@book{nelson_2022, title={Combinations of carnosine and zinc for the treatment and prevention of viral infections}, number={WO2022005848A1}, author={Nelson, D.J.}, year={2022}, month={Jan} } @article{chiang_rizk_nelson_krishnamurti_subbian_imig_khan_reddy_gupta_2022, title={Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath}, volume={2}, ISSN={["1744-7631"]}, DOI={10.1080/14728222.2022.2031975}, abstractNote={ABSTRACT Introduction In COVID-19 pneumonia, there is a massive increase in fatty acid levels and lipid mediators with a predominance of cyclooxygenase metabolites, notably TxB2 ≫ PGE2 > PGD2 in the lungs, and 11-dehydro-TxB2, a TxA2 metabolite, in the systemic circulation. While TxA2 stimulates thromboxane prostanoid (TP) receptors, 11-dehydro-TxB2 is a full agonist of DP2 (formerly known as the CRTh2) receptors for PGD2. Anecdotal experience of using ramatroban, a dual receptor antagonist of the TxA2/TP and PGD2/DP2 receptors, demonstrated rapid symptomatic relief from acute respiratory distress and hypoxemia while avoiding hospitalization. Areas covered Evidence supporting the role of TxA2/TP receptors and PGD2/DP2 receptors in causing rapidly progressive lung injury associated with hypoxemia, a maladaptive immune response and thromboinflammation is discussed. An innovative perspective on the dual antagonism of TxA2/TP and PGD2/DP2 receptor signaling as a therapeutic approach in COVID-19 is presented. This paper examines ramatroban an anti-platelet, immunomodulator, and antifibrotic agent for acute and long-haul COVID-19. Expert Opinion Ramatroban, a dual blocker of TP and DP2 receptors, has demonstrated efficacy in animal models of respiratory dysfunction, atherosclerosis, thrombosis, and sepsis, as well as preliminary evidence for rapid relief from dyspnea and hypoxemia in COVID-19 pneumonia. Ramatroban merits investigation as a promising antithrombotic and immunomodulatory agent for chemoprophylaxis and treatment.}, journal={EXPERT OPINION ON THERAPEUTIC TARGETS}, author={Chiang, Kate C. and Rizk, John G. and Nelson, Deanna J. and Krishnamurti, Lakshmanan and Subbian, Selvakumar and Imig, John D. and Khan, Imran and Reddy, Srinivasa T. and Gupta, Ajay}, year={2022}, month={Feb} } @book{nelson_komorowski_2021, title={Magnesium biotinate compositions and methods of use}, number={US20180071264A1}, author={Nelson, D.J. and Komorowski, J.R.}, year={2021}, month={Apr} } @book{nelson_2021, title={Pharmaceutical quality strontium L-lactate. U.S}, number={US11026906B2}, author={Nelson, D.J.}, year={2021} } @book{nelson_2020, title={Drug delivery via ferric citrate}, author={Nelson, D.J.}, year={2020} } @book{nelson_2020, title={Liquid concentrate of calcium and magnesium}, number={WO2020210608A1}, author={Nelson, D.J.}, year={2020}, month={Oct} } @book{nelson_2020, title={Pharmaceutical quality strontium L-lactate}, number={2019/02258}, author={Nelson, D.J.}, year={2020} } @book{nelson_2019, title={Pharmaceutical quality strontium L-lactate}, number={US10463636B2}, author={Nelson, D.J.}, year={2019} } @book{nelson_komorowski_2018, title={Magnesium biotinate compositions and methods of use}, number={20180071264}, author={Nelson, D.J. and Komorowski, J.R.}, year={2018}, month={Aug} } @book{nelson_komorowski_2018, title={Magnesium picolinate compositions and methods of use}, number={US20180098976}, author={Nelson, D.J. and Komorowski, J.R.}, year={2018}, month={Apr} } @book{nelson_2014, title={Phosphorus binder composition for treatment of hyperphosphatemia}, number={8,759,398. Filed 3US8759398B2}, author={Nelson, D.J.}, year={2014}, month={Jun} } @inbook{nelson_2013, edition={4th}, title={Blood Substitutes: Hemoglobin-Based Oxygen Carriers}, ISBN={9781841848204}, url={http://dx.doi.org/10.1081/e-ept4-120050203}, DOI={10.1081/e-ept4-120050203}, booktitle={Encyclopedia of Pharmaceutical Science and Technology, Fourth Edition}, publisher={CRC Press}, author={Nelson, D.J.}, editor={Swarbrick, J.Editor}, year={2013}, month={Jul}, pages={330–341} } @book{nelson_holberg_2012, title={Combined calcium, magnesium, and Vitamin D supplements}, number={8324191}, author={Nelson, D.J. and Holberg, W.C., III}, year={2012}, month={Dec} } @book{nelson_mosley_2012, title={Iron preparation suitable for pharmaceutical formulation and process for the preparation thereof}, number={US8178709B2}, author={Nelson, D.J. and Mosley, B.J.}, year={2012}, month={May} } @inproceedings{nelson_holberg_hruska_fang_2012, title={Phosphate Binder Comparison: Sevelamer Carbonate & CaSuccinate/MgLipoate}, author={Nelson, D.J. and Holberg, W.C. and Hruska, K.A. and Fang, Y.}, year={2012}, month={Nov} } @book{nelson_2011, title={Phosphorus binder for treatment of kidney disease}, number={8034833}, author={Nelson, D.J.}, year={2011}, month={Oct} } @book{nelson_2011, title={Phosphorus binder for treatment of kidney disease}, number={7862836}, author={Nelson, D.J.}, year={2011}, month={Jan} } @book{nelson_2011, title={Stable, water-insoluble R-(+)-alpha-lipoic acid salt useful for the treatment of diabetes mellitus and its co-morbidities}, number={8222432}, author={Nelson, D.J.}, year={2011}, month={May} } @article{zhu_glahn_nelson_miller_2009, title={Comparing Soluble Ferric Pyrophosphate to Common Iron Salts and Chelates as Sources of Bioavailable Iron in a Caco-2 Cell Culture Model}, volume={57}, ISSN={0021-8561 1520-5118}, url={http://dx.doi.org/10.1021/jf900328t}, DOI={10.1021/jf900328t}, abstractNote={Iron bioavailability from supplements and fortificants varies depending upon the form of the iron and the presence or absence of iron absorption enhancers and inhibitors. Our objectives were to compare the effects of pH and selected enhancers and inhibitors and food matrices on the bioavailability of iron in soluble ferric pyrophosphate (SFP) to other iron fortificants using a Caco-2 cell culture model with or without the combination of in vitro digestion. Ferritin formation was the highest in cells treated with SFP compared to those treated with other iron compounds or chelates. Exposure to pH 2 followed by adjustment to pH 7 markedly decreased FeSO(4) bioavailability but had a smaller effect on bioavailabilities from SFP and sodium iron(III) ethylenediaminetetraacetate (NaFeEDTA), suggesting that chelating agents minimize the effects of pH on iron bioavailability. Adding ascorbic acid (AA) and cysteine to SFP in a 20:1 molar ratio increased ferritin formation by 3- and 2-fold, respectively, whereas adding citrate had no significant effect on the bioavailability of SFP. Adding phytic acid (10:1) and tannic acid (1:1) to iron decreased iron bioavailability from SFP by 91 and 99%, respectively. The addition of zinc had a marked inhibitory effect on iron bioavailability. Calcium and magnesium also inhibited iron bioavailability but to a lesser extent. Incorporating SFP in rice greatly reduced iron bioavailability from SFP, but this effect can be partially reversed with the addition of AA. SFP and FeSO(4) were taken up similarly when added to nonfat dry milk. Our results suggest that dietary factors known to enhance and inhibit iron bioavailability from various iron sources affect iron bioavailability from SFP in similar directions. However, the magnitude of the effects of iron absorption inhibitors on SFP iron appears to be smaller than on iron salts, such as FeSO(4) and FeCl(3). This supports the hypothesis that SFP is a promising iron source for food fortification and dietary supplements.}, number={11}, journal={Journal of Agricultural and Food Chemistry}, publisher={American Chemical Society (ACS)}, author={Zhu, Le and Glahn, Raymond P. and Nelson, Deanna and Miller, Dennis D.}, year={2009}, month={May}, pages={5014–5019} } @book{nelson_2009, title={Non-hygroscopic L-carnitine salts}, number={7572832}, author={Nelson, D.J.}, year={2009}, month={Aug} } @book{malkar_nelson_2008, title={Methods for the preparation and formulation and use of lithium valproate}, number={7790921}, author={Malkar, N.B. and Nelson, D.J.}, year={2008}, month={Apr} } @book{malkar_nelson_2007, title={Methods for the preparation and formulation and use of lithium valproate}, number={7449598}, author={Malkar, N.B. and Nelson, D.J.}, year={2007}, month={Mar} } @book{malkar_nelson_2007, title={Methods for the preparation and formulation of L-carnitine valproate salts}, number={7456216}, author={Malkar, N.B. and Nelson, D.J.