David C Dorman
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Works (100)
Updated: September 12th, 2023 05:01
2023 review
The Role of Oxidative Stress in Manganese Neurotoxicity: A Literature Review Focused on Contributions Made by Professor Michael Aschner
[Review of ]. BIOMOLECULES, 13(8).
author keywords: manganese; neurotoxicity; oxidative stress; mechanisms; C. elegans
www.mdpi.com (publisher PDF)
Source: Web Of Science
Added: September 11, 2023
2022 journal article
The Current State of Veterinary Toxicology Education at AAVMC Member Veterinary Schools
VETERINARY SCIENCES, 9(12).
author keywords: curriculum; veterinary; toxicology; competency-based veterinary education; entrustable professional activities
Source: Web Of Science
Added: January 17, 2023
2022 article
Why Indoor Chemistry Matters: A National Academies Consensus Report
Habre, R., Dorman, D. C., Abbatt, J., Bahnfleth, W. P., Carter, E., Farmer, D., … Harries, M. E. (2022, August 2). ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol. 56, pp. 10560–10563.
author keywords: air pollution; air quality; indoor environmental quality; chemical exposure; collaborative research; research agenda
MeSH headings : Air Pollutants / analysis; Air Pollution, Indoor / analysis; Consensus; Environmental Monitoring
Source: Web Of Science
Added: August 29, 2022
2021 journal article
Effect of Delivery Format on Student Outcomes and Perceptions of a Veterinary Medicine Course: Synchronous Versus Asynchronous Learning
VETERINARY SCIENCES, 8(2).
author keywords: online learning; student perceptions; emergency remote teaching; toxicology
Source: Web Of Science
Added: March 29, 2021
2021 journal article
Training with Multiple Structurally Related Odorants Fails to Improve Generalization of Ammonium Nitrate Detection in Domesticated Dogs (Canis familiaris)
ANIMALS, 11(1).
author keywords: canine; scent detection; improvised explosive device; categorical formation
Source: Web Of Science
Added: February 15, 2021
2019 review
Language Consideration and Methodological Transparency in "Systematic" Reviews of Animal Toxicity Studies
[Review of ]. INTERNATIONAL JOURNAL OF TOXICOLOGY, 38(2), 135–145.
author keywords: toxicology; translation; foreign languages; publications; systematic review methodology; authorship
MeSH headings : Animals; Authorship; Language; Meta-Analysis as Topic; Research Design; Research Support as Topic; Systematic Reviews as Topic; Toxicity Tests
Source: Web Of Science
Added: April 22, 2019
2019 journal article
Use of Nasal Pathology in the Derivation of Inhalation Toxicity Values for Hydrogen Sulfide
TOXICOLOGIC PATHOLOGY, 47(8), 1043–1048.
author keywords: hydrogen sulfide; nasal toxicity; risk assessment; CFD modeling
MeSH headings : Animals; Dose-Response Relationship, Drug; Humans; Hydrogen Sulfide / toxicity; Inhalation Exposure / adverse effects; Nasal Mucosa / drug effects; Nasal Mucosa / pathology; No-Observed-Adverse-Effect Level; Nose / anatomy & histology; Nose / drug effects; Nose / pathology; Toxicity Tests
Source: Web Of Science
Added: November 18, 2019
2018 journal article
A pilot study documenting increased thrombin generation following abrupt withdrawal of heparin therapy in healthy dogs
Journal of Veterinary Emergency and Critical Care, 28(6), 518–526.
author keywords: hypercoagulable; rebound; thromboelastography
MeSH headings : Animals; Anticoagulants / administration & dosage; Anticoagulants / pharmacology; Dogs; Heparin / administration & dosage; Heparin / pharmacology; Infusions, Intravenous / veterinary; Male; Pilot Projects; Prospective Studies; Thrombelastography / veterinary; Thrombin / biosynthesis; Thrombin / drug effects
Sources: Web Of Science, Crossref
Added: November 26, 2018
2018 journal article
Carcinogenicity of some nitrobenzenes and other industrial chemicals
The Lancet Oncology, 19(12), e681–e682.
MeSH headings : Animals; Carcinogenicity Tests; Carcinogens, Environmental / adverse effects; Humans; Nitrobenzenes / adverse effects; Occupational Exposure / adverse effects; Predictive Value of Tests; Risk Assessment
Source: Crossref
Added: July 21, 2019
2018 journal article
Comparing Item Performance on Three- Versus Four-Option Multiple Choice Questions in a Veterinary Toxicology Course
Veterinary Sciences, 5(2), 55.
author keywords: assessment; medical education; veterinary medicine; testing; multiple-choice questions; psychology; toxicology; measurement; item writing; veterinary education
Sources: Crossref, ORCID
Added: February 11, 2019
2018 article
Neonatal C57BL/6J and parkin mice respond differently following developmental manganese exposure: Result of a high dose pilot study
Foster, M. L., Bartnikas, T. B., Maresca-Fichter, H. C., Mercadante, C., Dash, M., Miller, C., & Dorman, D. C. (2018, January). NEUROTOXICOLOGY, Vol. 64, pp. 291–299.
author keywords: Manganese; Neurotoxicity; Pharmacokinetics; Metabolism
MeSH headings : Animals; Animals, Newborn; Brain / drug effects; Brain / metabolism; Female; Liver / drug effects; Liver / metabolism; Male; Manganese / toxicity; Mice, Inbred C57BL; Mice, Knockout; Motor Activity / drug effects; Pilot Projects; Tissue Distribution; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism
Source: Web Of Science
Added: August 6, 2018
2018 article
Olfactory toxicity in rats following manganese chloride nasal instillation: A pilot study
Foster, M. L., Rao, D. B., Francher, T., Traver, S., & Dorman, D. C. (2018, January). NEUROTOXICOLOGY, Vol. 64, pp. 284–290.
author keywords: Manganese; Olfactory toxicity; Olfactory discrimination; Pharmacokinetics
MeSH headings : Administration, Inhalation; Animals; Chlorides / administration & dosage; Chlorides / metabolism; Chlorides / toxicity; Discrimination, Psychological / drug effects; Male; Manganese Compounds / administration & dosage; Manganese Compounds / metabolism; Odorants; Olfactory Bulb / drug effects; Olfactory Bulb / metabolism; Olfactory Bulb / pathology; Olfactory Mucosa / drug effects; Olfactory Mucosa / metabolism; Olfactory Mucosa / pathology; Pilot Projects; Rats, Inbred F344
Source: Web Of Science
Added: August 6, 2018
2018 review
Polybrominated diphenyl ether (PBDE) neurotoxicity: a systematic review and meta-analysis of animal evidence
[Review of ]. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS, 21(4), 269–289.
author keywords: Developmental neurotoxicity; systematic review; learning and memory
MeSH headings : Animals; Attention / drug effects; Environmental Exposure / analysis; Environmental Pollutants / toxicity; Female; Halogenated Diphenyl Ethers / toxicity; Learning / drug effects; Male; Memory / drug effects; Mice; Rats
Source: Web Of Science
Added: December 3, 2018
2018 personal communication
Response to Editor: Regarding Foster et al., Neonatal C57BL/6J and parkin mice respond differently following developmental manganese exposure: Result of a high dose pilot study
Dorman, D. C. (2018, December).
author keywords: Manganese; Developmental neurotoxicity; Parkin
MeSH headings : Animals; Manganese; Mice; Mice, Inbred C57BL; Pilot Projects
Source: Web Of Science
Added: December 10, 2018
2018 journal article
Student Engagement with Rubrics to Promote Enhanced Written Communication of Health Information
Medical Science Educator, 28(4), 591–596.
