Works (16)
Updated: July 5th, 2023 15:59
2008 review
Mass spectrometric assay and physiological-pharmacological activity of androgenic neurosteroids
[Review of ]. Neurochemistry International, 52(4-5), 541–553.
Source: NC State University Libraries
Added: August 6, 2018
2007 journal article
Differential anesthetic activity of ketamine and the GABAergic neurosteroid allopregnanolone in mice lacking progesterone receptor a and B subtypes
Methods and Findings in Experimental and Clinical Pharmacology, 29(10), 659–664.
MeSH headings : Analgesics / administration & dosage; Analgesics / chemistry; Analgesics / pharmacology; Animals; Dose-Response Relationship, Drug; Female; GABA Agonists / administration & dosage; GABA Agonists / chemistry; GABA Agonists / pharmacology; Genotype; Immunochemistry; Injections, Intraperitoneal; Injections, Subcutaneous; Ketamine / administration & dosage; Ketamine / chemistry; Ketamine / pharmacology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pregnanolone / administration & dosage; Pregnanolone / chemistry; Pregnanolone / pharmacology; Protein Isoforms / genetics; Protein Isoforms / metabolism; Reaction Time / drug effects; Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors; Receptors, Progesterone / genetics; Receptors, Progesterone / metabolism; Sex Factors; Stereoisomerism
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Hippocampal neurodegeneration, spontaneous seizures, and mossy fiber sprouting in the F344 rat model of temporal lobe epilepsy
JOURNAL OF NEUROSCIENCE RESEARCH, 83(6), 1088–1105.
author keywords: temporal lobe epilepsy; epilepsy; hippocampal neurodegeneration; spontaneous seizures; mossy fiber sprouting
MeSH headings : Animals; Behavior, Animal; Cell Death / drug effects; Disease Models, Animal; Electroencephalography / methods; Epilepsy, Temporal Lobe / chemically induced; Epilepsy, Temporal Lobe / complications; Epilepsy, Temporal Lobe / pathology; Epilepsy, Temporal Lobe / physiopathology; Fluoresceins; Forelimb / drug effects; Forelimb / physiopathology; Functional Laterality / physiology; Hippocampus / pathology; Immunohistochemistry / methods; In Situ Nick-End Labeling / methods; Kainic Acid / toxicity; Male; Mossy Fibers, Hippocampal / physiopathology; Neuropeptide Y / metabolism; Organic Chemicals; Phosphopyruvate Hydratase / metabolism; Rats; Rats, Inbred F344; Seizures / physiopathology; Silver Staining / methods; Time Factors
TL;DR:
The F344 model appears ideal for testing the efficacy of potential treatment strategies for mesial TLE, and the occurrence of SRMS in this model is always associated with considerable bilateral hippocampal neurodegeneration and aberrant MFS, however, more extensive hippocampal CA3 cell loss and aberant MFS do not appear to increase the frequency ofSRMS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Physiological role of adrenal deoxycorticosterone-derived neuroactive steroids in stress-sensitive conditions
NEUROSCIENCE, 138(3), 911–920.
author keywords: allopregnanolone; anxiety; deoxycorticosterone; depression; epilepsy; GABA(A) receptor
MeSH headings : Adrenal Cortex / physiology; Adrenal Cortex / physiopathology; Animals; Desoxycorticosterone / metabolism; Disease Models, Animal; Epilepsy / physiopathology; Humans; Models, Neurological; Receptors, GABA-A / physiology; Seizures / physiopathology; Steroids / physiology; Stress, Physiological / physiopathology
TL;DR:
These studies indicate that the anticonvulsant activity of deoxycorticosterone is mediated by its conversion to allotetrahydrodeoxycORTicosterone, which is a potent positive allosteric modulator of GABA(A) receptors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
A high-performance liquid chromatography-tandem mass spectrometry assay of the androgenic neurosteroid 3 alpha-androstanediol (5 alpha-androstane-3 alpha,17 beta-diol) in plasma
STEROIDS, 70(13), 879–885.
