Dragan Milenkovic

Stankovic, S., Mutavdzin, S., Djuric, D. M., Milosevic, V., & Milenkovic, D. (2025). Plant Polyphenols as Heart’s Best Friends: From Health Properties, to Cellular Effects, to Molecular Mechanisms of Action. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms26030915

Moumou, M., Mokhtari, I., Tayebi, A., Milenkovic, D., Amrani, S., & Harnafi, H. (2024, December 28). <i>Juniperus oxycedrus</i> L. fruit, leaves, and essential oil: a systematic literature review on bioactive compounds, pharmacological properties and toxicology. PHYTOCHEMISTRY REVIEWS, Vol. 12. https://doi.org/10.1007/s11101-024-10054-w

Mokhtari, I., Shahat, A. A., Noman, O. M., Milenkovic, D., Amrani, S., & Harnafi, H. (2024). Effects of <i>Cynara scolymus</i> L. Bract Extract on Lipid Metabolism Disorders Through Modulation of HMG-CoA Reductase, Apo A-1, PCSK-9, p-AMPK, SREBP-2, and CYP2E1 Expression. METABOLITES, 14(12). https://doi.org/10.3390/metabo14120728

Farrim, M. I., Gomes, A., Milenkovic, D., & Menezes, R. (2024). Gene expression analysis reveals diabetes-related gene signatures. Human Genomics. https://doi.org/10.1186/s40246-024-00582-z

Villablanca, A., Dugger, B., Nuthikattu, S., Chauhan, J., Cheung, S., Chuah, C.-N., … Brown, S. D. (2024). How cy pres promotes transdisciplinary convergence science: an academic health center for women’s cardiovascular and brain health. Journal of Clinical and Translational Science. https://doi.org/10.1017/cts.2023.705

Ruskovska, T., Postolov, F., & Milenkovic, D. (2024). Integrated Analysis of Genomic and Genome-Wide Association Studies Identified Candidate Genes for Nutrigenetic Studies in Flavonoids and Vascular Health: Path to Precision Nutrition for (Poly)phenols. Nutrients. https://doi.org/10.3390/nu16091362

Šošić-Jurjević, B., Borkovic-Mitic, S., Pavlović, S., Vlahović, D., Miler, M., Cesar, T., … Lütjohann, D. (2024). Lemon Flavonoid Extract Eriomin Improves Pro/Antioxidant Status and Interferes with Cholesterol Metabolism without Affecting Serum Cholesterol Levels in Aged Rats. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms25105221

Miler, M., Živanović, J., Ajdžanović, V., Milenkovic, D., Cesar, T., Filipović, M. R., & Milošević, V. (2024). Lemon extract reduces the hepatic oxidative stress and persulfidation levels by upregulating the Nrf2 and Trx1 expression in old rats. BioFactors. https://doi.org/10.1002/biof.2038

Castro Tobaruela, E., Brasili, E., Zeraik, L., Milenkovic, D., Hassimotto, N. M. A., & Lajolo, F. M. (2024). Plasma proteome profiling reveals molecular mechanisms underlying the effects of daily consumption of ‘Bahia’ and ‘Cara Cara’ orange juices. Food  Function. https://doi.org/10.1039/d3fo04091g

Milenkovic, D., Nuthikattu, S., Norman, J., & Villablanca, A. C. (2024). Single Nuclei Transcriptomics Reveals Obesity-Induced Endothelial and Neurovascular Dysfunction: Implications for Cognitive Decline. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms252011169

Milenkovic, D. (2024). Supplemental analysis.docx. https://doi.org/10.6084/m9.figshare.26122009

Milenkovic, D. (2024). Table S1.xls. https://doi.org/10.6084/m9.figshare.26121994

Milenkovic, D. (2024). Table S2.xlsx. https://doi.org/10.6084/m9.figshare.26121988

Norman, J., Milenkovic, D., Nuthikattu, S., & Villablanca, A. C. (2024). The Brain Metabolome Is Modified by Obesity in a Sex-Dependent Manner. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms25063475

Fraga, L. N., Milenkovic, D., Anacleto, S. L., Salemi, M., Lajolo, F. M., & Hassimotto, N. M. A. (2023). Citrus flavanone metabolites significantly modulate global proteomic profile in pancreatic β-cells under high-glucose-induced metabolic stress. Biochimica Et Biophysica Acta (BBA) - Proteins and Proteomics, 1871(3), 140898. https://doi.org/10.1016/j.bbapap.2023.140898

Krga, I., Ruskovska, T., & Milenkovic, D. (2023). Editorial: Plant food bioactives, genomics, and health effects. Frontiers in Nutrition. https://doi.org/10.3389/fnut.2023.1166149

Moumou, M., Mokhtari, I., Tayebi, A., Milenkovic, D., Amrani, S., & HARNAFI, H. (2024). Immature carob pods extract and its fractions prevent lipid metabolism disorders and lipoprotein-rich plasma oxidation in mice: A phytochemical and pharmacological study. Journal of Ethnopharmacology. https://doi.org/10.1016/j.jep.2023.117557

Ruskovska, T., Postolov, F., & Milenkovic, D. (2023). Integrated Analysis of Genomic and GWAS Data to Identify Candidate Genes for Genetic Studies in Flavonoids and Vascular Health: Path to Precise Nutrition for (Poly)phenols. Proceedings. https://doi.org/10.3390/proceedings2023091029

Fraga, L. N., Milenkovic, D., Coutinho, C. P., Rozenbaum, A. C., Lajolo, F. M., & Hassimotto, N. M. A. (2023). Interaction between APOE, APOA1, and LPL Gene Polymorphisms and Variability in Changes in Lipid and Blood Pressure following Orange Juice Intake: A Pilot Study. Molecular Nutrition  Food Research. https://doi.org/10.1002/mnfr.202200847

