Daniel L. Comins

Synthesis of MAPA Reagents and 2-Alkyl(aryl)aminopyridines from 2-Bromopyridine Using the Goldberg Reaction

MOLECULES, 27(6).

Preparation of substituted alkoxypyridines via directed metalation and metal-halogen exchange

ARKIVOC, 57–72.

Editorial for the Special Issue on Heterocycles

Comins, D., & Ma, D. (2016, November 4). JOURNAL OF ORGANIC CHEMISTRY, Vol. 81, pp. 10107–10108.

Studies toward the Synthesis of Lepadiformine A

JOURNAL OF ORGANIC CHEMISTRY, 81(21), 10433–10443.

Synthesis of C-4 Substituted Amido Nicotine Derivatives via Copper(I)- and (II)-Catalyzed Cross-Coupling Reactions

JOURNAL OF ORGANIC CHEMISTRY, 81(22), 11529–11534.

A concise synthesis of the Lycopodium alkaloid cermizine D

TETRAHEDRON LETTERS, 56(23), 3683–3685.

Novel approach toward the morphine skeleton. Synthesis of 1-(5-benzyloxy-2-bromo-4-methoxybenzyl)-6-oxo-3,4,6,7,8,8a-hexahydro-1H-isoquinoline-2-carboxylic acid phenyl ester via N-acylpyridinium salt chemistry

TETRAHEDRON, 71(39), 7354–7360.

A Twist on Facial Selectivity of Hydride Reductions of Cyclic Ketones: Twist-Boat Conformers in Cyclohexanone, Piperidone, and Tropinone Reactions

JOURNAL OF ORGANIC CHEMISTRY, 79(23), 11609–11618.

Studies toward the Total Synthesis of Dihydrolycolucine. Preparation of AB and CEF Ring Fragments

JOURNAL OF ORGANIC CHEMISTRY, 79(12), 5740–5745.

Total Synthesis of Alkaloid 205B

JOURNAL OF ORGANIC CHEMISTRY, 79(19), 9074–9085.

Dihydropyridine preparation and application in the synthesis of pyridine derivatives

[Review of ]. Advances in heterocyclic chemistry, vol 110, 110, 175–235.

Studies toward the synthesis of spirolucidine. Preparation of ABC and EF ring fragments

TETRAHEDRON LETTERS, 53(11), 1347–1350.

Concise Total Synthesis of the Frog Alkaloid (-)-205B

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50(37), 8626–8628.

Hydrophobic Derivatization of N-linked Glycans for Increased Ion Abundance in Electrospray Ionization Mass Spectrometry

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 22(8), 1309–1317.

Identification and replication of loci involved in camptothecin-induced cytotoxicity using CEPH pedigrees

PLoS One, 6(5).

A Five-Step Synthesis of (S)-Macrostomine from (S)-Nicotine

ORGANIC LETTERS, 12(20), 4513–4515.

Asymmetric Synthesis of All the Known Phlegmarine Alkaloids

JOURNAL OF ORGANIC CHEMISTRY, 75(24), 8564–8570.

Interplay of Permanent Charge and Hydrophobicity in the Electrospray Ionization of Glycans

Walker, S. H., Papas, B. N., Comins, D. L., & Muddiman, D. C. (2010, August 1). ANALYTICAL CHEMISTRY, Vol. 82, pp. 6636–6642.

Regiospecific synthesis of nicotine derivatives

Synthesis of Fused-Ring Nicotine Derivatives from (S)-Nicotine

JOURNAL OF ORGANIC CHEMISTRY, 75(5), 1706–1716.

[2+2] Photochemical Cycloaddition/Ring Opening of 6-Alkenyl-2,3-dihydro-4-pyridones

JOURNAL OF ORGANIC CHEMISTRY, 75(19), 6728–6731.

Chiral amino alcohols derived from (S)-6-chloronicotine as catalysts for asymmetric synthesis

TETRAHEDRON LETTERS, 50(16), 1806–1808.

