David Lawrence Aylor

Works (26)

Updated: April 3rd, 2024 17:03

2022 journal article

A cross-species approach using an in vivo evaluation platform in mice demonstrates that sequence variation in human RABEP2 modulates ischemic stroke outcomes

AMERICAN JOURNAL OF HUMAN GENETICS, 109(10), 1814–1827.

By: H. Lee*, D. Kwon *, D. Aylor n & D. Marchuk*

MeSH headings : Alleles; Animals; Brain / metabolism; Chromosome Mapping; Humans; Ischemic Stroke; Mice; Vesicular Transport Proteins / genetics; rab GTP-Binding Proteins / genetics; rab GTP-Binding Proteins / metabolism
TL;DR: This work established an in vivo evaluation platform in mice by using adeno-associated virus (AAV) gene replacement and verified that both mouse and human RABEP2 rescue the mouse Rabep2 knockout ischemic stroke volume and collateral vessel phenotypes, and chose four coding variants from the human population that are predicted by multiple in silico algorithms to be damaging to RAB EP2 function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 21, 2022

2022 article

Impacts of Gestational FireMaster 550 (FM 550) Exposure on the Neonatal Cortex are Sex Specific and Largely Attributable to the Organophosphate Esters

Witchey, S. K., Doyle, M. G., Fredenburg, J. D., St Armour, G., Horman, B., Odenkirk, M. T., … Patisaul, H. B. (2022, September 8). NEUROENDOCRINOLOGY, Vol. 9.

By: S. Witchey n, M. Doyle n, J. Fredenburg n, G. St Armour n, B. Horman n, M. Odenkirk n, D. Aylor n, E. Baker n , H. Patisaul n 

TL;DR: This study reveals multiple mechanisms by which the components of a common FR mixture are developmentally neurotoxic and that the OPFRs may be the compounds of greatest concern. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 26, 2022

2021 journal article

A Neuroprotective Locus Modulates Ischemic Stroke Infarction Independent of Collateral Vessel Anatomy

FRONTIERS IN NEUROSCIENCE, 15.

By: H. Lee *, S. Wetzel-Strong*, D. Aylor n & D. Marchuk *

author keywords: ischemic stroke; infarct volume; neuroprotection; wild-derived mouse strain; quantitative trait locus mapping
TL;DR: This study used quantitative trait locus mapping to identify novel gene targets modulating infarct size and identified Macrophage Scavenger Receptor 1 (Msr1) as a strong candidate gene that harbors multiple coding SNPs predicted to be damaging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 30, 2021

2020 journal article

Age and Genetic Background Modify Hybrid Male Sterility in House Mice

GENETICS, 216(2), 585–597.

By: S. Widmayer n, M. Handel * & D. Aylor n

author keywords: hybrid male sterility; aging; genetic background; spermatogenesis; mouse
MeSH headings : Aging / genetics; Aging / physiology; Animals; Female; Genetic Background; Genetic Loci; Hybridization, Genetic; Infertility, Male / genetics; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Multifactorial Inheritance
TL;DR: Results point to multiple segregating HMS modifier alleles, some of which have age-related modes of action, which will advance understanding both of the genetic architecture of HMS and of how reproductive barriers are maintained between house mouse subspecies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: November 2, 2020

2020 journal article

Derivation of stable embryonic stem cell-like, but transcriptionally heterogenous, induced pluripotent stem cells from non-permissive mouse strains

MAMMALIAN GENOME, 31(9-12), 263–286.

By: T. Garbutt n, K. Konganti*, T. Konneker n, A. Hillhouse *, D. Phelps n , A. Jones n, D. Aylor n, D. Threadgill*

MeSH headings : Animals; Biomarkers; Cell Differentiation; Cells, Cultured; Cellular Reprogramming / genetics; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genetic Heterogeneity; Immunophenotyping; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / metabolism; Mice; Platelet Endothelial Cell Adhesion Molecule-1; Species Specificity; Transcriptome
TL;DR: Heterogeneity is a naturally occurring, necessary quality of stem cells that allows for the maintenance of pluripotency and this study is the first study to derive stable ESC-like stem cells from the non-permissive NOD/ShiLtJ and WSB/EiJ strains, enabling easier and broader research possibilities into pluripOTency for these and similar non-Permissive mouse strains and species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 19, 2020

2019 journal article

Novel Neuroprotective Loci Modulating Ischemic Stroke Volume in Wild-Derived Inbred Mouse Strains

GENETICS, 213(3), 1079–1092.

