Works (18)
Updated: July 19th, 2023 21:17
2023 journal article
Tizoxanide Antiviral Activity on Dengue Virus Replication
VIRUSES-BASEL, 15(3).
author keywords: antiviral; tizoxanide; dengue virus; virucidal activity
MeSH headings : Chlorocebus aethiops; Animals; Humans; Antiviral Agents / pharmacology; Antiviral Agents / therapeutic use; Vero Cells; Dengue / drug therapy; Dengue Virus / genetics; Proteomics; Virus Replication
TL;DR:
TIZ is a promising therapeutic molecule for the treatment of DENV-2 infections and the study of the protein profile of infected not-treated and infected-treated Vero cells showed that TIZ interferes with cellular processes such as intracellular trafficking and vesicle-mediated transport and post-translational modifications when added after infection.
(via Semantic Scholar)
open access via www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: April 17, 2023
2021 journal article
Sulphate-reducing bacterial community structure from produced water of the Periquito and Galo de Campina onshore oilfields in Brazil
SCIENTIFIC REPORTS, 11(1).
MeSH headings : Biodiversity; Biofilms; Biotechnology; Brazil; DNA, Ribosomal / metabolism; Databases, Genetic; Desulfovibrionales / genetics; Ecology; Enterobacteriaceae / genetics; Gammaproteobacteria / genetics; Geography; Hydrogen Sulfide / chemistry; Microbiota; Oil and Gas Fields; RNA, Ribosomal, 16S / genetics; Sulfates / chemistry; Water; Water Microbiology
TL;DR:
These data provide the first description of SRB from onshore produced water in Brazil and reinforce the importance of Desulfovibrionales, Pseudomonadales, and Enterobacteriales in produced water globally.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: November 1, 2021
2021 journal article
Virucidal and antiviral activities of pomegranate (Punica granatum) extract against the mosquito-borne Mayaro virus
PARASITES & VECTORS, 14(1).
author keywords: Punicalagin; Biflavonoids; Alphavirus; Mayaro virus
MeSH headings : Alphavirus / classification; Alphavirus / drug effects; Animals; Antiviral Agents / pharmacology; Arboviruses / drug effects; Chlorocebus aethiops; Culicidae / virology; Hydrolyzable Tannins / pharmacology; Phytochemicals / pharmacology; Pomegranate / chemistry; Vero Cells; Virus Replication / drug effects
TL;DR:
P. granatum extract is a promising source of antiviral compounds against the alphavirus MAYV and represents an excellent candidate for future studies with other enveloped RNA viruses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(OpenAlex)
Source: Web Of Science
Added: September 20, 2021
2020 review
Antiviral Drug Discovery and Development for Mayaro Fever - What do we have so far?
[Review of ]. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 20(10), 921–928.
author keywords: Mayaro virus; mayaro fever; alphavirus; antivirals; tropical infectious; arboviruses
MeSH headings : Alphavirus / drug effects; Alphavirus / physiology; Alphavirus Infections / drug therapy; Antiviral Agents / chemistry; Antiviral Agents / pharmacology; Antiviral Agents / therapeutic use; Drug Discovery; Humans
TL;DR:
This mini review aims to provide an overview towards studies of anti-MAYV derivatives and highlight the importance of the discovery and development of promising drug candidates for Mayaro fever.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 22, 2020
2020 journal article
Quantitative proteomic analysis of the tizoxanide effect in vero cells
SCIENTIFIC REPORTS, 10(1).
