David S Lalush
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Works (48)
Updated: October 1st, 2024 05:01
2023 article
Delayed cartilage oligomeric matrix protein response to loading is associated with femoral cartilage composition post-ACLR
Lisee, C., Evans-Pickett, A., Davis-Wilson, H., Munsch, A. E., Longobardi, L., Schwartz, T. A., … Pietrosimone, B. (2023, June 16). EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY.
author keywords: Biomarkers; Serum; Cartilage; COMP; MRI
TL;DR:
Greater delayed sCOMP response to loading, a biomarker of cartilage breakdown, is associated with worse lateral femoral cartilage composition in the ACLR limb compared to the uninjured limb.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 26, 2023
2023 article
Striatal TSPO binding is associated with anhedonia severity and early life stress exposure in anhedonic patients with major depressive disorder
Phillips, R. D., Cummings, K., Dharanikota, A., Eisenlohr-Moul, T., Muscatell, K. A., Dichter, G. S., … Walsh, E. C. (2023, November). BRAIN BEHAVIOR AND IMMUNITY, Vol. 114, pp. 22–22.
Source: Web Of Science
Added: September 23, 2024
2023 journal article
Striatal dopamine in anhedonia: A simultaneous [11C]raclopride positron emission tomography and functional magnetic resonance imaging investigation
PSYCHIATRY RESEARCH-NEUROIMAGING, 333.
author keywords: Anhedonia; Dopamine; PET-MR; Reward; Mesolimbic; Self-reported stress
TL;DR:
Analysis of linkages between striatal DA, reward circuitry functioning, anhedonia, and, in an exploratory fashion, self-reported stress, in a transdiagnostic anhedonic sample provides evidence for reduced striatalDA functioning during reward processing and blunted mesocorticolimbic network functional connectivity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 12, 2024
2022 journal article
Loading during Midstance of Gait Is Associated with Magnetic Resonance Imaging of Cartilage Composition Following Anterior Cruciate Ligament Reconstruction
CARTILAGE, 13(1).
author keywords: biomechanics; vertical ground reaction force; posttraumatic osteoarthritis; T1 rho; ACL
MeSH headings : Adolescent; Adult; Anterior Cruciate Ligament Reconstruction / methods; Cartilage, Articular / pathology; Female; Gait; Humans; Knee Joint / diagnostic imaging; Knee Joint / surgery; Magnetic Resonance Imaging / methods; Male; Young Adult
TL;DR:
Biomechanical gait profiles that include greater vGRF during midstance are associated with MRI estimates of lesser proteoglycan density in the MFC, suggesting inability to unload the ACLR limb during midstances may be linked to joint tissue changes associated with PTOA development.
(via Semantic Scholar)
open access via journals.sagepub.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 21, 2022
2022 journal article
Worse Tibiofemoral Cartilage Composition Is Associated with Insufficient Gait Kinetics After ACL Reconstruction
MEDICINE & SCIENCE IN SPORTS & EXERCISE, 54(10), 1771–1781.
author keywords: POSTTRAUMATIC OSTEOARTHRITIS; T1 rho; MAGNETIC RESONANCE IMAGING; KNEE ADDUCTION MOMENT; GAIT
MeSH headings : Adolescent; Adult; Anterior Cruciate Ligament Injuries / surgery; Anterior Cruciate Ligament Reconstruction / methods; Biomechanical Phenomena; Cartilage, Articular; Female; Gait; Humans; Kinetics; Knee Joint; Magnetic Resonance Imaging / methods; Male; Osteoarthritis, Knee; Proteoglycans; Young Adult
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: September 29, 2022
2021 journal article
A simultaneous [C-11]raclopride positron emission tomography and functional magnetic resonance imaging investigation of striatal dopamine binding in autism
TRANSLATIONAL PSYCHIATRY, 11(1).
MeSH headings : Autism Spectrum Disorder / diagnostic imaging; Autistic Disorder / diagnostic imaging; Corpus Striatum / diagnostic imaging; Corpus Striatum / metabolism; Dopamine; Humans; Magnetic Resonance Imaging; Positron-Emission Tomography; Raclopride; Receptors, Dopamine D2 / metabolism
TL;DR:
The findings that ASD is characterized by impaired striatal phasic dopamine release to incentives provide support for the social motivation hypothesis of autism and PET-fMRI may be a suitable tool to evaluate novel ASD therapeutics targeting the striatal dopamine system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 15, 2021
2021 journal article
Association of Jump-Landing Biomechanics With Tibiofemoral Articular Cartilage Composition 12 Months After ACL Reconstruction
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE, 9(7).