Sources: Crossref, ORCID
Added: July 21, 2019
2018 review
Systematic reviews and meta-analyses of human and animal evidence of prenatal diethylhexyl phthalate exposure and changes in male anogenital distance
[Review of ]. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS, 21(4), 207–226.
author keywords: Reproductive toxicity; phthalate; anogenital distance; epidemiology
MeSH headings : Animals; Diethylhexyl Phthalate / adverse effects; Environmental Pollutants / adverse effects; Female; Genitalia, Male / anatomy & histology; Genitalia, Male / drug effects; Genitalia, Male / growth & development; Humans; Male; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / pathology
Source: Web Of Science
Added: December 3, 2018
2018 journal article
Toxicity associated with ingestion of a polyacrylic acid hydrogel dog pad
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 30(5), 708–714.
author keywords: Dogs; hydrogel; neurotoxicity; poisoning; sodium polyacrylate
MeSH headings : Acrylic Resins / poisoning; Acrylic Resins / toxicity; Animals; Dog Diseases / chemically induced; Dogs; Eating; Female; Hydrogels / poisoning; Hydrogels / toxicity; Male; North Carolina; Rats; Rats, Sprague-Dawley
Sources: Web Of Science, ORCID
Added: October 16, 2018
2017 journal article
Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory testing
Toxicology in Vitro, 41, 245–259.
author keywords: Acute systemic toxicity; Alternatives; LD50; Oral; Dermal Inhalation; 3Rs; In vitro; In silico
MeSH headings : Animal Testing Alternatives; Animals; Government Regulation; High-Throughput Screening Assays; Humans; Research; Toxicity Tests, Acute
Sources: Web Of Science, Crossref
Added: August 6, 2018
2017 journal article
Canine scent detection of canine cancer: a feasibility study
Veterinary Medicine: Research and Reports, Volume 8, 69–76.
author keywords: urinary tract cancer; cancer detection dogs; cancer odor; olfactory memory; multiple sample learning
Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
Caregiver placebo effect in analgesic clinical trials for cats with naturally occurring degenerative joint disease-associated pain
Veterinary Record, 180(19), 473–473.
MeSH headings : Analgesics / therapeutic use; Animals; Caregivers / psychology; Cat Diseases / drug therapy; Cats; Female; Humans; Joint Diseases / complications; Joint Diseases / veterinary; Male; Optimism; Osteoarthritis / complications; Osteoarthritis / veterinary; Pain / drug therapy; Pain / etiology; Pain / veterinary; Placebo Effect; Treatment Outcome
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2017 journal article
Effect of wearing a Telemetry jacket on behavioral and physiologic parameters of dogs in the open-field test
Journal of the American Association for Laboratory Animal Science, 56(4), 382–389.
Source: NC State University Libraries
Added: August 6, 2018
2017 article
Fifty years of contributions by the American Board of Veterinary Toxicology
Dorman, D. C., Beasley, V. R., & McClellan, R. O. (2017, August 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 251, pp. 268–270.
MeSH headings : Animals; Education, Veterinary; Toxicology; United States; Veterinary Medicine
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Interactions of manganese with iron, zinc, and copper in neonatal C57BL/6J and parkin mice following developmental oral manganese exposure
Data in Brief, 15, 908–915.
author keywords: Copper; Zinc; Iron; Manganese Toxicity; Mouse
Source: Crossref
Added: July 21, 2019
2017 article
Manganese Neurodegeneration
ENVIRONMENTAL FACTORS IN NEURODEGENERATIVE DISEASES, pp. 157–183.
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Metal imaging in the brain
Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics, 349–362.
Source: NC State University Libraries
Added: August 6, 2018
2017 article
Severity scoring of manganese health effects for categorical regression
Mattison, D. R., Milton, B., Krewski, D., Levy, L., Dorman, D. C., Aggett, P. J., … McGough, D. (2017, January). NEUROTOXICOLOGY, Vol. 58, pp. 203–216.
author keywords: Exposure-response assessment; Categorical regression; Database; Manganese toxicity
MeSH headings : Animals; Copper / toxicity; Databases, Factual; Dose-Response Relationship, Drug; Environmental Exposure; Female; Humans; Male; Manganese / toxicity; Manganese Poisoning / etiology; Regression Analysis
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Survey of Diplomates of the American Board of Veterinary Toxicology Regarding Perceptions of the Value of This Certification
INTERNATIONAL JOURNAL OF TOXICOLOGY, 36(5), 380–385.
author keywords: toxicology; specialty board; survey
MeSH headings : Adult; Aged; Aged, 80 and over; Certification; Female; Humans; Male; Middle Aged; Surveys and Questionnaires; Toxicology
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Teaching Tip: Improving Students' Email Communication through an Integrated Writing Assignment in a Third-Year Toxicology Course
Journal of Veterinary Medical Education, 44(2), 280–289.
author keywords: communication; writing; electronic mail; client education
MeSH headings : Curriculum; Education, Veterinary; Electronic Mail; Female; Humans; Male; Students, Medical; Teaching; Toxicology / education; Writing
Sources: Crossref, ORCID
Added: June 30, 2019
2017 journal article
Thromboelastographic monitoring of the effect of unfractionated heparin in healthy dogs
JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 27(1), 71–81.
author keywords: anticoagulation monitoring; anti-Xa; canine; RapidTEG; thrombosis
MeSH headings : Animals; Anticoagulants / administration & dosage; Anticoagulants / pharmacology; Blood Coagulation / drug effects; Dogs; Female; Heparin / administration & dosage; Heparin / pharmacology; Injections, Subcutaneous / veterinary; Male; Partial Thromboplastin Time / veterinary; Prospective Studies; Reference Values; Thrombelastography / veterinary
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Best practice recommendations for prehospital veterinary care of dogs and cats
Journal of Veterinary Emergency and Critical Care, 26(2), 166–233.
author keywords: cat; dog; first response; trauma; VetCOT
MeSH headings : Animals; Cats; Consensus; Databases, Factual; Dogs; Emergency Service, Hospital / standards; Practice Guidelines as Topic; Practice Management, Veterinary / standards; United States; Veterinary Medicine / standards; Wounds and Injuries / therapy; Wounds and Injuries / veterinary
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2016 journal article
Diphenhydramine exposure in dogs: 621 cases (2008-2013)
Journal of the American Veterinary Medical Association, 249(1), 77–82.
