharmacology; Cholinesterases / metabolism; Female; Fenitrothion / administration & dosage; Fenitrothion / blood; Fenitrothion / pharmacokinetics; Fenitrothion / pharmacology; Fetus / drug effects; Fetus / enzymology; Liver / drug effects; Liver / enzymology; Pregnancy; Rats
TL;DR:
Esterase inhibition occurred at a fenitrothion dose that has not been previously associated with reproductive toxicity, suggesting that esterase inhibition should be considered as the critical effect in risk assessments for this pesticide.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2007 journal article
Pharmacokinetic Modeling of Manganese. I. Dose Dependencies of Uptake and Elimination
Journal of Toxicology and Environmental Health, Part A, 70(18), 1493–1504.
MeSH headings : Animals; Bile / chemistry; Dose-Response Relationship, Drug; Intestinal Mucosa / metabolism; Liver / metabolism; Male; Manganese / pharmacokinetics; Mice; Models, Biological; Rats; Rats, Inbred Strains
TL;DR:
D dose dependencies in uptake and elimination are necessary inputs for comprehensive PK models guiding human health risk assessments with Mn, and differential control of absorption in single gavage oral dose studies versus continuous high oral doses in the feed is indicated.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2007 journal article
Pharmacokinetic Modeling of Manganese. II. Hepatic Processing After Ingestion and Inhalation
Journal of Toxicology and Environmental Health, Part A, 70(18), 1505–1514.
MeSH headings : Administration, Inhalation; Administration, Oral; Animals; Intestinal Absorption; Intestinal Mucosa / metabolism; Liver / metabolism; Male; Manganese / pharmacokinetics; Models, Biological; Rats; Rats, Inbred Strains
TL;DR:
Differences in hepatic processing of blood Mn derived from different dose routes need to be accounted for in more complete PK models for Mn that are intended to support human health risk assessments.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2007 journal article
Preliminary investigation of changes in the sexually dimorphic nucleus of the rat medial preoptic area following prenatal exposure to fenitrothion
Journal of Applied Toxicology, 27(6), 631–636.
author keywords: anti-androgen; SDN-POA; fenitrothion; developmental neurotoxicity
MeSH headings : Administration, Oral; Androgen Antagonists / administration & dosage; Androgen Antagonists / toxicity; Animals; Body Weight / drug effects; Cholinesterase Inhibitors / administration & dosage; Cholinesterase Inhibitors / toxicity; Dose-Response Relationship, Drug; Female; Fenitrothion / administration & dosage; Fenitrothion / toxicity; Gait / drug effects; Insecticides / administration & dosage; Insecticides / toxicity; Lacrimal Apparatus / drug effects; Lacrimal Apparatus / metabolism; Litter Size / drug effects; Male; Pilot Projects; Pregnancy; Prenatal Exposure Delayed Effects; Preoptic Area / drug effects; Preoptic Area / growth & development; Preoptic Area / pathology; Rats; Sexual Maturation; Tears / metabolism; Tremor / chemically induced
TL;DR:
There was a dose‐related increase in the SDN‐POA volume in males and a dose-related decrease in SDN-POAVolume in females exposed to fenitrothion, suggesting that fen itrothion may have mixed endocrine effects on the developing brain.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2006 journal article
Application of pharmacokinetic data to the risk assessment of inhaled manganese
NeuroToxicology, 27(5), 752–764.
author keywords: parkinsonism; manganese poisoning; pharmacokinetics; inhalation exposure
MeSH headings : Animals; Humans; Inhalation Exposure / statistics & numerical data; Manganese / pharmacokinetics; Manganese Poisoning / diagnosis; Manganese Poisoning / epidemiology; Manganese Poisoning / metabolism; Risk Assessment; United States; United States Environmental Protection Agency / standards
TL;DR:
The U.S. Environmental Protection Agency's current risk assessment for inhaled manganese is reviewed, contemporary pharmacokinetic studies are summarized, and how these data could inform future risk assessments of this metal following inhalation are considered.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2006 journal article
Changes in Intracellular pH Play a Secondary Role in Hydrogen Sulfide-Induced Nasal Cytotoxicity
Inhalation Toxicology, 18(3), 159–167.
