Douglas E. Brown

Works (16)

Updated: July 5th, 2023 16:00

2011 article

Diverse and tissue-enriched small RNAs in the plant pathogenic fungus, Magnaporthe oryzae

Nunes, C. C., Gowda, M., Sailsbery, J., Xue, M., Chen, F., Brown, D. E., … Dean, R. A. (2011, June 2). BMC Genomics, Vol. 12.

By: C. Nunes n, M. Gowda  n, J. Sailsbery n, M. Xue  n, F. Chen *, D. Brown n, Y. Oh n, T. Mitchell*, R. Dean n 

MeSH headings : Base Sequence; DNA, Intergenic / genetics; Gene Expression Profiling; Hyphae / genetics; Magnaporthe / genetics; Magnaporthe / physiology; Molecular Sequence Data; Plants / microbiology; RNA, Fungal / genetics; RNA, Small Untranslated / genetics; RNA, Transfer / genetics; Repetitive Sequences, Nucleic Acid / genetics; Sequence Analysis, RNA
topics (OpenAlex): Plant Disease Resistance and Genetics; Plant and Fungal Interactions Research; Plant-Microbe Interactions and Immunity
TL;DR: The authors' findings suggest M. oryzae small RNAs differentially accumulate in vegetative and specialized-infection tissues and may play an active role in genome integrity and regulating growth and development. (via Semantic Scholar)
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Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2009 article

Gene Ontology annotation of the rice blast fungus, Magnaporthe oryzae

Meng, S., Brown, D. E., Ebbole, D. J., Torto-Alalibo, T., Oh, Y. Y., Deng, J., … Dean, R. A. (2009, February 1). BMC Microbiology, Vol. 9.

By: S. Meng n, D. Brown n, D. Ebbole *, T. Torto-Alalibo*, Y. Oh n, J. Deng n, T. Mitchell n, R. Dean n 

MeSH headings : Computational Biology; Databases, Protein; Fungal Proteins / genetics; Genome, Fungal; Magnaporthe / genetics; Oryza / microbiology; Sequence Alignment; Sequence Analysis, Protein; Terminology as Topic; Vocabulary, Controlled
topics (OpenAlex): Fungal and yeast genetics research; Plant Pathogens and Fungal Diseases; Microbial Natural Products and Biosynthesis
TL;DR: This analysis provides comprehensive and robust GO annotations of the M. oryzae genome assemblies that will be solid foundations for further functional interrogation of M.oryzae. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

Transcriptome analysis reveals new insight into appressorium formation and function in the rice blast fungus Magnaporthe oryzae

Oh, Y., Donofrio, N., Pan, H., Coughlan, S., Brown, D. E., Meng, S., … Dean, R. A. (2008, May 20). Genome Biology, Vol. 9.

By: Y. Oh n, N. Donofrio n, H. Pan n, S. Coughlan*, D. Brown n, S. Meng n, T. Mitchell n, R. Dean n 

MeSH headings : Cell Wall / chemistry; Cell Wall / metabolism; Fungal Proteins / genetics; Fungal Proteins / metabolism; Gene Expression Profiling; Gene Expression Regulation, Fungal; Lipid Metabolism; Magnaporthe / cytology; Magnaporthe / genetics; Magnaporthe / physiology; Signal Transduction; Spores, Fungal / cytology; Spores, Fungal / genetics
topics (OpenAlex): Fungal and yeast genetics research; Plant-Microbe Interactions and Immunity; Microbial Natural Products and Biosynthesis
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 article

A systematic analysis of T-DNA insertion events in Magnaporthe oryzae

Meng, Y., Patel, G., Heist, M., Betts, M. F., Tucker, S. L., Galadima, N., … Farman, M. L. (2007, April 17). Fungal Genetics and Biology, Vol. 44, pp. 1050–1064.

By: Y. Meng *, G. Patel *, M. Heist*, M. Betts *, S. Tucker*, N. Galadima*, N. Donofrio n, D. Brown n ...

author keywords: agrobacterium-mediated transformation; insertional mutagenesis; inverse PCR
MeSH headings : 3' Flanking Region; 5' Flanking Region; Agrobacterium tumefaciens / genetics; Chromosomes, Fungal; DNA, Bacterial / analysis; DNA, Bacterial / genetics; Genome, Fungal; Magnaporthe / genetics; Mutagenesis, Insertional; Repetitive Sequences, Nucleic Acid; Transformation, Genetic
topics (OpenAlex): Protist diversity and phylogeny; Fungal and yeast genetics research; CRISPR and Genetic Engineering
TL;DR: Analysis of random T-DNA insertions that were generated as part of a large-scale insertional mutagenesis project for Magnaporthe oryzae found that the distribution of T- DNA inserts among the M.Oryzae chromosomes was not random and significant insertion bias was detected. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 article

Development of a high throughput transformation system for insertional mutagenesis in Magnaporthe oryzae

Betts, M. F., Tucker, S. L., Galadima, N., Meng, Y., Patel, G., Li, L., … Orbach, M. J. (2007, May 19). Fungal Genetics and Biology, Vol. 44, pp. 1035–1049.