author keywords: liquid chromatography; mass spectrometry; 3 alpha-androstanediol; finasteride; neurosteroids; testosterone
MeSH headings : 3-Oxo-5-alpha-Steroid 4-Dehydrogenase / metabolism; 5-alpha Reductase Inhibitors; Androstane-3,17-diol / biosynthesis; Androstane-3,17-diol / blood; Androstane-3,17-diol / standards; Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Finasteride / pharmacology; Mass Spectrometry / methods; Rats; Reproducibility of Results; Testosterone / pharmacology
TL;DR:
A liquid chromatography–tandem mass spectrometry (LC–MS–MS) assay to measure 3α-androstanediol in rat plasma has been established with excellent linearity, specificity, sensitivity, and reproducibility.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Anesthetic effects of progesterone are undiminished in progesterone receptor knockout mice
BRAIN RESEARCH, 1033(1), 96–101.
author keywords: progesterone; neurosteroid; allopregnanolone; progesterone receptor; sleep; righting reflex
MeSH headings : Analysis of Variance; Anesthetics / blood; Anesthetics / pharmacology; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors / pharmacology; Female; Finasteride / pharmacology; Mice; Mice, Inbred C57BL; Mice, Knockout; Pregnanolone / blood; Pregnanolone / pharmacology; Progesterone / pharmacology; Reaction Time / drug effects; Receptors, Progesterone / deficiency; Receptors, Progesterone / genetics; Reflex / drug effects
TL;DR:
The neurosteroid allopregnanolone partially mediates the anesthetic activity of progesterone by potentiation of GABA(A) receptor function, but this activity is not mediated by its interaction with PRs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Anxiolytic activity of progesterone in progesterone receptor knockout mice
NEUROPHARMACOLOGY, 48(1), 14–24.
author keywords: progesterone; progesterone receptor; allopregnanolone; finasteride; GABA(A) receptor; neurosteroid; anxiety; elevated plus maze
MeSH headings : Analysis of Variance; Animals; Anxiety / drug therapy; Behavior, Animal / drug effects; Brain / metabolism; Chromatography, High Pressure Liquid / methods; Dose-Response Relationship, Drug; Female; Finasteride / pharmacology; Genotype; Immunohistochemistry / methods; Male; Maze Learning / drug effects; Mice; Mice, Knockout; Pregnanolone / blood; Pregnanolone / pharmacology; Progesterone / pharmacology; Progesterone / therapeutic use; Receptors, Progesterone / deficiency; Receptors, Progesterone / genetics; Receptors, Progesterone / metabolism; Time Factors
TL;DR:
Progesterone knockout mice bearing a targeted null mutation of the PR gene that abrogates the function of both PR-A and PR-B subtypes were utilized to determine the requirement for PRs in the anxiolytic actions of progesterone, demonstrating that allopregnanolone (or other 5alpha-reduced metabolites of progestersone) accounts for the response to the parent steroid hormone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 310(1), 230–239.
MeSH headings : Animals; Anticonvulsants / therapeutic use; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors / pharmacology; Female; Finasteride / pharmacology; Kindling, Neurologic / drug effects; Male; Mice; Mice, Knockout; Mutation; Pregnanolone / blood; Progesterone / antagonists & inhibitors; Progesterone / therapeutic use; Receptors, Progesterone / deficiency; Receptors, Progesterone / genetics; Seizures / prevention & control; Steroids / therapeutic use
TL;DR:
These studies provide strong evidence that the PR is not required for the antiseizure effects of progesterone, which mainly occurs through its conversion to the neurosteroid allopregnanolone.
(via Semantic Scholar)
jpet.aspetjournals.org (publisher PDF)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Anticonvulsant activity of the testosterone-derived neurosteroid 3 alpha-androstanediol
NeuroReport, 15(3), 515–518.
Source: NC State University Libraries
Added: August 6, 2018
2004 review
Ganaxolone: a prospective overview
[Review of ]. DRUGS OF THE FUTURE, 29(3), 227–242.
TL;DR:
As a novel GABA a receptor modulator with unique, broad-spectrum protective efficacy, ganaxolone may have additional therapeutic potential in alcohol and cocaine withdrawal seizures, as well as in the treatment of anxiety and other mood disorders.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 review
Pharmacology of catamenial epilepsy
[Review of ]. Methods and Findings in Experimental and Clinical Pharmacology, 26(7), 547–561.