MeSH headings : Animals; Benzopyrans / metabolism; Cell Survival / drug effects; Cyanates / toxicity; Dose-Response Relationship, Drug; Hydrogen Sulfide / toxicity; Hydrogen-Ion Concentration; Male; Naphthols / metabolism; Nasal Mucosa / drug effects; Nasal Mucosa / metabolism; Rats; Rhodamines / metabolism
TL;DR:
The intracellular acidification of nasal epithelial cells by high-dose H2S exposure and the inhibition of cytochrome oxidase at much lower H1N1 concentrations suggest that changes in intrACEllular pH play a secondary role in H 2S-induced nasal injury.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2006 journal article
Effects of inhaled manganese on biomarkers of oxidative stress in the rat brain
NeuroToxicology, 27(5), 788–797.
author keywords: manganese; neurotoxicity; manganism; oxidative stress; reactive oxygen species
MeSH headings : Age Factors; Animals; Animals, Newborn; Biomarkers; Brain / metabolism; Brain / pathology; Brain Chemistry / drug effects; Female; Inhalation Exposure; Male; Manganese / toxicity; Oxidative Stress / drug effects; Oxidative Stress / physiology; Rats; Sex Factors; Time Factors
TL;DR:
The collective results of these studies argue against extensive involvement of ROS in Mn neurotoxicity in rats of differing genders and ages, but there are, however, instances of changes in individual endpoints consistent with oxidative stress in certain brain tissues.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2006 journal article
Lethargy and hind limb paralysis in a day-23 timed pregnant rat
Lab Animal, 35(2), 19–19.
MeSH headings : Animals; Dystocia / etiology; Dystocia / pathology; Dystocia / veterinary; Fatal Outcome; Female; Paralysis / etiology; Paralysis / veterinary; Pregnancy; Rats; Rats, Sprague-Dawley; Rodent Diseases / diagnosis; Rodent Diseases / pathology; Urinary Bladder Calculi / complications; Urinary Bladder Calculi / pathology; Urinary Bladder Calculi / veterinary
TL;DR:
Based on the clinical and necropsy findings what is the cause of the rat’s morbidity and paralysis?
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2006 journal article
Life beyond the air phase: adding tissue disposition to models of nasal airway transport
Journal of Biomechanics, 39, S270–S271.
Source: Crossref
Added: February 24, 2020
2006 journal article
Neurotoxicity of inhaled manganese: A reanalysis of human exposure arising from showering
Medical Hypotheses, 66(1), 199–200.
MeSH headings : Baths; Humans; Inhalation Exposure / analysis; Manganese / analysis; Manganese / toxicity; Manganese Poisoning / etiology; Neurotoxicity Syndromes / etiology; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / toxicity; Water Supply / analysis
Source: Crossref
Added: February 24, 2020
2006 journal article
Respiration in Sprague-Dawley Rats During Pregnancy
Inhalation Toxicology, 18(4), 305–312.
MeSH headings : Animals; Female; Plethysmography, Whole Body; Pregnancy / physiology; Pulmonary Ventilation; Rats; Rats, Sprague-Dawley; Reference Values; Respiration; Tidal Volume
TL;DR:
Important reference values that can be used in pharmacokinetic models during pregnancy are provided, including minute ventilation and tidal volume, which were significantly increased in pregnant rats compared to nonpregnant rats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: February 24, 2020
2006 journal article
The Speciation of Metals in Mammals Influences Their Toxicokinetics and Toxicodynamics and Therefore Human Health Risk Assessment
Journal of Toxicology and Environmental Health, Part B, 9(1), 63–85.
author keywords: metal speciation; risk assessment; toxicodynamics; toxicokinetics
MeSH headings : Biotransformation; Databases as Topic; Humans; Metals / chemistry; Metals / pharmacokinetics; Metals / toxicity; Particle Size; Risk Assessment
TL;DR:
The influence of speciation on metal toxicokinetics and toxicodynamics in mammals, and therefore the adverse effects of metals, is reviewed to illustrate how the physicochemical characteristics of metals and their handling in the body (toxicokinetics) can influence toxicity (t toxicodynamics).
(via Semantic Scholar)
Source: Crossref
Added: December 29, 2020
2005 journal article
Manganese Dosimetry: Species Differences and Implications for Neurotoxicity
Critical Reviews in Toxicology, 35(1), 1–32.
author keywords: biomarkers; brain; manganese; metabolism; neurotoxicity; pharmacokinetics
MeSH headings : Absorption; Adult; Blood-Brain Barrier; Central Nervous System / drug effects; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Inhalation Exposure; Male; Manganese / administration & dosage; Manganese / adverse effects; Manganese / pharmacokinetics; Maternal-Fetal Exchange; Pregnancy; Public Health; Risk Assessment
Source: Crossref
Added: February 24, 2020
2005 journal article
Maternal–fetal Distribution of Manganese in the Rat Following Inhalation Exposure to Manganese Sulfate
NeuroToxicology, 26(4), 625–632.
author keywords: manganese; inhalation; rat; pregnancy
MeSH headings : Animals; Body Burden; Female; Fetus / metabolism; Inhalation Exposure; Male; Manganese Compounds / administration & dosage; Manganese Compounds / pharmacokinetics; Maternal-Fetal Exchange / physiology; Organ Size / drug effects; Pregnancy; Rats; Sulfates / administration & dosage; Sulfates / pharmacokinetics; Tissue Distribution
TL;DR:
The results of this study demonstrate that the placenta partially sequesters inhaled manganese, thereby limiting exposure to the fetus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2004 journal article
Dose-dependent transitions in mechanisms of toxicity
Toxicology and Applied Pharmacology, 201(3), 203–225.
