Dianne Little

Works (19)

Updated: March 10th, 2025 12:15

2009 article

Osseous cyst‐like lesions of the lateral intertubercular groove of the proximal humerus: A report of 5 cases

Little, D., Redding, W. R., & Gerard, M. P. (2009, January 24). Equine Veterinary Education, Vol. 21, pp. 60–66.

By: D. Little n, W. Redding n & M. Gerard n 

author keywords: horse; lameness; bicipital bursa; humerus; osseous cyst
topics (OpenAlex): Veterinary Equine Medical Research; Shoulder Injury and Treatment; Tribology and Lubrication Engineering
TL;DR: OCLL of the lateral intertubercular groove of the proximal humerus should be considered in the evaluation of any mature horse with lameness isolated to the bicipital bursa. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Analysis of Sodium Carboxymethylcellulose Administration and Related Factors Associated with Postoperative Colic and Survival in Horses with Small Intestinal Disease

Veterinary Surgery, 37(6), 558–563.

By: C. Fogle n , M. Gerard n, Y. Elce n, D. Little n, A. Morton n, M. Correa n, A. Blikslager n 

Contributors: C. Fogle n , M. Gerard n, Y. Elce n, D. Little n, A. Morton n, M. Correa n, A. Blikslager n 

MeSH headings : Animals; Carboxymethylcellulose Sodium / therapeutic use; Colic / prevention & control; Colic / surgery; Colic / veterinary; Female; Horse Diseases / mortality; Horse Diseases / surgery; Horses; Kaplan-Meier Estimate; Male; Postoperative Complications / drug therapy; Postoperative Complications / epidemiology; Postoperative Complications / mortality; Postoperative Complications / veterinary; Proportional Hazards Models; Retrospective Studies; Risk Factors; Time Factors; Tissue Adhesions / prevention & control; Tissue Adhesions / veterinary
topics (OpenAlex): Veterinary Equine Medical Research; Veterinary Pharmacology and Anesthesia; Reproductive Physiology in Livestock
TL;DR: CBMC administration is seemingly protective against death and prolongs survival when used intraoperatively in horses with small intestine disease, particularly horses with postoperative colic or POI, both of which increased risk of death after surgery. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

Cyclooxygenase (COX) Inhibitors and the Intestine

Journal of Veterinary Internal Medicine, 21(3), 367–377.

By: D. Little n, S. Jones n  & A. Blikslager n 

topics (OpenAlex): Inflammatory mediators and NSAID effects; Eicosanoids and Hypertension Pharmacology; Estrogen and related hormone effects
TL;DR: The major noncyclooxygenase targets of the COX inhibitors of particular relevance to inflammation and the gastrointestinal tract are phosphatidylinositol 3'-kinase Akt signaling, uncoupling of oxidative phosphorylation, PPARgamma, nuclear factor KB, mitogen activated protein kinases, and heat shock proteins. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Sources: NC State University Libraries, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2007 journal article

Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunum

American Journal of Veterinary Research, 68(6), 614–624.

By: D. Little n, S. Brown, N. Campbell*, A. Moeser*, J. Davis* & A. Blikslager* 

Contributors: D. Little n, S. Brown, N. Campbell*, A. Moeser*, J. Davis* & A. Blikslager* 

MeSH headings : Animals; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Clonixin / therapeutic use; Cyclooxygenase Inhibitors / pharmacokinetics; Cyclooxygenase Inhibitors / therapeutic use; Horse Diseases / drug therapy; Horses; Intestinal Diseases / drug therapy; Intestinal Diseases / veterinary; Ischemia / veterinary; Jejunum / injuries; Meloxicam; Thiazines / pharmacokinetics; Thiazines / therapeutic use; Thiazoles / pharmacokinetics; Thiazoles / therapeutic use
topics (OpenAlex): Veterinary Equine Medical Research; Inflammatory mediators and NSAID effects; Veterinary Pharmacology and Anesthesia
TL;DR: It is suggested that IV administration of meloxicam may be a useful alternative to flunixin meglumine for postoperative treatment of horses with colic. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2006 journal article

Mucosal permeability of water-soluble drugs in the equine jejunum: a preliminary investigation

Journal of Veterinary Pharmacology and Therapeutics, 29(5), 379–385.