MeSH headings : Animals; Anti-Allergic Agents / poisoning; Diphenhydramine / poisoning; Dog Diseases / epidemiology; Dog Diseases / pathology; Dog Diseases / prevention & control; Dogs; Female; Illinois / epidemiology; Male; Poison Control Centers / statistics & numerical data; Poisoning / epidemiology; Poisoning / veterinary; Retrospective Studies; Severity of Illness Index
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure
Data in Brief, 6, 989–997.
author keywords: Inhalation; Iron; Manganese; Monkey
Source: Crossref
Added: July 21, 2019
2016 journal article
The effect of high dose oral manganese exposure on copper, iron and zinc levels in rats
BIOMETALS, 29(3), 417–422.
author keywords: Manganese; Copper; Iron; Zinc; Exposure
MeSH headings : Administration, Oral; Animals; Copper / metabolism; Diet; Homeostasis / drug effects; Iron / metabolism; Male; Manganese / administration & dosage; Manganese / analysis; Manganese / toxicity; Rats; Rats, Inbred F344; Zinc / metabolism
Source: Web Of Science
Added: August 6, 2018
2015 journal article
A comparison of pet and purpose-bred research dog (Canis familiaris) performance on human-guided object-choice tasks
BEHAVIOURAL PROCESSES, 110, 60–67.
author keywords: Domestic dog; Object-choice task; Social cognition; Purpose-bred dog
MeSH headings : Animals; Behavior, Animal / physiology; Choice Behavior / physiology; Cues; Dogs / physiology; Gestures; Human-Animal Bond; Humans; Male
Source: Web Of Science
Added: August 6, 2018
2015 journal article
A test for the evaluation of emotional reactivity in Labrador retrievers used for explosives detection
JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH, 10(2), 94–102.
author keywords: emotional reactivity test; anxiety scores; selection criteria; behavioral screening; explosives detection dog
Sources: Web Of Science, ORCID
Added: August 6, 2018
2015 article
Answering the Call for Improved Chemical Alternatives Assessments (CAA)
Tickner, J. A., Dorman, D. C., & Sheton-Davenport, M. (2015, February 17). ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol. 49, pp. 1995–1996.
MeSH headings : Chemical Industry; Green Chemistry Technology / methods; Green Chemistry Technology / standards; Humans; Research; Risk Assessment
Source: Web Of Science
Added: August 6, 2018
2015 chapter
Extrapyramidal system neurotoxicity
In Handbook of Clinical Neurology (pp. 207–223).
MeSH headings : Animals; Basal Ganglia Diseases / etiology; Disease Models, Animal; Humans; Neurotoxicity Syndromes / complications
Source: Crossref
Added: July 21, 2019
2015 journal article
Feasibility of flotation concentration of fungal spores as a method to identify toxigenic mushrooms
Veterinary Medicine: Research and Reports, 6, 1–9.
Source: NC State University Libraries
Added: July 28, 2019
2015 journal article
Olfactory discrimination and generalization of ammonium nitrate and structurally related odorants in Labrador retrievers
Animal Cognition, 18(6), 1255–1265.
MeSH headings : Aluminum; Ammonium Compounds; Animals; Discrimination Learning; Discrimination, Psychological; Dogs; Explosive Agents; Fertilizers; Iraq; Nitrates; Odorants; Smell / physiology; Soil
Sources: NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2015 journal article
Olfactory transport of manganese: Implications for neurotoxicity
Manganese in Health and Disease, 22, 119–132.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Pharmacokinetic Evaluation of the Equivalency of Gavage, Dietary, and Drinking Water Exposure to Manganese in F344 Rats
TOXICOLOGICAL SCIENCES, 145(2), 244–251.
author keywords: manganese; pharmacokinetics; oral exposure; dose rate
MeSH headings : Administration, Oral; Animals; Body Burden; Chlorides / administration & dosage; Chlorides / pharmacokinetics; Chlorides / toxicity; Diet; Food Contamination; Male; Manganese Compounds / administration & dosage; Manganese Compounds / pharmacokinetics; Manganese Poisoning / etiology; Rats, Inbred F344; Risk Assessment; Tissue Distribution; Water Pollutants, Chemical / administration & dosage; Water Pollutants, Chemical / pharmacokinetics; Water Pollutants, Chemical / toxicity
Source: Web Of Science
Added: August 6, 2018
2015 journal article
The use of an open-field model to assess sound-induced fear and anxiety-associated behaviors in Labrador retrievers
JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH, 10(4), 338–345.
author keywords: military working dogs; open-field test; fear; anxiety; thunderstorm; gunfire
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Acquisition of a visual discrimination and reversal learning task by Labrador retrievers
ANIMAL COGNITION, 17(3), 787–792.
author keywords: Dog; Canine; Cognition; Visual discrimination
MeSH headings : Animals; Cognition; Discrimination Learning; Discrimination, Psychological; Dogs / psychology; Female; Male; Neuropsychological Tests; Pattern Recognition, Visual; Reversal Learning; Visual Perception
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Evaluation of a point-of-care anticoagulant rodenticide test for dogs
Journal of Veterinary Emergency and Critical Care, 24(2), 168–173.
author keywords: bedside; canine; poisoning; rodenticide; toxicology
MeSH headings : Animals; Anticoagulants / blood; Anticoagulants / chemistry; Dogs / blood; Molecular Structure; Point-of-Care Systems; Rodenticides / blood; Rodenticides / chemistry
Sources: Crossref, Web Of Science
Added: August 6, 2018
2014 journal article
Explosives detection by military working dogs: Olfactory generalization from components to mixtures
APPLIED ANIMAL BEHAVIOUR SCIENCE, 151, 84–93.
author keywords: Dog; Olfactory; Explosives; Odor mixtures
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Assessment of geographical variation in the respiratory toxicity of desert dust particles
INHALATION TOXICOLOGY, 25(7), 405–416.
author keywords: Cytotoxicity; dust inhalation; in vitro; in vivo; particle toxicity; pulmonary toxicity; rat
MeSH headings : Administration, Inhalation; Afghanistan; Animals; Arsenic / analysis; Arsenic / toxicity; Bronchoalveolar Lavage Fluid / chemistry; Bronchoalveolar Lavage Fluid / cytology; Cell Count; Cell Line; Cell Survival / drug effects; Cytokines / metabolism; Dust / analysis; Endotoxins / analysis; Endotoxins / toxicity; Geography; Iraq; L-Lactate Dehydrogenase / metabolism; Lung / drug effects; Lung / metabolism; Lung / pathology; Male; Metals / analysis; Metals / toxicity; Rats; Silicon Dioxide / analysis; Silicon Dioxide / toxicity; United States
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Inhalation dosimetry of hexamethylene diisocyanate vapor in the rat and human respiratory tracts
INHALATION TOXICOLOGY, 25(3), 168–177.
author keywords: Computational fluid dynamics; dosimetry; hexamethylene diisocyanate; inhalation; lung; nose
MeSH headings : Air Pollutants, Occupational / pharmacokinetics; Air Pollutants, Occupational / toxicity; Animals; Cyanates / pharmacokinetics; Cyanates / toxicity; Dose-Response Relationship, Drug; Humans; Inhalation Exposure; Isocyanates; Lung / drug effects; Lung / metabolism; Lung / pathology; Male; Models, Biological; Rats; Rats, Inbred F344; Respiratory Mucosa / drug effects; Respiratory Mucosa / metabolism; Species Specificity; Volatilization
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Subject Matter Expert and Public Evaluations of a Veterinary Toxicology Course Brochure-Writing Assignment
JOURNAL OF VETERINARY MEDICAL EDUCATION, 40(1), 19–28.
