Daniel Comins

Works (121)

2016 journal article

Editorial for the special issue on heterocycles

Journal of Organic Chemistry, 81(21), 10107–10108.

By: D. Comins & D. Ma

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Studies toward the Synthesis of lepadiformine a

Journal of Organic Chemistry, 81(21), 10433–10443.

By: S. Tsukanov, L. Marks & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Synthesis of C-4 substituted amido nicotine derivatives via copper(I)- and (II)-catalyzed cross-coupling reactions

Journal of Organic Chemistry, 81(22), 11529–11534.

By: J. Zhu, M. Enamorado & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

A concise synthesis of the Lycopodium alkaloid cermizine D

Tetrahedron Letters, 56(23), 3683–3685.

By: M. Enamorado, C. Connelly, A. Deiters & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Novel approach toward the morphine skeleton. Synthesis of 1-(5-benzyloxy-2-bromo-4-methoxybenzyl)-6-oxo-3,4,6,7,8,8a-hexahydro-1H- isoquinoline-2-carboxylic acid phenyl ester via N-acylpyridinium salt chemistry

Tetrahedron, 71(39), 7354–7360.

By: A. Hiebel & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

A twist on facial selectivity of hydride reductions of cyclic ketones: Twist-boat conformers in cyclohexanone, piperidone, and tropinone reactions

Journal of Organic Chemistry, 79(23), 11609–11618.

By: S. Neufeldt, G. Jimenez-Oses, D. Comins & K. Houk

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Studies toward the total synthesis of Dihydrolycolucine. Preparation of AB and CEF ring fragments

Journal of Organic Chemistry, 79(12), 5740–5745.

By: B. Cash, N. Prevost, F. Wagner & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Total synthesis of alkaloid 205B

Journal of Organic Chemistry, 79(19), 9074–9085.

By: S. Tsukanov & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2013 review

Dihydropyridine preparation and application in the synthesis of pyridine derivatives

[Review of ]. Advances in heterocyclic chemistry, vol 110, 110, 175–235.

By: D. Comins, K. Higuchi & D. Young

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Studies toward the synthesis of spirolucidine. Preparation of ABC and EF ring fragments

Tetrahedron Letters, 53(11), 1347–1350.

By: J. Sahn, P. Bharathi & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Concise total synthesis of the frog alkaloid (-)-205b

Angewandte Chemie [International Edition in English], 50(37), 8626–8628.

By: S. Tsukanov & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Hydrophobic derivatization of N-linked glycans for increased ion abundance in electrospray ionization mass spectrometry

Journal of the American Society for Mass Spectrometry, 22(8), 1309–1317.

By: S. Walker, L. Lilley, M. Enamorado, D. Comins & D. Muddiman

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Identification and replication of loci involved in camptothecin-induced cytotoxicity using CEPH pedigrees

PLoS One, 6(5).

By: V. Watson, A. Motsinger-Reif, N. Hardison, E. Peters, T. Havener, L. Everitt, J. Auman, D. Comins, H. McLeod

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

A five-step synthesis of (S)-macrostomine from (S)-nicotine

Organic Letters, 12(20), 4513–4515.

By: M. Enamorado, P. Ondachi & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Asymmetric synthesis of all the known phlegmarine alkaloids

Journal of Organic Chemistry, 75(24), 8564–8570.

By: B. Wolfe, A. Libby, R. Al-Awar, C. Foti & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Improving limits of detection for B-type natriuretic peptide using PC-IDMS: An application of the ALiPHAT strategy

Analyst [London], 135(1), 36–41.

By: C. Shuford, D. Comins, J. Whitten, J. Burnett & D. Muddiman

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Increasing the hydrophobicity and electrospray response of glycans through derivatization with novel cationic hydrazides

Chemical Communications (Cambridge, England), 46(2), 237–239.

By: M. Bereman, D. Comins & D. Muddiman

Source: NC State University Libraries
Added: August 6, 2018

2010 conference paper

Interplay of permanent charge and hydrophobicity in the electrospray ionization of glycans

Analytical Chemistry, 82(15), 6636–6642.