}, year={2007}, month={Mar} } @book{nelson_2007, title={Synthesis of hydrazine and chlorinated derivatives of bicyclic pyridazines}, number={7220858}, author={Nelson, D.J.}, year={2007}, month={May} } @article{may_qu_nelson_2007, title={Uptake and reduction of α-lipoic acid by human erythrocytes}, volume={40}, ISSN={0009-9120}, url={http://dx.doi.org/10.1016/j.clinbiochem.2007.06.009}, DOI={10.1016/j.clinbiochem.2007.06.009}, abstractNote={The reducing capacity of erythrocytes has been used clinically as to estimate resistance to oxidant stress. In this work we targeted the antioxidant capacity of pyridine nucleotide disulfide reductases of these cells by measuring their ability to reduce the disulfide alpha-lipoic acid.Erythrocyte reduction of alpha-lipoic acid and related disulfides was measured as reduction of 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB) outside the cells.Lipoic acid-dependent DTNB reduction by human erythrocytes required d-glucose and consumed NADPH, but not NADH. This activity was inhibited by carmustine and phenylarsine oxide, as expected if alpha-lipoic acid is reduced by the glutathione and thioredoxin reductase systems. Reduction of hydroxyethyl disulfide, which provides an estimate of total erythrocyte disulfide reduction capacity, was similar to that of alpha-lipoic acid. Erythrocytes incubated with alpha-lipoic acid also reduced extracellular ferricyanide, although rates of dehydroascorbate reduction were several-fold greater, probably because intracellular GSH can recycle ascorbate but not alpha-lipoic acid in erythrocytes.These results show that alpha-lipoic acid-dependent DTNB reduction provides a simple method to selectively assess the capacity of pyridine nucleotide disulfide reductases of human erythrocytes. When coupled with other non-destructive assays, such as reduction of hydroxyethyl disulfide and ferricyanide, this assay provides a comprehensive approach to assessing erythrocyte reducing capacity in a variety of clinical conditions associated with oxidant stress.}, number={15}, journal={Clinical Biochemistry}, publisher={Elsevier BV}, author={May, James M. and Qu, Zhi-chao and Nelson, Deanna J.}, year={2007}, month={Oct}, pages={1135–1142} } @article{may_qu_nelson_2006, title={Cellular disulfide-reducing capacity: An integrated measure of cell redox capacity}, volume={344}, ISSN={0006-291X}, url={http://dx.doi.org/10.1016/j.bbrc.2006.04.065}, DOI={10.1016/j.bbrc.2006.04.065}, abstractNote={To assess the disulfide reduction capacity of intact cells, EA.hy926 endothelial cells were incubated with alpha-lipoic acid in the presence of 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB). Alpha-lipoic acid was reduced within cells to dihydrolipoic acid, which could be quantified upon efflux from the cells as reduction of DTNB. Uptake of both alpha-lipoic acid and alpha-lipoamide occurred at least in part via a medium chain fatty acid transporter, based on inhibition by octanoate. Alpha-lipoic acid was reduced within cells by pyridine nucleotide-disulfide oxidoreductases, since it is not reduced by GSH and since its reduction was inhibited by carmustine. Nonetheless, reduction was also dependent on the cellular redox environment, since it was inhibited by the redox cycling of menadione, by decreasing intracellular GSH, and by reduction of dehydroascorbate. Together, these results show that alpha-lipoic acid-dependent DTNB reduction provides a simple method to assess the disulfide-reducing capacity of intact cells, especially as determined by pyridine nucleotide-disulfide oxidoreductases.}, number={4}, journal={Biochemical and Biophysical Research Communications}, publisher={Elsevier BV}, author={May, James M. and Qu, Zhi-chao and Nelson, Deanna J.}, year={2006}, month={Jun}, pages={1352–1359} } @inbook{nelson_2006, title={DCLHb and rHb1.1}, ISBN={9780127597607}, url={http://dx.doi.org/10.1016/b978-012759760-7/50044-5}, DOI={10.1016/b978-012759760-7/50044-5}, booktitle={Blood Substitutes}, publisher={Elsevier}, author={Nelson, Deanna J.}, year={2006}, pages={399–414} } @inproceedings{nelson_driscoll_gupta_joy_silvestri_bistrian_2006, title={Stability of parenteral nutrition admixtures admixed with a novel parenteral iron dosage form}, author={Nelson, D.J. and Driscoll, D.F. and Gupta, A.J. and Joy, J. and Silvestri, A.P. and Bistrian, B.R.}, year={2006} } @book{nelson_malkar_2005, title={Methods for the preparation and formulation of magnesium valproate hydrate}, number={7482486}, author={Nelson, D.J. and Malkar, N.}, year={2005}, month={Oct} } @article{eiznhamer_flavin_jesmok_borgia_nelson_burhop_xu_2004, title={Effective attenuation of endotoxin-induced acute lung injury by 2,3-diacetyloxybenzoic acid in two independent animal models}, volume={17}, ISSN={1094-5539}, url={http://dx.doi.org/10.1016/j.pupt.2003.11.003}, DOI={10.1016/j.pupt.2003.11.003}, abstractNote={The pathology of acute lung injury (ALI) is often modeled in animal studies by the administration of lipopolysaccharide (LPS), which results in an endotoxemia with sequelae similar to that seen in acute respiratory distress syndrome (ARDS). Here we report the results of two studies designed to examine the efficacy of a novel agent, 2,3-diacetyloxybenzoic acid (2,3-DABA), in the treatment of LPS-induced ALI. In two separate animal models, 2,3-DABA was effective in significantly reducing lung microvascular permeability, a condition commonly seen in ARDS, which results in pulmonary edema and respiratory insufficiency. In each model, it is demonstrated that the mechanism by which 2,3-DABA exerts this effect occurs subsequent to the recruitment of neutrophils to the site of inflammation. Lung permeability was significantly decreased in both models by treatment with 2,3-DABA, suggesting that this agent, either alone or in combination therapy, may be useful in the treatment of ALI associated with ARDS.}, number={2}, journal={Pulmonary Pharmacology & Therapeutics}, publisher={Elsevier BV}, author={Eiznhamer, David A. and Flavin, Michael T. and Jesmok, Gary J. and Borgia, Julian F. and Nelson, Deanna J. and Burhop, Kenneth E. and Xu, Ze-Qi}, year={2004}, month={Apr}, pages={105–110} } @book{nelson_2004, title={Oligo(ethylene glycol)-terminated 1,2-dithiolanes and their conjugates useful for preparing self-assembled monolayers}, number={6756354}, author={Nelson, D.J.}, year={2004}, month={Jun} } @inproceedings{nelson_2004, title={Oxygen Carriers as Alternatives to Red Blood Cell Transfusions}, author={Nelson, D.J.}, year={2004}, month={May} } @book{nelson_2003, title={Aminosalicylate derivatives for treatment of inflammatory bowel disease}, number={7157444}, author={Nelson, D.J.}, year={2003}, month={Oct} } @book{nelson_barbeau_2003, title={Stable hydralazine pharmaceutical compositions}, number={7989452}, author={Nelson, D.J. and Barbeau, D.}, year={2003}, month={Dec} } @inbook{nelson_2002, place={New York}, title={Blood substitutes: Hemoglobin-based oxygen carriers}, volume={20}, booktitle={Encyclopedia of Pharmaceutical Technology}, publisher={Marcel Dekker, Inc}, author={Nelson, D.J.}, editor={Swarbrick, J and Boylan, J.C.Editors}, year={2002}, pages={236–262} } @book{nelson_hai_pereira_estep_2001, title={Biocompatible surfaces and a method for their preparation}, number={US6204254B1}, author={Nelson, D.J. and Hai, T.T. and Pereira, D.E. and Estep, T.N.}, year={2001}, month={Sep} } @inbook{nelson_2000, place={New York}, title={Blood substitutes: Hemoglobin-based oxygen carriers}, volume={19}, booktitle={Encyclopedia of Pharmaceutical Technology}, publisher={Marcel Dekker, Inc}, author={Nelson, D.J.}, editor={Swarbrick, J and Boylan, J.C.Editors}, year={2000}, pages={1–33} } @book{hai_pereira_nelson_2000, title={Reagents for isotropic size enhancement of a peptide, protein, nucleotide or other substrate}, number={6018035}, author={Hai, T.T. and Pereira, D.E. and Nelson, D.J.}, year={2000}, month={Jan} } @article{hai_pereira_nelson_catarello_srnak_2000, title={Surface Modification of Diaspirin Cross-linked Hemoglobin (DCLHb) with Chondroitin-4-sulfate Derivatives. Part 1}, volume={11}, ISSN={1043-1802 1520-4812}, url={http://dx.doi.org/10.1021/bc000021i}, DOI={10.1021/bc000021i}, abstractNote={Synthetic methodology was developed for the preparation of chondrotin-4-sulfate reagents that could be specifically attached to the surface of diaspirin cross-linked hemoglobin (DCLHb), a chemically stabilized human hemoglobin. The surface-modified hemoglobin solutions had a significantly higher colloidal osmotic pressures (COP) than DCLHb. The P(50) of the modified DCLHb was dependent upon the reactive end group of the chondrotin-4-sulfate reagents that was used for the protein modification. Modification of DCLHb with the chondroitin-4-sulfate derivatives containing the maleimide end group 23 provided a hemoglobin with a P(50) value of 23 mmHg, while the P(50) of hemoglobins prepared from chondroitin-4-sulfate derivatives containing the aldehyde end group 13 and 18 remained unchanged from that of DCLHb.