Evaluation of the ALiPHAT Method for PC-IDMS and Correlation of Limits-of-Detection with Nonpolar Surface Area

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 20(11), 2006–2012.

Improving limits of detection for B-type natriuretic peptide using PC-IDMS: An application of the ALiPHAT strategy

ANALYST, 135(1), 36–41.

Increasing the hydrophobicity and electrospray response of glycans through derivatization with novel cationic hydrazides

CHEMICAL COMMUNICATIONS, 46(2), 237–239.

Synthesis of 1,3-Amino Alcohol Derivatives via a Silicon-Mediated Ring-Opening of Substituted Piperidines

ORGANIC LETTERS, 11(13), 2940–2942.

Synthesis of nicotine derivatives from nicotine

Identification of cuticular lipids eliciting interspecific courtship in the German cockroach, Blattella germanica

NATURWISSENSCHAFTEN, 95(5), 403–412.

N-Acyldihydropyridones as Synthetic Intermediates. A Stereoselective Synthesis of Acyclic Amino Alcohols Containing Multiple Chiral Centers

JOURNAL OF ORGANIC CHEMISTRY, 73(24), 9744–9751.

Stereoselective synthesis of acyclic amino alcohols via von Braun ring opening of chiral piperidines

ORGANIC LETTERS, 10(15), 3255–3257.

Synthesis of nicotine derivatives from nicotine

Washington, DC: U.S. Patent and Trademark Office.

Synthesis, characterization, and application of lodoacetamide derivatives utilized for the ALiPHAT strategy

Journal of the American Chemical Society, 130(7), 2122-.

Achieving augmented limits of detection for peptides with hydrophobic alkyl tags

ANALYTICAL CHEMISTRY, 79(11), 3989–3995.

Asymmetric synthesis of C-2-symmetric vicinal diamines via reductive dimerization of N-acylpyridinium and related salts

ORGANIC LETTERS, 10(2), 221–223.

One-pot terminal alkene homologation using a tandem olefin cross-metathesis/allylic carbonate reduction sequence

CHEMICAL COMMUNICATIONS, (40), 4170–4171.

Recent advances in the synthesis of nicotine and its derivatives

TETRAHEDRON, 63(34), 8065–8082.

Regioselective halogenation of nicotine and substituted nicotines

Washington, DC: U.S. Patent and Trademark Office.

Regiospecific synthesis of nicotine derivatives

Washington, DC: U.S. Patent and Trademark Office.

Synthesis and regioselective substitution of C-6 alkoxy derivatives of (S)-nicotine

TETRAHEDRON LETTERS, 49(3), 569–572.

Synthesis of the benzo-fused indolizidine alkaloid mimics

Beilstein Journal of Organic Chemistry, 3.

A six-step synthesis of (S)-5-ethenyl-3-(1-methy1-2-pyrrolidinyl)pyridine (SIB-1508Y) from (S)-nicotine

TETRAHEDRON LETTERS, 47(9), 1449–1451.

Expedient five-step synthesis of SIB-1508Y from natural nicotine

JOURNAL OF ORGANIC CHEMISTRY, 71(22), 8673–8675.

Insecticidal activity and mode of action of novel nicotinoids synthesized by new acylpyridinium salt chemistry and directed lithiation

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 87(3), 211–219.

Regioselective 5-, 4-, and 2-substitution of (S)-6-chloronicotine and 4-substitution of (S)-5-chloronicotine

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2006(16), 3562–3565.

Regioselective halogenation of nicotine and substituted nicotines

Washington, DC: U.S. Patent and Trademark Office.

Regiospecific synthesis of nicotine derivatives

Washington, DC: U.S. Patent and Trademark Office.

Short synthesis of pyridine-based pharmaceutical intermediates

Washington, DC: U.S. Patent and Trademark Office.