author keywords: dose-dependent transitions; mechanisms of toxicity; dose-response
MeSH headings : Animals; DNA Adducts / drug effects; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Humans; Inactivation, Metabolic; Research Design; Risk Assessment
TL;DR:
This paper addresses the issues discussed at both workshops, and presents the consensus conclusions drawn by expert participants on the impact of dose-dependent transitions on the risk assessment process.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2004 journal article
Dose-dependent transitions in mechanisms of toxicity: case studies
Toxicology and Applied Pharmacology, 201(3), 226–294.
author keywords: dose-dependent transitions; mechanisms of toxicity; dose response; acetaminophen; butadiene; ethylene glycol; formaldehyde; manganese; methylene chloride; peroxisome proliferator-activated receptor; progesterone/hydroxyflutamide; propylene oxide; vinyl acetate; vinyl chloride; vinylidene chloride; zinc
MeSH headings : Acetaminophen / administration & dosage; Acetaminophen / pharmacokinetics; Acetaminophen / toxicity; Analgesics, Non-Narcotic / administration & dosage; Analgesics, Non-Narcotic / pharmacokinetics; Analgesics, Non-Narcotic / toxicity; Androgen Antagonists / administration & dosage; Androgen Antagonists / pharmacokinetics; Androgen Antagonists / toxicity; Animals; Butadienes / administration & dosage; Butadienes / pharmacokinetics; Butadienes / toxicity; Dichloroethylenes / administration & dosage; Dichloroethylenes / pharmacokinetics; Dichloroethylenes / toxicity; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions / chemically induced; Drug-Related Side Effects and Adverse Reactions / metabolism; Epoxy Compounds / administration & dosage; Epoxy Compounds / pharmacokinetics; Epoxy Compounds / toxicity; Ethylene Glycol / administration & dosage; Ethylene Glycol / pharmacokinetics; Ethylene Glycol / toxicity; Flutamide / administration & dosage; Flutamide / analogs & derivatives; Flutamide / pharmacokinetics; Flutamide / toxicity; Formaldehyde / administration & dosage; Formaldehyde / pharmacokinetics; Formaldehyde / toxicity; Humans; Manganese / administration & dosage; Manganese / pharmacokinetics; Manganese Poisoning / metabolism; Methylene Chloride / administration & dosage; Methylene Chloride / pharmacokinetics; Methylene Chloride / toxicity; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptors / physiology; Progesterone / administration & dosage; Progesterone / pharmacokinetics; Progesterone / toxicity; Vinyl Compounds / administration & dosage; Vinyl Compounds / pharmacokinetics; Vinyl Compounds / toxicity; Zinc / administration & dosage; Zinc / pharmacokinetics; Zinc / toxicity
TL;DR:
A group of academic, government, and industry scientists, formed under the leadership of the ILSI Health and Environmental Sciences Institute (HESI), developed a series of case studies to illustrate the existence of dose-dependent transitions in mechanisms of toxicity.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2004 journal article
Health and environmental testing of manganese exhaust products from use of methylcyclopentadienyl manganese tricarbonyl in gasoline
Science of The Total Environment, 334-335, 397–408.
author keywords: methylcyclopentadienyl manganese tricarbonyl; MMT; manganese; pharmacokinetics
MeSH headings : Animals; Carcinogens, Environmental; Environmental Exposure; Gasoline; Humans; Manganese; Organometallic Compounds / adverse effects; Organometallic Compounds / analysis; Organometallic Compounds / pharmacokinetics; Public Health; Risk Assessment; Rodentia; Vehicle Emissions / analysis
TL;DR:
A great amount of toxicological research has been carried out during the past few years that provides data for use in developing a PBPK model in rodents, and these data add greatly to the existing body of knowledge regarding the relationship between Mn exposure and tissue disposition.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2004 journal article
Manganese exposure and induced oxidative stress in the rat brain
Science of The Total Environment, 334-335, 409–416.
author keywords: brain; manganese; neurotoxicity; glutathione; metallothionein; glutamine synthetase; MMT
MeSH headings : Animals; Antioxidants / pharmacology; Biomarkers; Brain / drug effects; Brain / pathology; Environmental Pollutants / adverse effects; Manganese / adverse effects; Oxidation-Reduction; Oxidative Stress; Rats
TL;DR:
The link between manganese neurotoxicity in the rat brain and common pathways to oxidative stress is examined, particularly in rat brain tissue.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2004 journal article
Nasal Toxicity of Manganese Sulfate and Manganese Phosphate in Young Male Rats Following Subchronic (13-Week) Inhalation Exposure
Inhalation Toxicology, 16(6-7), 481–488.