Ramos, F. M. M., Ribeiro, C. B., Cesar, T., Milenkovic, D., Cabral, L., Noronha, M. F., & Sivieri, K. (2023). Lemon flavonoids nutraceutical (Eriomin®) attenuates prediabetes intestinal dysbiosis: A double‐blind randomized controlled trial. Food Science  Nutrition. https://doi.org/10.1002/fsn3.3654

Mokhtari, I., Moumou, M., Harnafi, M., Milenkovic, D., Amrani, S., & HARNAFI, H. (2023). Loquat fruit peel extract regulates lipid metabolism and liver oxidative stress in mice: In vivo and in silico approaches. Journal of Ethnopharmacology. https://doi.org/10.1016/j.jep.2023.116376

Mokhtari, I., Mokhtari, C., Moumou, M., Harnafi, M., Milenkovic, D., Amrani, S., … Harnafi, H. (2023). Polyphenol-rich extract from loquat fruit peel prevents hyperlipidemia and hepato-nephrotoxicity in mice: <i>in vivo</i> study and <i>in silico</i> prediction of possible mechanisms involving identified polyphenols and/or their circulating metabolites. Food  Function. https://doi.org/10.1039/d3fo01992f

Norman, J., Nuthikattu, S., Milenkovic, D., & Villablanca, A. C. (2023). Sex Modifies the Impact of Type 2 Diabetes Mellitus on the Murine Whole Brain Metabolome. Metabolites. https://doi.org/10.3390/metabo13091012

Norman, J., Nuthikattu, S., Milenkovic, D., Rutledge, J. C., & Villablanca, A. C. (2023). Sex-Specific Response of the Brain Free Oxylipin Profile to Soluble Epoxide Hydrolase Inhibition. Nutrients. https://doi.org/10.3390/nu15051214

Nuthikattu, S., Milenkovic, D., Norman, J. E., & Villablanca, A. C. (2024). Single nuclei transcriptomics in diabetic mice reveals altered brain hippocampal endothelial cell function, permeability, and behavior. Biochimica Et Biophysica Acta (BBA) - Molecular Basis of Disease. https://doi.org/10.1016/j.bbadis.2023.166970

Kang, J., Oteiza, P., & Milenkovic, D. (2022). (−)-Epicatechin exerts positive effects on anxiety in high fat diet-induced obese mice through multi-genomic modifications in the hippocampus. Food  Function, 13(20), 10623–10641. https://doi.org/10.1039/d2fo01897g

Norman, J. E., Nuthikattu, S., Milenkovic, D., Rutledge, J. C., & Villablanca, A. C. (2022). A high sucrose diet modifies brain oxylipins in a sex-dependent manner. Prostaglandins, Leukotrienes and Essential Fatty Acids, 186, 102506. https://doi.org/10.1016/j.plefa.2022.102506

Damián-Medina, K., Milenkovic, D., Salinas-Moreno, Y., Corral-Jara, K. F., Figueroa-Yáñez, L., Marino-Marmolejo, E., & Lugo-Cervantes, E. (2022). Anthocyanin-rich extract from black beans exerts anti-diabetic effects in rats through a multi-genomic mode of action in adipose tissue. Frontiers in Nutrition, 9. https://doi.org/10.3389/fnut.2022.1019259

Fraga, L. N., Milenkovic, D., Lajolo, F., & Hassimotto, N. M. A. (2022). Association between Single Nucleotide Polymorphisms of SULT1A1, SULT1C4, ABCC2 and Phase II Flavanone Metabolites Excretion after Orange Juice Intake. Nutrients. https://doi.org/10.3390/nu14183770

Duarte, I., Souza, M. C. M., Curinga, R., Mendonça, H., Oliveira, L., Milenkovic, D., … Santos Borges, T. K. (2022). Effect of <i>Passiflora setacea</i> juice and its phenolic metabolites on insulin resistance markers in overweight individuals and on microglial cell activity. Food  Function, 13(12), 6498–6509. https://doi.org/10.1039/d1fo04334j

Crowe-White, K., Evans, L. W., Kuhnle, G. G. C., Milenkovic, D., Stote, K., Wallace, T., … Senkus, K. E. (2022). Flavan-3-ols and Cardiometabolic Health: First Ever Dietary Bioactive Guideline. Advances in Nutrition, 13(6), 2070–2083. https://doi.org/10.1093/advances/nmac105

Milenkovic, D., Rodriguez‐Mateos, A., Lucosz, M., Istas, G., Declerck, K., Sansone, R., … Berghe, W. V. (2022). Flavanol Consumption in Healthy Men Preserves Integrity of Immunological‐Endothelial Barrier Cell Functions: Nutri(epi)genomic Analysis. Molecular Nutrition  Food Research, 66(21), 2100991. https://doi.org/10.1002/mnfr.202100991

Krga, I., Corral-Jara, K. F., Barber-Chamoux, N., Dubray, C., Morand, C., & Milenkovic, D. (2022). Grapefruit Juice Flavanones Modulate the Expression of Genes Regulating Inflammation, Cell Interactions and Vascular Function in Peripheral Blood Mononuclear Cells of Postmenopausal Women. Frontiers in Nutrition, 9. https://doi.org/10.3389/fnut.2022.907595

Nuthikattu, S., Milenkovic, D., Norman, J., Rutledge, J., & Villablanca, A. (2022). High Glycemia and Soluble Epoxide Hydrolase in Females: Differential Multiomics in Murine Brain Microvasculature. International Journal of Molecular Sciences, 23(21), 13044. https://doi.org/10.3390/ijms232113044