author keywords: communication; brochure; rubrics; toxicology; activity; educational
MeSH headings : Comprehension; Education, Veterinary; Health Communication; North Carolina; Pamphlets; Schools, Veterinary; Students, Health Occupations; Toxicology / education; Writing
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Application of a Multi-Route Physiologically Based Pharmacokinetic Model for Manganese to Evaluate Dose-Dependent Neurological Effects in Monkeys
TOXICOLOGICAL SCIENCES, 129(2), 432–446.
author keywords: manganese; neurotoxicity; dose response; physiologically based pharmacokinetic modeling
MeSH headings : Animals; Cebus; Dose-Response Relationship, Drug; Manganese / pharmacokinetics; Models, Biological; Risk Assessment
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Biological responses in rats exposed to cigarette smoke and Middle East sand (dust)
INHALATION TOXICOLOGY, 24(2), 109–124.
author keywords: Particle toxicity; nanoparticles; rat; in vivo; in vitro; pulmonary toxicity; cytotoxicity; dust inhalation
MeSH headings : Administration, Inhalation; Air Pollutants / toxicity; Animals; Behavior, Animal / drug effects; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid / chemistry; Bronchoalveolar Lavage Fluid / cytology; Dust / analysis; Gene Expression / drug effects; Hand Strength; Iraq; Larynx / drug effects; Larynx / pathology; Lung / drug effects; Lung / pathology; Lung / physiology; Male; Metals / analysis; Metals / toxicity; Motor Activity / drug effects; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Respiratory Function Tests; Respiratory Mucosa / drug effects; Respiratory Mucosa / pathology; Silicon Dioxide / analysis; Silicon Dioxide / toxicity; Tobacco Smoke Pollution / adverse effects; Trachea / drug effects; Trachea / pathology
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Neurological impacts from inhalation of pollutants and the nose-brain connection
NeuroToxicology, 33(4), 838–841.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Neurological impacts from inhalation of pollutants and the nose–brain connection
NeuroToxicology, 33(4), 838–841.
author keywords: Air pollution; Neurotoxicity; Olfactory tract
MeSH headings : Air Pollutants / adverse effects; Animals; Body Burden; Environmental Monitoring; Humans; Inhalation Exposure / adverse effects; Nervous System / drug effects; Nervous System / physiopathology; Neurotoxicity Syndromes / etiology; Neurotoxicity Syndromes / physiopathology; Nose / drug effects; Nose / physiopathology; Olfactory Pathways / drug effects; Olfactory Pathways / physiopathology; Risk Assessment; Risk Factors
Source: Crossref
Added: August 28, 2020
2012 journal article
The outdoor air pollution and brain health workshop
NeuroToxicology, 33(5), 972–984.
author keywords: Air pollution; Brain; Particulate matter; Ozone; Central nervous system; Susceptibility; Epidemiology; Neuroinflammation; Neurotoxicity; Behavior
MeSH headings : Air Pollutants / poisoning; Air Pollution / adverse effects; Brain / pathology; Cardiovascular Diseases / chemically induced; Cardiovascular Diseases / pathology; Disease Susceptibility; Encephalitis / etiology; Encephalitis / pathology; Humans; Lung Diseases / chemically induced; Lung Diseases / pathology; Neurotoxicity Syndromes / epidemiology; Neurotoxicity Syndromes / etiology; Neurotoxicity Syndromes / pathology
Source: Crossref
Added: February 24, 2020
2012 review
The outdoor air pollution and brain health workshop
[Review of]. NeuroToxicology, 33(5), 972–984.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Analysis of Manganese Tracer Kinetics and Target Tissue Dosimetry in Monkeys and Humans with Multi-Route Physiologically Based Pharmacokinetic Models
TOXICOLOGICAL SCIENCES, 120(2), 481–498.
author keywords: manganese; PBPK; inhalation exposure; risk assessment; neurotoxicity; pharmacokinetics
MeSH headings : Administration, Oral; Adult; Animals; Humans; Inhalation Exposure; Injections; Macaca mulatta; Manganese Compounds / pharmacokinetics; Metabolic Clearance Rate; Models, Biological; Organ Specificity; Physiology; Radioisotopes; Species Specificity; Time Factors; Tissue Distribution
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Physiologically Based Pharmacokinetic Modeling of Fetal and Neonatal Manganese Exposure in Humans: Describing Manganese Homeostasis during Development
TOXICOLOGICAL SCIENCES, 122(2), 297–316.
author keywords: manganese; potentially susceptible subpopulation; environmental exposure to Mn; formula; fetus; neonate
MeSH headings : Adult; Animals; Child, Preschool; Female; Fetus / drug effects; Fetus / metabolism; Homeostasis; Humans; Infant; Inhalation Exposure; Lactation; Male; Manganese / blood; Manganese / pharmacokinetics; Manganese / toxicity; Maternal Exposure; Milk, Human / chemistry; Models, Biological; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Tissue Distribution
Source: Web Of Science
Added: August 6, 2018
2010 article
Multi-Dose-Route, Multi-Species Pharmacokinetic Models for Manganese and Their Use in Risk Assessment
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, Vol. 73, pp. 217–234.
MeSH headings : Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Haplorhini; Humans; Manganese / adverse effects; Manganese / pharmacokinetics; Models, Biological; Nutritional Requirements; Rats; Risk Assessment; Tissue Distribution
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Pharmacokinetics of radiolabeled tungsten (W-188) in male Sprague-Dawley rats following acute sodium tungstate inhalation
INHALATION TOXICOLOGY, 22(1), 69–76.
author keywords: Inhalation; kinetics; tungsten
MeSH headings : Administration, Inhalation; Aerosols; Animals; Inhalation Exposure; Male; Metabolic Clearance Rate; Models, Biological; Radioisotopes; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tungsten Compounds / pharmacokinetics
Sources: Web Of Science, ORCID
Added: August 6, 2018
2009 journal article
Acute sodium tungstate inhalation is associated with minimal olfactory transport of tungsten (W-188) to the rat brain
NEUROTOXICOLOGY, 30(3), 445–450.
author keywords: Inhalation; Olfactory transport; Brain; Tungsten; Single-dose; Rat
MeSH headings : Administration, Inhalation; Aerosols; Animals; Corpus Striatum / metabolism; Male; Olfactory Pathways / metabolism; Pituitary Gland / metabolism; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tungsten Compounds / administration & dosage; Tungsten Compounds / blood; Tungsten Compounds / pharmacokinetics
Sources: Web Of Science, ORCID
Added: August 6, 2018
2009 journal article
Evaluating Placental Transfer and Tissue Concentrations of Manganese in the Pregnant Rat and Fetuses after Inhalation Exposures with a PBPK Model
TOXICOLOGICAL SCIENCES, 112(1), 44–58.
author keywords: manganese; inhalation exposure; gestation; placental transfer; homeostasis during gestation; PBPK
MeSH headings : Animals; Female; Fetus / metabolism; Homeostasis; Inhalation Exposure; Manganese / administration & dosage; Manganese / pharmacokinetics; Maternal-Fetal Exchange; Placenta / metabolism; Pregnancy; Rats; Rats, Wistar; Tissue Distribution
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Lactational Transfer of Manganese in Rats: Predicting Manganese Tissue Concentration in the Dam and Pups from Inhalation Exposure with a Pharmacokinetic Model
TOXICOLOGICAL SCIENCES, 112(1), 23–43.