author keywords: ACL; biomechanics; imaging; magnetic resonance; motion analysis; kinesiology
TL;DR:
At 12 months postoperatively, lower peak KEM and greater peak vGRF during jump landing were related to longer T1ρ relaxation times, suggesting worse articular cartilage composition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: September 13, 2021
2021 article
In Vivo Compositional Changes in the Articular Cartilage of the Patellofemoral Joint Following Anterior Cruciate Ligament Reconstruction
Boling, M. C., Dupell, M., Pfeiffer, S. J., Wallace, K., Lalush, D., Spang, J. T., … Pietrosimone, B. (2022, April 13). ARTHRITIS CARE & RESEARCH.
MeSH headings : Adolescent; Adult; Anterior Cruciate Ligament Injuries / surgery; Anterior Cruciate Ligament Reconstruction / methods; Cartilage, Articular / diagnostic imaging; Cartilage, Articular / surgery; Female; Humans; Knee Joint / surgery; Magnetic Resonance Imaging / methods; Male; Patellofemoral Joint / diagnostic imaging; Patellofemoral Joint / surgery; Young Adult
TL;DR:
To compare T1ρ relaxation times of the medial and lateral regions of the patella and femoral trochlea at 6 and 12 months following anterior cruciate ligament reconstruction (ACLR) on the ACLR and contralateral extremity, a comparison of proteoglycan density of articular cartilage is conducted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: April 25, 2022
2021 journal article
Tibiofemoral articular cartilage composition differs based on serum biochemical profiles following anterior cruciate ligament reconstruction
OSTEOARTHRITIS AND CARTILAGE, 29(12), 1732–1740.
author keywords: Magnetic resonance imaging; Biomarkers; Posttraumatic osteoarthritis; T1rho
MeSH headings : Anterior Cruciate Ligament Reconstruction; Biomarkers / blood; Cartilage Oligomeric Matrix Protein / blood; Cartilage, Articular / diagnostic imaging; Chemokine CCL2 / blood; Cohort Studies; Female; Humans; Knee Joint / diagnostic imaging; Longitudinal Studies; Magnetic Resonance Imaging; Male; Young Adult
TL;DR:
Profiles of increased serum levels of inflammation and matrix degradation markers preoperatively to 6-months post-ACLR are associated with MRI changes consistent with lesser lateral tibiofemoral cartilage proteoglycan density 12-months after anterior cruciate ligament reconstruction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 3, 2022
2019 article
ASSOCIATIONS BETWEEN LATERAL COMPARTMENT T1RHO MRI INTER-LIMB RATIOS AND CHANGES IN WALKING GAIT KINEMATICS FOLLOWING ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION
Pfeiffer, S. J., Spang, J. T., Nissman, D., Lalush, D., Wallace, K., Harkey, M. S., … Pietrosimone, B. (2019, April). OSTEOARTHRITIS AND CARTILAGE, Vol. 27, pp. S136–S137.
Source: Web Of Science
Added: April 20, 2020
2018 journal article
3D Auto-Context-Based Locality Adaptive Multi-Modality GANs for PET Synthesis
IEEE TRANSACTIONS ON MEDICAL IMAGING, 38(6), 1328–1339.
author keywords: Image synthesis; positron emission topography (PET); generative adversarial networks (GANs); locality adaptive fusion; multi-modality
MeSH headings : Brain / diagnostic imaging; Databases, Factual; Deep Learning; Humans; Imaging, Three-Dimensional / methods; Magnetic Resonance Imaging / methods; Phantoms, Imaging; Positron-Emission Tomography / methods; Radiation Dosage
TL;DR:
Experimental results show that the proposed 3D auto-context-based locality adaptive multi-modality generative adversarial networks model (LA-GANs) outperforms the traditional multi- modality fusion methods used in deep networks, as well as the state-of-the-art PET estimation approaches.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 20, 2020
2018 journal article
3D conditional generative adversarial networks for high-quality PET image estimation at low dose
NEUROIMAGE, 174, 550–562.
author keywords: Positron emission tomography (PET); Generative adversarial networks (GANs); 3D conditional GANs (3D c-GANs); Low-dose PET; Image estimation
MeSH headings : Adult; Brain / diagnostic imaging; Deep Learning; Female; Humans; Image Processing, Computer-Assisted / methods; Male; Positron-Emission Tomography / methods; Radiation Dosage; Reproducibility of Results; Signal-To-Noise Ratio; Young Adult
TL;DR:
Experimental results show that the proposed 3D c‐GANs method outperforms the benchmark methods and achieves much better performance than the state‐of‐the‐art methods in both qualitative and quantitative measures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Gait Mechanics and T1 rho MRI of Tibiofemoral Cartilage 6 Months after ACL Reconstruction
MEDICINE & SCIENCE IN SPORTS & EXERCISE, 51(4), 630–639.
