David Lawrence Aylor
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Works (26)
Updated: July 15th, 2023 21:15
2022 journal article
A cross-species approach using an in vivo evaluation platform in mice demonstrates that sequence variation in human RABEP2 modulates ischemic stroke outcomes
AMERICAN JOURNAL OF HUMAN GENETICS, 109(10), 1814–1827.
MeSH headings : Alleles; Animals; Brain / metabolism; Chromosome Mapping; Humans; Ischemic Stroke; Mice; Vesicular Transport Proteins / genetics; rab GTP-Binding Proteins / genetics; rab GTP-Binding Proteins / metabolism
doi.org (repository)
Source: Web Of Science
Added: November 21, 2022
2022 article
Impacts of Gestational FireMaster 550 (FM 550) Exposure on the Neonatal Cortex are Sex Specific and Largely Attributable to the Organophosphate Esters
Witchey, S. K., Doyle, M. G., Fredenburg, J. D., St Armour, G., Horman, B., Odenkirk, M. T., … Patisaul, H. B. (2022, September 8). NEUROENDOCRINOLOGY, Vol. 9.
Sources: Web Of Science, ORCID
Added: September 26, 2022
2021 journal article
A Neuroprotective Locus Modulates Ischemic Stroke Infarction Independent of Collateral Vessel Anatomy
FRONTIERS IN NEUROSCIENCE, 15.
author keywords: ischemic stroke; infarct volume; neuroprotection; wild-derived mouse strain; quantitative trait locus mapping
Source: Web Of Science
Added: August 30, 2021
2020 journal article
Age and Genetic Background Modify Hybrid Male Sterility in House Mice
GENETICS, 216(2), 585–597.
author keywords: hybrid male sterility; aging; genetic background; spermatogenesis; mouse
MeSH headings : Aging / genetics; Aging / physiology; Animals; Female; Genetic Background; Genetic Loci; Hybridization, Genetic; Infertility, Male / genetics; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Multifactorial Inheritance
Source: Web Of Science
Added: November 2, 2020
2020 journal article
Derivation of stable embryonic stem cell-like, but transcriptionally heterogenous, induced pluripotent stem cells from non-permissive mouse strains
MAMMALIAN GENOME, 31(9-12), 263–286.
MeSH headings : Animals; Biomarkers; Cell Differentiation; Cells, Cultured; Cellular Reprogramming / genetics; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genetic Heterogeneity; Immunophenotyping; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / metabolism; Mice; Platelet Endothelial Cell Adhesion Molecule-1; Species Specificity; Transcriptome
Sources: Web Of Science, ORCID
Added: October 19, 2020
2019 journal article
Novel Neuroprotective Loci Modulating Ischemic Stroke Volume in Wild-Derived Inbred Mouse Strains
GENETICS, 213(3), 1079–1092.
author keywords: ischemic stroke; wild-derived mouse strains; neuroprotection; quantitative trait mapping
MeSH headings : Animals; Female; Genetic Predisposition to Disease; Inbreeding; Infarction, Middle Cerebral Artery / genetics; Male; Mice; Polymorphism, Single Nucleotide; Quantitative Trait Loci
Source: Web Of Science
Added: November 25, 2019
2018 journal article
Animal models of endocrine disruption
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 32(3), 283–297.
author keywords: vole; peromyscus; toxicology; neurosciences; collaborative cross; PFOA
MeSH headings : Animals; Disease Models, Animal; Endocrine Disruptors / toxicity; Endocrine System / drug effects; Endocrine System Diseases / chemically induced; Endocrine System Diseases / pathology; Environmental Exposure / adverse effects; Environmental Illness / chemically induced; Environmental Illness / pathology; Humans; Reproducibility of Results; Reproduction / drug effects; Reproduction / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018
2018 journal article
Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus muscuius
SCIENTIFIC REPORTS, 8.
MeSH headings : Animals; Cells, Cultured; Cellular Reprogramming / drug effects; Cellular Reprogramming / genetics; Culture Media / metabolism; Culture Media / pharmacology; Evolution, Molecular; Female; Fibroblasts; Glycogen Synthase Kinase 3 beta / antagonists & inhibitors; Glycogen Synthase Kinase 3 beta / metabolism; Induced Pluripotent Stem Cells; Leukemia Inhibitory Factor / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / metabolism; Male; Mice / genetics; Mice, Inbred Strains / genetics; Mouse Embryonic Stem Cells; Primary Cell Culture; Protein Kinase Inhibitors / pharmacology; Sex Factors; Transcription, Genetic
Sources: Web Of Science, ORCID
Added: October 16, 2018
2018 journal article
Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse
MAMMALIAN GENOME, 29(1-2), 168–181.