Six-step synthesis of (S)-brevicolline from (S)-nicotine

ORGANIC LETTERS, 8(16), 3549–3552.

Synthesis of nicotine derivatives from nicotine

Washington, DC: U.S. Patent and Trademark Office.

Synthetic studies toward (-)-FR901483 using a conjugate allylation to install the C-1 quaternary carbon

JOURNAL OF ORGANIC CHEMISTRY, 71(25), 9393–9402.

A six-step asymmetric synthesis of (+)-hyperaspine

ORGANIC LETTERS, 7(23), 5227–5228.

Asymmetric synthesis of 3,3-disubstituted isoindolinones

TETRAHEDRON LETTERS, 46(34), 5639–5642.

Diels-alder reactions of N-acyl-2-alkyl(aryl)-5-vinyl-2,3-dihydro-4-pyridones

JOURNAL OF ORGANIC CHEMISTRY, 70(13), 5221–5234.

Regioselective C-2 and C-6 substitution of (S)-nicotine and nicotine derivatives

ORGANIC LETTERS, 7(24), 5457–5460.

Regioselective lithium-halogen exchange and palladium-catalyzed cross-coupling reactions of 2,4-dihaloquinolines

TETRAHEDRON LETTERS, 46(39), 6697–6699.

Short synthesis of pyridine-based pharmaceutical intermediates

Washington, DC: U.S. Patent and Trademark Office.

Synthesis of C-4 substituted nicotine derivatives via an N-acylpyridinium salt of (S)-nicotine

ORGANIC LETTERS, 7(22), 5059–5062.

Synthesis of nicotine derivatives via reductive disilylation of (S)-nicotine

ORGANIC LETTERS, 8(2), 179–182.

Tandem directed lithiations of N-boc-1,2-dihydropyridines toward highly functionalized 2,3-dihydro-4-pyridones

ORGANIC LETTERS, 7(25), 5661–5664.

Addition of indolyl and pyrrolyl grignard reagents to 1-acylpyridinium salts

JOURNAL OF ORGANIC CHEMISTRY, 69(8), 2863–2866.

Asymmetric synthesis of 3-substituted isoindolinones: Application to the total synthesis of (+)-lennoxamine

ORGANIC LETTERS, 7(1), 95–98.

Asymmetric total synthesis of (+)-cannabisativine

JOURNAL OF ORGANIC CHEMISTRY, 69(16), 5219–5231.

Novel heterocyclic systems. Synthesis of 2,7-dimethyl-10-oxa-1,8-diaza-anthracen-9-one and derivatives

TETRAHEDRON, 60(51), 11751–11758.

Preparation of a camptothecin derivative by intramolecular cyclisation

Washington, DC: U.S. Patent and Trademark Office.

Short synthesis of pyridine-based pharmaceutical intermediates

Washington, DC: U.S. Patent and Trademark Office.

Diels-Alder reactions of 5-vinyl-1-acyl-2-aryl-2,3-dihydro-4-pyridones: regio- and stereoselective synthesis of octahydroquinolines

ORGANIC LETTERS, 5(3), 321–323.

Preparation of a camptothecin derivative by intramolecular cyclisation

Washington, DC: U.S. Patent and Trademark Office.

Regioselective sonogashira couplings of 2,4-dibromoquinolines. A correction

JOURNAL OF ORGANIC CHEMISTRY, 68(9), 3736–3738.

Short synthesis of pyridine-based pharmaceutical intermediates

Washington, DC: U.S. Patent and Trademark Office.

Tandem Diels-Alder cyclization/aromatization reactions of 5-vinyl-1-acyl-2-aryl-2,3-dihydro-4-pyridones

TETRAHEDRON LETTERS, 44(22), 4179–4182.

A novel free-radical ring contraction of a cyclic carbamate

JOURNAL OF ORGANIC CHEMISTRY, 67(6), 1972–1973.

Preparation of a camptothecin derivative by intramolecular cyclisation

Washington, DC: U.S. Patent and Trademark Office.