MeSH headings : Animals; Anti-Infective Agents / pharmacology; Chlorocebus aethiops; Fatty Acid Synthases / genetics; Fatty Acid Synthases / metabolism; Proteome / drug effects; Proteome / genetics; Proteome / metabolism; Ribonucleoproteins / genetics; Ribonucleoproteins / metabolism; Thiazoles / pharmacology; Vero Cells
TL;DR:
The broad antimicrobial range of TIZ points towards its overall effect in lowering cell metabolism and RNA processing and modification, and the decreased levels of FASN, HNRNPH and HNRNPK with the treatment appear to be important for antiviral activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 5, 2020
2020 journal article
The impact of Zika virus infection on human semen: a case study
FUTURE VIROLOGY, 15(1), 5–12.
author keywords: assisted reproduction; Flavivirus persistence; immunofluorescence; longitudinal study; semen; semen donor; sexually transmitted virus; super-resolution microscopy; virus clearance; Zika virus
TL;DR:
A significant decrease in sperm concentration and in the percentage of progressive motility of sperm was observed, but the complete clearance of ZIKV from semen was not achieved.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: September 7, 2020
2019 journal article
High Prevalence of a Newly Discovered Wutai Mosquito Phasivirus in Mosquitoes from Rio de Janeiro, Brazil
INSECTS, 10(5).
author keywords: insect-specific viruses; Bunyavirus; Phasivirus; Wutai virus; entomological surveillance
TL;DR:
The detection and characterization of a recently discovered bunyavirus corresponding to the Wutai mosquito phasivirus is described, for the first time in South America, and its high prevalence in the Culex spp.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(OpenAlex)
Source: Web Of Science
Added: August 12, 2019
2019 journal article
Inhibition by Marine Algae of Chikungunya Virus Isolated From Patients in a Recent Disease Outbreak in Rio de Janeiro
FRONTIERS IN MICROBIOLOGY, 10.
author keywords: chikungunya; arbovirus; seaweed; antiviral; crude extracts
TL;DR:
The inhibitory effects of seaweed extracts on CHIKV replication were studied and indicate that the algal extracts may be promising novel candidates for the development of therapeutic agents against CHikV infections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: November 25, 2019
2019 journal article
Inhibition of Zika Virus Replication by Synthetic Bis-Naphthoquinones
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 30(8), 1697–1706.
author keywords: Zika virus; Flavivirus; arbovirus; antiviral; bis-naphthoquinones
TL;DR:
Results demonstrate that these bis-naphthoquinones are largely effective in inhibiting the replication of ZIKV.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 12, 2019
2019 journal article
Purification and Proteomic Analysis of Alphavirus Particles from Sindbis Virus Grown in Mammalian and Insect Cells
BIO-PROTOCOL, 9(10).
author keywords: Sindbis virus; Mass spectrometry; Virus proteome; Virus purification; Alphavirus; Proteomics
TL;DR:
To evaluate the efficacy of mass spec to determine the proteome of medically important viruses, Sindbis virus (SINV), the prototypical alphavirus was chosen for evaluation and it was found that in addition to the host proteins, SINV non-structural protein 2 (nsP2) was detected within virions grown in all host cells examined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 17, 2019
2018 review
History, epidemiology and diagnostics of dengue in the American and Brazilian contexts: a review
[Review of ]. PARASITES & VECTORS, 11.
author keywords: Dengue virus; Dengue history; Dengue epidemiology; Diagnostics of dengue; Serotyping
MeSH headings : Americas / epidemiology; Dengue / diagnosis; Dengue / epidemiology; Dengue / history; Dengue / pathology; Dengue Virus / isolation & purification; History, 19th Century; History, 20th Century; History, 21st Century; Humans
TL;DR:
The probable origins of dengue in America and the trajectories of its spread are presented, and the existing DENV polymerase chain reaction (PCR) diagnostic tests are summarized to provide an improved reference since these tests are useful and accurate at discriminating DENV from other flaviviruses that co-circulate in the Americas.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Prostaglandin A(1) triggers Mayaro virus inhibition and heat shock protein 70 expression in an epithelial cell model
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 51(5), 584–590.