By: J. Davis n, D. Little n, A. Blikslager n  & M. Papich* 

Contributors: J. Davis n, D. Little n, A. Blikslager n  & M. Papich* 

MeSH headings : Animals; Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacokinetics; Anti-Infective Agents / pharmacology; Biological Availability; Cephalexin / chemistry; Cephalexin / pharmacokinetics; Fluconazole / chemistry; Fluconazole / pharmacokinetics; Fluoroquinolones / chemistry; Fluoroquinolones / pharmacokinetics; Horses; Intestinal Mucosa / drug effects; Jejunum / metabolism; Linear Models; Metronidazole / chemistry; Metronidazole / pharmacokinetics; Permeability / drug effects; Quinolones / chemistry; Quinolones / pharmacokinetics; Solubility
topics (OpenAlex): Drug Transport and Resistance Mechanisms; Drug Solubulity and Delivery Systems; Advanced Drug Delivery Systems
TL;DR: The Ussing chamber is a promising method for determining mucosal permeability in the horse and the low permeability of cephalexin across the tissue may indicate a lack of active transporters that are found in other species. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2006 article

Pyrantel pamoate resistance in horses receiving daily administration of pyrantel tartrate

Brazik, E. L., Luquire, J. T., & Little, D. (2006, January 1). Journal of the American Veterinary Medical Association.

By: E. Brazik*, J. Luquire & D. Little*

MeSH headings : Administration, Oral; Animals; Anthelmintics / administration & dosage; Anthelmintics / therapeutic use; Drug Resistance; Feces / parasitology; Female; Horse Diseases / drug therapy; Horses; Male; Parasite Egg Count / veterinary; Parasitic Sensitivity Tests / veterinary; Pyrantel Pamoate / administration & dosage; Pyrantel Pamoate / therapeutic use; Pyrantel Tartrate / administration & dosage; Pyrantel Tartrate / therapeutic use; Treatment Outcome
topics (OpenAlex): Helminth infection and control; Veterinary Equine Medical Research; Coccidia and coccidiosis research
TL;DR: Fecal worm egg count reduction was calculated for each horse and should be monitored routinely in horses before and after treatment to ensure efficacy of cyathostome control measures. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig

American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(1), G173–G181.

By: A. Moeser*, C. Klok n, K. Ryan n, J. Wooten n, D. Little n, V. Cook n, A. Blikslager n 

Contributors: A. Moeser*, C. Klok n, K. Ryan n, J. Wooten n, D. Little n, V. Cook n, A. Blikslager n 

author keywords: barrier function; secretion
MeSH headings : Animals; Colon / physiopathology; Disease Models, Animal; Female; Jejunum / physiopathology; Male; Maternal Behavior; Muscle, Smooth / physiopathology; Signal Transduction; Stress, Psychological / physiopathology; Swine; Weaning
topics (OpenAlex): Gastrointestinal motility and disorders; Diet and metabolism studies; Stress Responses and Cortisol
TL;DR: The results indicate that weaning stress induces mucosal dysfunction mediated by intestinal CRF receptors and activated by enteric nerves and prostanoid pathways. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2005 article

Detection of differentially regulated genes in ischaemic equine intestinal mucosa

TSCHETTER, J. R., BLIKSLAGER, A. T., LITTLE, D., HOWARD, R. D., WOODY, S. L., BEEX, L. M., & CRISMAN, M. V. (2005, July 1). Equine Veterinary Journal, Vol. 37, pp. 319–324.

By: J. Tschetter *, A. Blikslager n , D. Little n, R. Howard*, S. Woody*, L. Beex*, M. Crisman *

author keywords: horse; equine; ischaemia; gene expression
MeSH headings : Animals; Base Sequence; Blotting, Northern / veterinary; Cloning, Molecular; Colic / etiology; Colic / veterinary; Gene Expression Profiling; Gene Expression Regulation; Gene Library; Horse Diseases / genetics; Horses; Immunoblotting / veterinary; Intestinal Mucosa / blood supply; Intestinal Mucosa / metabolism; Ischemia / genetics; Ischemia / veterinary; Jejunum / blood supply; Male; RNA / metabolism
topics (OpenAlex): Veterinary Equine Medical Research; Natural product bioactivities and synthesis; Genomics and Phylogenetic Studies
TL;DR: These initial results have identified a pool of equine intestinal epithelial genes that are differentially expressed following a 2 h ischaemic event, and genes indicative of deranged metabolic activity and those potentially involved in early repair events were identified. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 article

Faecal bile loss in horses following small intestinal resection

LITTLE, D., WHITE, C. E., YOUNG, K. M., & BLIKSLAGER, A. T. (2005, January 1). Equine Veterinary Journal.