Synthesis and reactions of enantiopure 1-acyl-2- [triaryl(alkyl)silyl]-2,3-dihydro-4-pyridones

Heterocycles, 58(2002 Nov 22), 505–519.

Synthetic applications of chiral 2,3-dihydro-4-pyridones

Current Opinion in Drug Discovery & Development, 5(6), 870–880.

Total synthesis of the putative structure of the lupin alkaloid plumerinine

ORGANIC LETTERS, 4(9), 1611–1613.

A practical six-step synthesis of (S)-camptothecin

ORGANIC LETTERS, 3(26), 4255–4257.

Asymmetric synthesis of (+)-deoxoprosopinine

Journal of Organic Chemistry, 66(20), 6829–6832.

Enantiopure 2,3-dihydro-4-pyridones as synthetic intermediates: A concise asymmetric synthesis of (+)-allopumiliotoxin 267A

ORGANIC LETTERS, 3(3), 469–471.

Enantiopure 2,3-dihydro-4-pyridones as synthetic intermediates: asymmetric synthesis of 1-deoxynojirimycin

TETRAHEDRON LETTERS, 42(39), 6839–6841.

Inter- and intramolecular Horner-Wadsworth-Emmons reactions of 5-(diethoxyphosphoryl)-1-acyl-2-alkyl(aryl)-2,3-dihydro-4-pyridones

TETRAHEDRON LETTERS, 42(25), 4115–4118.

Model studies toward the total synthesis of the Lycopodium alkaloid spirolucidine

ORGANIC LETTERS, 3(20), 3217–3220.

Reduction of N-acyl-2,3-dihydro-4-pyridones to N-acyl-4-piperidones using zinc/acetic acid

JOURNAL OF ORGANIC CHEMISTRY, 66(6), 2181–2182.

Synthesis and reactivity of N-acyl-5-(1-hydroxyalkyl)-2,3-dihydro-4-pyridones

ORGANIC LETTERS, 3(5), 769–771.

Addition of metallo enolates to chiral 1-acylpyridinium salts: Total synthesis of (+)-cannabisativine

ORGANIC LETTERS, 2(6), 855–857.

Asymmetric synthesis of (2S,4R)-4-hydroxypipecolic acid

TETRAHEDRON LETTERS, 41(19), 3551–3553.

Asymmetric synthesis of erythro- and threo-2-(1-hydroxyalkyl)piperidines via iodocyclocarbamation of 1-acyl-2-alkenyl-1,2,3,6-tetrahydropyridines

TETRAHEDRON LETTERS, 41(16), 2839–2842.

Preparation of a camptothecin derivative by intramolecular cyclisation

Washington, DC: U.S. Patent and Trademark Office.

Total synthesis of (+)-streptazolin

CHEMICAL COMMUNICATIONS, (7), 569–570.

Asymmetric synthesis and synthetic utility of 2,3-dihydro-4-pyridones

JOURNAL OF HETEROCYCLIC CHEMISTRY, Vol. 36, pp. 1491–1500.

Asymmetric synthesis of dienomycin C

TETRAHEDRON LETTERS, 40(2), 217–218.

Asymmetric synthesis of the Lycopodium alkaloid, N-a-acetyl-N-b-methylphlegmarine

Comins, D. L., Libby, A. H., Al-awar, R. S., & Foti, C. J. (1999, April 2).

Diastereoselective addition of prochiral metallo enolates to chiral 1-acylpyridinium salts

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 121(11), 2651–2652.

Enantiopure N-acyldihydropyridones as synthetic intermediates: Asymmetric synthesis of (-)-slaframine

ORGANIC LETTERS, 1(12), 1941–1943.

Enantiopure N-acyldihydropyridones as synthetic intermediates: Asymmetric synthesis of benzomorphans

ORGANIC LETTERS, 1(4), 657–659.