By: S. Walker, B. Papas, D. Comins & D. Muddiman

Source: NC State University Libraries
Added: August 6, 2018

2010 patent

Regiospecific synthesis of nicotine derivatives

By: L. King, E. Smith & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Synthesis of fused-ring nicotine derivatives from (S)-nicotine

Journal of Organic Chemistry, 75(5), 1706–1716.

By: P. Ondachi & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

[2+2] photochemical cycloaddition/ring opening of 6-alkenyl-2,3-dihydro-4-pyridones

Journal of Organic Chemistry, 75(19), 6728–6731.

By: J. Sahn & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Chiral amino alcohols derived from (S)-6-chloronicotine as catalysts for asymmetric synthesis

Tetrahedron Letters, 50(16), 1806–1808.

By: S. Capracotta & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Evaluation of the ALiPHAT method for PC-IDMS and correlation of limits-of-detection with nonpolar surface area

Journal of the American Society for Mass Spectrometry, 20(11), 2006–2012.

By: D. Williams, D. Comins, J. Whitten & D. Muddiman

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Synthesis of 1,3-amino alcohol derivatives via a silicon-mediated ring-opening of substituted piperidines

Organic Letters, 11(13), 2940–2942.

By: W. McCall & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2009 patent

Synthesis of nicotine derivatives from nicotine

By: D. Comins & E. Smith

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Asymmetric synthesis of C-2-symmetric vicinal diamines via reductive dimerization of N-acylpyridinium and related salts

Organic Letters, 10(2), 221–223.

By: P. Bharathi & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Identification of cuticular lipids eliciting interspecific courtship in the German cockroach, Blattella germanica

Naturwissenschaften (Berlin, Germany), 95(5), 403–412.

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

N-acyldihydropyridones as synthetic intermediates. A stereoselective synthesis of acyclic amino alcohols containing multiple chiral centers

Journal of Organic Chemistry, 73(24), 9744–9751.

By: W. McCall, T. Grillo & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Stereoselective synthesis of acyclic amino alcohols via von Braun ring opening of chiral piperidines

Organic Letters, 10(15), 3255–3257.

By: W. McCall, T. Grillo & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Synthesis and regioselective substitution of C-6 alkoxy derivatives of (S)-nicotine

Tetrahedron Letters, 49(3), 569–572.

By: P. Ondachi & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2008 patent

Synthesis of nicotine derivatives from nicotine

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins & S. D.

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Synthesis, characterization, and application of lodoacetamide derivatives utilized for the ALiPHAT strategy

Journal of the American Chemical Society, 130(7), 2122-.

By: D. Williams, C. Meadows, I. Bori, A. Hawkridge, D. Comins & D. Muddiman

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Achieving augmented limits of detection for peptides with hydrophobic alkyl tags

Analytical Chemistry, 79(11), 3989–3995.

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Insecticidal activity and mode of action of novel nicotinoids synthesized by new acylpyridinium salt chemistry and directed lithiation

Pesticide Biochemistry and Physiology, 87(3), 211–219.

By: C. Stumpf, D. Comins, T. Sparks, K. Donohue & R. Roe

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

One-pot terminal alkene homologation using a tandem olefin cross-metathesis/allylic carbonate reduction sequence

Chemical Communications (Cambridge, England), (40), 4170–4171.

By: D. Comins, J. Dinsmore & L. Marks

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Recent advances in the synthesis of nicotine and its derivatives

Tetrahedron, 63(34), 8065–8082.

By: F. Wagner & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2007 patent

Regioselective halogenation of nicotine and substituted nicotines

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins, F. Fevrier & E. Smith

Source: NC State University Libraries
Added: August 6, 2018

2007 patent

Regiospecific synthesis of nicotine derivatives

Washington, DC: U.S. Patent and Trademark Office.

By: L. King, E. Smith & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Synthesis of the benzo-fused indolizidine alkaloid mimics

Beilstein Journal of Organic Chemistry, 3.

By: D. Comins & K. Higuchi

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

A six-step synthesis of (S)-5-ethenyl-3-(1-methy1-2-pyrrolidinyl)pyridine (SIB-1508Y) from (S)-nicotine

Tetrahedron Letters, 47(9), 1449–1451.