author keywords: manganese; inhalation exposure; postnatal period; enhanced biliary excretion; homeostasis during lactation; PBPK
MeSH headings : Animals; Animals, Newborn; Female; Inhalation Exposure; Lactation; Manganese / administration & dosage; Manganese / pharmacokinetics; Milk / chemistry; Models, Biological; Pregnancy; Rats; Tissue Distribution
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Manganese Tissue Dosimetry in Rats and Monkeys: Accounting for Dietary and Inhaled Mn with Physiologically based Pharmacokinetic Modeling
TOXICOLOGICAL SCIENCES, 108(1), 22–34.
author keywords: manganese; nonhuman primates; dose-dependent regulation; saturable tissue binding; asymmetrical diffusional flux; biliary induction; inhalation exposures; PBPK
MeSH headings : Administration, Inhalation; Administration, Oral; Animals; Brain Chemistry; Calibration; Computer Simulation; Disease Models, Animal; Dose-Response Relationship, Drug; Inhalation Exposure / analysis; Liver / chemistry; Macaca mulatta; Manganese / administration & dosage; Manganese / pharmacokinetics; Models, Biological; Rats; Sensitivity and Specificity
Source: Web Of Science
Added: August 6, 2018
2009 review
Provisional Advisory Levels (PALs) for acrylonitrile
[Review of ]. INHALATION TOXICOLOGY, 21, 17–55.
author keywords: PALs; acrylonitrile; emergency response; inhalation; drinking water
MeSH headings : Acrylonitrile / adverse effects; Acrylonitrile / chemistry; Acrylonitrile / standards; Animals; Consultants; Environmental Exposure / adverse effects; Environmental Exposure / standards; Humans; Inhalation Exposure / adverse effects; Inhalation Exposure / standards; Occupational Exposure / adverse effects; Occupational Exposure / standards
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Provisional Advisory Levels (PALs) for hydrogen sulfide (H2S)
INHALATION TOXICOLOGY, 21, 56–72.
author keywords: PALs; hydrogen sulfide; emergency planning; inhalation; drinking water
MeSH headings : Animals; Consultants; Environmental Exposure / adverse effects; Environmental Exposure / standards; Humans; Hydrogen Sulfide / adverse effects; Hydrogen Sulfide / chemistry; Hydrogen Sulfide / standards; Inhalation Exposure / standards; Occupational Exposure / adverse effects; Occupational Exposure / standards
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Reproductive Toxicity and Pharmacokinetics of di-n-butyl Phthalate (DBP) Following Dietary Exposure of Pregnant Rats
BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY, 86(4), 345–354.
author keywords: anti-androgen; endocrine disruptor; phthalate
MeSH headings : Administration, Oral; Amniotic Fluid / chemistry; Androgen Antagonists / administration & dosage; Androgen Antagonists / pharmacokinetics; Androgen Antagonists / toxicity; Animals; Biotransformation; Body Weight / drug effects; Dibutyl Phthalate / administration & dosage; Dibutyl Phthalate / pharmacokinetics; Dibutyl Phthalate / toxicity; Dose-Response Relationship, Drug; Female; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation, Developmental / drug effects; Genitalia, Male / drug effects; Genitalia, Male / embryology; Genitalia, Male / pathology; Gestational Age; Glucuronides / analysis; Glucuronides / blood; Glucuronides / pharmacokinetics; Glucuronides / urine; Male; Phthalic Acids / analysis; Phthalic Acids / blood; Phthalic Acids / urine; Pregnancy; Random Allocation; Rats; Rats, Sprague-Dawley; Scavenger Receptors, Class B / drug effects; Steroids / biosynthesis; Testis / drug effects; Testis / embryology; Testis / metabolism; Testis / pathology; Testosterone / biosynthesis
Source: Web Of Science
Added: August 6, 2018
2008 review
"Current Pathology Techniques" Symposium Review: Advances and Issues in Neuropathology
[Review of ]. TOXICOLOGIC PATHOLOGY, 36(6), 871–889.
author keywords: neuropathology; neurotoxicity; review
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Application of Physiological Computational Fluid Dynamics Models to Predict Interspecies Nasal Dosimetry of Inhaled Acrolein
Inhalation Toxicology, 20(3), 227–243.
MeSH headings : Acrolein / pharmacokinetics; Acrolein / toxicity; Air Pollutants / pharmacokinetics; Air Pollutants / toxicity; Animals; Computer Simulation; Dose-Response Relationship, Drug; Humans; Inhalation Exposure; Models, Biological; Nasal Cavity / drug effects; Nasal Cavity / metabolism; Nasal Cavity / pathology; Nasal Mucosa / drug effects; Nasal Mucosa / metabolism; Nasal Mucosa / pathology; Rats
Source: Crossref
Added: February 24, 2020
2008 journal article
Derivation of an inhalation reference concentration based upon olfactory neuronal loss in male rats following subchronic acetaldehyde inhalation
INHALATION TOXICOLOGY, 20(3), 245–256.
MeSH headings : Acetaldehyde / toxicity; Air Pollutants / toxicity; Animals; Benchmarking; Cell Proliferation / drug effects; Cross-Linking Reagents / toxicity; DNA / chemistry; DNA / drug effects; Dose-Response Relationship, Drug; Inhalation Exposure; Male; Metaplasia / chemically induced; Metaplasia / pathology; Nasal Cavity / drug effects; Nasal Cavity / metabolism; Nasal Cavity / pathology; Neurons, Afferent / drug effects; Neurons, Afferent / pathology; No-Observed-Adverse-Effect Level; Olfactory Mucosa / drug effects; Olfactory Mucosa / pathology; Olfactory Pathways / drug effects; Olfactory Pathways / pathology; Protein Binding / drug effects; Proteins / chemistry; Proteins / drug effects; Rats; Rats, Inbred F344; Rhinitis / chemically induced; Rhinitis / pathology
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Duration of airborne-manganese exposure in rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity
NeuroToxicology, 29(3), 377–385.
author keywords: brain; monkey; air borne; manganese; glutathione; glutamate
MeSH headings : Amino Acid Transport System X-AG / metabolism; Animals; Biomarkers; Blotting, Northern; Blotting, Western; Brain / metabolism; Excitatory Amino Acid Transporter 2 / metabolism; Glutamate-Ammonia Ligase / metabolism; Glutathione / metabolism; Inhalation Exposure / adverse effects; Macaca mulatta; Male; Manganese / analysis; Manganese / pharmacokinetics; Manganese Poisoning / metabolism; Manganese Poisoning / pathology; Metallothionein / metabolism; Nerve Tissue Proteins / biosynthesis; Nerve Tissue Proteins / genetics; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Tyrosine 3-Monooxygenase / metabolism
Source: Crossref
Added: February 24, 2020
2008 journal article
Gene Expression Changes Following Acute Hydrogen Sulfide (H2S)-induced Nasal Respiratory Epithelial Injury
TOXICOLOGIC PATHOLOGY, 36(4), 560–567.
author keywords: gene expression; nasal respiratory epithelium; LCM; rat; H2S; inhalation; DNA microarray
MeSH headings : Air Pollutants / toxicity; Animals; Cluster Analysis; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Epithelial Cells / pathology; Gene Expression / drug effects; Gene Expression Profiling; Hydrogen Sulfide / toxicity; Inhalation Exposure / adverse effects; Male; Microdissection; Nasal Mucosa / drug effects; Nasal Mucosa / metabolism; Nasal Mucosa / pathology; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Genotoxicity of intermittent co-exposure to benzene and toluene in male CD-1 mice
Chemico-Biological Interactions, 173(3), 166–178.