IMDA/retro-Mannich approach to cis-perhydroquinoline Lycopodium alkaloids: Asymmetric synthesis of (+)-luciduline

ORGANIC LETTERS, 1(2), 229–231.

The Mukaiyama-Michael reaction of N-acyl-2,3-dihydro-4- pyridones: Regio- and stereoselective synthesis of cis-2,6- disubstituted 1,2,5,6-tetrahydropyridines

Organic Letters, 1(7), 1031–1033.

C-3 acetoxylation of N-acyl-2,3-dihydro-4-pyridones

TETRAHEDRON LETTERS, 39(32), 5693–5696.

Intramolecular photocycloaddition of a tethered bis-2,3-dihydro-4-pyridone: Stereochemistry and reactivity of the cycloadduct

TETRAHEDRON LETTERS, 39(3-4), 187–190.

Model studies toward the synthesis of N alpha-acetyl-N beta- methylphlegmarine: Addition of cyclohexylmethyl organometallics to 1-acylpyridinium salts

Heterocycles, 48(7), 1313–1317.

Photochemical reactions of chiral 2,3-dihydro-4(1H)-pyridones: asymmetric synthesis of (-)-perhydrohistrionicotoxin

CHEMICAL COMMUNICATIONS, (22), 2509–2510.

Asymmetric synthesis and synthetic utility of 2,3-dihydro-4-pyridones

Comins, D. L., Joseph, S. P., Hong, H., Alawar, R. S., Foti, C. J., Zhang, Y. M., … GuerraWeltzien, M. (1997, March). PURE AND APPLIED CHEMISTRY, Vol. 69, pp. 477–481.

Chiral auxiliary mediated Pictet-Spengler reactions - Asymmetric syntheses of (-)-laudanosine, (+)-glaucine and (-)-xylopinine.

TETRAHEDRON, 53(48), 16327–16340.

Enantiopure N-acyldihydropyridones as synthetic intermediates: Asymmetric syntheses of indolizidine alkaloids (-)-205A, (-)-207A, and (-)-235B

JOURNAL OF ORGANIC CHEMISTRY, 62(23), 8182–8187.

Enantiopure N-acyldihydropyridones as synthetic intermediates: Asymmetric synthesis of (-)-septicine and (-)-tylophorine

JOURNAL OF ORGANIC CHEMISTRY, 62(21), 7435–7438.

Method of making asymmetric DE ring intermediates for the synthesis of camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

Method of making asymmetric DE ring intermediates for the synthesis of camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

14-halo-camptothecins

Washington, DC: U.S. Patent and Trademark Office.

Camptothecin intermediates and method of making camptothecin and comptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

Method of making asymmetric de ring intermediates for the synthesis of camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

Method of making intermediates for camptothecin and its analogs

Washington, DC: U.S. Patent and Trademark Office.

Process for making DE ring intermediates for the synthesis of camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

Pyridinecarboxaldehyde D-ring intermediates useful for the synthesis of camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

Alkoxymethylpyridine d-ring intermediates useful for the synthesis of camptpthecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

Alkylpyridone DE ring intermediates useful for the manufacture of camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

Camptothecin intermediate and method of making camptothecin intermediates

Washington, DC: U.S. Patent and Trademark Office.

Camptothecin intermediates and method of making same

Washington, DC: U.S. Patent and Trademark Office.

Cycloalkyl-based chiral auxiliaries and method making the same

Washington, DC: U.S. Patent and Trademark Office.

D ring intermediates for the synthesis of camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

Method of making intermediates useful for the manufacture of camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

Methods and intermediates for the assymmetric synthesis of camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

Optically pure D,E ring intermediates useful for the synthesis of camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

Intermediates and method of making camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

PYRIDINE-DERIVED TRIFLATING REAGENTS - AN IMPROVED PREPARATION OF VINYL TRIFLATES FROM METALLO ENOLATES

TETRAHEDRON LETTERS, 33(42), 6299–6302.