Daniel L. Comins

Synthesis of MAPA Reagents and 2-Alkyl(aryl)aminopyridines from 2-Bromopyridine Using the Goldberg Reaction

Comins, D. L. (2022, March 11). Molecules.

Preparation of substituted alkoxypyridines via directed metalation and metal-halogen exchange

Bori, I. D., & Comins, D. L. (2021, February 2). ARKIVOC.

Editorial for the Special Issue on Heterocycles

Comins, D., & Ma, D. (2016, November 4). The Journal of Organic Chemistry.

Studies toward the Synthesis of Lepadiformine A

Tsukanov, S. V., Marks, L. R., & Comins, D. L. (2016, September 14). The Journal of Organic Chemistry.

Synthesis of C-4 Substituted Amido Nicotine Derivatives via Copper(I)- and (II)-Catalyzed Cross-Coupling Reactions

Zhu, J., Enamorado, M. F., & Comins, D. L. (2016, October 21). The Journal of Organic Chemistry.

A concise synthesis of the Lycopodium alkaloid cermizine D

Enamorado, M. F., Connelly, C. M., Deiters, A., & Comins, D. L. (2015, April 11). Tetrahedron Letters.

Novel approach toward the morphine skeleton. Synthesis of 1-(5-benzyloxy-2-bromo-4-methoxybenzyl)-6-oxo-3,4,6,7,8,8a-hexahydro-1H-isoquinoline-2-carboxylic acid phenyl ester via N-acylpyridinium salt chemistry

Hiebel, A.-C., & Comins, D. L. (2015, May 9). Tetrahedron.

A Twist on Facial Selectivity of Hydride Reductions of Cyclic Ketones: Twist-Boat Conformers in Cyclohexanone, Piperidone, and Tropinone Reactions

Neufeldt, S. R., Jiménez-Osés, G., Comins, D. L., & Houk, K. N. (2014, November 5). The Journal of Organic Chemistry.

Studies toward the Total Synthesis of Dihydrolycolucine. Preparation of AB and CEF Ring Fragments

Cash, B. M., Prevost, N., Wagner, F. F., & Comins, D. L. (2014, May 19). The Journal of Organic Chemistry.

Total Synthesis of Alkaloid 205B

Tsukanov, S. V., & Comins, D. L. (2014, September 2). The Journal of Organic Chemistry.

Dihydropyridine preparation and application in the synthesis of pyridine derivatives

[Review of ]. Advances in heterocyclic chemistry, vol 110, 110, 175–235.

Studies toward the synthesis of spirolucidine. Preparation of ABC and EF ring fragments

Sahn, J. J., Bharathi, P., & Comins, D. L. (2012, January 9). Tetrahedron Letters.

Concise Total Synthesis of the Frog Alkaloid (−)‐205 B

Tsukanov, S. V., & Comins, D. L. (2011, July 26). Angewandte Chemie International Edition.

Hydrophobic Derivatization of N-linked Glycans for Increased Ion Abundance in Electrospray Ionization Mass Spectrometry

Walker, S. H., Lilley, L. M., Enamorado, M. F., Comins, D. L., & Muddiman, D. C. (2011, May 2). Journal of the American Society for Mass Spectrometry, Vol. 22, pp. 1309–1317.

Identification and replication of loci involved in camptothecin-induced cytotoxicity using CEPH pedigrees

PLoS One, 6(5).

A Five-Step Synthesis of (S)-Macrostomine from (S)-Nicotine

Enamorado, M. F., Ondachi, P. W., & Comins, D. L. (2010, September 22). Organic Letters.

Asymmetric Synthesis of All the Known Phlegmarine Alkaloids

Wolfe, B. H., Libby, A. H., Al-awar, R. S., Foti, C. J., & Comins, D. L. (2010, November 15). The Journal of Organic Chemistry.

Interplay of Permanent Charge and Hydrophobicity in the Electrospray Ionization of Glycans

Walker, S. H., Papas, B. N., Comins, D. L., & Muddiman, D. C. (2010, June 30). Analytical Chemistry, Vol. 82, pp. 6636–6642.

Regiospecific synthesis of nicotine derivatives

Synthesis of Fused-Ring Nicotine Derivatives from (S)-Nicotine

Ondachi, P. W., & Comins, D. L. (2010, February 9). The Journal of Organic Chemistry.

[2 + 2] Photochemical Cycloaddition/Ring Opening of 6-Alkenyl-2,3-dihydro-4-pyridones

Sahn, J. J., & Comins, D. L. (2010, August 31). The Journal of Organic Chemistry.