author keywords: BIOMECHANICS; PROTEOGLYCAN DENSITY; POSTTRAUMATIC; OSTEOARTHRITIS
MeSH headings : Anterior Cruciate Ligament Injuries / diagnostic imaging; Anterior Cruciate Ligament Injuries / physiopathology; Anterior Cruciate Ligament Injuries / surgery; Anterior Cruciate Ligament Reconstruction / methods; Arthroscopy; Biomechanical Phenomena; Cartilage, Articular / chemistry; Cartilage, Articular / diagnostic imaging; Cartilage, Articular / physiopathology; Cross-Sectional Studies; Female; Gait / physiology; Humans; Knee Joint / chemistry; Knee Joint / diagnostic imaging; Knee Joint / physiopathology; Magnetic Resonance Imaging / methods; Male; Osteoarthritis, Knee / etiology; Proteoglycans / analysis; Risk Factors; Young Adult
TL;DR:
Associations between outcomes related to lesser mechanical loading during walking and greater T1&rgr; MRI ILR were found 6 months after ACLR, suggesting that underloading of the ACLR limb at 6 monthsAfter ACLR may be associated with lesser proteoglycan density in the ACLr limb compared with the uninjured limb.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: April 2, 2019
2018 article
Locality Adaptive Multi-modality GANs for High-Quality PET Image Synthesis
MEDICAL IMAGE COMPUTING AND COMPUTER ASSISTED INTERVENTION - MICCAI 2018, PT I, Vol. 11070, pp. 329–337.
MeSH headings : Algorithms; Electrons; Magnetic Resonance Imaging / methods; Multimodal Imaging / methods; Neural Networks, Computer; Positron-Emission Tomography / methods; Reproducibility of Results; Sensitivity and Specificity
TL;DR:
A locality adaptive multi-modality generative adversarial networks model (LA-GANs) is proposed to synthesize the full-dose PET image from both the low-dose one and the accompanying T1-weighted MRI to incorporate anatomical information for better PET image synthesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 19, 2019
2018 journal article
Quadriceps weakness associates with greater T1 rho relaxation time in the medial femoral articular cartilage 6months following anterior cruciate ligament reconstruction
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 27(8), 2632–2642.
author keywords: Posttraumatic osteoarthritis; T1rho; Knee extensor; Proteoglycan
MeSH headings : Adolescent; Adult; Anterior Cruciate Ligament Injuries / surgery; Anterior Cruciate Ligament Reconstruction; Cartilage, Articular / chemistry; Cartilage, Articular / diagnostic imaging; Cross-Sectional Studies; Female; Femur / surgery; Humans; Isometric Contraction; Knee Joint / diagnostic imaging; Knee Joint / surgery; Magnetic Resonance Imaging / methods; Male; Meniscus; Muscle Strength; Patellar Ligament / transplantation; Proteoglycans / analysis; Quadriceps Muscle / physiology; Transplantation, Autologous; Young Adult
TL;DR:
The association between weaker quadriceps and greater T1ρ relaxation times in the MFC suggests deficits in lower extremity muscle strength may be related to cartilage composition as early as 6 months following ACLR.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 12, 2019
2018 journal article
Quadriceps weakness is associated with lesser proteoglycan density in the medial femoral cartilage six-months following anterior cruciate ligament reconstruction
Osteoarthritis and Cartilage, 26, S372–S373.
Source: Crossref
Added: February 24, 2020
2017 journal article
Magnetic Resonance-Derived Improvements on PET Imaging
MAGNETIC RESONANCE IMAGING CLINICS OF NORTH AMERICA, 25(2), 257-+.
author keywords: PET-MR imaging; PET motion correction; PET partial volume correction; MR-based PET reconstruction
MeSH headings : Humans; Image Processing, Computer-Assisted / methods; Magnetic Resonance Imaging / methods; Multimodal Imaging / methods; Positron-Emission Tomography / methods
TL;DR:
Simultaneous PET-MR imaging improves deficiencies in PET images and partial volume correction or resolution improvement of PET governed by MR imaging anatomic information improves visualization of structures and quantitative accuracy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Alternate Metabolic Programs Define Regional Variation of Relevant Biological Features in Renal Cell Carcinoma Progression
CLINICAL CANCER RESEARCH, 22(12), 2950–2959.
