Douglas E. Brown

Works (16)

Updated: July 5th, 2023 16:00

2011 journal article

Diverse and tissue-enriched small RNAs in the plant pathogenic fungus, Magnaporthe oryzae

BMC Genomics, 12.

By: C. Nunes n, M. Gowda  n, J. Sailsbery n, M. Xue  n, F. Chen *, D. Brown n, Y. Oh n, T. Mitchell*, R. Dean n 

MeSH headings : Base Sequence; DNA, Intergenic / genetics; Gene Expression Profiling; Hyphae / genetics; Magnaporthe / genetics; Magnaporthe / physiology; Molecular Sequence Data; Plants / microbiology; RNA, Fungal / genetics; RNA, Small Untranslated / genetics; RNA, Transfer / genetics; Repetitive Sequences, Nucleic Acid / genetics; Sequence Analysis, RNA
TL;DR: The authors' findings suggest M. oryzae small RNAs differentially accumulate in vegetative and specialized-infection tissues and may play an active role in genome integrity and regulating growth and development. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2009 review

Gene Ontology annotation of the rice blast fungus, Magnaporthe oryzae

[Review of ]. BMC MICROBIOLOGY, 9.

By: S. Meng n, D. Brown n, D. Ebbole *, T. Torto-Alalibo*, Y. Oh n, J. Deng n, T. Mitchell n, R. Dean n 

MeSH headings : Computational Biology; Databases, Protein; Fungal Proteins / genetics; Genome, Fungal; Magnaporthe / genetics; Oryza / microbiology; Sequence Alignment; Sequence Analysis, Protein; Terminology as Topic; Vocabulary, Controlled
TL;DR: This analysis provides comprehensive and robust GO annotations of the M. oryzae genome assemblies that will be solid foundations for further functional interrogation of M.oryzae. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 review

Transcriptome analysis reveals new insight into appressorium formation and function in the rice blast fungus Magnaporthe oryzae

[Review of ]. GENOME BIOLOGY, 9(5).

By: Y. Oh n, N. Donofrio n, H. Pan n, S. Coughlan*, D. Brown n, S. Meng n, T. Mitchell n, R. Dean n 

MeSH headings : Cell Wall / chemistry; Cell Wall / metabolism; Fungal Proteins / genetics; Fungal Proteins / metabolism; Gene Expression Profiling; Gene Expression Regulation, Fungal; Lipid Metabolism; Magnaporthe / cytology; Magnaporthe / genetics; Magnaporthe / physiology; Signal Transduction; Spores, Fungal / cytology; Spores, Fungal / genetics
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

A systematic analysis of T-DNA insertion events in Magnaporthe oryzae

FUNGAL GENETICS AND BIOLOGY, 44(10), 1050–1064.

By: Y. Meng *, G. Patel *, M. Heist*, M. Betts, S. Tucker*, N. Galadima*, N. Donofrio n, D. Brown n ...

author keywords: agrobacterium-mediated transformation; insertional mutagenesis; inverse PCR
MeSH headings : 3' Flanking Region; 5' Flanking Region; Agrobacterium tumefaciens / genetics; Chromosomes, Fungal; DNA, Bacterial / analysis; DNA, Bacterial / genetics; Genome, Fungal; Magnaporthe / genetics; Mutagenesis, Insertional; Repetitive Sequences, Nucleic Acid; Transformation, Genetic
TL;DR: Analysis of random T-DNA insertions that were generated as part of a large-scale insertional mutagenesis project for Magnaporthe oryzae found that the distribution of T- DNA inserts among the M.Oryzae chromosomes was not random and significant insertion bias was detected. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Development of a high throughput transformation system for insertional mutagenesis in Magnaporthe oryzae

FUNGAL GENETICS AND BIOLOGY, 44(10), 1035–1049.

By: M. Betts, S. Tucker*, N. Galadima*, Y. Meng *, G. Patel *, L. Li *, N. Donofrio n, A. Floyd n ...

author keywords: Magnaporthe oryzae; Insertional mutagenesis; Agrobacterium tumefaciens-mediated transformation; CaCl2/PEG-mediated transformation; pathogenicity
MeSH headings : 3' Flanking Region; 5' Flanking Region; Agrobacterium tumefaciens / genetics; Magnaporthe / genetics; Mutagenesis, Insertional / methods; Phenotype; Protoplasts; Transformation, Genetic
TL;DR: A description of the high throughput transformation and analysis pipeline used to create the most comprehensive insertional mutagenesis analysis of a fungal pathogen is provided. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Global gene expression during nitrogen starvation in the rice blast fungus, Magnaporthe grisea

FUNGAL GENETICS AND BIOLOGY, 43(9), 605–617.