By: D. Little n, C. White n, K. Young n & A. Blikslager n 

author keywords: horse; small intestine; resection; bile; faeces
MeSH headings : Analysis of Variance; Animals; Bile Acids and Salts / analysis; Colic / metabolism; Colic / surgery; Colic / veterinary; Feces / chemistry; Horse Diseases / metabolism; Horse Diseases / surgery; Horses; Intestine, Small / surgery
topics (OpenAlex): Drug Transport and Resistance Mechanisms; Veterinary Equine Medical Research; Plant Toxicity and Pharmacological Properties
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Source: Web Of Science
Added: August 6, 2018

2005 article

Post operative neutrophilic inflammation in equine small intestine after manipulation and ischaemia

LITTLE, D., TOMLINSON, J. E., & BLIKSLAGER, A. T. (2005, July 1). Equine Veterinary Journal, Vol. 37, pp. 329–335.

By: D. Little n, J. Tomlinson n & A. Blikslager n 

MeSH headings : Analysis of Variance; Animals; Horse Diseases / immunology; Horses; Ileus / immunology; Ileus / veterinary; Immunohistochemistry / veterinary; Ischemia / immunology; Ischemia / veterinary; Jejunum / blood supply; Jejunum / pathology; Leukocyte L1 Antigen Complex / metabolism; Neutrophil Infiltration; Neutrophils / metabolism; Neutrophils / physiology; Postoperative Complications / immunology; Postoperative Complications / veterinary; Postoperative Period; Random Allocation
topics (OpenAlex): Enhanced Recovery After Surgery; Anesthesia and Pain Management; Cardiac, Anesthesia and Surgical Outcomes
TL;DR: This neutrophilic inflammation coincides with the clinical time point at which POI is identified and may indicate that inflammatory pathways, rather than solely neurogenic pathways, are responsible for POI in the horse. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 article

ClC-2 chloride secretion mediates prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum

Moeser, A. J., Haskell, M. M., Shifflett, D. E., Little, D., Schultz, B. D., & Blikslager, A. T. (2004, September 1). Gastroenterology, Vol. 127, pp. 802–815.

By: A. Moeser n, M. Haskell n, D. Shifflett n, D. Little n, B. Schultz* & A. Blikslager n 

Contributors: A. Moeser n, M. Haskell n, D. Shifflett n, D. Little n, B. Schultz* & A. Blikslager n 

MeSH headings : Animals; CLC-2 Chloride Channels; Chloride Channels / metabolism; Chlorides / metabolism; Dinoprostone / pharmacology; Electric Impedance; Female; Ileum / blood supply; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Mucosa / physiopathology; Ischemia / metabolism; Ischemia / physiopathology; Male; Models, Animal; Permeability / drug effects; Prostaglandins / pharmacology; Recovery of Function / drug effects; Recovery of Function / physiology; Swine
topics (OpenAlex): Barrier Structure and Function Studies; Neuroscience and Neuropharmacology Research; Ion Transport and Channel Regulation
TL;DR: ClC-2-mediated intestinal Cl - secretion restores TER in ischemia-injured intestine and may provide the basis for targeted pharmacologic therapy for diseases associated with impaired barrier function. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2003 article

Management of drug‐resistant cyathostominosis on a breeding farm in central North Carolina

LITTLE, D., FLOWERS, J. R., HAMMERBERG, B. H., & GARDNER, S. Y. (2003, May 1). Equine Veterinary Journal.