}, number={5}, journal={Bioconjugate Chemistry}, publisher={American Chemical Society (ACS)}, author={Hai, Ton T. and Pereira, David E. and Nelson, Deanna J. and Catarello, Jim and Srnak, Ana}, year={2000}, month={Aug}, pages={705–713} } @book{nelson_1999, title={Covalently modified hemoglobin composition having low temperature-dependent oxygen-binding function}, number={6180598}, author={Nelson, D.J.}, year={1999}, month={Oct} } @article{hai_pereira_nelson_srnak_catarello_1999, title={Polymerization of Diaspirin Cross-Linked Hemoglobin (DCLHb) with Water-Soluble, Nonimmunogenic Polyamide Cross-Linking Agents}, volume={10}, ISSN={1043-1802 1520-4812}, url={http://dx.doi.org/10.1021/bc9900486}, DOI={10.1021/bc9900486}, abstractNote={Diaspirin cross-linked hemoglobin (DCLHb), a human hemoglobin that is intramolecularly cross-linked between the alpha chains (lysine 99(alpha)(1)-lysine 99(alpha)(2)), was polymerized with a number of water-soluble, nonimmunogenic polyamide cross-linking agents. The degree of polymerization and the oxygen-carrying capacity depended upon the polyamide reagent, the starting concentration of DCLHb, the molar ratio of the polyamide reagent to DCLHb used, the reaction pH, and whether oxy- or deoxy-DCLHb was used in the polymerization reaction.}, number={6}, journal={Bioconjugate Chemistry}, publisher={American Chemical Society (ACS)}, author={Hai, Ton T. and Pereira, David E. and Nelson, Deanna J. and Srnak, Ana and Catarello, James}, year={1999}, month={Nov}, pages={1013–1020} } @article{hai_pereira_nelson_srnak_1999, title={Polymerization of diaspirin crosslinked hemoglobin (DCLHb) with PEG activated with benzenesulfonate bearing electron-withdrawing groups}, volume={55}, ISSN={0040-4020}, url={http://dx.doi.org/10.1016/s0040-4020(98)01230-7}, DOI={10.1016/s0040-4020(98)01230-7}, abstractNote={The hemoglobin-based oxygen carrier solution, DCLHb, was polymerized with novel polyethylene glycol polymerization reagents to provide a solution of monomers to tetramers of hemoglobin molecules. The polyethylene glycol reagents 4 and 5 were designed to be selective toward nucleophilic displacement of the substituted benzenesulfonates by the sulfhydryl groups of β93 Cys of DCLHb.}, number={8}, journal={Tetrahedron}, publisher={Elsevier BV}, author={Hai, Ton T. and Pereira, David E. and Nelson, Deanna J. and Srnak, Ana}, year={1999}, month={Feb}, pages={2147–2156} } @book{hai_nelson_pereira_estep_1999, title={Therapeutic hemoglobin composition having isotropically increased size}, number={5981710}, author={Hai, T.T. and Nelson, D.J. and Pereira, D.E. and Estep, T.N.}, year={1999}, month={Nov} } @inbook{nelson_1998, place={Boca Ration, FL}, title={*HemAssist™: Development and Clinical Profile}, ISBN={9780429175350}, url={http://dx.doi.org/10.1201/9781482269796-19}, DOI={10.1201/9781482269796-19}, booktitle={Red Blood Cell Substitutes}, publisher={CRC Press}, author={Nelson, D.J.}, editor={Rudolph, A.S. and Rabinovici, R and Feuerstein, G.Z.Editors}, year={1998}, pages={365–412} } @article{pereira_hai_nelson_1998, title={A Convenient Large Scale Synthesis of N, N'-Disuccinimidyl Carbonate}, volume={28}, ISSN={0039-7911 1532-2432}, url={http://dx.doi.org/10.1080/00397919808004962}, DOI={10.1080/00397919808004962}, abstractNote={Abstract An improved method for the large scale preparation of N, N'-disuccinimidyl carbonate from triphosgene and N-hydroxy-succinimide has been developed.}, number={21}, journal={Synthetic Communications}, publisher={Informa UK Limited}, author={Pereira, David and Hai, Ton That and Nelson, Deanna}, year={1998}, month={Nov}, pages={4019–4024} } @article{patel_webb_shelbourn_mattia-goldberg_george_zhang_moore_nelson_1998, title={Absence of Immunogenicity of Diaspirin Cross-Linked Hemoglobin in Humans}, volume={91}, ISSN={1528-0020 0006-4971}, url={http://dx.doi.org/10.1182/blood.v91.2.710}, DOI={10.1182/blood.v91.2.710}, abstractNote={Abstract}, number={2}, journal={Blood}, publisher={American Society of Hematology}, author={Patel, Mehul J. and Webb, Edwin J. and Shelbourn, Tina E. and Mattia-Goldberg, Cynthia and George, Andrew J.T. and Zhang, Feng and Moore, Edwin G. and Nelson, Deanna J.}, year={1998}, month={Jan}, pages={710–716} } @inproceedings{nelson_1998, title={Hemoglobin Therapeutics: Current status and clinical trials}, author={Nelson, D.J.}, year={1998}, month={Mar} } @article{hai_pereira_nelson_1998, title={Synthesis of Water-Soluble, Nonimmunogenic Polyamide Cross-Linking Agents†}, volume={9}, ISSN={1043-1802 1520-4812}, url={http://dx.doi.org/10.1021/bc970199d}, DOI={10.1021/bc970199d}, abstractNote={Novel polyamides were developed that can be used as cross-linking agents for proteins such as hemoglobin. Water-soluble, nonimmunogenic polyamides containing oxygen and sulfur atoms in the backbone were prepared by the polycondensation of the diacids bis(carboxymethyloxyacetyl)-1,4-diaminobutane (1a) or 3, 3'-thiodipropionic acid (1b) with diethylene glycol bis(3-aminopropyl) ether (2). The resulting alpha,omega-diacids were converted to the corresponding activated esters using any of a variety of carboxylic acid activating reagents including the novel reagent diphenyl(1-methylimidazol-2-thiyl)phosphonate (9). The resulting polyamides could be activated with a broad spectrum of groups that allow for the cross-linking and surface modification of proteins.}, number={6}, journal={Bioconjugate Chemistry}, publisher={American Chemical Society (ACS)}, author={Hai, Ton That and Pereira, David E. and Nelson, Deanna J.}, year={1998}, month={Nov}, pages={645–654} } @inbook{nelson_1997, place={New York}, title={Blood and HemAssist (DCLHb): Potentially a Complementary Therapeutic Team}, booktitle={Blood Substitutes: Principles, Methods, Products and Clinical Trials}, publisher={Karger Landes Systems}, author={Nelson, D.J.}, editor={Chang, T.M.SEditor}, year={1997}, pages={36–91} } @inproceedings{nelson_patel_shelbourn_webb_lo-tseng_moore_1997, title={DCLHb, a well-characterized hemoglobin}, number={P08-b}, booktitle={VII International Symposium on Blood Substitutes, Program and Abstracts}, author={Nelson, D. and Patel, M. and Shelbourn, T. and Webb, E. and Lo-Tseng, T. and Moore, E.}, year={1997}, pages={101} } @article{nelson_1997, title={Progress in developing therapeutic blood substitutes. Chicago Section of the American Chemical Society}, journal={Chemical Bulletin}, author={Nelson, D.J.}, year={1997}, month={Jan}, pages={1–2} } @book{hai_nelson_1997, title={Stabilization of therapeutic hemoglobin compositions}, number={WO1997039027A1}, author={Hai, T.T. and Nelson, D.J.}, year={1997} } @article{crandall_michaely_collonges_ayers_gajewski_nelson_1996, title={Cyclizations during the Grignard reactions of omega-bromoalkynes}, volume={69}, number={4}, journal={Croatica Chimica Acta}, author={Crandall, J.K. and Michaely, W.J. and Collonges, F. and Ayers, T.A. and Gajewski, J.J. and Nelson, D.J.}, year={1996}, pages={1473–1490} } @inproceedings{patel_webb_shelbourn_nelson_1996, title={Diaspirin Crosslinked Hemoglobin (DCLHb): Biocompatibility Studies}, author={Patel, M.J. and Webb, E.J. and Shelbourn, T.E. and Nelson, D.J.}, year={1996} } @inproceedings{nelson_1996, title={Hemoglobin Based Blood Substitutes: New Biologics with Unique and Unexpected Pharmacologic Properties}, author={Nelson, D.J.}, year={1996}, month={May} } @book{breillatt_woo_nelson_appl_weinless_pokropinski_soltys_barenburg_1996, title={Method and composition for administration of beneficial agent by controlled dissolution}, number={5510115}, author={Breillatt, J.P. and Woo, L. and Nelson, D.J. and Appl, R. and Weinless, N.L. and Pokropinski, S. and Soltys, P. and Barenburg, S.A.}, year={1996}, month={Apr} } @article{hai_pereira_srnak_nelson_1996, title={Modification of DCLHb with proprietary polyamides}, volume={24}, number={4}, journal={Artif Cells Blood Subs Immob Biotech}, author={Hai, T.T. and Pereira, D. and Srnak, A. and Nelson, D.