By: D. Comins & E. Smith

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Expedient five-step synthesis of SIB-1508Y from natural nicotine

Journal of Organic Chemistry, 71(22), 8673–8675.

By: F. Wagner & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Regioselective 5-, 4-, and 2-substitution of (S)-6-chloronicotine and 4-substitution of (S)-5-chloronicotine

European Journal of Organic Chemistry, (16), 3562–3565.

By: F. Wagner & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2006 patent

Regioselective halogenation of nicotine and substituted nicotines

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins, F. Fevrier & E. Smith

Source: NC State University Libraries
Added: August 6, 2018

2006 patent

Regiospecific synthesis of nicotine derivatives

Washington, DC: U.S. Patent and Trademark Office.

By: L. King, E. Smith & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2006 patent

Short synthesis of pyridine-based pharmaceutical intermediates

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins & S. Huang

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Six-step synthesis of (S)-brevicolline from (S)-nicotine

Organic Letters, 8(16), 3549–3552.

By: F. Wagner & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2006 patent

Synthesis of nicotine derivatives from nicotine

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins & E. Smith

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Synthesis of nicotine derivatives via reductive disilylation of (S)-nicotine

Organic Letters, 8(2), 179–182.

By: E. Smith, F. Fevrier & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Synthetic studies toward (-)-FR901483 using a conjugate allylation to install the C-1 quaternary carbon

Journal of Organic Chemistry, 71(25), 9393–9402.

By: D. Gotchev & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

A six-step asymmetric synthesis of (+)-hyperaspine

Organic Letters, 7(23), 5227–5228.

By: D. Comins & J. Sahn

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Asymmetric synthesis of 3,3-disubstituted isoindolinones

Tetrahedron Letters, 46(34), 5639–5642.

By: D. Comins & A. Hiebel

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Asymmetric synthesis of 3-substituted isoindolinones: Application to the total synthesis of (+)-lennoxamine

Organic Letters, 7(1), 95–98.

By: D. Comins, S. Schilling & Y. Zhang

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Diels-alder reactions of N-acyl-2-alkyl(aryl)-5-vinyl-2,3-dihydro-4-pyridones

Journal of Organic Chemistry, 70(13), 5221–5234.

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Regioselective C-2 and C-6 substitution of (S)-nicotine and nicotine derivatives

Organic Letters, 7(24), 5457–5460.

By: F. Fevrier, E. Smith & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Regioselective lithium-halogen exchange and palladium-catalyzed cross-coupling reactions of 2,4-dihaloquinolines

Tetrahedron Letters, 46(39), 6697–6699.

By: D. Comins, J. Nolan & I. Bori

Source: NC State University Libraries
Added: August 6, 2018

2005 patent

Short synthesis of pyridine-based pharmaceutical intermediates

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins & S. Huang

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Synthesis of C-4 substituted nicotine derivatives via an N-acylpyridinium salt of (S)-nicotine

Organic Letters, 7(22), 5059–5062.

By: D. Comins, L. King, E. Smith & F. Fevrier

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Tandem directed lithiations of N-boc-1,2-hydropyridines toward highly functionalized 2,3-dihydro-4-pyridones

Organic Letters, 7(25), 5661–5664.

By: D. Young & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Addition of indolyl and pyrrolyl grignard reagents to 1-acylpyridinium salts

Journal of Organic Chemistry, 69(8), 2863–2866.

By: J. Kuethe & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Asymmetric total synthesis of (+)-cannabisativine

Journal of Organic Chemistry, 69(16), 5219–5231.

By: J. Kuethe & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Novel heterocyclic systems. Synthesis of 2,7-dimethyl-10-oxa-1,8-diaza-anthracen-9-one and derivatives

Tetrahedron, 60(51), 11751–11758.

By: D. Gotchev & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2004 patent

Preparation of a camptothecin derivative by intramolecular cyclisation

Washington, DC: U.S. Patent and Trademark Office.