By: N. Donofrio n, Y. Oh, R. Lundy, H. Pan*, D. Brown*, J. Jeong*, S. Coughlan, T. Mitchell*, R. Dean* 

author keywords: nitrogen limitation; GATA transcription factors; metabolism; SPM1; protease; targeted gene disruption; pathogenicity
MeSH headings : Amino Acids / metabolism; Binding Sites; Biological Transport / genetics; DNA-Binding Proteins / genetics; GATA Transcription Factors / metabolism; Gene Expression; Gene Expression Regulation, Fungal; Genes, Fungal; Magnaporthe / genetics; Magnaporthe / pathogenicity; Nitrogen / metabolism; Oligonucleotide Array Sequence Analysis; Oryza / metabolism; Oryza / microbiology; Plant Diseases / microbiology; Promoter Regions, Genetic; Serine Endopeptidases / genetics
TL;DR: A genome-wide analysis of gene expression under nitrogen-limiting conditions in the rice blast pathogen Magnaporthe grisea resulted in targeted gene replacement on the vacuolar serine protease, SPM1, resulting in decreased sporulation and appressorial development as well as a greatly attenuated ability to cause disease. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

MGOS: A resource for studying Magnaporthe grisea and Oryza sativa interactions

MOLECULAR PLANT-MICROBE INTERACTIONS, 19(10), 1055–1061.

By: C. Soderlund *, K. Haller*, V. Pampanwar*, D. Ebbole *, M. Farman *, M. Orbach *, G. Wang *, R. Wing * ...

author keywords: host-pathogen
MeSH headings : Computational Biology; DNA, Complementary / chemistry; Databases, Genetic; Expressed Sequence Tags; Gene Expression Profiling; Genome, Fungal; Genome, Plant; Internet; Magnaporthe / genetics; Magnaporthe / physiology; Mutation; Oligonucleotide Array Sequence Analysis; Oryza / genetics; Oryza / microbiology; Phenotype
TL;DR: The MGOS (Magnaporthe grisea Oryza sativa) web-based database contains data from interaction experiments in which M.grisea is the fungal pathogen that causes the rice blast disease and a consortium of fungal and rice geneticists was formed to study the interactions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 review

Organization of chromosome ends in the rice blast fungus, Magnaporthe oryzae

[Review of ]. NUCLEIC ACIDS RESEARCH, 34(17), 4685–4701.

By: C. Rehmeyer *, W. Li *, M. Kusaba *, Y. Kim*, D. Brown n, C. Staben*, R. Dean n , M. Farman *

MeSH headings : Adenosine Triphosphatases / genetics; Base Sequence; Chromosomes, Fungal / chemistry; DNA Helicases / genetics; DNA Transposable Elements; Fungal Proteins / genetics; Gene Duplication; Genes, Fungal; Magnaporthe / genetics; Magnaporthe / metabolism; Molecular Sequence Data; Oryza / microbiology; RecQ Helicases; Sequence Analysis, DNA; Telomere / chemistry; Terminology as Topic
TL;DR: It is proposed that the M.oryzae chromosome termini play more subtle roles in host adaptation by promoting the loss of terminally-positioned genes that tend to trigger host defenses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 article

Whole genome comparison of Aspergillus flavus and A-oryzae

Payne, G. A., Nierman, W. C., Wortman, J. R., Pritchard, B. L., Brown, D., Dean, R. A., … Yu, J. (2006, September). MEDICAL MYCOLOGY, Vol. 44, pp. S9–S11.

By: G. Payne n, W. Nierman, J. Wortman, B. Pritchard, D. Brown n, R. Dean n , D. Bhatnagar, T. Cleveland, M. Machida *, J. Yu

author keywords: aflatoxin; secondary metabolism; koji moulds
TL;DR: The high degree of sequence similarity between the two fungi suggests that they may be ecotypes of the same species and that A. oryzae has resulted from the domestication of A. flavus. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Databases and information integration for the Medicago truncatula genome and transcriptome

PLANT PHYSIOLOGY, 138(1), 38–46.

By: S. Cannon  n, J. Crow  n, M. Heuer  n, X. Wang  n, E. Cannon  n, C. Dwan n, A. Lamblin n, J. Vasdewani n ...