}, year={1996}, pages={347} } @book{flavin_nelson_borgia_jesmok_1996, title={Use of 2,3-alkylcarbonyloxybenzoic acid in treating adult respiratory distress syndrome}, number={5502111}, author={Flavin, M.T. and Nelson, D.V. and Borgia, J.F. and Jesmok, G.}, year={1996}, month={Apr} } @inproceedings{nelson_1995, title={Hemoglobin Based Blood Substitutes}, author={Nelson, D.J.}, year={1995} } @article{bush_marshall_spicuzza_nelson_1994, title={Diaspirin Crosslinked Hemoglobin (DCLHbTM): Bioanalytical Studies in Swine}, volume={22}, ISSN={1073-1199 1532-4184}, url={http://dx.doi.org/10.3109/10731199409117930}, DOI={10.3109/10731199409117930}, abstractNote={These studies were a part of preclinical safety and efficacy studies of DCLHb. Their purpose was to analyze the characteristics of DCLHb during circulation, and the distribution of iron following the administration of DLCHb to swine. Swine were dosed (2 g/kg) with 10 g/dL DCLHb, infused intravenously at a rate of 1 mL/kg/min. Blood samples were collected up to 48 hours post-infusion for analysis. Tissue samples were obtained for iron determination. The data collected showed that the concentration of DCLHb in the plasma gradually decreased, while the concentration of methemoglobin remained low and essentially constant. The oxygen binding characteristics and stability of the crosslink were preserved following infusion, indicating that the DCLHb continued to function as an effective oxygen carrier. Iron concentrations in the liver and kidneys increased as expected, but plasma levels of iron did not saturate the iron binding capacity of transferrin, inferring a controlled process for the release of iron.}, number={3}, journal={Artificial Cells, Blood Substitutes, and Biotechnology}, publisher={Informa UK Limited}, author={Bush, S. and Marshall, T. and Spicuzza, J. and Nelson, D.}, year={1994}, month={Jan}, pages={917–922} } @article{hai_nelson_pereira_srnak_1994, title={Diaspirin Crosslinked Hemoglobin (DCLHbTM)Polymerization}, volume={22}, ISSN={1073-1199 1532-4184}, url={http://dx.doi.org/10.3109/10731199409117931}, DOI={10.3109/10731199409117931}, abstractNote={By employing proprietary polymerization agents possessing specific binding groups and by completing diaspirin crosslinked hemoglobin (DCLHb) polymerization under specific conditions, we have selectively achieved the following objectives: (1) the P50 was adjusted to the physiologic range or left- or right-shifted; (2) the surface of DCLHb was modified ("decorated"); (3) DCLHb was polymerized but not decorated; (4) DCLHb was polymerized and decorated; or (5) DCLHb was site-specifically modified and polymerized.}, number={3}, journal={Artificial Cells, Blood Substitutes, and Biotechnology}, publisher={Informa UK Limited}, author={Hai, T. T. and Nelson, D. and Pereira, D. and Srnak, A.}, year={1994}, month={Jan}, pages={923–931} } @book{hai_nelson_1994, title={Water-soluble nonimmunogenic polyamide crosslinking agents}, number={WO1994012220A2}, author={Hai, T.T. and Nelson, D.J.}, year={1994}, month={Jun} } @inproceedings{hai_nelson_pereira_srnak_1993, title={Diaspirin Crosslinked Hemoglobin (DCLHbTM) Polymerization}, number={H66}, booktitle={Vth International Symposium on Blood Substitutes, Program and Abstracts}, author={Hai, T.T. and Nelson, D. and Pereira, D. and Srnak, A.}, year={1993} } @inproceedings{bush_marshall_spicuzza_nelson_1993, title={Diaspirin Crosslinked Hemoglobin (DCLHb): Bioanalytical Studies in Swine}, number={H36}, booktitle={Vth International Symposium on Blood Substitutes, Program and Abstracts}, author={Bush, S. and Marshall, T. and Spicuzza, J. and Nelson, D.}, year={1993} } @book{breillatt_woo_nelson_appl_1993, title={Glassy sugar matrix for administration of beneficial agent in blood preservation and drug delivery}, number={EP0343239B1}, author={Breillatt, J.P. and Woo, L. and Nelson, D.J. and Appl, R.}, year={1993}, month={Jan} } @inproceedings{nelson_mozier_gard_1993, title={Interactions of Human Monocytes with Hemoglobins: In Vitro Assessment}, number={H37}, booktitle={Vth International Symposium on Blood Substitutes, Program and Abstracts}, author={Nelson, D. and Mozier, N. and Gard, K.}, year={1993} } @book{nelson_hai_srnak_1993, title={Oxirane-modified hemoglobin based composition}, number={US5248766A}, author={Nelson, D.J. and Hai, T.T. and Srnak, A.}, year={1993}, month={Sep} } @inproceedings{nelson_bush_farmer_picken_1992, title={Diaspirin cross-linked hemoglobin: an investigational drug exemplifying hemoglobin-based blood substitutes}, author={Nelson, D.J. and Bush, S.L. and Farmer, M.C. and Picken, J.}, year={1992}, month={Dec} } @inproceedings{nelson_bush_marshall_spicuzza_1992, title={New blood product: diaspirin cross-linked hemoglobin as a blood substitute, I: Characterization and oxygen transport.}, volume={32}, number={S8}, booktitle={Transfusion}, author={Nelson, D.J. and Bush, S.L. and Marshall, T.A. and Spicuzza, J.C.}, year={1992}, pages={S21} } @inproceedings{bush_nelson_shelbourn_1992, title={New blood product: diaspirin cross-linked hemoglobin as a blood substitute, II: Storage stability}, volume={32}, number={8S}, booktitle={Transfusion}, author={Bush, S.L. and Nelson, D.J. and Shelbourn, T.E.}, year={1992}, pages={S22} } @book{nelson_hai_1992, title={Non-immunogenic hemoglobin oligomer composition used as oxygen carrier, maintains normal oxygen tension in organs and tissues, is non-toxic or pyrogenic and free from contamination}, number={WO9203-155-AWO9203-155-A}, author={Nelson, D.J. and Hai, T.T.}, year={1992} } @article{nelson_azari_brown_burhop_bush_catarello_chuang_downing_estep_loewen_et al._1992, title={Preparation and Characterization of Diaspirin Cross-Linked Hemoglobin Solutions for Preclinical Studies}, volume={20}, ISSN={1055-7172}, url={http://dx.doi.org/10.3109/10731199209119662}, DOI={10.3109/10731199209119662}, abstractNote={During 1990 and 1991 the capability for repetitive, consecutive production of DCLHb solution to meet a rigorous and complete set of product criteria was demonstrated. In addition, through periodic monitoring of product stored under controlled conditions, the stability of all lots of DCLHb solution during frozen storage was demonstrated for more than a year. In this way, assurance was provided that the DCLHb solution used in preclinical testing met all product criteria throughout the biological testing period.}, number={2-4}, journal={Biomaterials, Artificial Cells and Immobilization Biotechnology}, publisher={Informa UK Limited}, author={Nelson, D. and Azari, M. and Brown, R. and Burhop, K. and Bush, S. and Catarello, J. and Chuang, H. and Downing, C. and Estep, T. and Loewen, A. and et al.}, year={1992}, month={Jan}, pages={423–427} } @book{hai_nelson_1992, title={Process for the Production of Crosslinked Hemoglobin in the Presence of Sodium Tripolyphosphate}, number={5128452}, author={Hai, T.T. and Nelson, D.J.}, year={1992}, month={Jul} } @article{nelson_hai_smak_ebeling_kunas_catarello_burhop_1992, title={Synthesis and Properties of Polymerized, Diaspirin Cross-Linked Hemoglobins}, volume={20}, ISSN={1055-7172}, url={http://dx.doi.org/10.3109/10731199209119640}, DOI={10.3109/10731199209119640}, abstractNote={During the course of our studies it became clear that there were therapeutic applications for which a polymeric hemoglobin having an extended half-life in circulation would be appropriate. Therefore, a process for the glutaraldehyde-polymerization of diaspirin cross-linked hemoglobin (DCLHb) was developed and used to prepare glutaraldehyde-polymerized DCLHb (GP-DCLHb) in lactated Ringer's solution in sufficient quantities for biological testing. Both isovolemic exchange-transfusion and "top-load" studies (rats; primates and swine, respectively) were completed in which a broad spectrum of physiologic, histopathologic and analytical parameters were monitored and assessed. In general, GP-DCLHb in lactated Ringer's solution was well-tolerated physiologically. When compared to DCLHb, GP-DCLHb offers the advantages of reduced renal clearance of hemoglobin and an extended half-life in circulation. GP-DCLHb has the disadvantages that (1) glutaraldehyde is an ineffective virucidal agent under the conditions of the polymerization reaction and a separate virus inactivation step is required; (2) low-endotoxin (LAL-negative) GP-DCLHb solutions are pyrogenic (rabbits); and (3) unusual deposition of hemoglobin-containing material in the small arterioles of the liver and kidney (rats) was sometimes seen even after a period of time (2 weeks) during which treatment-related organ pathologies are usually resolved, a finding peculiar to GP-DCLHb among the various hemoglobin derivatives we have tested.