Darby Roberts

Works (6)

Updated: December 18th, 2024 14:40

2024 journal article

Cold atmospheric plasma inactivates<i> Aspergillus</i><i> flavus</i> and Fusarium keratoplasticum biofilms and conidia in vitro

JOURNAL OF MEDICAL MICROBIOLOGY, 73(7).

By: D. Roberts n , J. Thomas n, J. Salmon  n, M. Cubeta n , K. Stapelmann n  & B. Gilger n 

author keywords: antifungal; Aspergillus; cold atmospheric plasma; Fusarium; fungal disease.
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Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 15, 2024

2023 journal article

AAV-mediated expression of HLA-G for the prevention of experimental ocular graft vs. host disease

Molecular Therapy - Methods & Clinical Development, 29, 227–235.

By: J. Nilles n, D. Roberts n , J. Salmon  n, L. Song *, C. O’Dea*, L. Marjoram*, J. Bower *, M. Hirsch*, B. Gilger n 

TL;DR: Evidence is provided that subconjunctival AAV targets ocular surface and corneal disease and support that HLA-G-based gene therapy may be an effective treatment for OGvHD. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: March 24, 2023

2023 journal article

Phase-Dependent Differential In Vitro and Ex Vivo Susceptibility of Aspergillus flavus and Fusarium keratoplasticum to Azole Antifungals

Journal of Fungi, 9(10), 966.

By: D. Roberts n , J. Salmon  n, M. Cubeta n  & B. Gilger n 

author keywords: Aspergillus; Fusarium; fungal keratitis; antifungal susceptibility; MIC; azole
TL;DR: It is concluded that traditional antifungal susceptibility testing with conidial suspensions does not correlate with fungal susceptibility in cultures of a more advanced developmental phase, and a revised method of antif fungus susceptibility testing that evaluates hyphal susceptibility may better predict fungal response in the clinical setting where treatment is often delayed until days after the initial insult. (via Semantic Scholar)
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Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: September 27, 2023

2023 manuscript

Phase-Dependent Differential In Vitro and Ex Vivo Susceptibility of Aspergillus flavus and Fusarium keratoplasticum to Azole Antifungals

By: D. Roberts n , J. Salmon  n, M. Cubeta  n & B. Gilger n 

Source: ORCID
Added: September 11, 2023

2022 journal article

Inhibition of experimental autoimmune uveitis by intravitreal AAV-Equine-IL10 gene therapy

PLOS ONE, 17(8).

By: E. Crabtree  n, K. Uribe n, S. Smith n, D. Roberts n , J. Salmon  n, J. Bower *, L. Song *, P. Bastola *, M. Hirsch*, B. Gilger n 

Ed(s): A. Taylor

MeSH headings : Animals; Autoimmune Diseases; Dependovirus / genetics; Genetic Therapy; Horses / genetics; Humans; Interleukin-10 / genetics; Interleukin-10 / therapeutic use; Rats; Uveitis
TL;DR: Safety and efficacy of AAV8-Equine-IL10 to prevent EAU are demonstrated and support continued exploration of A AV gene therapy for the treatment of equine and perhaps human recurrent uveitis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 19, 2022

2020 journal article

In vitro susceptibility of <i>Aspergillus</i> and <i>Fusarium</i> associated with equine keratitis to new antifungal drugs

Veterinary Ophthalmology, 23(5), 918–922.

By: D. Roberts n , H. Cotter  n, M. Cubeta  n & B. Gilger n 

author keywords: Aspergillus; Fusarium; luliconazole; voriconazole
MeSH headings : Animals; Antifungal Agents / pharmacology; Antifungal Agents / therapeutic use; Aspergillus / drug effects; Eye Infections, Fungal / drug therapy; Eye Infections, Fungal / microbiology; Eye Infections, Fungal / veterinary; Female; Fusarium / drug effects; Horse Diseases / drug therapy; Horse Diseases / microbiology; Horses; Imidazoles / pharmacology; Imidazoles / therapeutic use; Keratitis / drug therapy; Keratitis / microbiology; Keratitis / veterinary; Male; Microbial Sensitivity Tests
TL;DR: Luliconazole exhibited increased growth inhibition against both Aspergillus and Fusarium compared to commonly used, standard antifungal drugs, and warrants further investigation for its potential as an antIFungal drug for equine fungal keratitis. (via Semantic Scholar)
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Sources: ORCID, Crossref, NC State University Libraries
Added: May 17, 2020

Employment

Updated: March 13th, 2024 08:29

North Carolina State University Raleigh, US
Graduate Research Assistant Department of Clinical Sciences

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