By: M. Betts *, S. Tucker*, N. Galadima*, Y. Meng *, G. Patel *, L. Li *, N. Donofrio n, A. Floyd n ...

author keywords: Magnaporthe oryzae; Insertional mutagenesis; Agrobacterium tumefaciens-mediated transformation; CaCl2/PEG-mediated transformation; pathogenicity
MeSH headings : 3' Flanking Region; 5' Flanking Region; Agrobacterium tumefaciens / genetics; Magnaporthe / genetics; Mutagenesis, Insertional / methods; Phenotype; Protoplasts; Transformation, Genetic
topics (OpenAlex): Plant Pathogens and Fungal Diseases; Fungal Biology and Applications; Plant tissue culture and regeneration
TL;DR: A description of the high throughput transformation and analysis pipeline used to create the most comprehensive insertional mutagenesis analysis of a fungal pathogen is provided. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 article

Global gene expression during nitrogen starvation in the rice blast fungus, Magnaporthe grisea

Donofrio, N. M., Oh, Y., Lundy, R., Pan, H., Brown, D. E., Jeong, J. S., … Dean, R. A. (2006, June 1). Fungal Genetics and Biology, Vol. 43, pp. 605–617.

By: N. Donofrio n, Y. Oh  n, R. Lundy n, H. Pan n, D. Brown n, J. Jeong n, S. Coughlan*, T. Mitchell n, R. Dean n 

author keywords: nitrogen limitation; GATA transcription factors; metabolism; SPM1; protease; targeted gene disruption; pathogenicity
MeSH headings : Amino Acids / metabolism; Binding Sites; Biological Transport / genetics; DNA-Binding Proteins / genetics; GATA Transcription Factors / metabolism; Gene Expression; Gene Expression Regulation, Fungal; Genes, Fungal; Magnaporthe / genetics; Magnaporthe / pathogenicity; Nitrogen / metabolism; Oligonucleotide Array Sequence Analysis; Oryza / metabolism; Oryza / microbiology; Plant Diseases / microbiology; Promoter Regions, Genetic; Serine Endopeptidases / genetics
topics (OpenAlex): Fungal and yeast genetics research; Mycorrhizal Fungi and Plant Interactions; Plant-Microbe Interactions and Immunity
TL;DR: A genome-wide analysis of gene expression under nitrogen-limiting conditions in the rice blast pathogen Magnaporthe grisea resulted in targeted gene replacement on the vacuolar serine protease, SPM1, resulting in decreased sporulation and appressorial development as well as a greatly attenuated ability to cause disease. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 article

MGOS: A Resource for Studying Magnaporthe grisea and Oryza sativa Interactions

Soderlund, C., Haller, K., Pampanwar, V., Ebbole, D., Farman, M., Orbach, M. J., … Dean, R. (2006, October 1). Molecular Plant-Microbe Interactions, Vol. 19, pp. 1055–1061.

By: C. Soderlund *, K. Haller*, V. Pampanwar*, D. Ebbole *, M. Farman *, M. Orbach *, G. Wang *, R. Wing * ...

author keywords: host-pathogen
MeSH headings : Computational Biology; DNA, Complementary / chemistry; Databases, Genetic; Expressed Sequence Tags; Gene Expression Profiling; Genome, Fungal; Genome, Plant; Internet; Magnaporthe / genetics; Magnaporthe / physiology; Mutation; Oligonucleotide Array Sequence Analysis; Oryza / genetics; Oryza / microbiology; Phenotype
topics (OpenAlex): Fungal and yeast genetics research; Plant-Microbe Interactions and Immunity; Plant Pathogens and Fungal Diseases
TL;DR: The MGOS (Magnaporthe grisea Oryza sativa) web-based database contains data from interaction experiments in which M.grisea is the fungal pathogen that causes the rice blast disease and a consortium of fungal and rice geneticists was formed to study the interactions. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 article

Organization of chromosome ends in the rice blast fungus, Magnaporthe oryzae

Rehmeyer, C., Li, W., Kusaba, M., Kim, Y.-S., Brown, D., Staben, C., … Farman, M. (2006, September 8). Nucleic Acids Research, Vol. 34, pp. 4685–4701.