Chiral amino alcohols derived from (S)-6-chloronicotine as catalysts for asymmetric synthesis

Capracotta, S. S., & Comins, D. L. (2009, February 9). Tetrahedron Letters.

Evaluation of the ALiPHAT method for PC-IDMS and correlation of limits-of-detection with nonpolar surface area

Williams, D. K., Comins, D. L., Whitten, J. L., & Muddiman, D. C. (2009, August 11). Journal of the American Society for Mass Spectrometry, Vol. 20, pp. 2006–2012.

Improving limits of detection for B-type natriuretic peptide using PC-IDMS: An application of the ALiPHAT strategy

Shuford, C. M., Comins, D. L., Whitten, J. L., Burnett, J. C., Jr., & Muddiman, D. C. (2009, November 19). The Analyst, Vol. 135, pp. 36–41.

Increasing the hydrophobicity and electrospray response of glycans through derivatization with novel cationic hydrazides

Bereman, M. S., Comins, D. L., & Muddiman, D. C. (2009, November 18). Chemical Communications, Vol. 46, pp. 237–239.

Synthesis of 1,3-Amino Alcohol Derivatives via a Silicon-Mediated Ring-Opening of Substituted Piperidines

McCall, W. S., & Comins, D. L. (2009, June 11). Organic Letters.

Synthesis of nicotine derivatives from nicotine

N-Acyldihydropyridones as Synthetic Intermediates. A Stereoselective Synthesis of Acyclic Amino Alcohols Containing Multiple Chiral Centers

McCall, W. S., Grillo, T. A., & Comins, D. L. (2008, November 13). The Journal of Organic Chemistry.

Identification of cuticular lipids eliciting interspecific courtship in the German cockroach, Blattella germanica

Eliyahu, D., Nojima, S., Capracotta, S. S., Comins, D. L., & Schal, C. (2008, January 8). Die Naturwissenschaften, Vol. 95, pp. 403–412.

Stereoselective Synthesis of Acyclic Amino Alcohols via von Braun Ring Opening of Chiral Piperidines

McCall, W. S., Grillo, T. A., & Comins, D. L. (2008, June 27). Organic Letters.

Synthesis of nicotine derivatives from nicotine

Washington, DC: U.S. Patent and Trademark Office.

Synthesis, characterization, and application of lodoacetamide derivatives utilized for the ALiPHAT strategy

Journal of the American Chemical Society, Vol. 130, p. 2122-.

Achieving Augmented Limits of Detection for Peptides with Hydrophobic Alkyl Tags

Frahm, J. L., Bori, I. D., Comins, D. L., Hawkridge, A. M., & Muddiman, D. C. (2007, May 4). Analytical Chemistry, Vol. 79, pp. 3989–3995.

Asymmetric Synthesis of C₂-Symmetric Vicinal Diamines via Reductive Dimerization of N-Acylpyridinium and Related Salts

Bharathi, P., & Comins, D. L. (2007, December 20). Organic Letters.

One-pot terminal alkene homologation using a tandem olefin cross-metathesis/allylic carbonate reduction sequence

Comins, D. L., Dinsmore, J. M., & Marks, L. R. (2007, January 1). Chemical Communications.

Recent advances in the synthesis of nicotine and its derivatives

Wagner, F. F., & Comins, D. L. (2007, May 4). Tetrahedron.

Regioselective halogenation of nicotine and substituted nicotines

Washington, DC: U.S. Patent and Trademark Office.

Regiospecific synthesis of nicotine derivatives

Washington, DC: U.S. Patent and Trademark Office.

Synthesis and regioselective substitution of C-6 alkoxy derivatives of (S)-nicotine

Ondachi, P. W., & Comins, D. L. (2007, November 14). Tetrahedron Letters.

Synthesis of the benzo-fused indolizidine alkaloid mimics

Beilstein Journal of Organic Chemistry, 3.

A six-step synthesis of (S)-5-ethenyl-3-(1-methyl-2-pyrrolidinyl)pyridine (SIB-1508Y) from (S)-nicotine

Comins, D. L., & Smith, E. D. (2006, January 10). Tetrahedron Letters.

Expedient Five-Step Synthesis of SIB-1508Y from Natural Nicotine

Wagner, F. F., & Comins, D. L. (2006, October 1). The Journal of Organic Chemistry.

Insecticidal activity and mode of action of novel nicotinoids synthesized by new acylpyridinium salt chemistry and directed lithiation

Stumpf, C. F., Comins, D. L., Sparks, T. C., Donohue, K. V., & Roe, R. M. (2006, August 7). Pesticide Biochemistry and Physiology, Vol. 87, pp. 211–219.