}, number={2-4}, journal={Biomaterials, Artificial Cells and Immobilization Biotechnology}, publisher={Informa UK Limited}, author={Nelson, D. and Hai, Ton and Smak, A. and Ebeling, A. and Kunas, G. and Catarello, J. and Burhop, K.}, year={1992}, month={Jan}, pages={253–258} } @inproceedings{nelson_1991, title={Diaspirin Crosslinked Hemoglobin (DCLHb): An Update}, author={Nelson, D.}, year={1991} } @inproceedings{nelson_1991, title={Immunological Implications of Protein Formulations}, author={Nelson, D.}, year={1991} } @book{hai_nelson_1991, title={Pharmaceutical Grade 3,5-Dibromosalicylic Acid}, number={5013866}, author={Hai, T.T. and Nelson, D.J.}, year={1991}, month={May} } @article{nelson_azari_baron_bush_catarello_marshall_spicuzza_zieske_1991, title={Preparation and characterization of diaspirin cross-linked hemoglobin solutions for preclinical studies}, volume={19}, number={2}, journal={Biomaterials, Artificial Cells and Immobilization Biotechnology}, author={Nelson, D. and Azari, M. and Baron, C. and Bush, S. and Catarello, J. and Marshall, T. and Spicuzza, J. and Zieske, P.}, year={1991}, pages={452} } @book{hai_nelson_srnak_1991, title={Preparation of Bis(Salicyl) Diesters}, number={5041615}, author={Hai, T.T. and Nelson, D.J. and Srnak, A.}, year={1991}, month={Aug} } @article{nelson_hai_srnak_1991, title={Synthesis and properties of polymerized, diaspirin cross-linked hemoglobins}, volume={19}, number={2}, journal={Biomaterials, Artificial Cells and Immobilization Biotechnology}, author={Nelson, D. and Hai, T.T. and Srnak, A.}, year={1991}, pages={451} } @inproceedings{kandler_bush_spicuzza_bosman_marshall_baron_zieske_nelson_1990, title={Analytical Characterization of alpha,alpha-Crosslinked Hemoglobin}, author={Kandler, R. and Bush, S. and Spicuzza, J. and Bosman, K. and Marshall, T. and Baron, C. and Zieske, P. and Nelson, D.}, year={1990} } @inproceedings{baron_bush_nelson_1990, title={Determination of the Percent cross-linking in Diaspirin Cross-lined Hemoglobin (DCLHb) using Size-exclusion Chromatography}, author={Baron, C.D. and Bush, S.L. and Nelson, D.J.}, year={1990} } @inproceedings{nelson_estep_hai_bobka_bush_1990, title={Diaspirin Crosslinked Hemoglobin (DCLHb): Preparation and Properties}, author={Nelson, D.J. and Estep, T.N. and Hai, T.T. and Bobka, E.W. and Bush, S.}, year={1990} } @inproceedings{hai_nelson_srnak_1990, title={Directing Intramolecular Crosslinking of Hemoglobin}, author={Hai, T.T. and Nelson, D.J. and Srnak, A.}, year={1990} } @article{estep_bobka_ebeling_hai_nelson_pankau_srnak_1989, title={Novel aspects of diaspirin cross-linked hemoglobin synthesis and purification}, volume={17}, number={5}, journal={Biomaterials, Artificial Cells and Artificial Organs}, author={Estep, T.N. and Bobka, E.W. and Ebeling, A.A. and Hai, T.T. and Nelson, D.J. and Pankau, R.J. and Srnak, A.}, year={1989}, pages={636} } @inproceedings{smith_flavin_nelson_pereira_ziemnicka-merchant_1989, title={The Use of 31P NMR in Determining the Enan¬tiomeric Purity of Lactic and Malic Acid Samples}, author={Smith, W.J. and Flavin, M and Nelson, D. and Pereira, D. and Ziemnicka-Merchant, B.}, year={1989}, month={May} } @inproceedings{burhop_nelson_1988, title={Cardiovascular Maintenance with Blood Substitutes}, author={Burhop, K. and Nelson, D.}, year={1988} } @book{nelson_rowe_1987, title={Nutrient Monoesters}, number={4655057}, author={Nelson, D. and Rowe, B.}, year={1987}, month={May} } @book{nelson_rowe_1987, title={Nutrient Polyesters}, number={4701443}, author={Nelson, D. and Rowe, B.}, year={1987} } @article{nelson_lavin_1985, title={The Reaction of D-Glucose With Substituted Anilines: Investigation by Carbon-13 NMR Spectroscopy}, volume={4}, ISSN={0732-8303 1532-2327}, url={http://dx.doi.org/10.1080/07328308508062951}, DOI={10.1080/07328308508062951}, abstractNote={Abstract Carbon-13 NMR data are provided for a series of N-glycosyl amines and Amadori rearrangement products that were prepared by reaction of D-glucose with substituted anilines. These data demonstrate that 13C NMR is a useful method for characterizing the products isolated from reactions of D-glucose with amines.}, number={1}, journal={Journal of Carbohydrate Chemistry}, publisher={Informa UK Limited}, author={Nelson, Deanna J. and Lavin, Michael J.}, year={1985}, month={Mar}, pages={91–97} } @article{feather_nelson_1984, title={Maillard polymers derived from D-glucose, D-fructose, 5-(hydroxymethyl)-2-furaldehyde and glycine and methionine}, volume={32}, ISSN={0021-8561 1520-5118}, url={http://dx.doi.org/10.1021/jf00126a053}, DOI={10.1021/jf00126a053}, abstractNote={ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMaillard polymers derived from D-glucose, D-fructose, 5-(hydroxymethyl)-2-furaldehyde and glycine and methionineMilton S. Feather and Deanna NelsonCite this: J. Agric. Food Chem. 1984, 32, 6, 1428–1432Publication Date (Print):November 1, 1984Publication History Published online1 May 2002Published inissue 1 November 1984https://doi.org/10.1021/jf00126a053RIGHTS & PERMISSIONSArticle Views258Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (616 KB) Get e-Alerts Get e-Alerts}, number={6}, journal={Journal of Agricultural and Food Chemistry}, publisher={American Chemical Society (ACS)}, author={Feather, Milton S. and Nelson, Deanna}, year={1984}, month={Nov}, pages={1428–1432} } @article{nelson_1979, title={CIDNP/FTNMR as a mechanistic probe in the pulse radiolysis of aqueous acetone and acetaldehyde}, volume={83}, ISSN={0022-3654 1541-5740}, url={http://dx.doi.org/10.1021/j100480a002}, DOI={10.1021/j100480a002}, abstractNote={The utility of CIDNP/FTNMR in the study of reaction mechanism in pulse radiolysis of aqueous acetone and acetaldehyde is discussed. Using this technique, one can identify the principle radiolytic products. The high field polarization observed in these products is correlated with that expected from reactions of the radical intermediates most likely present in the solution, enabling identification of important reaction pathways. 6 figures, 5 tables.}, number={17}, journal={The Journal of Physical Chemistry}, publisher={American Chemical Society (ACS)}, author={Nelson, D. J.}, year={1979}, month={Aug}, pages={2186–2195} } @article{lawler_nelson_trifunac_1979, title={Carbon-13 CIDNP from reactions of some simple organic and inorganic radicals during pulse radiolysis}, volume={83}, ISSN={0022-3654 1541-5740}, url={http://dx.doi.org/10.1021/j100489a026}, DOI={10.1021/j100489a026}, abstractNote={Examples of carbon-13 NMR spectra exhibiting chemically induced dynamic nuclear polarization (CIDNP) during pulse radiolysis of aqueous solutions of simple organic and inorganic compounds in D/sub 2/O are presented. The following aspects of carbon-13 CIDNP are illustrated: (A) detection of CIDNP in a reaction where all protons have been replaced by deuterons, (B) generation of a theoretically ideal radical pair with only one I = 1/2 nucleus, and (C) use of isotopic enrichment to distinguish two different polarization pathways, and (D) comparison of proton and carbon-13 CIDNP from the same sample. The chemical systems studied include the radiolysis of CD/sub 3/OD in D/sub 2/O (D. and .CD/sub 2/OD radicals) and the radiolysis of sodium formate in D/sub 2/O (CO/sub 2//sup -/.radical), sodium carbonate (CO/sub 3//sup -/.), and sodium chloroacetate (.CH/sub 2/COO/sup -/).}, number={26}, journal={The Journal of Physical Chemistry}, publisher={American Chemical Society (ACS)}, author={Lawler, R. G. and Nelson, D. J. and Trifunac, A. D.}, year={1979}, month={Dec}, pages={3444–3448} } @article{nelson_trifunac_thurnauer_norris_1979, title={Chemically induced magnetic polarization studies in radiation and photochemistry}, volume={3}, ISSN={0162-7546}, url={http://dx.doi.org/10.1007/bf03052285}, DOI={10.1007/bf03052285}, number={1-2}, journal={Reviews of Chemical Intermediates}, publisher={Springer Science and Business Media LLC}, author={Nelson, D. J. and Trifunac, A. D. and Thurnauer, M. C. and Norris, J. R.}, year={1979}, month={Dec}, pages={131–168} } @article{nelson_1979, title={Synthesis of aryl alkynes}, volume={24}, number={1}, journal={Preprints, American Chemical Society Division of Petroleum Chemistry}, author={Nelson, D.J.