author keywords: Mayaro virus; Prostaglandin A; Heat shock proteins
MeSH headings : Alphavirus / drug effects; Alphavirus / ultrastructure; Animals; Antiviral Agents / pharmacology; Blotting, Western; Cattle; Cell Line; Electrophoresis, Polyacrylamide Gel; Epithelial Cells / ultrastructure; Epithelial Cells / virology; HSP70 Heat-Shock Proteins / pharmacology; Humans; Microscopy, Electron, Transmission; Prostaglandins A / pharmacology; Virus Replication / drug effects
TL;DR:
PGA1 inhibits MAYV replication in Hep-2 cells at early stages of viral replication, prior to production of viral structural proteins, possibly via HSP70 induction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 19, 2018
2013 journal article
Alphavirus Genome Delivery Occurs Directly at the Plasma Membrane in a Time- and Temperature-Dependent Process
JOURNAL OF VIROLOGY, 87(8), 4352–4359.
MeSH headings : Animals; Cell Membrane / virology; Cells, Cultured; Cricetinae; Microscopy, Immunoelectron; RNA, Viral / metabolism; Sindbis Virus / physiology; Staining and Labeling / methods; Temperature; Time Factors; Virus Internalization
TL;DR:
It is concluded that entry of alphaviruses is by direct penetration of cell plasma membranes through a pore structure formed by virus and, possibly, host proteins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Mutations in the endodomain of Sindbis virus glycoprotein E2 define sequences critical for virus assembly
JOURNAL OF VIROLOGY, 80(9), 4458–4468.
MeSH headings : Amino Acid Sequence; Animals; Capsid Proteins / genetics; Capsid Proteins / metabolism; Cell Line; Cricetinae; Gene Deletion; Microscopy, Electron, Transmission; Molecular Sequence Data; Mutation / genetics; Protein Structure, Tertiary; Sequence Alignment; Sindbis Virus / physiology; Sindbis Virus / ultrastructure; Tyrosine / genetics; Tyrosine / metabolism; Viral Envelope Proteins / chemistry; Viral Envelope Proteins / genetics; Viral Envelope Proteins / metabolism; Virus Assembly
TL;DR:
Submo acid substitutions and deletions in a region of the E2 tail (E2 amino acids 408 to 415) that is initially integrated into the endoplasmic reticulum are produced to define protein interactions critical for virus assembly and suggest a fundamental difference between Sindbis virus assembly in mammalian and insect cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Sindbis virus infection of two model insect cell systems - A comparative study
Virus Research, 122(1-2), 28–34.
MeSH headings : Animals; Cell Line; Cell Shape; Cell Survival; Culicidae; Cytopathogenic Effect, Viral; Drosophila; Microscopy, Electron, Transmission; Sindbis Virus / growth & development; Viral Plaque Assay
TL;DR:
A comparative study of Sindbis virus infection of Schnieder-2 Drosophila (S2) cells to cells of the mosquito Aedes albopictus (clone U4.4) was undertaken, establishing S2 cells as an additional invertebrate model system to study the interactions of an invertebrates host with Sindbisirus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Single amino acid insertions at the junction of the Sindbis virus e2 transmembrane domain and endodomain disrupt virus envelopment and alter infectivity
Journal of Virology, 79(12), 7682–7697.
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
Conformational changes in Sindbis virions resulting from exposure to low pH and interactions with cells suggest that cell penetration may occur at the cell surface in the absence of membrane fusion
Virology, 324(2), 373–386.
Source: NC State University Libraries
Added: August 6, 2018
2003 journal article
Deletions in the transmembrane domain of a Sindbis virus glycoprotein alter virus infectivity, stability, and host range
JOURNAL OF VIROLOGY, 77(23), 12710–12719.
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cricetinae; DNA Primers; Lipid Bilayers; Molecular Sequence Data; Reverse Transcriptase Polymerase Chain Reaction; Sequence Deletion; Sequence Homology, Amino Acid; Sindbis Virus / genetics; Sindbis Virus / physiology; Virus Assembly
TL;DR:
It is found that progressive truncations in the transmembrane domain profoundly affected production of infectious virus in a cyclic fashion and also found that membrane composition effects protein-protein and protein- Membrane interactions during virus assembly.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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