By: F. Fang, E. Huie, S. Xie & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2004 patent

Short synthesis of pyridine-based pharmaceutical intermediates

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins & S. Huang

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Diels-Alder reactions of 5-vinyl-1-acyl-2-aryl-2,3-dihydro-4- pyridones: regio- and stereoselective synthesis of octahydroquinolines

Organic Letters, 5(3), 321–323.

By: J. Kuethe, C. Brooks & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2003 patent

Preparation of a camptothecin derivative by intramolecular cyclisation

Washington, DC: U.S. Patent and Trademark Office.

By: F. Fang, E. Huie, S. Xie & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Regioselective Sonogashira couplings of 2,4-dibromoquinolines. A correction

Journal of Organic Chemistry, 68(9), 3736–3738.

By: J. Nolan & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2003 patent

Short synthesis of pyridine-based pharmaceutical intermediates

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins & S. Huang

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Tandem Diels-Alder cyclization/aromatization reactions of 5- vinyl-1-acyl-2-aryl-2,3-dihydro-4-pyridones

Tetrahedron Letters, 44(22), 4179–4182.

By: J. Kuethe & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

A novel free-radical ring contraction of a cyclic carbamate

Journal of Organic Chemistry, 67(6), 1972–1973.

By: A. Williams, T. Grillo & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2002 patent

Preparation of a camptothecin derivative by intramolecular cyclisation

Washington, DC: U.S. Patent and Trademark Office.

By: F. Fang, E. Huie, S. Xie & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Synthesis and reactions of enantiopure 1-acyl-2- [triaryl(alkyl)silyl]-2,3-dihydro-4-pyridones

Heterocycles, 58(2002 Nov 22), 505–519.

By: D. Comins, M. Killpack, E. Despagnet & E. Zeller

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Synthetic applications of chiral 2,3-dihydro-4-pyridones

Current Opinion in Drug Discovery & Development, 5(6), 870–880.

By: S. Joseph & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Total synthesis of the putative structure of the lupin alkaloid plumerinine

Organic Letters, 4(9), 1611–1613.

By: D. Comins, X. Zheng & R. Goehring

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

A practical six-step synthesis of (S)-camptothecin

Organic Letters, 3(26), 4255–4257.

By: D. Comins & J. Nolan

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Asymmetric synthesis of (+)-deoxoprosopinine

Journal of Organic Chemistry, 66(20), 6829–6832.

By: D. Comins, M. Sandelier & T. Grillo

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Enantiopure 2,3-dihydro-4-pyridones as synthetic intermediates: A concise asymmetric synthesis of (+)-allopumiliotoxin 267A

Organic Letters, 3(3), 469–471.

By: D. Comins, S. Huang, C. Mcardle & C. Ingalls

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Enantiopure 2,3-dihydro-4-pyridones as synthetic intermediates: asymmetric synthesis of 1-deoxynojirimycin

Tetrahedron Letters, 42(39), 6839–6841.

By: D. Comins & A. Fulp

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Inter- and intramolecular Horner-Wadsworth-Emmons reactions of 5-(diethoxyphosphoryl)-1-acyl-2-alkyl(aryl)-2,3-dihydro-4-pyridones

Tetrahedron Letters, 42(25), 4115–4118.

By: D. Comins & C. Ollinger

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Model studies toward the total synthesis of the Lycopodium alkaloid Spirolucidine

Organic Letters, 3(20), 3217–3220.

By: D. Comins & A. Williams

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Reduction of N-acyl-2,3-dihydro-4-pyridones to N-acyl-4-piperidones using zinc/acetic acid

Journal of Organic Chemistry, 66(6), 2181–2182.

By: D. Comins, C. Brooks & C. Ingalls

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Synthesis and reactivity of N-acyl-5-(1-hydroxyalkyl)-2,3-dihydro-4-pyridones

Organic Letters, 3(5), 769–771.

By: D. Comins, A. Hiebel & S. Huang

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Addition of metallo enolates to chiral 1-acylpyridinium salts: Total synthesis of (+)-cannabisativine

Organic Letters, 2(6), 855–857.