}, year={1979}, pages={240–242} } @article{nelson_1978, title={CIDNP in pulse radiolysis of aqueous dimethyl sulfoxide}, volume={82}, ISSN={0022-3654 1541-5740}, url={http://dx.doi.org/10.1021/j100501a016}, DOI={10.1021/j100501a016}, abstractNote={ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCIDNP in pulse radiolysis of aqueous dimethyl sulfoxideD. J. NelsonCite this: J. Phys. Chem. 1978, 82, 12, 1400–1403Publication Date (Print):June 1, 1978Publication History Published online1 May 2002Published inissue 1 June 1978https://doi.org/10.1021/j100501a016RIGHTS & PERMISSIONSArticle Views39Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (458 KB) Get e-Alerts}, number={12}, journal={The Journal of Physical Chemistry}, publisher={American Chemical Society (ACS)}, author={Nelson, D. J.}, year={1978}, month={Jun}, pages={1400–1403} } @article{nelson_mottley_trifunac_1978, title={CIDNP in the radiolysis of aqueous methanol indication of methoxy radical involvement}, volume={55}, ISSN={0009-2614}, url={http://dx.doi.org/10.1016/0009-2614(78)87029-8}, DOI={10.1016/0009-2614(78)87029-8}, abstractNote={The unusual high-field polarization in ethylene glycol observed in the NMR spectra of irradiated aqueous methanol implies that an encounter of a hydroxymethyl radical with a radical having a higher g-factor precedes dimerization. Arguments are presented supporting identification of CH3O· as the glycol polarizing species. Participation of e−aq in the formation of CH3O· in a spur process is considered.}, number={2}, journal={Chemical Physics Letters}, publisher={Elsevier BV}, author={Nelson, D.J. and Mottley, C. and Trifunac, A.D.}, year={1978}, month={Apr}, pages={323–326} } @article{trifunac_nelson_mottley_1978, title={Chemically induced dynamic electron polarization. Examples; of S-T±1 polarization}, volume={30}, ISSN={0022-2364}, url={http://dx.doi.org/10.1016/0022-2364(78)90100-2}, DOI={10.1016/0022-2364(78)90100-2}, abstractNote={Abstract The observation of excess emission in the CIDEP-pulse radiolysis study of several radicals is ascribed to S - T ±1 , polarization. Observations of this S - T ±1 polarization in H -radical reactions provide examples of the hyperfine effect while the study of micellar systems and viscous solutions illustrates the effect of restricting radical diffusion.}, number={2CONF-7705101-1}, journal={Journal of Magnetic Resonance (1969)}, publisher={Elsevier BV}, author={Trifunac, A.D and Nelson, D.J and Mottley, C}, year={1978}, month={May}, pages={263–272} } @article{trifunac_nelson_1978, title={Time-resolved electron paramagnetic resonance and flow-Fourier transform nuclear magnetic resonance study in radiation chemistry. An example of Overhauser CIDNP}, volume={100}, ISSN={0002-7863 1520-5126}, url={http://dx.doi.org/10.1021/ja00484a074}, DOI={10.1021/ja00484a074}, abstractNote={ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTime-resolved electron paramagnetic resonance and flow-Fourier transform nuclear magnetic resonance study in radiation chemistry. An example of Overhauser CIDNPA. D. Trifunac and D. J. NelsonCite this: J. Am. Chem. Soc. 1978, 100, 16, 5244–5246Publication Date (Print):August 1, 1978Publication History Published online1 May 2002Published inissue 1 August 1978https://doi.org/10.1021/ja00484a074RIGHTS & PERMISSIONSArticle Views57Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (387 KB) Get e-Alerts Get e-Alerts}, number={16}, journal={Journal of the American Chemical Society}, publisher={American Chemical Society (ACS)}, author={Trifunac, A. D. and Nelson, D. J.}, year={1978}, month={Aug}, pages={5244–5246} } @article{petersen_nelson_symons_1978, title={Unstable intermediates. Part 179. Electron spin resonance studies of radicals formed in irradiated organic sulphides and disulphides}, ISSN={0300-9580 1364-5471}, url={http://dx.doi.org/10.1039/p29780000225}, DOI={10.1039/p29780000225}, abstractNote={Various organic sulphides, including dimethyl and di-t-butyl sulphide and methionine, together with disulphides, including dimethyl and dibutyl disulphides, cystine and lipoic acid have been exposed to 60Co γ-rays at 77 K, both in the pure state and in various solvents. E.s.r. and, in selected cases, optical spectra of the resulting intermediates are reported and discussed. In particular, the reaction R2S˙++ R2S → R2S–SR2+ is considered and it is suggested that certain species, previously identified as R2S˙+, are better identified as R2S–SR2+. The structure of species having g values close to 2.058, 2.025, and 2.001 is also discussed.}, number={3}, journal={Journal of the Chemical Society, Perkin Transactions 2}, publisher={Royal Society of Chemistry (RSC)}, author={Petersen, Richard L. and Nelson, Deanna J. and Symons, Martyn C. R.}, year={1978}, pages={225} } @inproceedings{trifunac_nelson_1977, title={Chemically Induced Dynamic Electron Polarization (CIDEP) in Pulse Radiolysis Examples of S-T-1 Polarization}, author={Trifunac, A.C. and Nelson, D.J.}, year={1977} } @inproceedings{trifunac_nelson_1977, title={Chemically Induced Dynamic Nuclear Polarization in Pulse Radiolysis of Aqueous Solutions}, author={Trifunac, A.C. and Nelson, D.J.}, year={1977} } @article{trifunac_nelson_1977, title={Chemically induced dynamic electron polarization in pulse radiolysis. S-T.+-.1 polarization from hydrogen radical reactions}, volume={99}, ISSN={0002-7863 1520-5126}, url={http://dx.doi.org/10.1021/ja00443a071}, DOI={10.1021/ja00443a071}, abstractNote={ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemically induced dynamic electron polarization in pulse radiolysis. S-T.+-.1 polarization from hydrogen radical reactionsA. D. Trifunac and D. J. NelsonCite this: J. Am. Chem. Soc. 1977, 99, 1, 289–290Publication Date (Print):January 1, 1977Publication History Published online1 May 2002Published inissue 1 January 1977https://doi.org/10.1021/ja00443a071Request reuse permissions Article Views43Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts}, number={1}, journal={Journal of the American Chemical Society}, publisher={American Chemical Society (ACS)}, author={Trifunac, A. D. and Nelson, D. J.}, year={1977}, month={Jan}, pages={289–290} } @article{trifunac_nelson_1977, title={Chemically induced dynamic electron polarization. Pulse radiolysis of aqueous solutions of micelles}, volume={46}, ISSN={0009-2614}, url={http://dx.doi.org/10.1016/0009-2614(77)85278-0}, DOI={10.1016/0009-2614(77)85278-0}, abstractNote={Pulse radiolysis of aqueous micelle systems has been studied by time-resolved EPR. Chemically induced dynamic electron polarization (CIDEP) is observed in the spectra of the alkyl radicals produced. At all surfactant concentrations S–TO contributions to polarization are observed. At concentrations greater than the critical micelle concentration (CMC) excess emission is also observed in the CIDEP of radicals produced from micelles. The latter, S–T−1 contributions to polarization, apparently become important because of the reduction in diffusion in micelle solutions.}, number={2}, journal={Chemical Physics Letters}, publisher={Elsevier BV}, author={Trifunac, A.D. and Nelson, D.J.}, year={1977}, month={Mar}, pages={346–348} } @article{nelson_symons_1977, title={Electron addition to organic halides: an ESR study of PhC2I−}, volume={47}, ISSN={0009-2614}, url={http://dx.doi.org/10.1016/0009-2614(77)85010-0}, DOI={10.1016/0009-2614(77)85010-0}, abstractNote={Abstract Exposure of the morpholine complex of β-iodophenylacetylene to 60Co γ-rays gave a radical exhibiting a very large hyperfine coupling to 127I which is identified as the electron addcut, PhC2I−. The unpaired electron is shown to be in the C-I σ* orbital. These results, together with others for similar σ* radicals are discussed, and it is suggested that such covalent σ* complexes (Rhal−) will only be formed when the R· radical largely retains the configuration and orbital hybridisation present in the parent molecule.}, number={3}, journal={Chemical Physics Letters}, publisher={Elsevier BV}, author={Nelson, Deanna J. and Symons, Martyn C.R.