Regioselective 5‐, 4‐, and 2‐Substitution of (S)‐6‐Chloronicotine and 4‐Substitution of (S)‐5‐Chloronicotine

Wagner, F. F., & Comins, D. L. (2006, August 1). European Journal of Organic Chemistry.

Regioselective halogenation of nicotine and substituted nicotines

Washington, DC: U.S. Patent and Trademark Office.

Regiospecific synthesis of nicotine derivatives

Washington, DC: U.S. Patent and Trademark Office.

Short synthesis of pyridine-based pharmaceutical intermediates

Washington, DC: U.S. Patent and Trademark Office.

Six-Step Synthesis of (S)-Brevicolline from (S)-Nicotine

Wagner, F. F., & Comins, D. L. (2006, July 13). Organic Letters.

Synthesis of nicotine derivatives from nicotine

Washington, DC: U.S. Patent and Trademark Office.

Synthetic Studies Toward (−)-FR901483 Using a Conjugate Allylation To Install the C-1 Quaternary Carbon

Gotchev, D. B., & Comins, D. L. (2006, November 3). The Journal of Organic Chemistry.

A Six-Step Asymmetric Synthesis of (+)-Hyperaspine

Comins, D. L., & Sahn, J. J. (2005, October 21). Organic Letters.

Asymmetric synthesis of 3,3-disubstituted isoindolinones

Comins, D. L., & Hiebel, A.-C. (2005, July 7). Tetrahedron Letters.

Diels−Alder Reactions of N-Acyl-2-alkyl(aryl)-5-vinyl-2,3-dihydro-4-pyridones

Comins, D. L., Kuethe, J. T., Miller, T. M., Février, F. C., & Brooks, C. A. (2005, May 25). The Journal of Organic Chemistry.

Regioselective C-2 and C-6 Substitution of (S)-Nicotine and Nicotine Derivatives

Février, F. C., Smith, E. D., & Comins, D. L. (2005, November 1). Organic Letters.

Regioselective lithium–halogen exchange and palladium-catalyzed cross-coupling reactions of 2,4-dihaloquinolines

Comins, D. L., Nolan, J. M., & Bori, I. D. (2005, August 11). Tetrahedron Letters.

Short synthesis of pyridine-based pharmaceutical intermediates

Washington, DC: U.S. Patent and Trademark Office.

Synthesis of C-4 Substituted Nicotine Derivatives via an N-Acylpyridinium Salt of (S)-Nicotine

Comins, D. L., King, L. S., Smith, E. D., & Février, F. C. (2005, September 28). Organic Letters.

Synthesis of Nicotine Derivatives via Reductive Disilylation of (S)-Nicotine

Smith, E. D., Février, F. C., & Comins, D. L. (2005, December 22). Organic Letters.

Tandem Directed Lithiations of N-Boc-1,2-dihydropyridines toward Highly Functionalized 2,3-Dihydro-4-pyridones

Young, D. W., & Comins, D. L. (2005, November 8). Organic Letters.

Addition of Indolyl and Pyrrolyl Grignard Reagents to 1-Acylpyridinium Salts

Kuethe, J. T., & Comins, D. L. (2004, March 9). The Journal of Organic Chemistry.

Asymmetric Synthesis of 3-Substituted Isoindolinones:  Application to the Total Synthesis of (+)-Lennoxamine

Comins, D. L., Schilling, S., & Zhang, Y. (2004, December 15). Organic Letters.

Asymmetric Total Synthesis of (+)-Cannabisativine

Kuethe, J. T., & Comins, D. L. (2004, April 29). The Journal of Organic Chemistry.

Novel heterocyclic systems. Synthesis of 2,7-dimethyl-10-oxa-1,8-diaza-anthracen-9-one and derivatives

Gotchev, D. B., & Comins, D. L. (2004, November 12). Tetrahedron.

Preparation of a camptothecin derivative by intramolecular cyclisation

Washington, DC: U.S. Patent and Trademark Office.

Short synthesis of pyridine-based pharmaceutical intermediates

Washington, DC: U.S. Patent and Trademark Office.

Diels−Alder Reactions of 5-Vinyl-1-acyl-2-aryl-2,3-dihydro-4-pyridones:  Regio- and Stereoselective Synthesis of Octahydroquinolines

Kuethe, J. T., Brooks, C. A., & Comins, D. L. (2003, January 16). Organic Letters.