MeSH headings : Biomarkers, Tumor / genetics; Biomarkers, Tumor / metabolism; Carcinoma, Renal Cell / diagnostic imaging; Carcinoma, Renal Cell / genetics; Carcinoma, Renal Cell / pathology; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms / diagnostic imaging; Kidney Neoplasms / genetics; Kidney Neoplasms / pathology; Magnetic Resonance Imaging / methods; Microarray Analysis; Positron Emission Tomography Computed Tomography / methods
TL;DR:
Higher tumor dependency on exogenous glucose accompanies the development of features associated with the poor risk ccB subgroup, and linking these panels of features may provide the opportunity to create functional maps to enable enhanced visualization of the heterogeneous biologic processes of an individual's disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Data on biodistribution and radiation absorbed dose profile of a novel 64Cu-labeled high affinity cell-specific peptide for positron emission tomography imaging of tumor vasculature
Data in Brief, 7, 480–484.
author keywords: Molecular imaging; Tumor angiogenesis; Radiation absorbed dose; Diagnostic radiopharmaceuticals
TL;DR:
Biodistribution measurements in mice are reported and the radiation absorbed doses to normal organs are calculated using a modified Medical Internal Radiation Dosimetry (MIRD) methodology that accounts for physical and geometric factors and cross-organ beta doses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: November 21, 2020
2016 journal article
Multi-Level Canonical Correlation Analysis for Standard-Dose PET Image Estimation
IEEE TRANSACTIONS ON IMAGE PROCESSING, 25(7), 3303–3315.
author keywords: PET estimation; multi-level CCA; sparse representation; locality-constrained linear coding; multi-modal MRI
TL;DR:
Validations on phantom and real human brain data sets show that the proposed data-driven multi-level canonical correlation analysis scheme effectively estimates S-PET images and well preserves critical clinical quantification measures, such as standard uptake value.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Predicting standard-dose PET image from low-dose PET and multimodal MR images using mapping-based sparse representation
Physics in Medicine and Biology, 61(2), 791–812.
author keywords: positron emission tomography (PET); sparse representation; mapping-based sparse representation; incremental refinement; standard-dose PET prediction; multimodal MR images
MeSH headings : Brain / diagnostic imaging; Brain Mapping / methods; Humans; Image Processing, Computer-Assisted / methods; Magnetic Resonance Imaging / methods; Multimodal Imaging / methods; Positron-Emission Tomography / methods; Radiation Dosage
TL;DR:
Inspired by the success of patch-based sparse representation (SR) in super-resolution image reconstruction, a mapping-based SR (m-SR) framework is proposed for standard-dose PET image prediction and can outperform benchmark methods in both qualitative and quantitative measures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science
Added: August 6, 2018
2016 journal article
Semisupervised Tripled Dictionary Learning for Standard-Dose PET Image Prediction Using Low-Dose PET and Multimodal MRI
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 64(3), 569–579.
author keywords: Local coordinate coding (LCC); positron emission tomography (PET); semisupervised tripled dictionary learning (SSTDL); sparse representation (SR)
MeSH headings : Algorithms; Humans; Image Enhancement / methods; Magnetic Resonance Imaging / methods; Multimodal Imaging / methods; Pattern Recognition, Automated / methods; Positron-Emission Tomography / methods; Radiation Dosage; Radiation Exposure / prevention & control; Radiation Protection / methods; Reproducibility of Results; Sensitivity and Specificity; Subtraction Technique; Supervised Machine Learning
TL;DR:
A new S-PET prediction method is proposed, which can significantly improve the PET image quality with low-dose injection and is favorable in clinical application since it can decrease the potential radiation risk for patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Synthesis and comparative evaluation of novel Cu-64-labeled high affinity cell-specific peptides for positron emission tomography imaging of tumor vasculature
BIOMATERIALS, 84, 241–249.
author keywords: Molecular imaging; Tumor angiogenesis; Cu-64-labeled cell-specific peptides; Diagnostic PET radiopharmaceuticals; Radiation absorbed dose
MeSH headings : Animals; Cell Line, Tumor; Copper Radioisotopes / chemistry; Dose-Response Relationship, Radiation; Female; Humans; Isotope Labeling; Mice, Inbred C57BL; Neoplasms / blood supply; Neoplasms / diagnostic imaging; Peptides / chemical synthesis; Peptides / chemistry; Positron-Emission Tomography / methods; Radiation Dosage; Tissue Distribution; Tomography, X-Ray Computed
TL;DR:
The findings from this investigation warrant further development of (64)Cu-NOTA-FHT as a potential targeted diagnostic radiopharmaceutical for PET imaging of aggressive tumor vasculature.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 chapter
A Multi-level Canonical Correlation Analysis Scheme for Standard-Dose PET Image Estimation
In Patch-Based Techniques in Medical Imaging (pp. 1–9).