By: H. Lee *, S. Widmayer n, M. Huang*, D. Aylor n & D. Marchuk *

author keywords: ischemic stroke; wild-derived mouse strains; neuroprotection; quantitative trait mapping
MeSH headings : Animals; Female; Genetic Predisposition to Disease; Inbreeding; Infarction, Middle Cerebral Artery / genetics; Male; Mice; Polymorphism, Single Nucleotide; Quantitative Trait Loci
TL;DR: This study expanded the pool of allelic variation among classical inbred mouse strains by utilizing the eight founder strains of the Collaborative Cross and found a wild-derived strain, WSB/EiJ, that breaks this general rule that collateral vessel density inversely correlates with infarct volume. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 25, 2019

2018 journal article

Animal models of endocrine disruption

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 32(3), 283–297.

By: H. Patisaul n , S. Fenton * & D. Aylor n

author keywords: vole; peromyscus; toxicology; neurosciences; collaborative cross; PFOA
MeSH headings : Animals; Disease Models, Animal; Endocrine Disruptors / toxicity; Endocrine System / drug effects; Endocrine System Diseases / chemically induced; Endocrine System Diseases / pathology; Environmental Exposure / adverse effects; Environmental Illness / chemically induced; Environmental Illness / pathology; Humans; Reproducibility of Results; Reproduction / drug effects; Reproduction / physiology
TL;DR: Advances in genomics, neuroimaging and other tools are making a wider range of animal models more widely available to EDC researchers, and a greater diversity of species are used to effectively model more subtle but significant outcomes such as changes in pubertal timing, mammary gland development, and social behaviors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus muscuius

SCIENTIFIC REPORTS, 8.

By: T. Garbutt n, T. Konneker n, K. Konganti*, A. Hillhouse *, F. Swift-Haire n, A. Jones n, D. Phelps n , D. Aylor n, D. Threadgill*

MeSH headings : Animals; Cells, Cultured; Cellular Reprogramming / drug effects; Cellular Reprogramming / genetics; Culture Media / metabolism; Culture Media / pharmacology; Evolution, Molecular; Female; Fibroblasts; Glycogen Synthase Kinase 3 beta / antagonists & inhibitors; Glycogen Synthase Kinase 3 beta / metabolism; Induced Pluripotent Stem Cells; Leukemia Inhibitory Factor / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / metabolism; Male; Mice / genetics; Mice, Inbred Strains / genetics; Mouse Embryonic Stem Cells; Primary Cell Culture; Protein Kinase Inhibitors / pharmacology; Sex Factors; Transcription, Genetic
TL;DR: iPSC derived in 2iS are more transcriptionally similar to ESC than EpiSC, indicating that iPSC reprogramming acts to overcome genetic background constraints, and only some M. musculus strains are permissive under LIF culture conditions suggesting that this is an evolutionarily derived characteristic in the M.Mus musculus lineage. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 16, 2018

2018 journal article

Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse

MAMMALIAN GENOME, 29(1-2), 168–181.

By: A. Venkatratnam*, J. House n , K. Konganti*, C. McKenney n, D. Threadgill *, W. Chiu *, D. Aylor n, F. Wright n, I. Rusyn *

Contributors: A. Venkatratnam*, J. House n , K. Konganti*, C. McKenney n, D. Threadgill *, W. Chiu *, D. Aylor n, F. Wright n, I. Rusyn *

MeSH headings : Animals; Dose-Response Relationship, Drug; Genetics, Population; Kidney / drug effects; Kidney / metabolism; Liver / drug effects; Liver / metabolism; Mice; Transcription, Genetic / drug effects; Transcriptome / genetics; Trichloroacetic Acid / metabolism; Trichloroethylene / toxicity
TL;DR: The usefulness of mouse population-based studies in assessing inter-individual variation in toxicological responses is highlighted, but it is cautioned that genetic mapping may be challenging because of the complexity in gene exposure–dose relationships. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2018 journal article

The NIEHS TaRGET II Consortium and environmental epigenomics

Nature Biotechnology, 36(3), 225–227.

By: T. Wang *, E. Pehrsson *, D. Purushotham*, D. Li *, X. Zhuo *, B. Zhang, H. Lawson *, M. Province * ...