Preparation of a camptothecin derivative by intramolecular cyclisation

Washington, DC: U.S. Patent and Trademark Office.

Regioselective Sonogashira Couplings of 2,4-Dibromoquinolines. A Correction

Nolan, J. M., & Comins, D. L. (2003, April 2). The Journal of Organic Chemistry.

Short synthesis of pyridine-based pharmaceutical intermediates

Washington, DC: U.S. Patent and Trademark Office.

Tandem Diels–Alder cyclization/aromatization reactions of 5-vinyl-1-acyl-2-aryl-2,3-dihydro-4-pyridones

Kuethe, J. T., & Comins, D. L. (2003, May 1). Tetrahedron Letters.

A Novel Free-Radical Ring Contraction of a Cyclic Carbamate

Williams, A. L., Grillo, T. A., & Comins, D. L. (2002, February 16). The Journal of Organic Chemistry.

Preparation of a camptothecin derivative by intramolecular cyclisation

Washington, DC: U.S. Patent and Trademark Office.

Synthesis and reactions of enantiopure 1-acyl-2- [triaryl(alkyl)silyl]-2,3-dihydro-4-pyridones

Heterocycles, 58(2002 Nov 22), 505–519.

Synthetic applications of chiral 2,3-dihydro-4-pyridones

Current Opinion in Drug Discovery & Development, 5(6), 870–880.

Total Synthesis of the Putative Structure of the Lupin Alkaloid Plumerinine

Comins, D. L., Zheng, X., & Goehring, R. R. (2002, March 26). Organic Letters.

A Practical Six-Step Synthesis of (S)-Camptothecin

Comins, D. L., & Nolan, J. M. (2001, November 22). Organic Letters.

Asymmetric Synthesis of (+)-Deoxoprosopinine

Comins, D. L., Sandelier, M. J., & Grillo, T. A. (2001, September 6). The Journal of Organic Chemistry.

Enantiopure 2,3-Dihydro-4-pyridones as Synthetic Intermediates:  A Concise Asymmetric Synthesis of (+)-Allopumiliotoxin 267A

Comins, D. L., Huang, S., McArdle, C. L., & Ingalls, C. L. (2001, January 10). Organic Letters.

Enantiopure 2,3-dihydro-4-pyridones as synthetic intermediates: asymmetric synthesis of 1-deoxynojirimycin

Comins, D. L., & Fulp, A. B. (2001, September 1). Tetrahedron Letters.

Inter- and intramolecular Horner–Wadsworth–Emmons reactions of 5-(diethoxyphosphoryl)-1-acyl-2-alkyl(aryl)-2,3-dihydro-4-pyridones

Comins, D. L., & Ollinger, C. G. (2001, June 1). Tetrahedron Letters.

Model Studies toward the Total Synthesis of the Lycopodium Alkaloid Spirolucidine

Comins, D. L., & Williams, A. L. (2001, September 11). Organic Letters.

Reduction ofN-Acyl-2,3-dihydro-4-pyridones toN-Acyl-4-piperidones Using Zinc/Acetic Acid

Comins, D. L., Brooks, C. A., & Ingalls, C. L. (2001, February 23). The Journal of Organic Chemistry.

Synthesis and Reactivity of N-Acyl-5- (1-hydroxyalkyl)-2,3-dihydro-4-pyridones

Comins, D. L., Hiebel, A.-C., & Huang, S. (2001, February 14). Organic Letters.

Addition of Metallo Enolates to Chiral 1-Acylpyridinium Salts:  Total Synthesis of (+)-Cannabisativine

Kuethe, J. T., & Comins, D. L. (2000, February 15). Organic Letters.

Asymmetric synthesis of (2S,4R)-4-hydroxypipecolic acid

Brooks, C. A., & Comins, D. L. (2000, May 1). Tetrahedron Letters.

Asymmetric synthesis of erythro- and threo-2-(1-hydroxyalkyl)piperidines via iodocyclocarbamation of 1-acyl-2-alkenyl-1,2,3,6-tetrahydropyridines

Comins, D. L., & Williams, A. L. (2000, April 1). Tetrahedron Letters.

Preparation of a camptothecin derivative by intramolecular cyclisation

Washington, DC: U.S. Patent and Trademark Office.

Total synthesis of (+)-streptazolin

Huang, S., & Comins, D. L. (2000, January 1). Chemical Communications.

Asymmetric Synthesis of the Lycopodium Alkaloid, N_a-Acetyl-N_b-methylphlegmarine

Comins, D. L., Libby, A. H., Al-awar, R. S., & Foti, C. J. (1999, March 6). The Journal of Organic Chemistry.