TL;DR:
A data-driven multi-level Canonical Correlation Analysis scheme that uses a subset of training data that are most useful in estimating a target S-PET patch are identified in each level, and using these selected training data in the subsequent level leads to more accurate common space mapping and improved estimation.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2015 journal article
MR-based attenuation correction for PET/MRI neurological studies with continuous-valued attenuation coefficients for bone through a conversion from R2*to CT-Hounsfield units
NEUROIMAGE, 112, 160–168.
MeSH headings : Adipose Tissue / anatomy & histology; Aged; Air; Algorithms; Aniline Compounds; Bone and Bones / anatomy & histology; Bone and Bones / diagnostic imaging; Brain / anatomy & histology; Brain / diagnostic imaging; Ethylene Glycols; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging / methods; Magnetic Resonance Imaging / statistics & numerical data; Male; Middle Aged; Neuroimaging / statistics & numerical data; Positron-Emission Tomography / methods; Positron-Emission Tomography / statistics & numerical data; Radiopharmaceuticals; Skull / anatomy & histology; Skull / diagnostic imaging
TL;DR:
The proposed CAR-RiDR method closely approaches (<3% error) the gold standard CT-scaled method in PET reconstruction accuracy and provides a low whole-brain mean absolute percent-error in PET reconstructions across subjects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 chapter
Predicting Standard-Dose PET Image from Low-Dose PET and Multimodal MR Images Using Mapping-Based Sparse Representation
In Machine Learning in Medical Imaging (pp. 127–135).
Source: Crossref
Added: February 24, 2020
2015 journal article
Prediction of standard-dose brain PET image by using MRI and low-dose brain [F-18]FDG PET images
MEDICAL PHYSICS, 42(9), 5301–5309.
author keywords: positron emission tomography (PET); [F-18]FDG; brain [F-18]FDG PET prediction; regression forest
MeSH headings : Brain / diagnostic imaging; Fluorodeoxyglucose F18; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Positron-Emission Tomography / methods; Radiation Dosage
TL;DR:
Both the visual and quantitative results indicate that the standard-dose brain [(18)F]FDG PET can be well-predicted using MRI and low-dose head PET images, and substantially enhanced image quality of low- doses PET and PET image.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination
Molecular and Cellular Endocrinology, 413, 36–48.
author keywords: Cardiomyocyte; Peroxisome proliferator-activated receptor alpha; Fatty acid metabolism; Cardiac metabolism; Monoubiquitination; Muscle ring finger-1
MeSH headings : Active Transport, Cell Nucleus / genetics; Animals; Cell Nucleus / genetics; Cell Nucleus / metabolism; Cell Nucleus / pathology; Heart Failure / genetics; Heart Failure / metabolism; Heart Failure / pathology; Mice; Mice, Knockout; Muscle Proteins / genetics; Muscle Proteins / metabolism; Myocardium / metabolism; Myocardium / pathology; PPAR alpha / genetics; PPAR alpha / metabolism; Tripartite Motif Proteins; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Ubiquitination
TL;DR:
An ubiquitin ligase (muscle ring finger-1/MuRF1) that inhibits fatty acid oxidation by inhibiting PPARα, but not PPARβ/δ or PPARγ in cardiomyocytes in vitro is reported.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2013 journal article
Cyclic Tensile Strain Enhances Osteogenesis and Angiogenesis in Mesenchymal Stem Cells from Osteoporotic Donors
TISSUE ENGINEERING PART A, 20(1-2), 67–78.