MeSH headings : Environmental Exposure / adverse effects; Epigenomics; Genome / drug effects; Humans; National Institute of Environmental Health Sciences (U.S.); United States
TL;DR: It is critical to determine whether epigenetic alterations are conserved across tissues in such a way that easily sampled surrogate tissues could be used to assess the impact of environmental exposure on diseaserelevant but inaccessible target tissues. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: January 25, 2020

2018 personal communication

The NIEHS TaRGET II Consortium and environmental epigenomics

By: T. Wang, E. Pehrsson, D. Purushotham, D. Li, X. Zhuo, B. Zhang, H. Lawson, M. Province ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Editor's Highlight: Collaborative Cross Mouse Population Enables Refinements to Characterization of the Variability in Toxicokinetics of Trichloroethylene and Provides Genetic Evidence for the Role of PPAR Pathway in Its Oxidative Metabolism

TOXICOLOGICAL SCIENCES, 158(1), 48–62.

By: A. Venkatratnam*, S. Furuya *, O. Kosyk*, A. Gold *, W. Bodnar *, K. Konganti*, D. Threadgill *, K. Gillespie n ...

author keywords: population; trichloroethylene; mouse
MeSH headings : Alcohol Dehydrogenase / biosynthesis; Aldehyde Dehydrogenase / biosynthesis; Animals; Dose-Response Relationship, Drug; Enzyme Induction; Female; Gene-Environment Interaction; Kidney / drug effects; Liver / drug effects; Liver / enzymology; Liver / metabolism; Male; Mice; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptors / genetics; Peroxisome Proliferator-Activated Receptors / metabolism; Quantitative Trait Loci; Species Specificity; Toxicokinetics; Trichloroethylene / blood; Trichloroethylene / pharmacokinetics; Trichloroethylene / toxicity
TL;DR: This study shows that CC mouse population is a valuable tool to quantitatively evaluate inter-individual variability in chemical metabolism and to identify genes and pathways that may underpin population differences. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Male Infertility Is Responsible for Nearly Half of the Extinction Observed in the Mouse Collaborative Cross

GENETICS, 206(2), 557–572.

By: J. Shorter *, F. Odet*, D. Aylor n, W. Pan *, C. Kao*, C. Fu *, A. Morgan*, S. Greenstein* ...

author keywords: QTL mapping; line extinction; sperm motility; infertility; mouse; multiparental populations; MPP
MeSH headings : Alleles; Animals; Chromosome Mapping; Chromosomes / genetics; Crosses, Genetic; Female; Haplotypes; Inbreeding; Infertility, Male / genetics; Male; Mice; Mice, Inbred Strains / genetics; Phenotype; Quantitative Trait Loci / genetics; Reproduction / genetics; Sperm Motility / genetics
TL;DR: By comparing extinct CC lines to living CC strains, it is concluded that a complex genetic architecture is driving extinction, and selection pressures are different on the autosomes and chromosome X, and hypothesize that incompatibilities between alleles with different subspecific origins is a key driver of infertility. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Genetic Background, Maternal Age, and Interaction Effects Mediate Rates of Crossing Over in Drosophila melanogaster Females

G3-GENES GENOMES GENETICS, 6(5), 1409–1416.

By: C. Hunter  n, M. Robinson n, D. Aylor n & N. Singh n

author keywords: meiosis; recombination; aging
MeSH headings : Animals; Crossing Over, Genetic; Drosophila melanogaster / genetics; Female; Genetic Background; Genetic Loci; Genome, Insect; Genomics / methods; Male; Meiosis / genetics; Models, Genetic; Recombination, Genetic
TL;DR: The hypothesis that maternal age influences rates of crossing over in a genotypic-specific manner is tested and a new role of genotype by maternal age interactions in mediating recombination rate is revealed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

A Multi-Megabase Copy Number Gain Causes Maternal Transmission Ratio Distortion on Mouse Chromosome 2

PLOS GENETICS, 11(2).

By: J. Didion *, A. Morgan *, A. Clayshulte*, R. Mcmullan*, L. Yadgary*, P. Petkov *, T. Bell*, D. Gatti * ...

MeSH headings : Alleles; Animals; Chromosomes / genetics; Crosses, Genetic; DNA Copy Number Variations / genetics; Female; Genomics; Genotyping Techniques; Haplotypes / genetics; Inheritance Patterns / genetics; Male; Meiosis / genetics; Mice; Mutation
TL;DR: It is found that transmission ratios in R2d2WSB heterozygous females vary between Mendelian segregation and complete distortion depending on the genetic background, and that TRD is under genetic control of unlinked distorter loci. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance

Nature Genetics, 47(4), 353–360.

By: J. Crowley *, V. Zhabotynsky *, W. Sun *, S. Huang *, I. Pakatci*, Y. Kim*, J. Wang *, A. Morgan* ...