Asymmetric synthesis and synthetic utility of 2,3‐dihydro‐4‐pyridones

Comins, D. L. (1999, November 1). Journal of Heterocyclic Chemistry.

Asymmetric synthesis of dienomycin C

Comins, D. L., & Green, G. M. (1999, January 1). Tetrahedron Letters.

Diastereoselective Addition of Prochiral Metallo Enolates to Chiral 1-Acylpyridinium Salts

Comins, D. L., Kuethe, J. T., Hong, H., Lakner, F. J., Concolino, T. E., & Rheingold, A. L. (1999, March 1). Journal of the American Chemical Society.

Enantiopure N-Acyldihydropyridones as Synthetic Intermediates:  Asymmetric Synthesis of (−)-Slaframine

Comins, D. L., & Fulp, A. B. (1999, November 12). Organic Letters.

Enantiopure N-Acyldihydropyridones as Synthetic Intermediates:  Asymmetric Synthesis of Benzomorphans

Comins, D. L., Zhang, Y.-mei, & Joseph, S. P. (1999, July 9). Organic Letters.

IMDA/Retro-Mannich Approach to cis-Perhydroquinoline Lycopodium Alkaloids:  Asymmetric Synthesis of (+)-Luciduline

Comins, D. L., Brooks, C. A., Al-awar, R. S., & Goehring, R. R. (1999, June 11). Organic Letters.

The Mukaiyama-Michael Reaction of N-Acyl-2,3-dihydro-4-pyridones:  Regio- and Stereoselective Synthesis of cis-2,6-Disubstituted 1,2,5,6-Tetrahydropyridines

Kuethe, J. T., & Comins, D. L. (1999, September 3). Organic Letters.

C-3 Acetoxylation of N-acyl-2,3-dihydro-4-pyridones

Comins, D. L., Stolze, D. A., Thakker, F., & McArdle, C. L. (1998, August 1). Tetrahedron Letters.

Intramolecular photocycloaddition of a tethered bis-2,3-dihydro-4-pyridone: Stereochemistry and reactivity of the cycloadduct

Comins, D. L., Lee, Y. S., & Boyle, P. D. (1998, January 1). Tetrahedron Letters.

Model Studies toward the Synthesis of Na-Acetyl-Nb-methylphlegmarine: Addition of Cyclohexylmethyl Organometallics to 1-Acylpyridinium Salts

Comins, D. L., Foti, C. J., & Libby, A. H. (1998, January 1). Heterocycles.

Photochemical reactions of chiral 2,3-dihydro-4(1H)-pyridones: asymmetric synthesis of (−)-perhydrohistrionicotoxin

Comins, D. L., Zhang, Y.-mei, & Zheng, X. (1998, January 1). Chemical Communications.

Asymmetric synthesis and synthetic utility of 2,3-dihydro-4-pyridones

Comins, D. L., Joseph, S. P., Hong, H., Al-awar, R. S., Foti, C. J., Zhang, Y.-m., … Guerra-Weltzien, M. (1997, January 1). Pure and Applied Chemistry.

Chiral auxiliary mediated pictet-spengler reactions: Asymmetric syntheses of (−)-laudanosine, (+)-glaucine and (−)-xylopinine

Comins, D. L., Thakker, P. M., Baevsky, M. F., & Badawi, M. M. (1997, December 1). Tetrahedron.

Enantiopure N-Acyldihydropyridones as Synthetic Intermediates:  Asymmetric Syntheses of Indolizidine Alkaloids (−)-205A, (−)-207A, and (−)-235B

Comins, D. L., LaMunyon, D. H., & Chen, X. (1997, November 1). The Journal of Organic Chemistry.

Enantiopure N-Acyldihydropyridones as Synthetic Intermediates:  Asymmetric Synthesis of (−)-Septicine and (−)-Tylophorine

Comins, D. L., Chen, X., & Morgan, L. A. (1997, October 1). The Journal of Organic Chemistry.

Method of making asymmetric DE ring intermediates for the synthesis of camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

Method of making asymmetric DE ring intermediates for the synthesis of camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

14-halo-camptothecins

Washington, DC: U.S. Patent and Trademark Office.

Camptothecin intermediates and method of making camptothecin and comptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

Method of making asymmetric de ring intermediates for the synthesis of camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

Method of making intermediates for camptothecin and its analogs

Washington, DC: U.S. Patent and Trademark Office.