MeSH headings : Animals; Atmosphere Exposure Chambers; Benzene / toxicity; Benzene Derivatives / urine; Body Weight / drug effects; Bone Marrow Cells / drug effects; DNA / chemistry; DNA / drug effects; Drug Administration Schedule; Glutathione / blood; Glutathione / metabolism; Inhalation Exposure; Liver / drug effects; Liver / metabolism; Male; Mice; Micronuclei, Chromosome-Defective / chemically induced; Molecular Structure; Mutagenicity Tests; Time Factors; Toluene / toxicity
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
Metabolomic analyses of body fluids after subchronic manganese inhalation in rhesus monkeys
TOXICOLOGICAL SCIENCES, 106(1), 46–54.
author keywords: metabolomics; metal; neurotoxicity
MeSH headings : Air Pollutants / blood; Air Pollutants / toxicity; Air Pollutants / urine; Animals; Biomarkers / blood; Biomarkers / urine; Chromatography, Liquid; Cluster Analysis; Environmental Monitoring; Globus Pallidus / drug effects; Globus Pallidus / metabolism; Inhalation Exposure; Macaca mulatta; Male; Manganese Compounds / blood; Manganese Compounds / urine; Metabolomics / methods; Principal Component Analysis; Sulfates / blood; Sulfates / toxicity; Sulfates / urine; Tandem Mass Spectrometry
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Nasal uptake of inhaled acrolein in rats
INHALATION TOXICOLOGY, 20(3), 217–225.
MeSH headings : Acrolein / pharmacokinetics; Air Pollutants / pharmacokinetics; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Glutathione / metabolism; Inhalation Exposure; Lung / metabolism; Male; Nasal Cavity / metabolism; Rats; Rats, Inbred F344; Respiratory Mucosa / metabolism
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Pharmacokinetic Modeling of Manganese in the Rat IV: Assessing Factors that Contribute to Brain Accumulation During Inhalation Exposure
Journal of Toxicology and Environmental Health, Part A, 71(7), 413–426.
MeSH headings : Administration, Oral; Air Pollutants / pharmacokinetics; Animals; Brain / drug effects; Brain Chemistry; Disease Models, Animal; Dust; Environmental Exposure / adverse effects; Inhalation Exposure / adverse effects; Liver / drug effects; Manganese / administration & dosage; Manganese / pharmacokinetics; Models, Biological; Rats; Risk Assessment
Source: Crossref
Added: February 24, 2020
2008 journal article
Respiratory tract responses in male rats following subchronic acrolein inhalation
INHALATION TOXICOLOGY, 20(3), 205–216.
MeSH headings : Acrolein / toxicity; Air Pollutants / toxicity; Animals; Body Weight / drug effects; Dose-Response Relationship, Drug; Inhalation Exposure; Male; Metaplasia / chemically induced; Metaplasia / pathology; Nasal Mucosa / drug effects; Nasal Mucosa / pathology; Neurons, Afferent / drug effects; Neurons, Afferent / pathology; Olfactory Pathways / drug effects; Olfactory Pathways / pathology; Rats; Rats, Inbred F344; Respiratory System / drug effects; Respiratory System / pathology; Rhinitis / chemically induced; Rhinitis / pathology; Turbinates / drug effects; Turbinates / pathology
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Basal Gene Expression in Male and Female Sprague-Dawley Rat Nasal Respiratory and Olfactory Epithelium
Inhalation Toxicology, 19(11), 941–949.
MeSH headings : Animals; Female; Gene Expression Profiling / methods; Gene Expression Regulation / physiology; Male; Nasal Mucosa / metabolism; Nasal Mucosa / physiology; Nasal Mucosa / ultrastructure; Olfactory Mucosa / metabolism; Olfactory Mucosa / physiology; Olfactory Mucosa / ultrastructure; Rats; Rats, Sprague-Dawley; Xenobiotics / metabolism
Source: Crossref
Added: February 24, 2020
2007 journal article
Basal ganglia neurotransmitter concentrations in rhesus monkeys following subchronic manganese sulfate inhalation
American Journal of Industrial Medicine, 50(10), 772–778.
author keywords: parkinsonism; neurochemistry; inhalation; macaca mulatta; manganese
MeSH headings : 3,4-Dihydroxyphenylacetic Acid / metabolism; Animals; Basal Ganglia / drug effects; Basal Ganglia / metabolism; Disease Models, Animal; Dopamine / metabolism; Glutamic Acid / metabolism; Hydroxyindoleacetic Acid / metabolism; Inhalation; Macaca mulatta; Manganese Compounds / analysis; Neurotransmitter Agents / analysis; Neurotransmitter Agents / metabolism; Norepinephrine / metabolism; Parkinsonian Disorders / physiopathology; Serotonin / metabolism; Sulfates / analysis; Sulfates / toxicity; gamma-Aminobutyric Acid / metabolism
Source: Crossref
Added: February 24, 2020
2007 journal article
Inhibition and recovery of maternal and foetal cholinesterase enzymes following fenitrothion administration in CD rats
Xenobiotica, 37(1), 19–29.
author keywords: toxicology; pharmacokinetics; fenitrothion; neurotoxicity; esterases; rodent
MeSH headings : Animals; Brain / drug effects; Brain / enzymology; Cholinesterase Inhibitors / administration & dosage; Cholinesterase Inhibitors / blood; Cholinesterase Inhibitors / pharmacokinetics; Cholinesterase Inhibitors / pharmacology; Cholinesterases / metabolism; Female; Fenitrothion / administration & dosage; Fenitrothion / blood; Fenitrothion / pharmacokinetics; Fenitrothion / pharmacology; Fetus / drug effects; Fetus / enzymology; Liver / drug effects; Liver / enzymology; Pregnancy; Rats
Source: Crossref
Added: February 24, 2020
2007 journal article
Pharmacokinetic Modeling of Manganese. I. Dose Dependencies of Uptake and Elimination
Journal of Toxicology and Environmental Health, Part A, 70(18), 1493–1504.
MeSH headings : Animals; Bile / chemistry; Dose-Response Relationship, Drug; Intestinal Mucosa / metabolism; Liver / metabolism; Male; Manganese / pharmacokinetics; Mice; Models, Biological; Rats; Rats, Inbred Strains
Source: Crossref
Added: February 24, 2020
2007 journal article
Pharmacokinetic Modeling of Manganese. II. Hepatic Processing After Ingestion and Inhalation
Journal of Toxicology and Environmental Health, Part A, 70(18), 1505–1514.