MeSH headings : Aged, 80 and over; Calcium / metabolism; Cell Differentiation; Cell Proliferation; Cell Separation; Female; Gene Expression Regulation; Gene Regulatory Networks; Humans; Mesenchymal Stem Cells / metabolism; Mesenchymal Stem Cells / pathology; Neovascularization, Physiologic / genetics; Oligonucleotide Array Sequence Analysis; Osteogenesis / genetics; Osteoporosis, Postmenopausal / genetics; Osteoporosis, Postmenopausal / pathology; Proto-Oncogene Mas; Real-Time Polymerase Chain Reaction; Signal Transduction / genetics; Stress, Mechanical; Tensile Strength; Tissue Donors; White People
TL;DR:
It is demonstrated that hMSC from aged, osteoporotic donors are capable of enhanced osteogenic differentiation in response to 10% cyclic tensile strain with significant increases in the expression of genes associated with enhanced cell proliferation, musculoskeletal development, and angiogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Development of a New Positron Emission Tomography Tracer for Targeting Tumor Angiogenesis: Synthesis, Small Animal Imaging, and Radiation Dosimetry
MOLECULES, 18(5), 5594–5610.
author keywords: development of new 64Cu radiolabeled peptide; radiopharmaceuticals; targeted radioconjugates; positron emission tomography (PET) imaging; tumor angiogenesis; tumor aggressiveness; responses to therapy
MeSH headings : Animals; Carcinoma, Lewis Lung / diagnostic imaging; Carcinoma, Lewis Lung / metabolism; Copper / chemistry; Female; Isotopes / chemistry; Mice; Neovascularization, Pathologic / diagnostic imaging; Neovascularization, Pathologic / metabolism; Peptides / chemical synthesis; Peptides / chemistry; Peptides / pharmacology; Positron-Emission Tomography; Radiography; Radiopharmaceuticals / chemical synthesis; Radiopharmaceuticals / chemistry; Radiopharmaceuticals / pharmacology
TL;DR:
The results from this study show that, in the context of the s.c. LLC immunocompetent mouse model, the QFP-tracer can target tumor blood vessels selectively, however, further optimization of the biodistribution and dosimetry profile of the tracer is necessary to ensure efficient radiopharmaceutical applications enabled by the biological specificity of the Q FP-peptide.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Eigenvector decomposition of full-spectrum x-ray computed tomography
PHYSICS IN MEDICINE AND BIOLOGY, 57(5), 1309–1323.
MeSH headings : Absorption; Algorithms; Contrast Media / pharmacology; Humans; Image Processing, Computer-Assisted; Models, Statistical; Phantoms, Imaging; Photons; Radiographic Image Interpretation, Computer-Assisted / methods; Scattering, Radiation; Tomography, X-Ray Computed / methods; X-Rays
TL;DR:
It is concluded that the noise–resolution trade off along the energy axis was significantly improved using the eigenvalue decomposition basis functions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Efficient In Vivo Selection of a Novel Tumor-Associated Peptide from a Phage Display Library
MOLECULES, 16(1), 900–914.
author keywords: in vivo phage display; circulating bone marrow derived tumor homing cells; tumor-associated peptides; targeting neovascular growth; positron emission tomography (PET) imaging
MeSH headings : Amino Acid Sequence; Animals; Bacteriophages / genetics; Mice; Neoplasms, Experimental / genetics; Peptides / chemistry; Peptides / genetics; Peptides / isolation & purification
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Microarray Analysis of Human Adipose-Derived Stem Cells in Three-Dimensional Collagen Culture: Osteogenesis Inhibits Bone Morphogenic Protein and Wnt Signaling Pathways, and Cyclic Tensile Strain Causes Upregulation of Proinflammatory Cytokine Regulators and Angiogenic Factors
TISSUE ENGINEERING PART A, 17(21-22), 2615–2627.
MeSH headings : Adipose Tissue / cytology; Adult; Angiogenesis Inducing Agents / metabolism; Bone Morphogenetic Proteins / genetics; Bone Morphogenetic Proteins / metabolism; Cells, Cultured; Collagen / metabolism; Cytokines / genetics; Cytokines / metabolism; Humans; Insulin-Like Growth Factor I / genetics; Middle Aged; Oligonucleotide Array Sequence Analysis / methods; Osteogenesis / genetics; Osteogenesis / physiology; Platelet-Derived Growth Factor / genetics; Signal Transduction / genetics; Signal Transduction / physiology; Stem Cells / cytology; Stem Cells / metabolism; Wnt Signaling Pathway / genetics; Wnt Signaling Pathway / physiology
TL;DR:
This first study to investigate the effects of both 3D culture and mechanical load on hASC osteogenic differentiation and response to mechanical stimuli identified specific genes and pathways associated with mechanical response and osteogenic potential of hASC, thus providing significant information toward improved understanding of its use for functional bone tissue engineering applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Full-Spectrum CT Reconstruction Using a Weighted Least Squares Algorithm With an Energy-Axis Penalty
IEEE TRANSACTIONS ON MEDICAL IMAGING, 30(2), 173–183.