Source: NC State University Libraries
Added: August 6, 2018
2004 review
Role of neurosteroids in catamenial epilepsy
[Review of ]. EPILEPSY RESEARCH, 62(2-3), 99–118.
author keywords: neurosteroid; GABA(A) receptor; progesterone; ganaxolone; catamenial epilepsy
MeSH headings : Animals; Anticonvulsants / therapeutic use; Brain Chemistry / physiology; Disease Models, Animal; Epilepsy / classification; Epilepsy / drug therapy; Epilepsy / etiology; Epilepsy / metabolism; Female; Humans; Menstruation Disturbances / complications; Menstruation Disturbances / therapy; Models, Molecular; Pregnanolone / analogs & derivatives; Pregnanolone / therapeutic use; Progesterone / analogs & derivatives; Progesterone / metabolism; Progesterone / therapeutic use; Receptors, GABA-A / metabolism; Steroids / chemistry; Steroids / physiology
TL;DR:
Synthetic neuroactive steroids, such as ganaxolone, which are orally active and devoid of hormonal side effects, represent a novel treatment strategy for catamenial epilepsy, however, their clinical efficacy in catamenian epilepsy has yet to be explored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3 alpha-androstanediol and 17 beta-estradiol
NEUROSCIENCE, 129(1), 195–207.
author keywords: neurosteroid; testosterone; epilepsy; 3 alpha-androstanediol; 17 beta-estradiol; GABA(A) receptor
MeSH headings : Androstane-3,17-diol / metabolism; Animals; Aromatase Inhibitors / pharmacology; Chromatography; Convulsants / pharmacology; Dose-Response Relationship, Drug; Enzyme Inhibitors / pharmacology; Estradiol / metabolism; Finasteride / pharmacology; Hippocampus / drug effects; Hippocampus / physiology; Letrozole; Male; Mass Spectrometry; Mice; Nitriles / pharmacology; Organ Culture Techniques; Patch-Clamp Techniques; Pentylenetetrazole / pharmacology; Rats; Receptors, GABA-A / drug effects; Receptors, GABA-A / metabolism; Seizures / chemically induced; Seizures / prevention & control; Testosterone / metabolism; Testosterone / pharmacology; Triazoles / pharmacology
TL;DR:
Testosterone-derived neurosteroids 3α-Diol and 17β-estradiol could contribute to the net cellular actions of testosterone on neural excitability and seizure susceptibility.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Is there a physiological role for the neurosteroid THDOC in stress-sensitive conditions?
TRENDS IN PHARMACOLOGICAL SCIENCES, 24(3), 103–106.
MeSH headings : Animals; Anti-Anxiety Agents / pharmacology; Brain / metabolism; Desoxycorticosterone / analogs & derivatives; Desoxycorticosterone / pharmacology; Desoxycorticosterone / physiology; GABA-A Receptor Antagonists; Humans; Stress, Physiological / metabolism
TL;DR:
Recent studies indicate that stress induces THDOC to levels that can activate GABA(A) receptors, which might have significant implications for human stress-sensitive conditions such as epilepsy, post-traumatic stress disorder and depression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 review
Newer gabaergic agents for pharmacotherapy of infantile spasms
[Review of ]. DRUGS OF TODAY, 38(10), 657–675.
MeSH headings : Adrenocorticotropic Hormone / genetics; Adrenocorticotropic Hormone / therapeutic use; Amino Acid Sequence; GABA Agents / chemistry; GABA Agents / metabolism; GABA Agents / therapeutic use; Humans; Infant; Molecular Sequence Data; Spasms, Infantile / drug therapy; Spasms, Infantile / metabolism
TL;DR:
Recent studies indicate that several newer anticonvulsant agents, which are positive allosteric modulators of GABA(A) receptors, are as effective as ACTH in acutely controlling infantile spasms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2002 review
The clinical potentials of endogenous neurosteroids
[Review of ]. DRUGS OF TODAY, 38(7), 465–485.
MeSH headings : Animals; Brain / metabolism; Desoxycorticosterone / analogs & derivatives; Desoxycorticosterone / biosynthesis; Desoxycorticosterone / metabolism; Desoxycorticosterone / physiology; Humans; Pregnanolone / biosynthesis; Pregnanolone / metabolism; Pregnanolone / physiology; Receptors, GABA-A / drug effects; Seizures / prevention & control; Stress, Psychological / metabolism
TL;DR:
Physiological neurosteroid fluctuations have potential implications for stress-sensitive neurological conditions such as epilepsy, infantile spasms, as well as psychiatric disorders such as schizophrenia, posttraumatic stress disorder and depression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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