Mićović, T., Stanković, J. S. K., Bauer, R., Nöst, X., Marković, Z., Milenković, D., … Maksimović, Z. (2022). In vitro, in vivo and in silico evaluation of the anti-inflammatory potential of Hyssopus officinalis L. subsp. aristatus (Godr.) Nyman (Lamiaceae). Journal of Ethnopharmacology, 293, 115201. https://doi.org/10.1016/j.jep.2022.115201

Milenkovic, D., & Ruskovska, T. (2023). Mechanistic insights into dietary (poly)phenols and vascular dysfunction-related diseases using multi-omics and integrative approaches: Machine learning as a next challenge in nutrition research. Molecular Aspects of Medicine, 89, 101101. https://doi.org/10.1016/j.mam.2022.101101

Ruskovska, T., Konic-Ristic, A., Mazur, A., & Milenkovic, D. (2023). Molecular mechanisms underlying hypertensive effect of fructose and the preventive properties of inulin – Global transcriptomic analysis in rat aorta. Nutrition, Metabolism and Cardiovascular Diseases, 33(2), 441–456. https://doi.org/10.1016/j.numecd.2022.11.009

Ruskovska, T., Morand, C., Bonetti, C. I., Gebara, K. S., Junior, E. L. C., & Milenkovic, D. (2023). Multigenomic modifications in human circulating immune cells in response to consumption of polyphenol-rich extract of yerba mate (<i>Ilex paraguariensis A. St.-Hil.</i>) are suggestive of cardiometabolic protective effects. British Journal of Nutrition, 129(2), 185–205. https://doi.org/10.1017/s0007114522001027

Corral-Jara, K. F., Nuthikattu, S., Rutledge, J., Villablanca, A., Fong, R., Heiss, C., … Milenkovic, D. (2022). Structurally related (−)-epicatechin metabolites and gut microbiota derived metabolites exert genomic modifications via VEGF signaling pathways in brain microvascular endothelial cells under lipotoxic conditions: Integrated multi-omic study. Journal of Proteomics, 263, 104603. https://doi.org/10.1016/j.jprot.2022.104603

Ruskovska, T., Budić-Leto, I., Corral-Jara, K. F., Ajdžanović, V., Arola-Arnal, A., Bravo, F. I., … Milenkovic, D. (2022). Systematic analysis of nutrigenomic effects of polyphenols related to cardiometabolic health in humans – Evidence from untargeted mRNA and miRNA studies. Ageing Research Reviews, 79, 101649. https://doi.org/10.1016/j.arr.2022.101649

Milenkovic, D., Capel, F., Combaret, L., Comte, B., Dardevet, D., Evrard, B., … Savary-Auzeloux, I. (2022). Targeting the gut to prevent and counteract metabolic disorders and pathologies during aging. Critical Reviews in Food Science and Nutrition, 6, 1–26. https://doi.org/10.1080/10408398.2022.2089870

Nuthikattu, S., Milenkovic, D., Norman, J., Rutledge, J., & Villablanca, A. (2022). The Brain’s Microvascular Response to High Glycemia and to the Inhibition of Soluble Epoxide Hydrolase Is Sexually Dimorphic. Nutrients, 14(17), 3451. https://doi.org/10.3390/nu14173451

Underlying evidence for the health benefits of fermented foods in humans. (2022). Food & Function. https://doi.org/10.1039/d1fo03989j

Duarte, I., Milenkovic, D., Borges, T. K., Oliveira, L., & Costa, A. M. (2021). Brazilian passion fruit as a new healthy food: from its composition to health properties and mechanisms of action. Food  Function, 12(22), 11106–11120. https://doi.org/10.1039/d1fo01976g

Carecho, R., Figueira, I., Terrasso, A. P., Godinho‐Pereira, J., Oliveira Sequeira, C., Pereira, S. A., … Santos, C. N. (2022). Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson's Disease. Molecular Nutrition  Food Research, 66(21), 2100959. https://doi.org/10.1002/mnfr.202100959

Duque, A. L. R. F., Demarqui, F. M., Santoni, M. M., Zanelli, C. F., Adorno, M. A. T., Milenkovic, D., … Sivieri, K. (2021). Effect of probiotic, prebiotic, and synbiotic on the gut microbiota of autistic children using an in vitro gut microbiome model. Food Research International, 149, 110657. https://doi.org/10.1016/j.foodres.2021.110657

Verny, M.-A., Milenkovic, D., Macian, N., Pereira, B., Evrard, R., Gilcher, C., … MORAND, C. (2021). Evaluating the role of orange juice, HESPERidin in vascular HEALTH benefits (HESPER-HEALTH study): protocol for a randomised controlled trial. BMJ Open, 11(11), e053321. https://doi.org/10.1136/bmjopen-2021-053321

Nuthikattu, S., Milenkovic, D., Norman, J., Rutledge, J., & Villablanca, A. (2021). Inhibition of Soluble Epoxide Hydrolase Is Protective against the Multiomic Effects of a High Glycemic Diet on Brain Microvascular Inflammation and Cognitive Dysfunction. Nutrients, 13(11), 3913. https://doi.org/10.3390/nu13113913

Milanović, Ž. B., Antonijević, M., Amić, A. D., Avdović, E. H., Dimic, D., Milenković, D., & Marković, Z. (2021). Inhibitory activity of quercetin, its metabolite, and standard antiviral drugs towards enzymes essential for SARS-CoV-2: the role of acid–base equilibria. RSC Advances, 11(5), 2838–2847. https://doi.org/10.1039/d0ra09632f