By: J. Kuethe & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Asymmetric synthesis of (2S,4R)-4-hydroxypipecolic acid

Tetrahedron Letters, 41(19), 3551–3553.

By: C. Brooks & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Asymmetric synthesis of erythro- and threo-2-(1- hydroxyalkyl)piperidines via iodocyclocarbamation of 1-acyl-2- alkenyl-1,2,3,6-tetrahydropyridines

Tetrahedron Letters, 41(16), 2839–2842.

By: D. Comins & A. Williams

Source: NC State University Libraries
Added: August 6, 2018

2000 patent

Preparation of a camptothecin derivative by intramolecular cyclisation

Washington, DC: U.S. Patent and Trademark Office.

By: F. Fang, E. Huie, S. Xie & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Total synthesis of (+)-streptazolin

Chemical Communications (Cambridge, England), (7), 569–570.

By: S. Huang & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Asymmetric synthesis and synthetic utility of 2,3-dihydro-4- pyridones

Journal of Heterocyclic Chemistry, 36(6), 1491–1500.

By: D. Comins

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Asymmetric synthesis of dienomycin C

Tetrahedron Letters, 40(2), 217–218.

By: D. Comins & G. Green

Source: NC State University Libraries
Added: August 6, 2018

1999 personal communication

Asymmetric synthesis of the Lycopodium alkaloid, N-a-acetyl-N- b-methylphlegmarine

By: D. Comins, A. Libby, R. Al-Awar & C. Foti

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Diastereoselective addition of prochiral metallo enolates to chiral 1-acylpyridinium salts

Journal of the American Chemical Society, 121(11), 2651–2652.

By: D. Comins, J. Kuethe, H. Hong, F. Lakner, T. Concolino & A. Rheingold

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Enantiopure N-acyldihydropyridones as synthetic intermediates: Asymmetric synthesis of (-)-slaframine

Organic Letters, 1(12), 1941–1943.

By: D. Comins & A. Fulp

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Enantiopure N-acyldihydropyridones as synthetic intermediates: Asymmetric synthesis of benzomorphans

Organic Letters, 1(4), 657–659.

By: D. Comins, Y. Zhang & S. Joseph

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

IMDA/retro-Mannich approach to cis-perhydroquinoline Lycopodiumalkaloids: Asymmetric synthesis of (+)-luciduline

Organic Letters, 1(2), 229–231.

By: D. Comins, C. Brooks, R. Al-Awar & R. Goehring

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

The Mukaiyama-Michael reaction of N-acyl-2,3-dihydro-4- pyridones: Regio- and stereoselective synthesis of cis-2,6- disubstituted 1,2,5,6-tetrahydropyridines

Organic Letters, 1(7), 1031–1033.

By: J. Kuethe & D. Comins

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

C-3 acetoxylation of N-acyl-2,3-dihydro-4-pyridones

Tetrahedron Letters, 39(32), 5693–5696.

By: D. Comins, D. Stolze, P. Thakker & C. McArdle

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Intramolecular photocycloaddition of a tethered Bis-2,3-dihydro-4-pyridone: Stereochemistry and reactivity of the cycloadduct

Tetrahedron Letters, 39(3-4), 187–190.

By: D. Comins, Y. Lee & P. Boyle

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Model studies toward the synthesis of N alpha-acetyl-N beta- methylphlegmarine: Addition of cyclohexylmethyl organometallics to 1-acylpyridinium salts

Heterocycles, 48(7), 1313–1317.

By: D. Comins, C. Foti & A. Libby

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Photochemical reactions of chiral 2,3-dihydro-4(1H)-pyridones: asymmetric synthesis of (-)-perhydrohistrionicotoxin

Chemical Communications (Cambridge, England), (22), 2509–2510.

By: D. Comins, Y. Zhang & X. Zheng

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Asymmetric synthesis and synthetic utility of 2,3-dihydro-4-pyridones

Pure and Applied Chemistry, 69(3), 477–481.