MeSH headings : Administration, Inhalation; Administration, Oral; Animals; Intestinal Absorption; Intestinal Mucosa / metabolism; Liver / metabolism; Male; Manganese / pharmacokinetics; Models, Biological; Rats; Rats, Inbred Strains
Source: Crossref
Added: February 24, 2020
2007 journal article
Preliminary investigation of changes in the sexually dimorphic nucleus of the rat medial preoptic area following prenatal exposure to fenitrothion
Journal of Applied Toxicology, 27(6), 631–636.
author keywords: anti-androgen; SDN-POA; fenitrothion; developmental neurotoxicity
MeSH headings : Administration, Oral; Androgen Antagonists / administration & dosage; Androgen Antagonists / toxicity; Animals; Body Weight / drug effects; Cholinesterase Inhibitors / administration & dosage; Cholinesterase Inhibitors / toxicity; Dose-Response Relationship, Drug; Female; Fenitrothion / administration & dosage; Fenitrothion / toxicity; Gait / drug effects; Insecticides / administration & dosage; Insecticides / toxicity; Lacrimal Apparatus / drug effects; Lacrimal Apparatus / metabolism; Litter Size / drug effects; Male; Pilot Projects; Pregnancy; Prenatal Exposure Delayed Effects; Preoptic Area / drug effects; Preoptic Area / growth & development; Preoptic Area / pathology; Rats; Sexual Maturation; Tears / metabolism; Tremor / chemically induced
Source: Crossref
Added: February 24, 2020
2006 journal article
Application of pharmacokinetic data to the risk assessment of inhaled manganese
NeuroToxicology, 27(5), 752–764.
author keywords: parkinsonism; manganese poisoning; pharmacokinetics; inhalation exposure
MeSH headings : Animals; Humans; Inhalation Exposure / statistics & numerical data; Manganese / pharmacokinetics; Manganese Poisoning / diagnosis; Manganese Poisoning / epidemiology; Manganese Poisoning / metabolism; Risk Assessment; United States; United States Environmental Protection Agency / standards
Source: Crossref
Added: February 24, 2020
2006 journal article
Changes in Intracellular pH Play a Secondary Role in Hydrogen Sulfide-Induced Nasal Cytotoxicity
Inhalation Toxicology, 18(3), 159–167.
MeSH headings : Animals; Benzopyrans / metabolism; Cell Survival / drug effects; Cyanates / toxicity; Dose-Response Relationship, Drug; Hydrogen Sulfide / toxicity; Hydrogen-Ion Concentration; Male; Naphthols / metabolism; Nasal Mucosa / drug effects; Nasal Mucosa / metabolism; Rats; Rhodamines / metabolism
Source: Crossref
Added: February 24, 2020
2006 journal article
Effects of inhaled manganese on biomarkers of oxidative stress in the rat brain
NeuroToxicology, 27(5), 788–797.
author keywords: manganese; neurotoxicity; manganism; oxidative stress; reactive oxygen species
MeSH headings : Age Factors; Animals; Animals, Newborn; Biomarkers; Brain / metabolism; Brain / pathology; Brain Chemistry / drug effects; Female; Inhalation Exposure; Male; Manganese / toxicity; Oxidative Stress / drug effects; Oxidative Stress / physiology; Rats; Sex Factors; Time Factors
Source: Crossref
Added: February 24, 2020
2006 journal article
Lethargy and hind limb paralysis in a day-23 timed pregnant rat
Lab Animal, 35(2), 19–19.
MeSH headings : Animals; Dystocia / etiology; Dystocia / pathology; Dystocia / veterinary; Fatal Outcome; Female; Paralysis / etiology; Paralysis / veterinary; Pregnancy; Rats; Rats, Sprague-Dawley; Rodent Diseases / diagnosis; Rodent Diseases / pathology; Urinary Bladder Calculi / complications; Urinary Bladder Calculi / pathology; Urinary Bladder Calculi / veterinary
Source: Crossref
Added: February 24, 2020
2006 journal article
Life beyond the air phase: adding tissue disposition to models of nasal airway transport
Journal of Biomechanics, 39, S270–S271.
Source: Crossref
Added: February 24, 2020
2006 journal article
Neurotoxicity of inhaled manganese: A reanalysis of human exposure arising from showering
Medical Hypotheses, 66(1), 199–200.
MeSH headings : Baths; Humans; Inhalation Exposure / analysis; Manganese / analysis; Manganese / toxicity; Manganese Poisoning / etiology; Neurotoxicity Syndromes / etiology; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / toxicity; Water Supply / analysis
Source: Crossref
Added: February 24, 2020
2006 journal article
Respiration in Sprague-Dawley Rats During Pregnancy
Inhalation Toxicology, 18(4), 305–312.
MeSH headings : Animals; Female; Plethysmography, Whole Body; Pregnancy / physiology; Pulmonary Ventilation; Rats; Rats, Sprague-Dawley; Reference Values; Respiration; Tidal Volume
Source: Crossref
Added: February 24, 2020
2006 journal article
The Speciation of Metals in Mammals Influences Their Toxicokinetics and Toxicodynamics and Therefore Human Health Risk Assessment
Journal of Toxicology and Environmental Health, Part B, 9(1), 63–85.
author keywords: metal speciation; risk assessment; toxicodynamics; toxicokinetics
MeSH headings : Biotransformation; Databases as Topic; Humans; Metals / chemistry; Metals / pharmacokinetics; Metals / toxicity; Particle Size; Risk Assessment
Source: Crossref
Added: December 29, 2020
2005 journal article
Manganese Dosimetry: Species Differences and Implications for Neurotoxicity
Critical Reviews in Toxicology, 35(1), 1–32.
author keywords: biomarkers; brain; manganese; metabolism; neurotoxicity; pharmacokinetics
MeSH headings : Absorption; Adult; Blood-Brain Barrier; Central Nervous System / drug effects; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Inhalation Exposure; Male; Manganese / administration & dosage; Manganese / adverse effects; Manganese / pharmacokinetics; Maternal-Fetal Exchange; Pregnancy; Public Health; Risk Assessment
Source: Crossref
Added: February 24, 2020
2005 journal article
Maternal–fetal Distribution of Manganese in the Rat Following Inhalation Exposure to Manganese Sulfate
NeuroToxicology, 26(4), 625–632.
author keywords: manganese; inhalation; rat; pregnancy
MeSH headings : Animals; Body Burden; Female; Fetus / metabolism; Inhalation Exposure; Male; Manganese Compounds / administration & dosage; Manganese Compounds / pharmacokinetics; Maternal-Fetal Exchange / physiology; Organ Size / drug effects; Pregnancy; Rats; Sulfates / administration & dosage; Sulfates / pharmacokinetics; Tissue Distribution
Source: Crossref
Added: August 28, 2020
2004 journal article
Dose-dependent transitions in mechanisms of toxicity
Toxicology and Applied Pharmacology, 201(3), 203–225.
author keywords: dose-dependent transitions; mechanisms of toxicity; dose-response
MeSH headings : Animals; DNA Adducts / drug effects; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Humans; Inactivation, Metabolic; Research Design; Risk Assessment
Source: Crossref
Added: August 28, 2020
2004 journal article
Dose-dependent transitions in mechanisms of toxicity: case studies
Toxicology and Applied Pharmacology, 201(3), 226–294.