Corral-Jara, K. F., Nuthikattu, S., Rutledge, J., Villablanca, A., Morand, C., Schroeter, H., & Milenkovic, D. (2021). Integrated Multi-Omic Analyses of the Genomic Modifications by Gut Microbiome-Derived Metabolites of Epicatechin, 5-(4′-Hydroxyphenyl)-γ-Valerolactone, in TNFalpha-Stimulated Primary Human Brain Microvascular Endothelial Cells. Frontiers in Neuroscience, 15. https://doi.org/10.3389/fnins.2021.622640

Monfoulet, L.-E., Ruskovska, T., Ajdžanović, V., Havlik, J., VAUZOUR, D., Bayram, B., … Milenkovic, D. (2021). Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies. Molecular Nutrition  Food Research, 65(16), 2100227. https://doi.org/10.1002/mnfr.202100227

Milenkovic, D., Ruskovska, T., Rodriguez-Mateos, A., & Heiss, C. (2021). Polyphenols Could Prevent SARS-CoV-2 Infection by Modulating the Expression of miRNAs in the Host Cells. Aging and Disease, 12(5), 1169. https://doi.org/10.14336/ad.2021.0223

Ajdžanović, V., Miler, M., Šošić-Jurjević, B., Filipović, B., Milenkovic, D., Jakovljević, V., & Milošević, V. (2021). Soy isoflavone-caused shunting of the corticosteroidogenesis pathways in andropausal subjects: Top-down impulse for the optimal supplementation design. Medical Hypotheses, 148, 110516. https://doi.org/10.1016/j.mehy.2021.110516

Ruskovska, T., Budić-Leto, I., Corral-Jara, K. F., Ajdžanović, V., Arola-Arnal, A., Bravo, F. I., … Milenkovic, D. (2021). Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans—Evidence from Targeted Nutrigenomic Studies. Nutrients, 13(7), 2326. https://doi.org/10.3390/nu13072326

Duarte, I., Milenkovic, D., Santos Borges, T. K., Rosa, A. J. M., Morand, C., Oliveira, L., & Costa, A. M. (2020). Acute Effects of the Consumption of Passiflora setacea Juice on Metabolic Risk Factors and Gene Expression Profile in Humans. Nutrients, 12(4), 1104. https://doi.org/10.3390/nu12041104

Milenkovic, D., Paslawski, R., Gomulkiewicz, A., Gladine, C., Janczak, D., Grzegorek, I., … Szuba, A. (2020). Alterations of aorta intima and media transcriptome in swine fed high-fat diet over 1-year follow-up period and of the switch to normal diet. Nutrition, Metabolism and Cardiovascular Diseases, 30(7), 1201–1215. https://doi.org/10.1016/j.numecd.2020.04.007

Miler, M., Živanović, J., Ajdžanović, V., Milenkovic, D., Jarić, I., Šošić-Jurjević, B., & Milošević, V. (2020). Citrus Flavanones Upregulate Thyrotroph Sirt1 and Differently Affect Thyroid Nrf2 Expressions in Old-Aged Wistar Rats. Journal of Agricultural and Food Chemistry, 68(31), 8242–8254. https://doi.org/10.1021/acs.jafc.0c03079

Anacleto, S., Milenkovic, D., Kroon, P., Needs, P. W., Lajolo, F. M., & Hassimotto, N. M. A. (2020). Citrus flavanone metabolites protect pancreatic-β cells under oxidative stress induced by cholesterol. Food  Function, 11(10), 8612–8624. https://doi.org/10.1039/d0fo01839b

Monisha, K. G., Prabu, P., Chokkalingam, M., Murugesan, R., Milenkovic, D., & Ahmed, S. S. S. J. (2020). Clinical utility of brain-derived neurotrophic factor as a biomarker with left ventricular echocardiographic indices for potential diagnosis of coronary artery disease. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-73296-6

Monfoulet, L.-E., Buffière, C., Istas, G., Dufour, C., Bourvellec, C. L., Mercier, S., … Morand, C. (2020). Effects of the apple matrix on the postprandial bioavailability of flavan-3-ols and nutrigenomic response of apple polyphenols in minipigs challenged with a high fat meal. Food  Function, 11(6), 5077–5090. https://doi.org/10.1039/d0fo00346h

Sinegre, T., Milenkovic, D., Bourgne, C., Teissandier, D., Nasri, Y., Dannus, L.-T., … Lebreton, A. (2020). Impact of Epicatechin on the Procoagulant Activities of Microparticles. Nutrients, 12(10), 2935. https://doi.org/10.3390/nu12102935

Sinegre, T., Milenkovic, D., Teissandier, D., Fully, P., Bourdin, J., Morand, C., & Lebreton, A. (2021). Impact of epicatechin on fibrin clot structure. European Journal of Pharmacology, 893, 173830. https://doi.org/10.1016/j.ejphar.2020.173830

Damián-Medina, K., Salinas-Moreno, Y., Milenkovic, D., Figueroa-Yáñez, L., Marino-Marmolejo, E., Higuera-Ciapara, I., … Lugo-Cervantes, E. (2020). In silico analysis of antidiabetic potential of phenolic compounds from blue corn (Zea mays L.) and black bean (Phaseolus vulgaris L.). Heliyon, 6(3), e03632. https://doi.org/10.1016/j.heliyon.2020.e03632

Nuthikattu, S., Milenkovic, D., Rutledge, J. C., & Villablanca, A. C. (2020). Lipotoxic Injury Differentially Regulates Brain Microvascular Gene Expression in Male Mice. Nutrients, 12(6), 1771. https://doi.org/10.3390/nu12061771

Fidélix, M. P., Milenkovic, D., Sivieri, & Cesar, T. (2020). Microbiota modulation and effects on metabolic biomarkers by orange juice: a controlled clinical trial. Food and Function, 11(2), 1599–1610. https://doi.org/10.1039/c9fo02623a

