Works (2)

Updated: February 13th, 2024 05:00

2024 article

Effects of 4 Testing Arena Sizes and 11 Types of Embryo Media on Sensorimotor Behaviors in Wild-Type and <i>chd7</i> Mutant Zebrafish Larvae

Hodorovich, D. R., Harris, T. F., Burton, D. F., Neese, K. M., Bieler, R. A., Chudasama, V., & Marsden, K. C. (2024, February 1). ZEBRAFISH, Vol. 2.

By: D. Hodorovich n, T. Harris n, D. Burton n, K. Neese n, R. Bieler n, V. Chudasama n, K. Marsden n

author keywords: zebrafish; behavior; acoustic startle; embryo media; arena size; chd7
TL;DR: The data show that testing arena size impacts acoustic startle sensitivity and kinematics, as well as spontaneous locomotion and thigmotaxis, with fish tested in larger arenas displaying reduced startle sensitivity and increased locomotion. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 2, 2024

2023 article

Morphological and sensorimotor phenotypes in a zebrafish CHARGE syndrome model are domain-dependent

Hodorovich, D. R. R., Lindsley, P. M. M., Berry, A. A. A., Burton, D. F. F., & Marsden, K. C. C. (2023, January 30). GENES BRAIN AND BEHAVIOR, Vol. 1.

By: D. Hodorovich n, P. Lindsley n, A. Berry n, D. Burton n & K. Marsden n

author keywords: behavior; CHARGE syndrome; chd7; CRISPR; Cas9; zebrafish
MeSH headings : Animals; CHARGE Syndrome / genetics; CHARGE Syndrome / metabolism; Zebrafish / genetics; Zebrafish / metabolism; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Reflex, Startle; Phenotype; Mutation
TL;DR: A mutant chd7 zebrafish line is established using CRISPR/Cas9 that recapitulates multiple CHARGE phenotypes and it is shown that the penetrance of morphological and behavioral phenotypes depends on the mutation location. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 31, 2023

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