@article{oh_shiels_shiels_blondel_campbell_saah_lloyd_thomas_gould_abdo_et al._2021, title={Population genomics of invasive rodents on islands: Genetic consequences of colonization and prospects for localized synthetic gene drive}, volume={14}, ISSN={["1752-4571"]}, DOI={10.1111/eva.13210}, abstractNote={Abstract}, number={5}, journal={EVOLUTIONARY APPLICATIONS}, author={Oh, Kevin P. and Shiels, Aaron B. and Shiels, Laura and Blondel, Dimitri V and Campbell, Karl J. and Saah, J. Royden and Lloyd, Alun L. and Thomas, Paul Q. and Gould, Fred and Abdo, Zaid and et al.}, year={2021}, month={May}, pages={1421–1435} }
 @article{manser_cornell_sutter_blondel_serr_godwin_price_2019, title={Controlling invasive rodents via synthetic gene drive and the role of polyandry}, volume={286}, ISSN={0962-8452 1471-2954}, url={http://dx.doi.org/10.1098/rspb.2019.0852}, DOI={10.1098/rspb.2019.0852}, abstractNote={
            House mice are a major ecosystem pest, particularly threatening island ecosystems as a non-native invasive species. Rapid advances in synthetic biology offer new avenues to control pest species for biodiversity conservation. Recently, a synthetic sperm-killing gene drive construct called
            t-Sry
            has been proposed as a means to eradicate target mouse populations owing to a lack of females. A factor that has received little attention in the discussion surrounding such drive applications is polyandry. Previous research has demonstrated that sperm-killing drivers are extremely damaging to a male’s sperm competitive ability. Here, we examine the importance of this effect on the
            t-Sry
            system using a theoretical model. We find that polyandry substantially hampers the spread of
            t-Sry
            such that release efforts have to be increased three- to sixfold for successful eradication. We discuss the implications of our finding for potential pest control programmes, the risk of drive spread beyond the target population, and the emergence of drive resistance. Our work highlights that a solid understanding of the forces that determine drive dynamics in a natural setting is key for successful drive application, and that exploring the natural diversity of gene drives may inform effective gene drive design.
          }, number={1909}, journal={Proceedings of the Royal Society B: Biological Sciences}, publisher={The Royal Society}, author={Manser, Andri and Cornell, Stephen J. and Sutter, Andreas and Blondel, Dimitri V. and Serr, Megan and Godwin, John and Price, Tom A. R.}, year={2019}, month={Aug}, pages={20190852} }
 @article{blondel_sansone_rosenberg_godin_yang_jaglom-kurtz_linnenbrink-garcia_schwartz-bloom_2019, title={Development of an Online Experiment Platform for High School Biology}, volume={3}, ISSN={["2509-8039"]}, DOI={10.1007/s41686-019-00030-5}, abstractNote={We developed a novel online platform, Rex (Real experiments) that immerses students in a scientific investigative process. Rex is a virtual web-based biological science experiment platform, hosted by real scientists, and uses actual lab experiments that generate real data for students to collect, analyze, and interpret. Seven neuroscience experiments use zebrafish and rats as model systems to study the effects of drugs such as tetrahydrocannabinol (THC), caffeine, alcohol, and cigarette smoke, which are of interest to high school students. We carried out a small field-test of Rex in a variety of high school biology classrooms (e.g., standard, honors, AP, anatomy/physiology) to obtain student and teacher feedback about the implementation and usability of the program. We also assessed student situational interest (SI) to determine whether the Rex experiment captured students' attention, and whether it was an enjoyable and meaningful experience. Overall, students reported a moderate level of SI after participating in the Rex experiments. Situational interest did not differ across teachers, class section, class level, or the type of experiment. In addition, we present details of the technical issues encountered in the classroom, and we provide guidance to readers who may want to use the resource in their classrooms.}, number={1}, journal={JOURNAL OF FORMATIVE DESIGN IN LEARNING}, author={Blondel, Dimitri V and Sansone, Anna and Rosenberg, Joshua M. and Godin, Elizabeth A. and Yang, Brenda W. and Jaglom-Kurtz, Lawson T. and Linnenbrink-Garcia, Lisa and Schwartz-Bloom, Rochelle D.}, year={2019}, month={Jun}, pages={62–81} }
 @article{sudweeks_hollingsworth_blondel_campbell_dhole_eisemann_edwards_godwin_howald_oh_et al._2019, title={Locally Fixed Alleles: A method to localize gene drive to island populations}, volume={9}, ISSN={["2045-2322"]}, DOI={10.1038/s41598-019-51994-0}, abstractNote={Abstract}, journal={SCIENTIFIC REPORTS}, author={Sudweeks, Jaye and Hollingsworth, Brandon and Blondel, Dimitri V and Campbell, Karl J. and Dhole, Sumit and Eisemann, John D. and Edwards, Owain and Godwin, John and Howald, Gregg R. and Oh, Kevin P. and et al.}, year={2019}, month={Nov} }
 @article{barnhill-dilling_serr_blondel_godwin_2019, title={Sustainability as a Framework for Considering Gene Drive Mice for Invasive Rodent Eradication}, volume={11}, ISSN={2071-1050}, url={http://dx.doi.org/10.3390/su11051334}, DOI={10.3390/su11051334}, abstractNote={Gene drives represent a dynamic and controversial set of technologies with applications that range from mosquito control to the conservation of biological diversity on islands. Currently, gene drives are being developed in mice that may one day serve as an important tool for reducing invasive rodent pests, a key threat to island biodiversity and economies. Gene drives in mice are still in development in laboratories, and wild release of modified mice is likely a distant reality. However, technological changes outpace the existing capacity of regulatory frameworks, and thus require integrated governance frameworks. We suggest sustainability—which gives equal consideration to the environment, economy, and society—as one framework for addressing complexity and uncertainty in the governance of emerging gene drive technologies for invasive species management. We explore the impacts of rodent gene drives on island environments, including potential conservation and restoration of island biodiversity. We outline considerations for rodent gene drives on island economies, including impacts on agricultural and tourism losses, and reductions in biosecurity costs. Finally, we address the social dimension as an essential space for deliberation that will be integral to evaluating the potential deployment of gene drive rodents on islands.}, number={5}, journal={Sustainability}, publisher={MDPI AG}, author={Barnhill-Dilling, S. and Serr, Megan and Blondel, Dimitri and Godwin, John}, year={2019}, month={Mar}, pages={1334} }