By: C. Rehmeyer *, W. Li *, M. Kusaba *, Y. Kim*, D. Brown n, C. Staben*, R. Dean n , M. Farman *

MeSH headings : Adenosine Triphosphatases / genetics; Base Sequence; Chromosomes, Fungal / chemistry; DNA Helicases / genetics; DNA Transposable Elements; Fungal Proteins / genetics; Gene Duplication; Genes, Fungal; Magnaporthe / genetics; Magnaporthe / metabolism; Molecular Sequence Data; Oryza / microbiology; RecQ Helicases; Sequence Analysis, DNA; Telomere / chemistry; Terminology as Topic
topics (OpenAlex): Plant-Microbe Interactions and Immunity; Plant Pathogens and Fungal Diseases; Fungal and yeast genetics research
TL;DR: It is proposed that the M.oryzae chromosome termini play more subtle roles in host adaptation by promoting the loss of terminally-positioned genes that tend to trigger host defenses. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 article

Whole genome comparison ofAspergillus flavusandA. oryzae

Payne, G. A., Nierman, W. C., Wortman, J. R., Pritchard, B. L., Brown, D., Dean, R. A., … Yu, J. (2006, January 1). Medical Mycology, Vol. 44, pp. S9–S11.

By: G. Payne n, W. Nierman, J. Wortman, B. Pritchard n, D. Brown n, R. Dean n , D. Bhatnagar, T. Cleveland, M. Machida, J. Yu

author keywords: aflatoxin; secondary metabolism; koji moulds
topics (OpenAlex): Mycotoxins in Agriculture and Food; Plant Pathogens and Fungal Diseases; Tannin, Tannase and Anticancer Activities
TL;DR: The high degree of sequence similarity between the two fungi suggests that they may be ecotypes of the same species and that A. oryzae has resulted from the domestication of A. flavus. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 article

Databases and Information Integration for the Medicago truncatula Genome and Transcriptome

Cannon, S. B., Crow, J. A., Heuer, M. L., Wang, X., Cannon, E. K. S., Dwan, C., … Retzel, E. F. (2005, May 1). PLANT PHYSIOLOGY.

By: S. Cannon  n, J. Crow  n, M. Heuer  n, X. Wang  n, E. Cannon  n, C. Dwan n, A. Lamblin n, J. Vasdewani n ...

MeSH headings : Base Sequence; Chromosomes, Artificial, Bacterial; Databases, Genetic; Genome, Plant; Internet; Medicago truncatula / genetics; Transcription, Genetic
topics (OpenAlex): Plant-Microbe Interactions and Immunity; Plant Pathogens and Resistance; Plant nutrient uptake and metabolism
TL;DR: D databases and Web resources for the Medicago truncatula euchromatic genespace sequencing project are described, which provide support for physical and genetic maps, genome sequence assembly, gene prediction, and integration of EST data. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

PACLIMS: A component LIM system for high-throughput functional genomic analysis

BMC Bioinformatics, 6.

By: N. Donofrio, R. Rajagopalon, D. Brown, S. Diener, D. Windham, S. Nolin, A. Floyd, T. Mitchell ...

Source: NC State University Libraries
Added: August 6, 2018

2005 article

The genome sequence of the rice blast fungus Magnaporthe grisea

Dean, R. A., Talbot, N. J., Ebbole, D. J., Farman, M. L., Mitchell, T. K., Orbach, M. J., … Birren, B. W. (2005, April 1). Nature, Vol. 434, pp. 980–986.

By: R. Dean n , N. Talbot *, D. Ebbole *, M. Farman *, T. Mitchell n, M. Orbach *, M. Thon *, R. Kulkarni n ...