Harnafi, M., Bekkouch, O., Touiss, I., Khatib, S., Mokhtari, I., Milenkovic, D., … Amrani, S. (2020). Phenolic-Rich Extract from Almond (Prunus dulcis ) Hulls Improves Lipid Metabolism in Triton WR-1339 and High-Fat Diet-Induced Hyperlipidemic Mice and Prevents Lipoprotein Oxidation: A Comparison with Fenofibrate and Butylated Hydroxyanisole. Preventive Nutrition and Food Science, 25(3), 254–262. https://doi.org/10.3746/pnf.2020.25.3.254

Nuthikattu, S., Milenkovic, D., Rutledge, J. C., & Villablanca, A. C. (2020). Sex-Dependent Molecular Mechanisms of Lipotoxic Injury in Brain Microvasculature: Implications for Dementia. International Journal of Molecular Sciences, 21(21), 8146. https://doi.org/10.3390/ijms21218146

Ruskovska, T., Massaro, M., Carluccio, M. A., Arola-Arnal, A., Muguerza, B., Berghe, W. V., … Milenkovic, D. (2020). Systematic bioinformatic analysis of nutrigenomic data of flavanols in cell models of cardiometabolic disease. Food  Function, 11(6), 5040–5064. https://doi.org/10.1039/d0fo00701c

MORAND, C., Roos, B., Garcia-Conesa, M.-T., Gibney, E., Landberg, R., Manach, C., … Tomas-Barberan, F. A. (2020). Why interindividual variation in response to consumption of plant food bioactives matters for future personalised nutrition. Proceedings of the Nutrition Society, 79(2), 225–235. https://doi.org/10.1017/S0029665120000014

Milenkovic, D., Declerck, K., Guttman, Y., Kerem, Z., Claude, S., Weseler, A. R., … Berghe, W. V. (2020). (−)-Epicatechin metabolites promote vascular health through epigenetic reprogramming of endothelial-immune cell signaling and reversing systemic low-grade inflammation. Biochemical Pharmacology, 173, 113699. https://doi.org/10.1016/j.bcp.2019.113699

Krga, I., & Milenkovic, D. (2019). Anthocyanins: From Sources and Bioavailability to Cardiovascular-Health Benefits and Molecular Mechanisms of Action. Journal of Agricultural and Food Chemistry, 67(7), 1771–1783. https://doi.org/10.1021/acs.jafc.8b06737

Rodriguez-Mateos, A., Istas, G., Boschek, L., Feliciano, R. P., Mills, C. E., Boby, C., … Heiss, C. (2019). Circulating Anthocyanin Metabolites Mediate Vascular Benefits of Blueberries: Insights from Randomized Controlled Trials, Metabolomics, and Nutrigenomics. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 74(7), 967–976. https://doi.org/10.1093/gerona/glz047

Sinegre, T., Teissandier, D., Milenkovic, D., Morand, C., & Lebreton, A. (2019). Epicatechin influences primary hemostasis, coagulation and fibrinolysis. Food and Function, 10(11), 7291–7298. https://doi.org/10.1039/c9fo00816k

Factors influencing the cardiometabolic response to (poly)phenols and phytosterols: a review of the COST Action POSITIVe activities. (2019). European Journal of Nutrition, 58, 37–47. https://doi.org/10.1007/s00394-019-02066-6

Leroux, C., Milenkovic, D., Mobuchon, L., Le Guillou, S., Faulconnier, Y., German, B., & Le Provost, F. (2019). Nutritional regulation of mammary miRNome: Implications for human studies. In Handbook of Nutrition, Diet, and Epigenetics (Vol. 3, pp. 1495–1511). https://doi.org/10.1007/978-3-319-55530-0_88

Ruskovska, T., Maksimova, V., & Milenkovic, D. (2020). Polyphenols in human nutrition: From the in vitro antioxidant capacity to the beneficial effects on cardiometabolic health and related inter-individual variability - An overview and perspective. British Journal of Nutrition, 123(3), 241–254. https://doi.org/10.1017/S0007114519002733

Roos, B., Aura, A.-M., Bronze, M., Cassidy, A., Conesa, M.-T. G., Gibney, E. R., … Morand, C. (2019). Targeting the delivery of dietary plant bioactives to those who would benefit most: from science to practical applications. European Journal of Nutrition, 58, 65–73. https://doi.org/10.1007/s00394-019-02075-5

Nuthikattu, S., Milenkovic, D., Rutledge, J., & Villablanca, A. (2019). The Western Diet Regulates Hippocampal Microvascular Gene Expression: An Integrated Genomic Analyses in Female Mice. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-019-55533-9

Milenkovic, D., Berghe, W. V., Morand, C., Claude, S., Sandt, A., Gorressen, S., … Kelm, M. (2018). A systems biology network analysis of nutri(epi)genomic changes in endothelial cells exposed to epicatechin metabolites. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-33959-x

Krga, I., Tamaian, R., Mercier, S., Boby, C., Monfoulet, L.-E., Glibetic, M., … Milenkovic, D. (2018). Anthocyanins and their gut metabolites attenuate monocyte adhesion and transendothelial migration through nutrigenomic mechanisms regulating endothelial cell permeability. Free Radical Biology and Medicine, 124, 364–379. https://doi.org/10.1016/j.freeradbiomed.2018.06.027

Yokoyama, A. S., Dunaway, K., Rutkowsky, J., Rutledge, J. C., & Milenkovic, D. (2018). Chronic consumption of a western diet modifies the DNA methylation profile in the frontal cortex of mice. Food and Function, 9(2), 1187–1198. https://doi.org/10.1039/c7fo01602f