MeSH headings : Base Sequence; Chromosomes, Artificial, Bacterial; Databases, Genetic; Genome, Plant; Internet; Medicago truncatula / genetics; Transcription, Genetic
TL;DR: D databases and Web resources for the Medicago truncatula euchromatic genespace sequencing project are described, which provide support for physical and genetic maps, genome sequence assembly, gene prediction, and integration of EST data. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

PACLIMS: A component LIM system for high-throughput functional genomic analysis

BMC Bioinformatics, 6.

By: N. Donofrio, R. Rajagopalon, D. Brown, S. Diener, D. Windham, S. Nolin, A. Floyd, T. Mitchell ...

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

The genome sequence of the rice blast fungus Magnaporthe grisea

NATURE, 434(7036), 980–986.

By: R. Dean n , N. Talbot *, D. Ebbole *, M. Farman *, T. Mitchell n, M. Orbach *, M. Thon *, R. Kulkarni n ...

MeSH headings : Fungal Proteins / genetics; Fungal Proteins / metabolism; Genes, Fungal / genetics; Genome, Fungal; Guanosine Diphosphate / metabolism; Guanosine Triphosphate / metabolism; Magnaporthe / classification; Magnaporthe / genetics; Magnaporthe / metabolism; Magnaporthe / pathogenicity; Oryza / microbiology; Plant Diseases / microbiology; Point Mutation / genetics; Proteome / genetics; Proteome / metabolism; Receptors, G-Protein-Coupled / genetics; Repetitive Sequences, Nucleic Acid / genetics; Saccharomyces cerevisiae / metabolism; Signal Transduction; Virulence / genetics
TL;DR: The draft sequence of the M. grisea genome is reported, reflecting the clonal nature of this fungus imposed by widespread rice cultivation and analysis of the gene set provides an insight into the adaptations required by a fungus to cause disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 chapter

Trust-Based Secure Workflow Path Construction

In B. Benatallah, F. Casati, & P. Traverso (Eds.), Service-Oriented Computing – ICSOC 2007 (pp. 382–395).

By: M. Altunay n, D. Brown n, G. Byrd n  & R. Dean n 

Contributors: M. Altunay n, D. Brown n, G. Byrd n  & R. Dean n 

Ed(s): B. Benatallah, F. Casati & P. Traverso

TL;DR: A workflow management framework that fully integrates trust and security into the workflow planning logic, which considers not only trust relationships between the workflow requestor and individual services, but also trust relationships among the services themselves. (via Semantic Scholar)
Sources: NC State University Libraries, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2003 review

The rice blast pathosystem as a case study for the development of new tools and raw materials for genome analysis of fungal plant pathogens

[Review of ]. NEW PHYTOLOGIST, 159(1), 53–61.

By: T. Mitchell n, M. Thon  n, J. Jeong n, D. Brown n, J. Deng  n & R. Dean n 

author keywords: Magnaporthe grisea; rice blast; genomic tools; BAC; physical map; synteny; whole genome comparison; fungi
TL;DR: This review will describe the recent development of tools for whole or partial genome analysis and multigenome comparisons and focuses on the rice blast pathosystem as a case study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Transcriptional regulation of biomass-degrading enzymes in the filamentous fungus Trichoderma reesei

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(34), 31988–31997.

By: P. Foreman, D. Brown n, L. Dankmeyer, R. Dean n , S. Diener n, N. Dunn-Coleman, F. Goedegebuur, T. Houfek n ...

MeSH headings : Biomass; DNA, Complementary; Enzymes / genetics; Enzymes / metabolism; Expressed Sequence Tags; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Hydrolysis; Molecular Sequence Data; Transcription, Genetic; Trichoderma / enzymology
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

MagnaportheDB: a federated solution for integrating physical and genetic map data with BAC end derived sequences for the rice blast fungus Magnaporthe grisea

NUCLEIC ACIDS RESEARCH, 30(1), 121–124.

By: S. Martin  n, B. Blackmon, R. Rajagopalan, T. Houfek, R. Sceeles, S. Denn, T. Mitchell, D. Brown, R. Wing, R. Dean 

MeSH headings : Base Sequence; Chromosome Mapping; Chromosomes, Artificial, Bacterial; Chromosomes, Fungal; Database Management Systems; Databases, Genetic; Forecasting; Genetic Markers; Genome, Fungal; Genomic Library; Information Storage and Retrieval; Internet; Magnaporthe / genetics; Oryza / microbiology; Plant Diseases
TL;DR: A federated database for genome studies of Magnaporthe grisea, the causal agent of rice blast disease, is created by integrating end sequence data from BAC clones, genetic marker data and BAC contig assembly data. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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