MeSH headings : Fungal Proteins / genetics; Fungal Proteins / metabolism; Genes, Fungal / genetics; Genome, Fungal; Guanosine Diphosphate / metabolism; Guanosine Triphosphate / metabolism; Magnaporthe / classification; Magnaporthe / genetics; Magnaporthe / metabolism; Magnaporthe / pathogenicity; Oryza / microbiology; Plant Diseases / microbiology; Point Mutation / genetics; Proteome / genetics; Proteome / metabolism; Receptors, G-Protein-Coupled / genetics; Repetitive Sequences, Nucleic Acid / genetics; Saccharomyces cerevisiae / metabolism; Signal Transduction; Virulence / genetics
topics (OpenAlex): Fungal and yeast genetics research; Plant-Microbe Interactions and Immunity; Microbial Natural Products and Biosynthesis
TL;DR: The draft sequence of the M. grisea genome is reported, reflecting the clonal nature of this fungus imposed by widespread rice cultivation and analysis of the gene set provides an insight into the adaptations required by a fungus to cause disease. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 chapter

Trust-Based Secure Workflow Path Construction

In B. Benatallah, F. Casati, & P. Traverso (Eds.), Service-Oriented Computing – ICSOC 2007 (pp. 382–395).

By: M. Altunay n, D. Brown n, G. Byrd n  & R. Dean n 

Contributors: M. Altunay n, D. Brown n, G. Byrd n  & R. Dean n 

Ed(s): B. Benatallah, F. Casati & P. Traverso

topics (OpenAlex): Access Control and Trust; Business Process Modeling and Analysis; Cloud Data Security Solutions
TL;DR: A workflow management framework that fully integrates trust and security into the workflow planning logic, which considers not only trust relationships between the workflow requestor and individual services, but also trust relationships among the services themselves. (via Semantic Scholar)
Sources: NC State University Libraries, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2003 article

The rice blast pathosystem as a case study for the development of new tools and raw materials for genome analysis of fungal plant pathogens

Mitchell, T. K., Thon, M. R., Jeong, J. S., Brown, D., Deng, J., & Dean, R. A. (2003, June 12). New Phytologist, Vol. 159, pp. 53–61.

By: T. Mitchell n, M. Thon  n, J. Jeong n, D. Brown n, J. Deng n & R. Dean n 

author keywords: Magnaporthe grisea; rice blast; genomic tools; BAC; physical map; synteny; whole genome comparison; fungi
topics (OpenAlex): Wheat and Barley Genetics and Pathology; Mycotoxins in Agriculture and Food; Plant-Microbe Interactions and Immunity
TL;DR: This review will describe the recent development of tools for whole or partial genome analysis and multigenome comparisons and focuses on the rice blast pathosystem as a case study. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 article

Transcriptional Regulation of Biomass-degrading Enzymes in the Filamentous Fungus Trichoderma reesei

Foreman, P. K., Brown, D., Dankmeyer, L., Dean, R., Diener, S., Dunn-Coleman, N. S., … Ward, M. (2003, August 1). Journal of Biological Chemistry, Vol. 278, pp. 31988–31997.

By: P. Foreman *, D. Brown n, L. Dankmeyer, R. Dean n , S. Diener n, N. Dunn-Coleman, F. Goedegebuur, T. Houfek n ...

MeSH headings : Biomass; DNA, Complementary; Enzymes / genetics; Enzymes / metabolism; Expressed Sequence Tags; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Hydrolysis; Molecular Sequence Data; Transcription, Genetic; Trichoderma / enzymology
topics (OpenAlex): Biofuel production and bioconversion; Fungal and yeast genetics research; Microbial Metabolic Engineering and Bioproduction
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 article

MagnaportheDB: a federated solution for integrating physical and genetic map data with BAC end derived sequences for the rice blast fungus Magnaporthe grisea

Martin, S. L., Blackmon, B. P., Rajagopalan, R., Houfek, T. D., Sceeles, R. G., Denn, S. O., … Dean, R. (2002, January 1). Nucleic Acids Research, Vol. 30, pp. 121–124.

By: S. Martin  n, B. Blackmon, R. Rajagopalan, T. Houfek, R. Sceeles, S. Denn, T. Mitchell, D. Brown, R. Wing, R. Dean 

MeSH headings : Base Sequence; Chromosome Mapping; Chromosomes, Artificial, Bacterial; Chromosomes, Fungal; Database Management Systems; Databases, Genetic; Forecasting; Genetic Markers; Genome, Fungal; Genomic Library; Information Storage and Retrieval; Internet; Magnaporthe / genetics; Oryza / microbiology; Plant Diseases
topics (OpenAlex): Fungal and yeast genetics research; Plant Pathogens and Fungal Diseases; Genomics and Phylogenetic Studies
TL;DR: A federated database for genome studies of Magnaporthe grisea, the causal agent of rice blast disease, is created by integrating end sequence data from BAC clones, genetic marker data and BAC contig assembly data. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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