Krga, I., Vidovic, N., Milenkovic, D., Konic-Ristic, A., Stojanovic, F., Morand, C., & Glibetic, M. (2018). Effects of anthocyanins and their gut metabolites on adenosine diphosphate-induced platelet activation and their aggregation with monocytes and neutrophils. Archives of Biochemistry and Biophysics, 645, 34–41. https://doi.org/10.1016/j.abb.2018.03.016

Monfoulet, L.-E., Mercier, S., Bayle, D., Tamaian, R., Barber-Chamoux, N., Morand, C., & Milenkovic, D. (2017). Curcumin modulates endothelial permeability and monocyte transendothelial migration by affecting endothelial cell dynamics. Free Radical Biology and Medicine, 112, 109–120. https://doi.org/10.1016/j.freeradbiomed.2017.07.019

Impact of flavonols on cardiometabolic biomarkers: A meta-analysis of randomized controlled human trials to explore the role of inter-individual variability. (2017). Nutrients, 9(2). https://doi.org/10.3390/nu9020117

Milenkovic, D., Morand, C., Cassidy, A., Konic-Ristic, A., Tomás-Barberán, F., Ordovas, J. M., … Rodriguez-Mateos, A. (2017). Interindividual variability in biomarkers of cardiometabolic health after consumption of major plant-food bioactive compounds and the determinants involved. Advances in Nutrition, 8(4), 558–570. https://doi.org/10.3945/an.116.013623

Poor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventions. (2018). Ageing Research Reviews, 42, 40–55. https://doi.org/10.1016/j.arr.2017.12.004

Barber-Chamoux, N., Milenkovic, D., Verny, M.-A., Habauzit, V., Pereira, B., Lambert, C., … Morand, C. (2018). Substantial Variability Across Individuals in the Vascular and Nutrigenomic Response to an Acute Intake of Curcumin: A Randomized Controlled Trial. Molecular Nutrition and Food Research, 62(5). https://doi.org/10.1002/mnfr.201700418

Manach, C., Milenkovic, D., Wiele, T., Rodriguez-Mateos, A., Roos, B., Garcia-Conesa, M. T., … Morand, C. (2017). Addressing the inter-individual variation in response to consumption of plant food bioactives: Towards a better understanding of their role in healthy aging and cardiometabolic risk reduction. Molecular Nutrition and Food Research, 61(6). https://doi.org/10.1002/mnfr.201600557

Krga, I., Milenkovic, D., Morand, C., & Monfoulet, L.-E. (2016). An update on the role of nutrigenomic modulations in mediating the cardiovascular protective effect of fruit polyphenols. Food and Function, 7(9), 3656–3676. https://doi.org/10.1039/c6fo00596a

Krga, I., Monfoulet, L.-E., Konic-Ristic, A., Mercier, S., Glibetic, M., Morand, C., & Milenkovic, D. (2016). Anthocyanins and their gut metabolites reduce the adhesion of monocyte to TNFα-activated endothelial cells at physiologically relevant concentrations. Archives of Biochemistry and Biophysics, 599, 51–59. https://doi.org/10.1016/j.abb.2016.02.006

Citrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats. (2016). Experimental Gerontology, 84, 49–60. https://doi.org/10.1016/j.exger.2016.08.014

Diosgenin-caused changes of the adrenal gland histological parameters in a rat model of the menopause. (2017). Acta Histochemica, 119(1), 48–56. https://doi.org/10.1016/j.acthis.2016.11.006

Declerck, K., Szic, K., Palagani, A., Heyninck, K., Haegeman, G., Morand, C., … Vanden Berghe, W. (2016). Epigenetic control of cardiovascular health by nutritional polyphenols involves multiple chromatin-modifying writer-reader-eraser proteins. Current Topics in Medicinal Chemistry, 16(7), 788–806. Retrieved from http://www.scopus.com/inward/record.url?eid=2-s2.0-84983219829&partnerID=MN8TOARS

Epigenetic control of cardiovascular health by nutritional polyphenols involves multiple chromatin-modifying writer-reader-eraser proteins. (2016). Current Topics in Medicinal Chemistry. Retrieved from http://www.scopus.com/inward/record.url?eid=2-s2.0-84983219829&partnerID=MN8TOARS

Angeloni, C., Maraldi, T., Milenkovic, D., & Vauzour, D. (2015). Dietary polyphenols and their effects on cell biochemistry and pathophysiology 2014. Oxidative Medicine and Cellular Longevity, 2015. https://doi.org/10.1155/2015/782424

Habauzit, V., Verny, M.-A., Milenkovic, D., Barber-Chamoux, N., Mazur, A., Dubray, C., & Morand, C. (2015). Flavanones protect from arterial stiffness in postmenopausal women consuming grapefruit juice for 6 mo: A randomized, controlled, crossover trial. American Journal of Clinical Nutrition, 102(1), 66–74. https://doi.org/10.3945/ajcn.114.104646

Positive effects of naringenin on near-surface membrane fluidity in human erythrocytes. (2015). Acta Physiologica Hungarica, 102(2), 131–136. https://doi.org/10.1556/036.102.2015.2.3

Milenkovic, D., Vanden Berghe, W., Boby, C., Leroux, C., Declerck, K., Szic, K. S. V., … Weseler, A. R. (2014). Dietary flavanols modulate the transcription of genes associated with cardiovascular pathology without changes in their DNA methylation state. PLoS ONE, 9(4). https://doi.org/10.1371/journal.pone.0095527

Claude, S., Boby, C., Rodriguez-Mateos, A., Spencer, J. P. E., Gérard, N., Morand, C., & Milenkovic, D. (2014). Flavanol metabolites reduce monocyte adhesion to endothelial cells through modulation of expression of genes via p38-MAPK and p65-Nf-kB pathways. Molecular Nutrition and Food Research, 58(5), 1016–1027. https://doi.org/10.1002/mnfr.201300658