author keywords: Attenuation curve; cadmium zinc telluride (CZT) detectors; penalized weighted least squares (PWLS); X-ray computed tomography
MeSH headings : Algorithms; Cadmium; Image Processing, Computer-Assisted / methods; Least-Squares Analysis; Phantoms, Imaging; Reproducibility of Results; Tellurium; Tomography, X-Ray Computed / instrumentation; Tomography, X-Ray Computed / methods; Zinc
TL;DR:
This paper proposes a penalized weighted least squares (PWLS) algorithm for reconstruction of polychromatic energy-differentiated X-ray CT data and a unique experimental setup to take energy- differentiatedX-rayCT data, and concludes that this algorithm is an effective method for reconstructing energy-sensitive CT data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Three-Dimensional Imaging Properties of Rotation-Free Square and Hexagonal Micro-CT Systems
IEEE TRANSACTIONS ON MEDICAL IMAGING, 29(3), 916–923.
author keywords: Carbon-nanotube; image reconstruction; micro-computed tomography (CT); X-ray computed tomography
MeSH headings : Animals; Artifacts; Computer Simulation; Image Processing, Computer-Assisted / methods; Imaging, Three-Dimensional / methods; Mice; Nanotubes, Carbon; Phantoms, Imaging; Poisson Distribution; Whole Body Imaging / methods; X-Ray Microtomography / methods
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
A dynamic micro-CT scanner based on a carbon nanotube field emission x-ray source
PHYSICS IN MEDICINE AND BIOLOGY, 54(8), 2323–2340.
MeSH headings : Anesthesia; Animals; Feasibility Studies; Linear Models; Mice; Nanotubes, Carbon; Prospective Studies; Radiation Dosage; Respiration; Respiratory-Gated Imaging Techniques; Time Factors; X-Ray Microtomography / instrumentation
TL;DR:
A prototype physiologically gated micro-computed tomography (micro-CT) scanner based on a carbon nanotube field emission micro-focus x-ray source with high spatial and temporal resolutions that is well suited for high-resolution imaging of free-breathing small animals.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
A faster ordered-subset convex algorithm for iterative reconstruction in a rotation-free micro-CT system
Physics in Medicine and Biology, 54(4), 1061–1072.
MeSH headings : Algorithms; Artificial Intelligence; Imaging, Three-Dimensional / methods; Pattern Recognition, Automated / methods; Phantoms, Imaging; Radiographic Image Enhancement / methods; Radiographic Image Interpretation, Computer-Assisted / methods; Reproducibility of Results; Sensitivity and Specificity; Tomography, X-Ray Computed / methods
TL;DR:
The modified OSC (MOSC) algorithm was applied to a rotation-free micro-CT system that was proposed previously, observed its performance, and compared with the OSC algorithm for 3D cone-beam reconstruction and concluded that the MOSC algorithm is more efficient than OSC and provides comparable images.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: August 28, 2020
2009 journal article
Comparison of diffraction-enhanced computed tomography and monochromatic synchrotron radiation computed tomography of human trabecular bone
PHYSICS IN MEDICINE AND BIOLOGY, 54(20), 6123–6133.
Event: at UK
MeSH headings : Absorption; Bone and Bones / diagnostic imaging; Bone and Bones / pathology; Equipment Design; Humans; Normal Distribution; Radiographic Image Interpretation, Computer-Assisted / methods; Scattering, Radiation; Silicon; Synchrotrons; Tibia / diagnostic imaging; Tibia / pathology; Tomography, X-Ray Computed / methods; X-Rays
TL;DR:
The apparent absorption DECT images have significantly higher spatial resolution and CNR than the corresponding SRCT images, and will prove to be a useful tool for imaging applications in which high contrast and high spatial resolution are required for both soft tissue features and bone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2009 journal article
Design and characterization of a spatially distributed multibeam field emission x-ray source for stationary digital breast tomosynthesis
MEDICAL PHYSICS, 36(10), 4389–4399.
author keywords: tomosynthesis; breast imaging; x-ray; carbon nanotube; field emission
MeSH headings : Computer-Aided Design; Equipment Design; Equipment Failure Analysis; Mammography / instrumentation; Radiographic Image Enhancement / instrumentation; Radiometry; Reproducibility of Results; Scattering, Radiation; Sensitivity and Specificity; Tomography, X-Ray Computed / instrumentation; Transducers; X-Rays
TL;DR:
The authors demonstrate experimentally the feasibility of achieving 11 s scanning time at full detector resolution with 0.3 mm source resolution without motion blur and evaluate the emission current, current variation, lifetime, and focal spot sizes of the source array.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Improved Dynamic Cardiac Phantom Based on 4D NURBS and Tagged MRI
IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 56(5), 2728–2738.