}, year={1977}, month={May}, pages={436–439} } @article{nelson_difrancesco_petters_1977, title={Modification of the Grignard reaction}, volume={54}, ISSN={0021-9584 1938-1328}, url={http://dx.doi.org/10.1021/ed054p648}, DOI={10.1021/ed054p648}, abstractNote={ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModification of the Grignard reactionD. J. Nelson , R. DiFrancesco , and D. Petters Cite this: J. Chem. Educ. 1977, 54, 10, 648Publication Date (Print):October 1, 1977Publication History Received3 August 2009Published online1 October 1977Published inissue 1 October 1977https://doi.org/10.1021/ed054p648RIGHTS & PERMISSIONSArticle Views1207Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (310 KB) Get e-Alerts Get e-Alerts}, number={10}, journal={Journal of Chemical Education}, publisher={American Chemical Society (ACS)}, author={Nelson, D. J. and DiFrancesco, R. and Petters, D.}, year={1977}, month={Oct}, pages={648} } @article{trifunac_nelson_1977, title={Nuclear magnetic resonance in pulse radiolysis. 2. CIDNP in radiolysis of aqueous solutions}, volume={99}, ISSN={0002-7863 1520-5126}, url={http://dx.doi.org/10.1021/ja00448a011}, DOI={10.1021/ja00448a011}, abstractNote={Applications of magnetic resonance to the study of radiolysis are illustrated. The products of radiolytically produced radicals exhibit CIDNP when examined, seconds after their creation, by NMR. Irradiation with a pulsed electron beam (3 MeV) was carried out in variable magnetic fields and the irradiated solutions were transferred to the NMR sample tube using a fast flow system. Aqueous solutions of methanol, iodomethane, ethylene glycol, acetate, and chloroacetate were studied. In these systems CIDNP in numerous products and starting materials can be observed. The ''primary radicals'' of radiolysis e/sub aq//sup -/ and H play a significant role in the polarization pathways. Applicability of the radical pair model of CIDNP to radiation chemistry is illustrated.}, number={6}, journal={Journal of the American Chemical Society}, publisher={American Chemical Society (ACS)}, author={Trifunac, A. D. and Nelson, D. J.}, year={1977}, month={Mar}, pages={1745–1752} } @article{nelson_uschak_1977, title={Synthesis of aryl alkynes. 1. 2-Ethyl-4-methoxyphenylacetylene}, volume={42}, ISSN={0022-3263 1520-6904}, url={http://dx.doi.org/10.1021/jo00440a028}, DOI={10.1021/jo00440a028}, abstractNote={ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of aryl alkynes. 1. 2-Ethyl-4-methoxyphenylacetyleneDeanna J. Nelson and Ellen A. UschakCite this: J. Org. Chem. 1977, 42, 20, 3308–3309Publication Date (Print):September 1, 1977Publication History Published online1 May 2002Published inissue 1 September 1977https://doi.org/10.1021/jo00440a028Request reuse permissionsArticle Views243Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (321 KB) Get e-Alertsclose Get e-Alerts}, number={20}, journal={The Journal of Organic Chemistry}, publisher={American Chemical Society (ACS)}, author={Nelson, Deanna J. and Uschak, Ellen A.}, year={1977}, month={Sep}, pages={3308–3309} } @article{nelson_symons_1977, title={Unstable intermediates. Part 169. Electron capture processes in organic phosphates: an electron spin resonance study}, ISSN={0300-9580 1364-5471}, url={http://dx.doi.org/10.1039/p29770000286}, DOI={10.1039/p29770000286}, abstractNote={A range of mono-, di-, and tri-alkyl phosphates have been exposed to 60Co γ-rays at 77 K and at ambient temperature, together with their solutions in CD3OD at 77 K. Monoalkyl phosphates (as the sodium, potassium, magnesium, or calcium salts) gave alkyl radicals on electron capture at 77 K, but a low yield of ·PO32– was detected after irradiation at ambient temperature. The major electron loss centre was formed by loss of α-hydrogen (R2ĊOPO32–). In general, the 31P hyperfine coupling for these radicals was in the range 0–10 G, but for the radical MeĊHOPO32– in the calcium salt a coupling of 45 G indicated considerable hyperconjugative interaction. Dialkyl phosphates gave the phosphoryl radicals ROPO2– on irradiation at 77 K, together with alkyl radicals. Some sodium and potassium salts also gave relatively low yields of the parent anions, (RO)2PO22–(phosphoranyl radicals). These were not obtained from CD3OD solutions, but the phosphoryl radicals and alkyl radicals were detected. Only phosphoryl radicals were obtained on irradiation at ambient temperature. The major electron-loss centres were again R2ĊOPO2(OR)–. Trialkyl phosphates at 77 K gave predominant yields of the parent phosphoranyl anions, (RO)3PO–, although phosphoryl radicals were also detected. On annealing, there was no evidence for the conversion of phosphoranyl radicals into phosphoryl radicals. Solutions in CD3OD gave the same species, but the phosphoryl radicals were obtained in relatively greater yields. Again, the major electron-loss centres seemed to be R2ĊOPO(OR)2 radicals. A doublet species having A∥ 237 and A⊥ 179 G was also obtained from MeOPO3Na2, MeOPO3Mg, and other methyl esters after irradiating at 77 K and slight annealing. In some cases, an extra 8 G splitting was observed on these features. Possible structures for this species are discussed.}, number={3}, journal={Journal of the Chemical Society, Perkin Transactions 2}, publisher={Royal Society of Chemistry (RSC)}, author={Nelson, Deanna and Symons, Martyn C. R.}, year={1977}, pages={286} } @article{nelson_petersen_symons_1977, title={Unstable intermediates. Part 178. The structure of intermediates formed in the radiolysis of thiols}, ISSN={0300-9580 1364-5471}, url={http://dx.doi.org/10.1039/p29770002005}, DOI={10.1039/p29770002005}, abstractNote={A wide range of thiols have been exposed to 60Co γ-rays at 77 K both in the pure state and in dilute methanolic or aqueous glasses. Spectra assigned to RS· radicals had gz values (z is along the C–S bond) which varied with the environment, but which were all close to 2.158 in methanol. Dissociative electron capture at sulphur (RSH + e–→ R·+ SH–) was only observed in methanolic or aqueous glasses, and it is postulated that solvation of the ejected SH– ion plays an important role. The structure of a species (X) containing two sulphur atoms and having g values close to 2.058, 2.025, and 2.001 is discussed. Two rival structures, RS·–SR2 and RSS· are considered in depth and it is concluded that the former is most probable unless both species have very similar properties. Electron loss to give RSH+ followed by reaction to give R(H)S·–S(H)R+ cations is postulated to explain certain features in the e.s.r. spectra, as an alternative to proton loss to give RS· radicals.}, number={15}, journal={Journal of the Chemical Society, Perkin Transactions 2}, publisher={Royal Society of Chemistry (RSC)}, author={Nelson, Deanna J. and Petersen, Richard L. and Symons, Martyn C. R.}, year={1977}, pages={2005} } @inproceedings{symons_nelson_1976, title={An ESR Study of Radiation Damage in Organophosphates}, author={Symons, M.C.R. and Nelson, D.J.}, year={1976} } @inproceedings{symons_nelson_1975, title={Electron Capture by Phosphate Esters}, number={D19}, author={Symons, M.C.R. and Nelson, D.J.}, year={1975} } @article{mishra_nelson_symons_1975, title={Electron capture by pyrophosphate ions: an electron spin resonance study}, volume={7}, ISSN={0020-7055}, url={http://dx.doi.org/10.1016/0020-7055(75)90025-x}, DOI={10.1016/0020-7055(75)90025-x}, abstractNote={Abstract Exposure of alkali metal pyrophosphates to 60Co γ-rays at 77 K gave centres shown by E.S.R. spectroscopy to be electron excess species with the unpaired electron localized on one phosphorus atom.}, number={4}, journal={International Journal for Radiation Physics and Chemistry}, publisher={Elsevier BV}, author={Mishra, Shuddhodan P. and Nelson, Deanna J. and Symons, Martyn C.R.}, year={1975}, month={Aug}, pages={581–583} } @article{nelson_symons_1975, title={On the conformation of β-bromo radicals}, volume={16}, ISSN={0040-4039}, url={http://dx.doi.org/10.1016/s0040-4039(00)75041-6}, DOI={10.1016/s0040-4039(00)75041-6}, number={34}, journal={Tetrahedron Letters}, publisher={Elsevier BV}, author={Nelson, Deanna and Symons, M.C.R.}, year={1975}, month={Jan}, pages={2953–2954} } @article{nelson_symons_1975, title={The detection of thiyl radicals by ESR spectroscopy}, volume={36}, ISSN={0009-2614}, url={http://dx.doi.org/10.1016/0009-2614(75)80250-8}, DOI={10.1016/0009-2614(75)80250-8}, abstractNote={Thiyl radicals (RS), formed by radiolysis of rigid solutions of a wide range of thiols at 77 K, are characterised by parallel features with high g-values which are markedly solvent dependent. However, in methanol at 77 K g−= 2.158 in all cases and this can be taken as diagnostic of RS radicals. Also in methanol, R2S molecules undergo ready dissociative electron capture to give R· + RS−.