By: D. Little n, J. Flowers n, B. Hammerberg n & S. Gardner n

author keywords: horse; cyathostome; resistant; benzimidazole; pyrantel
MeSH headings : Animals; Antinematodal Agents / pharmacology; Antinematodal Agents / therapeutic use; Drug Resistance; Drug Resistance, Multiple; Feces / parasitology; Female; Fenbendazole / pharmacology; Fenbendazole / therapeutic use; Horses; Intestinal Diseases, Parasitic / drug therapy; Intestinal Diseases, Parasitic / parasitology; Intestinal Diseases, Parasitic / veterinary; Ivermectin / pharmacology; Ivermectin / therapeutic use; North Carolina; Parasite Egg Count / veterinary; Parasitic Sensitivity Tests / veterinary; Pyrantel / pharmacology; Pyrantel / therapeutic use; Strongyle Infections, Equine / drug therapy; Strongyle Infections, Equine / parasitology; Strongyloidea / drug effects; Treatment Outcome
topics (OpenAlex): Helminth infection and control; Plant and fungal interactions; Coccidia and coccidiosis research
TL;DR: Targeted ivermectin treatment may be an economically viable method of managing multiple drug resistant cyathostome infection in consecutive foal crops and should be monitored closely for development of resistance. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

PI3K signaling is required for prostaglandin-induced mucosal recovery in ischemia-injured porcine ileum

American Journal of Physiology-Gastrointestinal and Liver Physiology, 284(1), G46–G56.

By: D. Little*, R. Dean* , K. Young*, S. McKane n, L. Martin n, S. Jones* , A. Blikslager* 

author keywords: phosphatidylinositol 3-kinase; tight junction; occludin; zonula occludens-1
MeSH headings : 16,16-Dimethylprostaglandin E2 / pharmacology; Animals; Anti-Ulcer Agents / pharmacology; Electric Impedance; Epoprostenol / analogs & derivatives; Epoprostenol / pharmacology; Female; Humans; Ileum / metabolism; Intestinal Mucosa / enzymology; Intestinal Mucosa / ultrastructure; Ischemia / metabolism; Male; Membrane Proteins / metabolism; Microscopy, Electron; Occludin; Osmotic Pressure; Phosphatidylinositol 3-Kinases / metabolism; Phosphoproteins / metabolism; Platelet Aggregation Inhibitors / pharmacology; Recovery of Function / physiology; Signal Transduction / drug effects; Signal Transduction / physiology; Swine; Tight Junctions / enzymology; Urea / pharmacology; Zonula Occludens-1 Protein
topics (OpenAlex): Barrier Structure and Function Studies; Drug Transport and Resistance Mechanisms; Connexins and lens biology
TL;DR: These experiments suggest that PGs stimulate recovery of paracellular resistance via a mechanism involving transepithelial osmotic gradients and PI3K-dependent restoration of tight junction protein distribution. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2002 journal article

Equine rounds - Case presentation: Idiopathic eosinophilic enteritis in a 10-week-old colt

Compendium on Continuing Education for the Practicing Veterinarian, 24(4), 342–344.

By: L. Stanar, D. Little, W. Redding & S. Jones 

Source: NC State University Libraries
Added: August 6, 2018

2002 article

Factors associated with development of ileal impaction in horses with surgical colic: 78 cases (1986–2000)

LITTLE, D., & BLIKSLAGER, A. T. (2002, July 1). Equine Veterinary Journal, Vol. 34, pp. 464–468.

By: D. Little* & A. Blikslager n 

author keywords: horse; colic; ileal impaction, hay, pyrantel salt
MeSH headings : Animal Feed; Animals; Antinematodal Agents / administration & dosage; Cestode Infections / complications; Cestode Infections / prevention & control; Cestode Infections / veterinary; Colic / surgery; Colic / veterinary; Cynodon / adverse effects; Female; Horse Diseases / etiology; Horse Diseases / surgery; Horses; Ileal Diseases / etiology; Ileal Diseases / surgery; Ileal Diseases / veterinary; Intestinal Obstruction / etiology; Intestinal Obstruction / surgery; Intestinal Obstruction / veterinary; Logistic Models; Male; Odds Ratio; Pyrantel / administration & dosage; Retrospective Studies; Risk Factors; United States
topics (OpenAlex): Helminth infection and control; Coccidia and coccidiosis research; Veterinary Equine Medical Research
TL;DR: It is confirmed that feeding Coastal Bermuda hay places horses at risk of ileal impaction, although the quality of the hay may also play a role, and periodic administration of anthelmintics with efficacy against tapeworms should be considered to reduce risk. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 article

Percutaneous retrieval of a jugular catheter fragment from the pulmonary artery of a foal

Little, D., Keene, B. W., Bruton, C., Smith, L. J., Powell, S., & Jones, S. L. (2002, January 15). Journal of the American Veterinary Medical Association, Vol. 220, pp. 212–214.