Afman, L., Milenkovic, D., & Roche, H. M. (2014). Nutritional aspects of metabolic inflammation in relation to health-insights from transcriptomic biomarkers in PBMC of fatty acids and polyphenols. Molecular Nutrition and Food Research, 58(8), 1708–1720. https://doi.org/10.1002/mnfr.201300559

Chanet, A., Milenkovic, D., Claude, S., Maier, J. A. M., Kamran Khan, M., Rakotomanomana, N., … Morand, C. (2013). Flavanone metabolites decrease monocyte adhesion to TNF-α-activated endothelial cells by modulating expression of atherosclerosis-related genes. British Journal of Nutrition, 110(4), 587–598. https://doi.org/10.1017/S0007114512005454

Habauzit, V., Milenkovic, D., & Morand, C. (2013). Vascular Protective Effects of Fruit Polyphenols. In Polyphenols in Human Health and Disease (Vol. 2, pp. 875–893). https://doi.org/10.1016/B978-0-12-398456-2.00068-2

Milenkovic, D., Jude, B., & Morand, C. (2013). miRNA as molecular target of polyphenols underlying their biological effects. Free Radical Biology and Medicine, 64, 40–51. https://doi.org/10.1016/j.freeradbiomed.2013.05.046

Chanet, A., Milenkovic, D., Manach, C., Mazur, A., & Morand, C. (2012). Citrus flavanones: What is their role in cardiovascular protection? Journal of Agricultural and Food Chemistry, 60(36), 8809–8822. https://doi.org/10.1021/jf300669s

Coban, D., Milenkovic, D., Chanet, A., Khallou-Laschet, J., Sabbe, L., Palagani, A., … Morand, C. (2012). Dietary curcumin inhibits atherosclerosis by affecting the expression of genes involved in leukocyte adhesion and transendothelial migration. Molecular Nutrition and Food Research, 56(8), 1270–1281. https://doi.org/10.1002/mnfr.201100818

Simon, J., Milenkovic, D., Godet, E., Cabau, C., Collin, A., Métayer-Coustard, S., … Cogburn, L. A. (2012). Insulin immuno-neutralization in fed chickens: Effects on liver and muscle transcriptome. Physiological Genomics, 44(5), 283–292. https://doi.org/10.1152/physiolgenomics.00057.2011

Milenkovic, D., Deval, C., Gouranton, E., Landrier, J.-F., Scalbert, A., Morand, C., & Mazur, A. (2012). Modulation of miRNA expression by dietary polyphenols in apoE deficient mice: A new mechanism of the action of polyphenols. PLoS ONE, 7(1). https://doi.org/10.1371/journal.pone.0029837

Chanet, A., Wizinska, P., Polakof, S., Mazur, A., Bennetau-Pelissero, C., Morand, C., … Milenkovic, D. (2012). Naringin at a nutritional dose modulates expression of genes related to lipid metabolism and inflammation in liver of mice fed a high-fat diet. Nutrition and Aging, 1(2), 113–121. https://doi.org/10.3233/NUA-2012-0010

Milenkovic, D., Deval, C., Dubray, C., Mazur, A., & Morand, C. (2011). Hesperidin displays relevant role in the nutrigenomic effect of orange juice on blood leukocytes in human volunteers: A randomized controlled Cross-Over study. PLoS ONE, 6(11). https://doi.org/10.1371/journal.pone.0026669

Chanet, A., Milenkovic, D., Deval, C., Potier, M., Constans, J., Mazur, A., … Bérard, A. M. (2012). Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in mice. Journal of Nutritional Biochemistry, 23(5), 469–477. https://doi.org/10.1016/j.jnutbio.2011.02.001

Mauray, A., Felgines, C., Morand, C., Mazur, A., Scalbert, A., & Milenkovic, D. (2012). Bilberry anthocyanin-rich extract alters expression of genes related to atherosclerosis development in aorta of apo E-deficient mice. Nutrition, Metabolism and Cardiovascular Diseases, 22(1), 72–80. https://doi.org/10.1016/j.numecd.2010.04.011

Morand, C., Dubray, C., Milenkovic, D., Lioger, D., Martin, J. F., Scalbert, A., & Mazur, A. (2011). Hesperidin contributes to the vascular protective effects of orange juice: A randomized crossover study in healthy volunteers. American Journal of Clinical Nutrition, 93(1), 73–80. https://doi.org/10.3945/ajcn.110.004945

Dejeans, N., Maier, J. A. M., Tauveron, I., Milenkovic, D., & Mazur, A. (2010). Modulation of gene expression in endothelial cells by hyperlipaemic postprandial serum from healthy volunteers. Genes and Nutrition, 5(3), 263–274. https://doi.org/10.1007/s12263-010-0166-x

Mauray, A., Felgines, C., Morand, C., Mazur, A., Scalbert, A., & Milenkovic, D. (2010). Nutrigenomic analysis of the protective effects of bilberry anthocyanin-rich extract in apo E-deficient mice. Genes and Nutrition, 5(4), 343–353. https://doi.org/10.1007/s12263-010-0171-0

Auclair, S., Chironi, G., Milenkovic, D., Hollman, P. C. H., Renard, C. M. G. C., Mégnien, J.-L., … Scalbert, A. (2010). The regular consumption of a polyphenol-rich apple does not influence endothelial function: A randomised double-blind trial in hypercholesterolemic adults. European Journal of Clinical Nutrition, 64(10), 1158–1165. https://doi.org/10.1038/ejcn.2010.135