MeSH headings : Air Pollutants / toxicity; Animals; Cerebellum / metabolism; Corpus Striatum / metabolism; Dose-Response Relationship, Drug; Drug Administration Schedule; Glial Fibrillary Acidic Protein / metabolism; Inhalation Exposure; Male; Manganese Compounds / administration & dosage; Manganese Compounds / pharmacokinetics; Nasal Mucosa / drug effects; Nasal Mucosa / metabolism; Nasal Mucosa / pathology; Olfactory Bulb / metabolism; Organometallic Compounds / administration & dosage; Organometallic Compounds / pharmacokinetics; Organometallic Compounds / toxicity; Rats; Rats, Inbred Strains; Sulfates / administration & dosage; Sulfates / pharmacokinetics; Sulfates / toxicity
TL;DR:
It is confirmed that high-doseManganese inhalation can result in nasal toxicity (irritation) and increased delivery of manganese to the brain; however, it is not confirmed that mangane inhalation would result in altered brain GFAP concentrations.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2004 journal article
Old age and gender influence the pharmacokinetics of inhaled manganese sulfate and manganese phosphate in rats
Toxicology and Applied Pharmacology, 197(2), 113–124.
author keywords: age; gender; manganese
MeSH headings : Administration, Inhalation; Aging / metabolism; Animals; Body Weight / drug effects; Female; Male; Manganese / metabolism; Manganese Compounds / administration & dosage; Manganese Compounds / pharmacokinetics; Neostriatum / drug effects; Neostriatum / metabolism; Organ Size / drug effects; Organometallic Compounds / administration & dosage; Organometallic Compounds / pharmacokinetics; Organometallic Compounds / toxicity; Radioisotopes; Rats; Sex Characteristics; Sulfates / administration & dosage; Sulfates / pharmacokinetics; Sulfates / toxicity; Tissue Distribution
TL;DR:
Gender and age did not affect manganese delivery to the striatum, a known target site for neurotoxicity in humans, but did influenceManganese concentrations in other tissues, and end-of-exposure olfactory bulb, lung, and blood manganes concentrations were higher in young male rats than in female or aged male rats and may reflect a portal-of theentry effect.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2004 journal article
Old age and gender influence the pharmacokinetics of inhaled manganese sulfate and manganese phosphate in rats
Toxicology and Applied Pharmacology, 197(2), 113–124.
Source: Crossref
Added: February 24, 2020
2004 journal article
Respiratory tract toxicity of inhaled hydrogen sulfide in Fischer-344 rats, Sprague–Dawley rats, and B6C3F1 mice following subchronic (90-day) exposure
Toxicology and Applied Pharmacology, 198(1), 29–39.
author keywords: rat; mouse; inhalation; hydrogen sulfide; nose; lung; toxicity; pathology
MeSH headings : Administration, Inhalation; Air Pollutants / toxicity; Animals; Body Weight / drug effects; Bronchi / drug effects; Bronchi / pathology; Dose-Response Relationship, Drug; Eating / drug effects; Epithelial Cells / drug effects; Epithelial Cells / pathology; Female; Hydrogen Sulfide / administration & dosage; Hydrogen Sulfide / toxicity; Male; Mice; Mice, Inbred Strains; No-Observed-Adverse-Effect Level; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Respiratory System / drug effects; Respiratory System / pathology; Rhinitis / chemically induced; Rhinitis / pathology; Species Specificity; Toxicity Tests, Chronic; Turbinates / drug effects; Turbinates / pathology
TL;DR:
The results confirm that the rodent nose, and less so the lung, are highly sensitive to H2S-induced toxicity, with 10 ppm representing the NOAEL for ONL following subchronic inhalation.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2002 journal article
OLFACTORY TRANSPORT: A DIRECT ROUTE OF DELIVERY OF INHALED MANGANESE PHOSPHATE TO THE RAT BRAIN
Journal of Toxicology and Environmental Health, Part A, 65(20), 1493–1511.
MeSH headings : Administration, Inhalation; Analysis of Variance; Animals; Autoradiography; Axonal Transport; Brain / metabolism; Linear Models; Male; Manganese / administration & dosage; Manganese / pharmacokinetics; Nasal Mucosa / metabolism; Olfactory Bulb / metabolism; Rats; Spectrometry, Gamma
TL;DR:
The results demonstrate that the olfactory route contributes to 54 Mn delivery to the rat Olfactory bulb and tubercle, however, this pathway does not significantly contribute to striatal 54 Mn concentrations following a single, short-term inhalation exposure to54 MnHPO 4.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
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