By: D. Comins, S. Joseph, H. Hong, R. Al-Awar, C. Foti, Y. Zhang, X. Chen, D. Lamunyon, M. Guerra-Weltzien

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Chiral auxiliary mediated Pictet-Spengler reactions: asymmetric syntheses of (-)-laudanosine, (+)-Glaucine and (-)-xylopinine

Tetrahedron, 53(48), 16327–16340.

By: D. Comins, P. Thakker, M. Baevsky & M. Badawi

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Enantiopure N-acyldihydropyridones as synthetic intermediates: Asymmetric syntheses of indolizidine alkaloids (-)-205a, (-)-207a, and (-)-235b

Journal of Organic Chemistry, 62(23), 8182–8187.

By: D. Comins, D. Lamunyon & X. Chen

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Enantiopure N-acyldihydropyridones as synthetic intermediates: Asymmetric synthesis of (-)-septicine and (-)-tylophorine

Journal of Organic Chemistry, 62(21), 7435–7438.

By: D. Comins, X. Chen & L. Morgan

Source: NC State University Libraries
Added: August 6, 2018

1996 patent

Method of making asymmetric DE ring intermediates for the synthesis of camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins

Source: NC State University Libraries
Added: August 6, 2018

1996 patent

Method of making asymmetric DE ring intermediates for the synthesis of camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins

Source: NC State University Libraries
Added: August 6, 2018

1995 patent

14-halo-camptothecins

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins

Source: NC State University Libraries
Added: August 6, 2018

1995 patent

Camptothecin intermediates and method of making camptothecin and comptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins & M. Baevsky

Source: NC State University Libraries
Added: August 6, 2018

1995 patent

Method of making asymmetric de ring intermediates for the synthesis of camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins

Source: NC State University Libraries
Added: August 6, 2018

1995 patent

Method of making intermediates for camptothecin and its analogs

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins & M. Baevsky

Source: NC State University Libraries
Added: August 6, 2018

1994 patent

Process for making DE ring intermediates for the synthesis of camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins & M. Baesky

Source: NC State University Libraries
Added: August 6, 2018

1994 patent

Pyridinecarboxaldehyde D-ring intermediates useful for the synthesis of camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins & M. Baevsky

Source: NC State University Libraries
Added: August 6, 2018

1993 patent

Alkoxymethylpyridine d-ring intermediates useful for the synthesis of camptpthecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins & M. Baesky

Source: NC State University Libraries
Added: August 6, 2018

1993 patent

Alkylpyridone DE ring intermediates useful for the manufacture of camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins & M. Baesky

Source: NC State University Libraries
Added: August 6, 2018

1993 patent

Camptothecin intermediate and method of making camptothecin intermediates

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins & M. Baesky

Source: NC State University Libraries
Added: August 6, 2018

1993 patent

Camptothecin intermediates and method of making same

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins & M. Baesky

Source: NC State University Libraries
Added: August 6, 2018

1993 patent

Cycloalkyl-based chiral auxiliaries and method making the same

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins & J. Salvador

Source: NC State University Libraries
Added: August 6, 2018

1993 patent

D ring intermediates for the synthesis of camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins & M. Baevsky

Source: NC State University Libraries
Added: August 6, 2018

1993 patent

Method of making intermediates useful for the manufacture of camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins & M. Baesky

Source: NC State University Libraries
Added: August 6, 2018

1993 patent

Methods and intermediates for the assymmetric synthesis of camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins & M. Baesky

Source: NC State University Libraries
Added: August 6, 2018

1993 patent

Optically pure D,E ring intermediates useful for the synthesis of camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins & M. Baesky

Source: NC State University Libraries
Added: August 6, 2018

1992 patent

Intermediates and method of making camptothecin and camptothecin analogs

Washington, DC: U.S. Patent and Trademark Office.

By: D. Comins & M. Baesky

Source: NC State University Libraries
Added: August 6, 2018

1992 journal article

Pyridine-derived triflating reagents - an improved preparation of vinyl triflates from metallo enolates

Tetrahedron Letters, 33(42), 6299–6302.

By: D. Comins & A. Dehghani

Source: NC State University Libraries
Added: August 6, 2018