Mauray, A., Milenkovic, D., Besson, C., Caccia, N., Morand, C., Michel, F., … Felgines, C. (2009). Atheroprotective effects of bilberry extracts in apo E-deficient mice. Journal of Agricultural and Food Chemistry, 57(23), 11106–11111. https://doi.org/10.1021/jf9035468

Dejeans, N., Auclair, S., Chauvet, S., Milenkovic, D., & Mazur, A. (2009). Transcriptomic analysis of aorta from a short-term high-fat diet fed mouse reveals changes in the expression of vessel structure genes. Journal of Physiology and Pharmacology, 60(SUPPL. 1), 37–45. Retrieved from http://www.scopus.com/inward/record.url?eid=2-s2.0-67749145262&partnerID=MN8TOARS

Transcriptomic analysis of aorta from a short-term high-fat diet fed mouse reveals changes in the expression of vessel structure genes. (2009). Journal of Physiology and Pharmacology. Retrieved from http://www.scopus.com/inward/record.url?eid=2-s2.0-67749145262&partnerID=MN8TOARS

Deval, C., Chaveroux, C., Maurin, A.-C., Cherasse, Y., Parry, L., Carraro, V., … Fafournoux, P. (2009). Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways. FEBS Journal, 276(3), 707–718. https://doi.org/10.1111/j.1742-4658.2008.06818.x

Auclair, S., Silberberg, M., Gueux, E., Morand, C., Mazur, A., Milenkovic, D., & Scalbert, A. (2008). Apple polyphenols and fibers attenuate atherosclerosis in apolipoprotein E-deficient mice. Journal of Agricultural and Food Chemistry, 56(14), 5558–5563. https://doi.org/10.1021/jf800419s

Auclair, S., Milenkovic, D., Besson, C., Chauvet, S., Gueux, E., Morand, C., … Scalbert, A. (2009). Catechin reduces atherosclerotic lesion development in apo E-deficient mice: A transcriptomic study. Atherosclerosis, 204(2). https://doi.org/10.1016/j.atherosclerosis.2008.12.007

Hamelin, M., Sayd, T., Chambon, C., Bouix, J., Bibé, B., Milenkovic, D., … Laville, E. (2007). Differential expression of sarcoplasmic proteins in four heterogeneous ovine skeletal muscles. Proteomics, 7(2), 271–280. https://doi.org/10.1002/pmic.200600309

Clop, A., Marcq, F., Takeda, H., Pirottin, D., Tordoir, X., Bibé, B., … Georges, M. (2006). A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep. Nature Genetics, 38(7), 813–818. https://doi.org/10.1038/ng1810

Georges, M., Clop, A., Marcq, F., Takeda, H., Pirottin, D., Hiard, S., … Charlier, C. (2006). Polymorphic microRNA-target interactions: A novel source of phenotypic variation. In Cold Spring Harbor Symposia on Quantitative Biology (Vol. 71, pp. 343–350). https://doi.org/10.1101/sqb.2006.71.056

Hamelin, M., Sayd, T., Chambon, C., Bouix, J., Bibé, B., Milenkovic, D., … Laville, E. (2006). Proteomic analysis of ovine muscle hypertrophy. Journal of Animal Science, 84(12), 3266–3276. https://doi.org/10.2527/jas.2006-162

Milenkovic, D., Mariat, D., Swinburne, J., Chadi-Taourit, S., Binns, M., & Guérin, G. (2005). Characterization and localization of 17 microsatellites derived from BACs in the horse. Animal Genetics, 36(2), 164–166. https://doi.org/10.1111/j.1365-2052.2004.01235.x

Milenkovic, D., Mata, X., Chadi, S., & Guérin, G. (2005). cDNA sequence of the horse (Equus caballus) LAMA3 gene and characterization of two intronic SNP markers. DNA Sequence - Journal of DNA Sequencing and Mapping, 16(6), 468–473. https://doi.org/10.1080/10425170500287674

Milenkovic, D., Chaffaux, S., Taourit, S., & Guérin, G. (2003). A mutation in the LAMC2 gene causes the Herlitz junctional epidermolysis bullosa (H-JEB) in two French draft horse breeds. Genetics Selection Evolution, 35(2), 249–256. Retrieved from http://www.scopus.com/inward/record.url?eid=2-s2.0-0038372743&partnerID=MN8TOARS

A mutation in the LAMC2 gene causes the Herlitz junctional epidermolysis bullosa (H-JEB) in two French draft horse breeds. (2003). Genetics Selection Evolution. Retrieved from http://www.scopus.com/inward/record.url?eid=2-s2.0-0038372743&partnerID=MN8TOARS

Genetic mapping of GBE1 and its association with glycogen storage disease IV in American Quarter horses. (2003). Cytogenetic and Genome Research, 102(1-4), 201–206. https://doi.org/10.1159/000075749

A specific pattern of splicing for the horse aS1-Casein mRNA and partial genomic characterization of the relevant locus. (2002). Genetics Selection Evolution. Retrieved from http://www.scopus.com/inward/record.url?eid=2-s2.0-0036653955&partnerID=MN8TOARS

Milenkovic, D., Martin, P., Guérin, G., & Leroux, C. (2002). A specific pattern of splicing for the horse αS1-Casein mRNA and partial genomic characterization of the relevant locus. Genetics Selection Evolution, 34(4), 509–519. Retrieved from http://www.scopus.com/inward/record.url?eid=2-s2.0-0036653955&partnerID=MN8TOARS

Milenkovic, D., Oustry-Vaiman, A., Lear, T. L., Billault, A., Mariat, D., Piumi, F., … Guérin, G. (2002). Cytogenetic localization of 136 genes in the horse: Comparative mapping with the human genome. Mammalian Genome, 13(9), 524–534. https://doi.org/10.1007/s00335-001-2137-4