Dustin M. Lockney

Works (3)

Updated: July 7th, 2023 21:18

2012 article

Avidity‐mediated virus separation using a hyperthermophilic affinity ligand

Hussain, M., Lockney, D., Wang, R., Gera, N., & Rao, B. M. (2012, November 1). Biotechnology Progress, Vol. 29, pp. 237–246.

By: M. Hussain n, D. Lockney n, R. Wang n, N. Gera n & B. Rao n 

Contributors: M. Hussain n, D. Lockney n, R. Wang n, N. Gera n & B. Rao n 

author keywords: avidity; affinity ligand; hyperthermophilic; multivalent
MeSH headings : Archaeal Proteins / chemistry; Archaeal Proteins / isolation & purification; Archaeal Proteins / metabolism; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / isolation & purification; DNA-Binding Proteins / metabolism; Ligands; Molecular Weight; Plant Extracts; Plant Leaves / virology; Sulfolobus solfataricus / chemistry; Sulfolobus solfataricus / metabolism; Tobacco / virology; Tombusviridae / isolation & purification
topics (OpenAlex): Monoclonal and Polyclonal Antibodies Research; Protein purification and stability; HIV/AIDS drug development and treatment
TL;DR: The approach may be broadly relevant to cases where capture of large multivalent species from complex mixtures and subsequent release without the use of harsh elution conditions is necessary, and bypasses chemical conjugation of the affinity ligand to the capture surface. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 article

Mass Spectrometric Detection of Targeting Peptide Bioconjugation to Red clover necrotic mosaic virus

Wang, R., Lockney, D. M., Goshe, M. B., & Franzen, S. (2011, August 22). Bioconjugate Chemistry, Vol. 22, pp. 1970–1982.

By: R. Wang, D. Lockney*, M. Goshe* & S. Franzen* 

MeSH headings : Amino Acid Sequence; Capsid / chemistry; Cross-Linking Reagents / chemistry; Drug Delivery Systems; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Peptides / chemistry; Tombusviridae / chemistry
topics (OpenAlex): Plant Virus Research Studies; Transgenic Plants and Applications; Bacteriophages and microbial interactions
TL;DR: Results show that heterobifunctional linkers may not be the most efficient method for attachment of peptides to plant virus capsids, and maleimide peptides were used to conjugate with the virus in a one-step reaction. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 article

The Red clover necrotic mosaic virus Capsid as a Multifunctional Cell Targeting Plant Viral Nanoparticle

Lockney, D. M., Guenther, R. N., Loo, L., Overton, W., Antonelli, R., Clark, J., … Franzen, S. (2010, December 2). Bioconjugate Chemistry, Vol. 22, pp. 67–73.

By: D. Lockney n, R. Guenther n, L. Loo n, W. Overton  n, R. Antonelli n, J. Clark  n, M. Hu n, C. Luft n, S. Lommel n, S. Franzen n 

MeSH headings : Amino Acid Sequence; Biological Availability; Biological Transport; Capsid / chemistry; Capsid / metabolism; Doxorubicin / chemistry; Doxorubicin / pharmacokinetics; Fluorescent Dyes / chemistry; HeLa Cells; Humans; Models, Molecular; Nanoparticles / chemistry; Peptides / chemistry; Peptides / metabolism; Plants / virology; Protein Conformation; Surface Properties; Tombusviridae
topics (OpenAlex): Plant Virus Research Studies; Bacteriophages and microbial interactions; Transgenic Plants and Applications
TL;DR: It is shown that targeting peptides (less than 16 amino acids) can be conjugated to the capsid using the heterobifunctional chemical linker sulfosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (Sulfo-SMCC). (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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