Michelle Carin DeSimone

Works (1)

Updated: July 5th, 2023 15:43

2013 journal article

Pleiotropic Effects of the Trichloroethylene-Associated P81S VHL Mutation on Metabolism, Apoptosis, and ATM-Mediated DNA Damage Response

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 105(18), 1355–1364.

By: M. DeSimone n, W. Rathmell  n & D. Threadgill n

MeSH headings : Animals; Apoptosis; Arginine; Ataxia Telangiectasia Mutated Proteins; Carcinoma, Renal Cell / genetics; Carcinoma, Renal Cell / metabolism; Cell Cycle Proteins / metabolism; DNA Damage; DNA-Binding Proteins / metabolism; Embryonic Stem Cells; Glutamine; Humans; Hypoxia-Inducible Factor 1 / metabolism; Immunohistochemistry; Kidney Neoplasms / genetics; Kidney Neoplasms / metabolism; Mice; Occupational Exposure; Point Mutation; Proline; Protein Array Analysis; Protein Serine-Threonine Kinases / metabolism; Serine; Teratoma / genetics; Trichloroethylene / toxicity; Tumor Suppressor Proteins / metabolism; Ubiquitin-Protein Ligases / metabolism; Von Hippel-Lindau Tumor Suppressor Protein / genetics
topics (OpenAlex): Cancer, Hypoxia, and Metabolism; Metabolomics and Mass Spectrometry Studies; Eicosanoids and Hypertension Pharmacology
TL;DR: The TCE-associated P81S VHL mutation can initiate a unique adaptive response required for selective tumor growth through pleiotropic effects on metabolic diversification, apoptosis suppression, and alteration of the DNA damage response. (via Semantic Scholar)
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