author keywords: dose-dependent transitions; mechanisms of toxicity; dose response; acetaminophen; butadiene; ethylene glycol; formaldehyde; manganese; methylene chloride; peroxisome proliferator-activated receptor; progesterone/hydroxyflutamide; propylene oxide; vinyl acetate; vinyl chloride; vinylidene chloride; zinc
MeSH headings : Acetaminophen / administration & dosage; Acetaminophen / pharmacokinetics; Acetaminophen / toxicity; Analgesics, Non-Narcotic / administration & dosage; Analgesics, Non-Narcotic / pharmacokinetics; Analgesics, Non-Narcotic / toxicity; Androgen Antagonists / administration & dosage; Androgen Antagonists / pharmacokinetics; Androgen Antagonists / toxicity; Animals; Butadienes / administration & dosage; Butadienes / pharmacokinetics; Butadienes / toxicity; Dichloroethylenes / administration & dosage; Dichloroethylenes / pharmacokinetics; Dichloroethylenes / toxicity; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions / chemically induced; Drug-Related Side Effects and Adverse Reactions / metabolism; Epoxy Compounds / administration & dosage; Epoxy Compounds / pharmacokinetics; Epoxy Compounds / toxicity; Ethylene Glycol / administration & dosage; Ethylene Glycol / pharmacokinetics; Ethylene Glycol / toxicity; Flutamide / administration & dosage; Flutamide / analogs & derivatives; Flutamide / pharmacokinetics; Flutamide / toxicity; Formaldehyde / administration & dosage; Formaldehyde / pharmacokinetics; Formaldehyde / toxicity; Humans; Manganese / administration & dosage; Manganese / pharmacokinetics; Manganese Poisoning / metabolism; Methylene Chloride / administration & dosage; Methylene Chloride / pharmacokinetics; Methylene Chloride / toxicity; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptors / physiology; Progesterone / administration & dosage; Progesterone / pharmacokinetics; Progesterone / toxicity; Vinyl Compounds / administration & dosage; Vinyl Compounds / pharmacokinetics; Vinyl Compounds / toxicity; Zinc / administration & dosage; Zinc / pharmacokinetics; Zinc / toxicity
Source: Crossref
Added: August 28, 2020
2004 journal article
Health and environmental testing of manganese exhaust products from use of methylcyclopentadienyl manganese tricarbonyl in gasoline
Science of The Total Environment, 334-335, 397–408.
author keywords: methylcyclopentadienyl manganese tricarbonyl; MMT; manganese; pharmacokinetics
MeSH headings : Animals; Carcinogens, Environmental; Environmental Exposure; Gasoline; Humans; Manganese; Organometallic Compounds / adverse effects; Organometallic Compounds / analysis; Organometallic Compounds / pharmacokinetics; Public Health; Risk Assessment; Rodentia; Vehicle Emissions / analysis
Source: Crossref
Added: February 24, 2020
2004 journal article
Manganese exposure and induced oxidative stress in the rat brain
Science of The Total Environment, 334-335, 409–416.
author keywords: brain; manganese; neurotoxicity; glutathione; metallothionein; glutamine synthetase; MMT
MeSH headings : Animals; Antioxidants / pharmacology; Biomarkers; Brain / drug effects; Brain / pathology; Environmental Pollutants / adverse effects; Manganese / adverse effects; Oxidation-Reduction; Oxidative Stress; Rats
Source: Crossref
Added: February 24, 2020
2004 journal article
Nasal Toxicity of Manganese Sulfate and Manganese Phosphate in Young Male Rats Following Subchronic (13-Week) Inhalation Exposure
Inhalation Toxicology, 16(6-7), 481–488.
MeSH headings : Air Pollutants / toxicity; Animals; Cerebellum / metabolism; Corpus Striatum / metabolism; Dose-Response Relationship, Drug; Drug Administration Schedule; Glial Fibrillary Acidic Protein / metabolism; Inhalation Exposure; Male; Manganese Compounds / administration & dosage; Manganese Compounds / pharmacokinetics; Nasal Mucosa / drug effects; Nasal Mucosa / metabolism; Nasal Mucosa / pathology; Olfactory Bulb / metabolism; Organometallic Compounds / administration & dosage; Organometallic Compounds / pharmacokinetics; Organometallic Compounds / toxicity; Rats; Rats, Inbred Strains; Sulfates / administration & dosage; Sulfates / pharmacokinetics; Sulfates / toxicity
Source: Crossref
Added: February 24, 2020
2004 journal article
Old age and gender influence the pharmacokinetics of inhaled manganese sulfate and manganese phosphate in rats
Toxicology and Applied Pharmacology, 197(2), 113–124.
author keywords: age; gender; manganese
MeSH headings : Administration, Inhalation; Aging / metabolism; Animals; Body Weight / drug effects; Female; Male; Manganese / metabolism; Manganese Compounds / administration & dosage; Manganese Compounds / pharmacokinetics; Neostriatum / drug effects; Neostriatum / metabolism; Organ Size / drug effects; Organometallic Compounds / administration & dosage; Organometallic Compounds / pharmacokinetics; Organometallic Compounds / toxicity; Radioisotopes; Rats; Sex Characteristics; Sulfates / administration & dosage; Sulfates / pharmacokinetics; Sulfates / toxicity; Tissue Distribution
Source: Crossref
Added: February 24, 2020
2004 journal article
Old age and gender influence the pharmacokinetics of inhaled manganese sulfate and manganese phosphate in rats
Toxicology and Applied Pharmacology, 197(2), 113–124.
Source: Crossref
Added: February 24, 2020
2004 journal article
Respiratory tract toxicity of inhaled hydrogen sulfide in Fischer-344 rats, Sprague–Dawley rats, and B6C3F1 mice following subchronic (90-day) exposure
Toxicology and Applied Pharmacology, 198(1), 29–39.
author keywords: rat; mouse; inhalation; hydrogen sulfide; nose; lung; toxicity; pathology
MeSH headings : Administration, Inhalation; Air Pollutants / toxicity; Animals; Body Weight / drug effects; Bronchi / drug effects; Bronchi / pathology; Dose-Response Relationship, Drug; Eating / drug effects; Epithelial Cells / drug effects; Epithelial Cells / pathology; Female; Hydrogen Sulfide / administration & dosage; Hydrogen Sulfide / toxicity; Male; Mice; Mice, Inbred Strains; No-Observed-Adverse-Effect Level; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Respiratory System / drug effects; Respiratory System / pathology; Rhinitis / chemically induced; Rhinitis / pathology; Species Specificity; Toxicity Tests, Chronic; Turbinates / drug effects; Turbinates / pathology
Source: Crossref
Added: August 28, 2020
2002 journal article
OLFACTORY TRANSPORT: A DIRECT ROUTE OF DELIVERY OF INHALED MANGANESE PHOSPHATE TO THE RAT BRAIN
Journal of Toxicology and Environmental Health, Part A, 65(20), 1493–1511.
MeSH headings : Administration, Inhalation; Analysis of Variance; Animals; Autoradiography; Axonal Transport; Brain / metabolism; Linear Models; Male; Manganese / administration & dosage; Manganese / pharmacokinetics; Nasal Mucosa / metabolism; Olfactory Bulb / metabolism; Rats; Spectrometry, Gamma
Source: Crossref
Added: February 24, 2020