}, number={3}, journal={Chemical Physics Letters}, publisher={Elsevier BV}, author={Nelson, Deanna and Symons, Martyn C.R.}, year={1975}, month={Nov}, pages={340–341} } @article{nelson_symons_1975, title={Unstable intermediates. Part CLIII. Electron spin resonance spectra and structure of dichlorophosphoranyl radicals}, ISSN={0300-9246 1364-5447}, url={http://dx.doi.org/10.1039/dt9750001164}, DOI={10.1039/dt9750001164}, abstractNote={A range of dichlorophosphoranyl radicals [(RO)P(O)Cl2][graphic omitted] have been prepared by exposure of the neutral molecules, (RO)P(O)Cl2, to 60Co γ-rays at 77 K [R = Me, Et, Ph, C10H7(α-naphthyl), MeOCH2CH2, or ClCH2CH2]. Well resolved e.s.r. spectra obtained from [(MeO)POCl2][graphic omitted] and [(EtO)POCl2][graphic omitted] have enabled the components of the 31P and 35,37Cl hyperfine-coupling tensors to be derived. The results show that both tensors are nearly axial, but their principal axes are at right angles to each other. The two chlorine ligands must be nearly coaxial with the phosphorus atom and they share ca. 50% of the total spin density, the remainder being confined to 3s and 3p orbitals on phosphorus.}, number={12}, journal={Journal of the Chemical Society, Dalton Transactions}, publisher={Royal Society of Chemistry (RSC)}, author={Nelson, Deanna J. and Symons, Martyn C. R.}, year={1975}, pages={1164} } @article{nelson_1973, title={A new synthesis of allene alcohols}, journal={Journal of the Chemical Society, Chemical Communications}, author={Nelson, D.J.}, year={1973}, pages={444} } @article{nelson_miller_1973, title={Synthesis of a 5,6-dienol}, ISSN={0022-4936}, url={http://dx.doi.org/10.1039/c3973000444a}, DOI={10.1039/c3973000444a}, abstractNote={Treatment of 2-(phenylethynyl)tetrahydropyran with ethylmagnesium bromide gives 7-phenylnona-5,6-dien-1-ol.}, number={13}, journal={Journal of the Chemical Society, Chemical Communications}, publisher={Royal Society of Chemistry (RSC)}, author={Nelson, Deanna J. and Miller, William J.}, year={1973}, pages={444a} } @inproceedings{nelson_1970, title={Synthetic Route to Polycyclic Conjugated Systems Containing Fused Four-Membered Rings}, number={115}, author={Nelson, D.J.}, year={1970} } @article{hoogenboom_el-faghi_fink_hoganson_lindberg_lindell_linn_nelson_olson_rennerfeldt_et al._1969, title={Chemistry of sulfoacetic acid derivatives. II. Reactions of phenyl esters and anilides of sulfoacetic acid}, volume={34}, ISSN={0022-3263 1520-6904}, url={http://dx.doi.org/10.1021/jo01263a044}, DOI={10.1021/jo01263a044}, abstractNote={ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of sulfoacetic acid derivatives. II. Reactions of phenyl esters and anilides of sulfoacetic acidBernard E. Hoogenboom and Cite this: J. Org. Chem. 1969, 34, 11, 3414–3420Publication Date (Print):November 1, 1969Publication History Published online1 May 2002Published inissue 1 November 1969https://doi.org/10.1021/jo01263a044RIGHTS & PERMISSIONSArticle Views105Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (803 KB) Get e-Alerts Get e-Alerts}, number={11}, journal={The Journal of Organic Chemistry}, publisher={American Chemical Society (ACS)}, author={Hoogenboom, Bernard E. and El-Faghi, Muhammed S. and Fink, Steven C. and Hoganson, Edward D. and Lindberg, Steven E. and Lindell, Thomas J. and Linn, Carol J. and Nelson, Deanna J. and Olson, John O. and Rennerfeldt, Larrie and et al.}, year={1969}, month={Nov}, pages={3414–3420} } @article{crandall_keyton_1969, title={Cyclization of acetylenic alkyl radicals}, volume={10}, ISSN={0040-4039}, url={http://dx.doi.org/10.1016/s0040-4039(01)87971-5}, DOI={10.1016/s0040-4039(01)87971-5}, number={21}, journal={Tetrahedron Letters}, publisher={Elsevier BV}, author={Crandall, J.K. and Keyton, D.J.}, year={1969}, month={Jan}, pages={1653–1656} } @inproceedings{crandall_nelson_1969, title={Organolithium Cyclizations of Acetylene Derivatives}, number={98}, author={Crandall, J.K. and Nelson, D.J.}, year={1969}, month={Jan} } @inproceedings{hoogenboom_nelson_1969, title={The Chemistry of Sulfoacetic Acid Derivatives}, number={184}, author={Hoogenboom, B.E. and Nelson, D.J.}, year={1969} } @article{keyton_griffin_kuehne_bayha_1969, title={The reaction of arynes with enamines: A new ring expansion leading to benzocycloheptenone}, volume={10}, ISSN={0040-4039}, url={http://dx.doi.org/10.1016/s0040-4039(01)88643-3}, DOI={10.1016/s0040-4039(01)88643-3}, number={47}, journal={Tetrahedron Letters}, publisher={Elsevier BV}, author={Keyton, D.J. and Griffin, G.W. and Kuehne, M.E. and Bayha, C.E.}, year={1969}, month={Jan}, pages={4163–4168} } @article{crandall_keyton_kohne_1968, title={Allenes by lithium aluminum hydride reduction of propargyl derivatives}, volume={33}, ISSN={0022-3263 1520-6904}, url={http://dx.doi.org/10.1021/jo01273a074}, DOI={10.1021/jo01273a074}, abstractNote={ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAllenes by lithium aluminum hydride reduction of propargyl derivativesJ. K. Crandall, Deanna J. Keyton, and John KohneCite this: J. Org. Chem. 1968, 33, 9, 3655–3657Publication Date (Print):September 1, 1968Publication History Published online1 May 2002Published inissue 1 September 1968https://doi.org/10.1021/jo01273a074RIGHTS & PERMISSIONSArticle Views193Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (467 KB) Get e-Alerts Get e-Alerts}, number={9}, journal={The Journal of Organic Chemistry}, publisher={American Chemical Society (ACS)}, author={Crandall, J. K. and Keyton, Deanna J. and Kohne, John}, year={1968}, month={Sep}, pages={3655–3657} } @article{crandall_keyton_1968, title={An intramolecular alkylation route to cycloalkylacetylenes}, ISSN={0009-241X}, url={http://dx.doi.org/10.1039/c19680001069}, DOI={10.1039/c19680001069}, abstractNote={The first page of this article is displayed as the abstract.}, number={18}, journal={Chemical Communications (London)}, publisher={Royal Society of Chemistry (RSC)}, author={Crandall, J. K. and Keyton, D. J.}, year={1968}, pages={1069} } @phdthesis{nelson_1968, title={Organometallic cyclization of acetylene derivatives}, school={Indiana University}, author={Nelson, D.J.}, year={1968}, month={Aug} } @inproceedings{nelson_azari_moore_estep_picken_rohn, title={DCLHb, a hemoglobin-based oxygen carrier: manufacture and characterization for use in clinical studies}, number={3B-04}, booktitle={VII International Symposium on Blood Substitutes, Program and Abstracts}, author={Nelson, D.J. and Azari, M. and Moore, E. and Estep, T. and Picken, J. and Rohn, K.}, pages={34} } @inproceedings{nelson_webb_shelbourn_moore_mattia-goldberg_patel, title={Evaluation of the immunogenicity of diaspirin crosslinked hemoglobin (DCLHb)}, number={P09-b}, booktitle={VII International Symposium on Blood Substitutes, Program and Abstracts}, author={Nelson, D. and Webb, E. and Shelbourn, T. and Moore, E. and Mattia-Goldberg, C. and Patel, M.}, pages={102} } @inproceedings{ryan_nelson, title={Moisture Analysis in Pharmaceutical Products}, author={Ryan, J.A. and Nelson, D.} } @inproceedings{ryan_lavin_nelson, title={New Light on an old Reaction: An NMR Study of Glucose-Amine Adducts}, author={Ryan, J.A. and Lavin, M. and Nelson, D.J.}, pages={327} } @unpublished{physiological calcium phosphate management in two biofluids, DOI={10.20944/preprints202306.0464.v1}, abstractNote={Management of calcium and phosphate in biofluids is key to maintaining physiological mineral homeostasis (i.e., appropriate mineralization of hard tissues and an absence of mineral deposition in soft tissues). This review describes and contrasts the ways vertebrates manage calcium phosphate in two biological fluids (breast milk and serum) and illustrates the benefits of mineral sequestration by proteins. In milk, phosphoprotein-sequestered calcium magnesium phosphates provide nutritional support, whereas in serum, protein-sequestered calcium phosphates control transport and delivery of calcium and phosphate to tissues for biological function or excretion. In addition, subsets of sequestered phosphates in serum have been identified as culprits underlying ectopic deposition of calcium phosphates and toxicity.} } @inproceedings{nelson, title={Synthesis of Aryl Alkynes}, author={Nelson, D.J.} } @inproceedings{nelson, title={Variable Field CIDNP in Pulse Radiolysis}, author={Nelson, D.J.} } @inproceedings{nelson, title={Variable Field CIDNP/Flow FTNMR in the Study of Pulse Radiolysis}, author={Nelson, D.J.} }