By: D. Little n, B. Keene*, C. Bruton, L. Smith, S. Powell & S. Jones* 

MeSH headings : Animals; Catheterization / adverse effects; Catheterization / veterinary; Catheters, Indwelling; Diarrhea / therapy; Diarrhea / veterinary; Foreign-Body Migration / surgery; Horse Diseases / etiology; Horse Diseases / surgery; Horse Diseases / therapy; Horses; Jugular Veins; Male; Pulmonary Artery
topics (OpenAlex): Veterinary Equine Medical Research; Hemodynamic Monitoring and Therapy; Central Venous Catheters and Hemodialysis
TL;DR: This is the first report of successful retrieval of a catheter fragment from the pulmonary artery in a horse, and the owner inadvertently cut the catheter at the level of the hub during attempted removal. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2002 journal article

Recovery of ischaemic injured porcine ileum: evidence for a contributory role of COX-1 and COX-2

Gut, 50(5), 615–623.

By: A. Blikslager n , D. Zimmel*, K. Young*, N. Campbell, D. Little* & R. Argenzio*

Contributors: A. Blikslager n , D. Zimmel*, K. Young*, N. Campbell, D. Little* & R. Argenzio*

MeSH headings : Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / pharmacology; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Eicosanoids / biosynthesis; Female; Ileum / blood supply; Ileum / drug effects; Indomethacin / pharmacology; Intestinal Mucosa / blood supply; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Ischemia / enzymology; Ischemia / pathology; Isoenzymes / antagonists & inhibitors; Isoenzymes / physiology; Male; Nitrobenzenes / pharmacology; Permeability; Prostaglandin-Endoperoxide Synthases / physiology; Sulfonamides / pharmacology; Swine
topics (OpenAlex): Inflammatory mediators and NSAID effects; Neuropeptides and Animal Physiology; Eicosanoids and Hypertension Pharmacology
TL;DR: The results suggest that recovery of resistance is triggered by PGE and PGI2, which may be elaborated by either COX-1 orCOX-2. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2001 article

Risk factors for reduced postoperative fecal output in horses: 37 cases (1997–1998)

Little, D., Redding, W. R., & Blikslager, A. T. (2001, February 1). Journal of the American Veterinary Medical Association, Vol. 218, pp. 414–420.

By: D. Little n, W. Redding* & A. Blikslager* 

MeSH headings : Anesthesia / veterinary; Animals; Colic / complications; Colic / veterinary; Defecation / physiology; Female; Horse Diseases / etiology; Horse Diseases / pathology; Horses; Intestinal Obstruction / etiology; Intestinal Obstruction / pathology; Intestinal Obstruction / veterinary; Logistic Models; Male; Orthopedics / veterinary; Postoperative Complications / etiology; Postoperative Complications / pathology; Postoperative Complications / veterinary; Prevalence; Regression Analysis; Retrospective Studies; Risk Factors
topics (OpenAlex): Veterinary Equine Medical Research; Veterinary Pharmacology and Anesthesia; Anesthesia and Pain Management
TL;DR: Results suggest that after surgery unrelated to the gastrointestinal tract in horses, there is an intermediate clinical phase characterized by reduced fecal output preceding overt signs of colic, which may reduce morbidity and mortality of such horses. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 article

Unusual presentation of nutritional secondary hyperparathyroidism in a Paint colt

Little, D., Redding, W. R., Spaulding, K. A., Dupree, S. H., & Jones, S. L. (2000, December 1). Equine Veterinary Education, Vol. 2, pp. 388–394.

By: D. Little n, W. Redding n, K. Spaulding n, S. Dupree n & S. Jones n 

topics (OpenAlex): Parathyroid Disorders and Treatments; Cancer Diagnosis and Treatment; Oral and gingival health research
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2. Zero Hunger (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

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