author keywords: Cardiac; medical imaging; phantom; simulation
TL;DR:
The new cardiac model was incorporated into the 4D NURBS-based Cardiac-Torso (NCAT) phantom widely used in imaging research and will provide a useful tool in the study of cardiac imaging and the effects of cardiac motion in medical images.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Binary encoding of multiplexed images in mixed noise
IEEE TRANSACTIONS ON MEDICAL IMAGING, 27(9), 1323–1332.
author keywords: binary coding; Hadamard spectroscopy; mixed noise; multiplexing
MeSH headings : Algorithms; Animals; Information Storage and Retrieval / methods; Mice; Radiographic Image Enhancement / methods; Radiographic Image Interpretation, Computer-Assisted / methods; Signal Processing, Computer-Assisted
TL;DR:
The model developed provides a simple framework for analysis, discovery, and optimization of binary coding patterns used in multiplexed imaging systems and predicts trends and rank order of performance in regions of nonuniform images and in a simple tomosynthesis reconstruction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Semiautomated finite element mesh generation methods for a long bone
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, 85(3), 196–202.
author keywords: canine radius; CT to FEA; four-point bending; strain gage
MeSH headings : Animals; Bone and Bones / diagnostic imaging; Cadaver; Computer Simulation; Dogs; Finite Element Analysis; North Carolina; Tomography, X-Ray Computed
TL;DR:
A semi-automated finite element mesh generation method using computed tomography image data of a canine radius is developed and test to minimize user interaction and eliminate the need for mesh smoothing to produce a model suitable for finite element analysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 conference paper
A faster ordered-subset convex algorithm for iterative reconstruction
2006 ieee nuclear science symposium conference record, vol 1-6, 3424–3427.
TL;DR:
A faster iterative reconstruction algorithm based on the ordered-subset convex (OSC) algorithm for transmission CT, modified such that it calculates the normalization term before the iterative process in order to save computational cost.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
2006 conference paper
Three-dimensional tomosynthesis reconstruction from 1D and 2D X-ray source arrays
2006 ieee nuclear science symposium conference record, vol 1-6, 1670–1673.
TL;DR:
In a tomosynthesis system such as that described here, a 2D source array will outperform a 1D array in terms of contrast-to-noise and resolution, while also increasing the usable field-of-view, and that further studies encompassing the effects of scatter will be needed to optimize such systems.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
A nanotube-based field emission x-ray source for microcomputed tomography
Review of Scientific Instruments, 76(9), 094301.
Source: Crossref
Added: August 28, 2020
2005 journal article
An observer study methodology for evaluating detection of motion abnormalities in gated myocardial perfusion SPECT
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 52(3), 480–485.
author keywords: gated SPECT; myocardial SPECT
MeSH headings : Artificial Intelligence; Gated Blood-Pool Imaging / instrumentation; Gated Blood-Pool Imaging / methods; Heart Ventricles / diagnostic imaging; Heart Ventricles / physiopathology; Humans; Image Interpretation, Computer-Assisted / methods; Movement; Observer Variation; Phantoms, Imaging; Reproducibility of Results; Sample Size; Sensitivity and Specificity; Task Performance and Analysis; Tomography, Emission-Computed, Single-Photon / instrumentation; Tomography, Emission-Computed, Single-Photon / methods; Ventricular Dysfunction, Left / diagnostic imaging; Ventricular Dysfunction, Left / physiopathology; Video Recording / methods
TL;DR:
It is concluded that, for the task of detecting abnormal motion, increasing the number of gated frames from 8 to 16 offers no apparent advantage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Optimization of acquisition parameters for simultaneous Tl-201 and Tc-99m dual-isotope myocardial imaging
IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 52(5), 1227–1235.
author keywords: listmode; optimization; simultaneous dual-isotope imaging; (99m) Tc, Tl-201
TL;DR:
This work seeks the acquisition parameters (i.e., energy window width and center) that have the optimal tradeoff between minimizing the crosstalk and maximizing the detection efficiency in /sup 201/Tl//sup 99m/Tc dual-isotope simultaneous-acquisition myocardial imaging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
An observer study evaluating dual-plane circular-orbit cone- beam brain SPECT
Journal of Nuclear Medicine, 43(11), 1578–1583.
Source: NC State University Libraries
Added: August 6, 2018
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