Michelle Carin DeSimone

Works (1)

Updated: July 5th, 2023 15:43

2013 journal article

Pleiotropic Effects of the Trichloroethylene-Associated P81S VHL Mutation on Metabolism, Apoptosis, and ATM-Mediated DNA Damage Response

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 105(18), 1355–1364.

By: M. DeSimone n, W. Rathmell  n & D. Threadgill n

MeSH headings : Animals; Apoptosis; Arginine; Ataxia Telangiectasia Mutated Proteins; Carcinoma, Renal Cell / genetics; Carcinoma, Renal Cell / metabolism; Cell Cycle Proteins / metabolism; DNA Damage; DNA-Binding Proteins / metabolism; Embryonic Stem Cells; Glutamine; Humans; Hypoxia-Inducible Factor 1 / metabolism; Immunohistochemistry; Kidney Neoplasms / genetics; Kidney Neoplasms / metabolism; Mice; Occupational Exposure; Point Mutation; Proline; Protein Array Analysis; Protein Serine-Threonine Kinases / metabolism; Serine; Teratoma / genetics; Trichloroethylene / toxicity; Tumor Suppressor Proteins / metabolism; Ubiquitin-Protein Ligases / metabolism; Von Hippel-Lindau Tumor Suppressor Protein / genetics
TL;DR: The TCE-associated P81S VHL mutation can initiate a unique adaptive response required for selective tumor growth through pleiotropic effects on metabolic diversification, apoptosis suppression, and alteration of the DNA damage response. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2025) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.