MeSH headings : Animals; Dose-Response Relationship, Drug; Genetics, Population; Kidney / drug effects; Kidney / metabolism; Liver / drug effects; Liver / metabolism; Mice; Transcription, Genetic / drug effects; Transcriptome / genetics; Trichloroacetic Acid / metabolism; Trichloroethylene / toxicity
Sources: Web Of Science, ORCID
Added: August 6, 2018
2018 journal article
The NIEHS TaRGET II Consortium and environmental epigenomics
Nature Biotechnology, 36(3), 225–227.
MeSH headings : Environmental Exposure / adverse effects; Epigenomics; Genome / drug effects; Humans; National Institute of Environmental Health Sciences (U.S.); United States
Source: Crossref
Added: January 25, 2020
2018 personal communication
The NIEHS TaRGET II Consortium and environmental epigenomics
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Editor's Highlight: Collaborative Cross Mouse Population Enables Refinements to Characterization of the Variability in Toxicokinetics of Trichloroethylene and Provides Genetic Evidence for the Role of PPAR Pathway in Its Oxidative Metabolism
TOXICOLOGICAL SCIENCES, 158(1), 48–62.
author keywords: population; trichloroethylene; mouse
MeSH headings : Alcohol Dehydrogenase / biosynthesis; Aldehyde Dehydrogenase / biosynthesis; Animals; Dose-Response Relationship, Drug; Enzyme Induction; Female; Gene-Environment Interaction; Kidney / drug effects; Liver / drug effects; Liver / enzymology; Liver / metabolism; Male; Mice; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptors / genetics; Peroxisome Proliferator-Activated Receptors / metabolism; Quantitative Trait Loci; Species Specificity; Toxicokinetics; Trichloroethylene / blood; Trichloroethylene / pharmacokinetics; Trichloroethylene / toxicity
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Male Infertility Is Responsible for Nearly Half of the Extinction Observed in the Mouse Collaborative Cross
GENETICS, 206(2), 557–572.
author keywords: QTL mapping; line extinction; sperm motility; infertility; mouse; multiparental populations; MPP
MeSH headings : Alleles; Animals; Chromosome Mapping; Chromosomes / genetics; Crosses, Genetic; Female; Haplotypes; Inbreeding; Infertility, Male / genetics; Male; Mice; Mice, Inbred Strains / genetics; Phenotype; Quantitative Trait Loci / genetics; Reproduction / genetics; Sperm Motility / genetics
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Genetic Background, Maternal Age, and Interaction Effects Mediate Rates of Crossing Over in Drosophila melanogaster Females
G3-GENES GENOMES GENETICS, 6(5), 1409–1416.
author keywords: meiosis; recombination; aging
MeSH headings : Animals; Crossing Over, Genetic; Drosophila melanogaster / genetics; Female; Genetic Background; Genetic Loci; Genome, Insect; Genomics / methods; Male; Meiosis / genetics; Models, Genetic; Recombination, Genetic
Source: Web Of Science
Added: August 6, 2018
2015 journal article
A Multi-Megabase Copy Number Gain Causes Maternal Transmission Ratio Distortion on Mouse Chromosome 2
PLOS GENETICS, 11(2).
MeSH headings : Alleles; Animals; Chromosomes / genetics; Crosses, Genetic; DNA Copy Number Variations / genetics; Female; Genomics; Genotyping Techniques; Haplotypes / genetics; Inheritance Patterns / genetics; Male; Meiosis / genetics; Mice; Mutation
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance
Nature Genetics, 47(4), 353–360.
MeSH headings : Alleles; Allelic Imbalance / genetics; Animals; Crosses, Genetic; Dosage Compensation, Genetic; Female; Gene Expression; Genetic Speciation; Humans; Male; Mice / genetics; Mice, Knockout; Phylogeny; Polymorphism, Single Nucleotide
Sources: Crossref, ORCID
Added: February 24, 2020
2015 journal article
Erratum: Corrigendum: Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance
Nature Genetics, 47(6), 690–690.
Source: Crossref
Added: February 24, 2020
2015 journal article
Impact of Low-Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study
TOXICOLOGICAL SCIENCES, 148(2), 341–354.
author keywords: bisphenol A; CLARITY; behavior; anxiety; exploratory activity; endocrine disruption; EDC; sexually dimorphic; brain; BPA; plastic
MeSH headings : Age Factors; Animals; Anxiety / chemically induced; Anxiety / psychology; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Exploratory Behavior / drug effects; Female; Gestational Age; Lactation; Male; Maternal Exposure / adverse effects; Motor Activity / drug effects; Neurotoxicity Syndromes / etiology; Neurotoxicity Syndromes / psychology; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Risk Assessment; Sex Factors
Sources: Web Of Science, ORCID
Added: August 6, 2018
2015 journal article
The Founder Strains of the Collaborative Cross Express a Complex Combination of Advantageous and Deleterious Traits for Male Reproduction
G3-GENES GENOMES GENETICS, 5(12), 2671–2683.