MeSH headings : Alleles; Allelic Imbalance / genetics; Animals; Crosses, Genetic; Dosage Compensation, Genetic; Female; Gene Expression; Genetic Speciation; Humans; Male; Mice / genetics; Mice, Knockout; Phylogeny; Polymorphism, Single Nucleotide
TL;DR: It is concluded that, as with humans, pervasive regulatory variation influences complex genetic traits in mice and provide a new resource toward understanding the genetic control of transcription in mammals. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020

2015 journal article

Erratum: Corrigendum: Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance

Nature Genetics, 47(6), 690–690.

By: J. Crowley, V. Zhabotynsky, W. Sun, S. Huang, I. Pakatci, Y. Kim, J. Wang, A. Morgan ...

Source: Crossref
Added: February 24, 2020

2015 journal article

Impact of Low-Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study

TOXICOLOGICAL SCIENCES, 148(2), 341–354.

By: M. Rebuli n, L. Camacho*, M. Adonay n, D. Reif n , D. Aylor n & H. Patisaul n 

Contributors: M. Rebuli n, L. Camacho*, M. Adonay n, D. Reif n , D. Aylor n & H. Patisaul n 

author keywords: bisphenol A; CLARITY; behavior; anxiety; exploratory activity; endocrine disruption; EDC; sexually dimorphic; brain; BPA; plastic
MeSH headings : Age Factors; Animals; Anxiety / chemically induced; Anxiety / psychology; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Exploratory Behavior / drug effects; Female; Gestational Age; Lactation; Male; Maternal Exposure / adverse effects; Motor Activity / drug effects; Neurotoxicity Syndromes / etiology; Neurotoxicity Syndromes / psychology; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Risk Assessment; Sex Factors
TL;DR: No consistent effects of BPA were observed for any endpoint, in either sex, at either age compared to vehicle controls; however, significant differences between BPA-exposed and ethinyl estradiol-exp exposed groups were identified for some endpoints. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

The Founder Strains of the Collaborative Cross Express a Complex Combination of Advantageous and Deleterious Traits for Male Reproduction

G3-GENES GENOMES GENETICS, 5(12), 2671–2683.

By: F. Odet*, W. Pan *, T. Bell*, S. Goodson*, A. Stevans*, Z. Yun*, D. Aylor n, C. Kao* ...

author keywords: sperm; motility; vacuole; Collaborative Cross
MeSH headings : Animals; Crosses, Genetic; Female; Founder Effect; Infertility, Male / genetics; Lactic Acid / biosynthesis; Male; Mice; Mice, Inbred Strains; Phenotype; Quantitative Trait Loci; Quantitative Trait, Heritable; Reproduction / genetics; Sperm Count; Sperm Motility; Spermatozoa / cytology; Spermatozoa / physiology; Testis / anatomy & histology; Testis / cytology; Testis / physiology
TL;DR: The CAST/EiJ strain is an outlier, with an unusual combination of deleterious male reproductive traits including low sperm counts, high levels of morphologically abnormal sperm, and poor motility, while sperm from the PWK/PhJ and WSB/eiJ strains had the greatest percentages of normal morphology and vigorous motility. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Genetic Regulation of Zfp30, CXCL1, and Neutrophilic Inflammation in Murine Lung

GENETICS, 198(2), 735–U376.

By: H. Rutledge*, D. Aylor n, D. Carpenter*, B. Peck*, P. Chines*, L. Ostrowski *, E. Chesler *, G. Churchill *, F. Villena n, S. Kelada*

author keywords: asthma; CXCL1; neutrophil; expression quantitative trait locus (eQTL); systems genetics; complex traits; Multiparent Advanced Generation Inter-Cross (MAGIC); multiparental populations; MPP
MeSH headings : Animals; Chemokine CXCL1 / genetics; Chemokine CXCL1 / metabolism; DNA-Binding Proteins / physiology; Gene Expression; Gene Expression Regulation / immunology; Lung / immunology; Lung / pathology; Male; Mice, Transgenic; Neutrophil Infiltration; Pneumonia / genetics; Quantitative Trait Loci; Trachea / immunology; Trachea / pathology; Transcription Factors / physiology
TL;DR: It is shown that Zfp30 is expressed in airway epithelia in the normal mouse lung and that altering ZFP30 expression in vitro affects CXCL1 responses to an immune stimulus, providing strong evidence that Z FP30 is a novel regulator of neutrophilic airway inflammation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Integrative Genetic Analysis of Allergic Inflammation in the Murine Lung

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 51(3), 436–445.

