David Brodsky

College of Agriculture and Life Sciences

Works (4)

Updated: May 20th, 2024 08:03

2024 journal article

A TriAdj-Adjuvanted <i>Chlamydia trachomatis</i> CPAF Protein Vaccine Is Highly Immunogenic in Pigs

VACCINES, 12(4).

By: J. Proctor  n, M. Stadler*, L. Cortes  n, D. Brodsky n, L. Poisson n , V. Gerdts *, A. Smirnov  n, T. Smirnova n  ...

author keywords: Chlamydia trachomatis; vaccination; adjuvant; chlamydial-protease-like activity factor; animal model; swine; one health
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 22, 2024

2022 journal article

Chalcones from Angelica keiskei (ashitaba) inhibit key Zika virus replication proteins

BIOORGANIC CHEMISTRY, 120.

By: M. Mottin *, L. Caesar *, D. Brodsky n, N. Mesquita*, K. Oliveira*, G. Noske  n, B. Sousa*, P. Ramos* ...

author keywords: Angelica keiskei; Ashitaba; Chalcones; Zika virus; Polymerase; Protease
MeSH headings : Angelica / chemistry; Animals; Chalcone / pharmacology; Chalcones / chemistry; Chalcones / pharmacology; Chlorocebus aethiops; Humans; RNA; RNA-Dependent RNA Polymerase; Vero Cells; Virus Replication; Zika Virus; Zika Virus Infection
TL;DR: With their simple structures and relative ease of modification, the chalcones represent attractive candidates for hit-to-lead optimization in the search of new anti-ZIKV therapeutics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: July 18, 2022

2022 journal article

Heterologous vaccine immunogenicity, efficacy, and immune correlates of protection of a modified-live virus porcine reproductive and respiratory syndrome virus vaccine

Frontiers in Microbiology, 13.

By: J. Proctor n, I. Wolf n, D. Brodsky n, L. Cortes n, A. Frias-De-Diego  n, G. Almond n , E. Crisci n , T. Negrão Watanabe n, J. Hammer *, T. Käser n

Contributors: E. Crisci n 

author keywords: porcine reproductive and respiratory syndrome virus (PRRSV); correlates of protection (CoP); vaccination; swine; immunity; pig
TL;DR: Overall, the Prevacent elicited various degrees of efficacy and immunogenicity against four heterologous and phylogenetically distant strains of PRRSV-2, and correlation analyses revealed that the (non-PRRSV strain-specific) serum IgG levels and the PRRSv strain- specific CD4 T-cell response were the best immune correlates of protection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: September 25, 2022

2022 journal article

Immunologic and pathologic characterization of a novel swine biomedical research model for eosinophilic esophagitis

FRONTIERS IN ALLERGY, 3.

By: L. Cortes  n, D. Brodsky n, C. Chen, T. Pridgen n, J. Odle n , D. Snider n, G. Cruse n , A. Putikova* ...

author keywords: pig; food allergy; animal model; immunology; gastrointestinal; eosinophilic esophagitis
TL;DR: Swine is established as a relevant large animal model for translational biomedical research in EoE with the potential to facilitate development of therapeutics and it is demonstrated that the sensitization and oral challenge protocol not only induces the underlying immune markers but also the micro- and macro-pathological hallmarks of human EiE. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: September 25, 2023

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