author keywords: sperm; motility; vacuole; Collaborative Cross
MeSH headings : Animals; Crosses, Genetic; Female; Founder Effect; Infertility, Male / genetics; Lactic Acid / biosynthesis; Male; Mice; Mice, Inbred Strains; Phenotype; Quantitative Trait Loci; Quantitative Trait, Heritable; Reproduction / genetics; Sperm Count; Sperm Motility; Spermatozoa / cytology; Spermatozoa / physiology; Testis / anatomy & histology; Testis / cytology; Testis / physiology
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Genetic Regulation of Zfp30, CXCL1, and Neutrophilic Inflammation in Murine Lung
GENETICS, 198(2), 735–U376.
author keywords: asthma; CXCL1; neutrophil; expression quantitative trait locus (eQTL); systems genetics; complex traits; Multiparent Advanced Generation Inter-Cross (MAGIC); multiparental populations; MPP
MeSH headings : Animals; Chemokine CXCL1 / genetics; Chemokine CXCL1 / metabolism; DNA-Binding Proteins / physiology; Gene Expression; Gene Expression Regulation / immunology; Lung / immunology; Lung / pathology; Male; Mice, Transgenic; Neutrophil Infiltration; Pneumonia / genetics; Quantitative Trait Loci; Trachea / immunology; Trachea / pathology; Transcription Factors / physiology
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Integrative Genetic Analysis of Allergic Inflammation in the Murine Lung
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 51(3), 436–445.
author keywords: allergic airway disease; systems genetics; gene expression quantitative trait loci
MeSH headings : Animals; Antigens, Dermatophagoides / immunology; Bronchial Hyperreactivity / immunology; Dermatophagoides pteronyssinus / metabolism; Disease Models, Animal; Gene Expression Regulation; Genetics; Hypersensitivity / immunology; Hypersensitivity / metabolism; Immunoglobulin E / blood; Inflammation; Lung / immunology; Lung / metabolism; Male; Mice; Phenotype; Quantitative Trait Loci; Respiratory Hypersensitivity / immunology
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Genetically Determined Severity of Anti-Myeloperoxidase Glomerulonephritis
The American Journal of Pathology, 182(4), 1219–1226.
MeSH headings : Animals; Antibodies, Antineutrophil Cytoplasmic / immunology; Bone Marrow Cells / pathology; Chimera; Crosses, Genetic; Female; Genetic Linkage; Genome / genetics; Genotype; Glomerulonephritis / genetics; Glomerulonephritis / immunology; Glomerulonephritis / pathology; Immunoglobulin G / immunology; Male; Mice; Mice, Inbred Strains; Neutrophil Activation / genetics; Peroxidase / genetics; Peroxidase / immunology; Polymorphism, Single Nucleotide / genetics
Source: Crossref
Added: August 28, 2020
2013 journal article
Using the emerging Collaborative Cross to probe the immune system
Genes & Immunity, 15(1), 38–46.
author keywords: Collaborative Cross; Fc epsilon R; QTL
MeSH headings : Animals; B-Lymphocytes / physiology; CD11c Antigen / metabolism; CD8-Positive T-Lymphocytes / physiology; Genetic Variation; Genome-Wide Association Study; Haplotypes; Immunogenetics / methods; Lymphocyte Subsets / physiology; Mice; Mice, Inbred Strains / genetics; Mice, Inbred Strains / immunology; Quantitative Trait Loci; Receptors, IgE / metabolism; T-Lymphocytes / physiology
Sources: Crossref, Web Of Science
Added: August 6, 2018
2011 journal article
Architecture of energy balance traits in emerging lines of the Collaborative Cross
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 300(6), E1124–E1134.
author keywords: genetics; wheel running; adiposity; body weight; quantitative trait loci
MeSH headings : Alleles; Analysis of Variance; Animals; Body Fat Distribution; Body Weight / genetics; Body Weight / physiology; Chromosome Mapping; Chromosomes / genetics; Crosses, Genetic; Eating / genetics; Eating / physiology; Energy Metabolism / genetics; Energy Metabolism / physiology; Genotype; Linkage Disequilibrium; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Motor Activity / physiology; Phenotype; Physical Conditioning, Animal / physiology; Quantitative Trait Loci; Running / physiology; Sample Size
Source: Web Of Science
Added: August 6, 2018
2008 journal article
From classical genetics to quantitative genetics to systems biology: Modeling epistasis
PLoS Genetics, 4(3).
Source: NC State University Libraries
Added: August 6, 2018
2007 journal article
eQTL Viewer: visualizing how sequence variation affects genome-wide transcription
BMC Bioinformatics, 8(7).
Source: NC State University Libraries
Added: August 6, 2018