By: S. Kelada*, D. Carpenter*, D. Aylor n, P. Chines*, H. Rutledge, E. Chesler *, G. Churchill *, F. Villena*, D. Schwartz *, F. Collins *

author keywords: allergic airway disease; systems genetics; gene expression quantitative trait loci
MeSH headings : Animals; Antigens, Dermatophagoides / immunology; Bronchial Hyperreactivity / immunology; Dermatophagoides pteronyssinus / metabolism; Disease Models, Animal; Gene Expression Regulation; Genetics; Hypersensitivity / immunology; Hypersensitivity / metabolism; Immunoglobulin E / blood; Inflammation; Lung / immunology; Lung / metabolism; Male; Mice; Phenotype; Quantitative Trait Loci; Respiratory Hypersensitivity / immunology
TL;DR: The results demonstrate that hallmark allergic airway disease phenotypes are associated with distinct genetic loci on Chrs 4 and 11, and that gene expression in the allergically inflamed lung is controlled by both cis and trans regulatory factors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Genetically Determined Severity of Anti-Myeloperoxidase Glomerulonephritis

The American Journal of Pathology, 182(4), 1219–1226.

By: H. Xiao *, D. Ciavatta*, D. Aylor*, P. Hu *, F. de Villena*, R. Falk*, J. Jennette *

MeSH headings : Animals; Antibodies, Antineutrophil Cytoplasmic / immunology; Bone Marrow Cells / pathology; Chimera; Crosses, Genetic; Female; Genetic Linkage; Genome / genetics; Genotype; Glomerulonephritis / genetics; Glomerulonephritis / immunology; Glomerulonephritis / pathology; Immunoglobulin G / immunology; Male; Mice; Mice, Inbred Strains; Neutrophil Activation / genetics; Peroxidase / genetics; Peroxidase / immunology; Polymorphism, Single Nucleotide / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 28, 2020

2013 journal article

Using the emerging Collaborative Cross to probe the immune system

Genes & Immunity, 15(1), 38–46.

By: J. Phillippi*, Y. Xie *, D. Miller *, T. Bell*, Z. Zhang*, A. Lenarcic*, D. Aylor*, S. Krovi * ...

author keywords: Collaborative Cross; Fc epsilon R; QTL
MeSH headings : Animals; B-Lymphocytes / physiology; CD11c Antigen / metabolism; CD8-Positive T-Lymphocytes / physiology; Genetic Variation; Genome-Wide Association Study; Haplotypes; Immunogenetics / methods; Lymphocyte Subsets / physiology; Mice; Mice, Inbred Strains / genetics; Mice, Inbred Strains / immunology; Quantitative Trait Loci; Receptors, IgE / metabolism; T-Lymphocytes / physiology
TL;DR: Comparison of overall strain effects in the CC founders with strain effects at QTL in the pre-CC revealed sharp contrasts in the genetic architecture of two traits with significant loci: variation in CD23 can be explained largely by additive genetics at one locus, whereas variation in B-to-T ratio has a more complex etiology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Sources: Crossref, Web Of Science
Added: August 6, 2018

2011 journal article

Architecture of energy balance traits in emerging lines of the Collaborative Cross

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 300(6), E1124–E1134.

By: W. Mathes*, D. Aylor*, D. Miller *, G. Churchill *, E. Chesler *, F. Villena*, D. Threadgill n, D. Pomp*

author keywords: genetics; wheel running; adiposity; body weight; quantitative trait loci
MeSH headings : Alleles; Analysis of Variance; Animals; Body Fat Distribution; Body Weight / genetics; Body Weight / physiology; Chromosome Mapping; Chromosomes / genetics; Crosses, Genetic; Eating / genetics; Eating / physiology; Energy Metabolism / genetics; Energy Metabolism / physiology; Genotype; Linkage Disequilibrium; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Motor Activity / physiology; Phenotype; Physical Conditioning, Animal / physiology; Quantitative Trait Loci; Running / physiology; Sample Size
TL;DR: The results suggest that the CC will be a powerful, high-precision tool for examining the genetic architecture of complex traits such as those involved in regulation of energy balance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
7. Affordable and Clean Energy (OpenAlex)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

From classical genetics to quantitative genetics to systems biology: Modeling epistasis

PLoS Genetics, 4(3).

By: D. Aylor & Z. Zeng

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

eQTL Viewer: visualizing how sequence variation affects genome-wide transcription

BMC Bioinformatics, 8(7).

By: W. Zou, D. Aylor & Z. Zeng

Source: NC State University Libraries
Added: August 6, 2018

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