Drew W Koch

Works (12)

Updated: December 11th, 2024 05:01

2024 journal article

Controlled Stiffness of Direct-Write, Near-Field Electrospun Gelatin Fibers Generates Differences in Tenocyte Morphology and Gene Expression

Journal of Biomechanical Engineering, 146(9).

By: Z. Davis n , D. Koch n, S. Watson  n, G. Scull n, A. Brown n , L. Schnabel n, M. Fisher n

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Sources: Web Of Science, Crossref, NC State University Libraries
Added: May 17, 2024

2024 article

Fighting fibrin with fibrin: Vancomycin delivery into coagulase-mediated <i>Staphylococcus aureus</i> biofilms via fibrin-based nanoparticle binding

Scull, G., Aligwekwe, A., Rey, Y., Koch, D., Nellenbach, K., Sheridan, A., … Brown, A. C. (2024, June 14). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol. 6.

By: G. Scull n, A. Aligwekwe n, Y. Rey n, D. Koch n, K. Nellenbach n, A. Sheridan n, S. Pandit n, J. Sollinger n ...

author keywords: biofilm; dermal infection; fibrin; nanoparticle; Staphylococcus aureus; vancomycin
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Sources: Web Of Science, NC State University Libraries
Added: June 24, 2024

2024 journal article

IL-1β + TGF-β2 dual-licensed mesenchymal stem cells have reduced major histocompatibility class I expression and positively modulate tenocyte migration, metabolism, and gene expression

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 262.

By: D. Koch n, A. Froneberger n, A. Berglund n, S. Connard n, A. Souther n & L. V. Schnabel  n

author keywords: mesenchymal stem cell; tendon; MHC class I; IL-1 beta; TGF-beta 2
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Source: Web Of Science
Added: July 22, 2024

2024 article

Matrikine stimulation of equine synovial fibroblasts and chondrocytes results in an in vitro osteoarthritis phenotype

Gagliardi, R., Koch, D. W., Loeser, R., & Schnabel, L. V. (2024, November 1). JOURNAL OF ORTHOPAEDIC RESEARCH.

By: R. Gagliardi n, D. Koch n, R. Loeser * & L. Schnabel n

author keywords: equine; fibronectin fragments; in vitro; osteoarthritis
Source: Web Of Science
Added: December 2, 2024

2024 journal article

Plasma and synovial fluid extracellular vesicles display altered microRNA profiles in horses with naturally occurring post-traumatic osteoarthritis: an exploratory study

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 262, 83–96.

By: S. Connard n, A. Gaesser*, E. Clarke *, R. Linardi *, K. Even *, J. Engiles *, D. Koch n, M. Peffers *, K. Ortved *

author keywords: equine; exosomes; joint disease; miRNA; small non-coding RNA
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Source: Web Of Science
Added: July 22, 2024

2024 journal article

Ultrasoft platelet-like particles stop bleeding in rodent and porcine models of trauma

SCIENCE TRANSLATIONAL MEDICINE, 16(742).

By: K. Nellenbach n, E. Mihalko n, S. Nandi n, D. Koch n, J. Shetty *, L. Moretti *, J. Sollinger n, N. Moiseiwitsch n ...

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Sources: Web Of Science, NC State University Libraries
Added: April 22, 2024

2023 journal article

A Case Report of Uterine Body Constriction Precluding Normal Parturition Leading to Dystocia in a Mare

VETERINARY SCIENCES, 10(2).

By: J. Willette*, A. Gerras*, D. Sledge* & D. Koch n

author keywords: equine; dystocia; uterus; broad ligament; constriction
TL;DR: This case report is the first case report to describe uterine body constriction that precluded vaginal delivery of a fetus in a late gestation mare, ultimately resulting in fetal mortality with humane euthanasia of the mare. (via Semantic Scholar)
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Source: Web Of Science
Added: March 27, 2023

2023 journal article

Mesenchymal stem cell licensing: enhancing MSC function as a translational approach for the treatment of tendon injury

AMERICAN JOURNAL OF VETERINARY RESEARCH, 84(10).

By: D. Koch n & L. Schnabel n

author keywords: mesenchymal stem cell; licensing; activation; tendon; MSC function
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Source: Web Of Science
Added: August 26, 2024

2023 journal article

Pneumatic compression therapy using the EQ Press accelerates lymphatic flow in healthy equine forelimbs as determined by lymphoscintigraphy

AMERICAN JOURNAL OF VETERINARY RESEARCH, 84(4).

By: D. Koch n, L. Schnabel n, J. Reynolds n & C. Berry  n

MeSH headings : Horses; Animals; Lymphoscintigraphy / veterinary; Technetium Tc 99m Sulfur Colloid; Lymph Nodes; Lymphedema / diagnostic imaging; Lymphedema / therapy; Lymphedema / veterinary; Forelimb / diagnostic imaging; Radiopharmaceuticals; Horse Diseases / pathology
TL;DR: Pneumatic compression therapy as provided by an equine-specific device encouraged lymphatic flow in healthy, nonedematous equine forelimbs and data support further study of the EQ Press for pneumatic compressor therapy in horses clinically affected by lymphedema and lymphatic drainage disorders. (via Semantic Scholar)
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Source: Web Of Science
Added: May 22, 2023

2023 journal article

Use of mesenchymal stem cells for tendon healing in veterinary and human medicine: getting to the "core" of the problem through a one health approach

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 261(10), 1435–1442.

By: L. V. Schnabel  n & D. Koch n

author keywords: mesenchymal stem cell; Achilles tendon; superficial digital flexor tendon; core lesion; one health
TL;DR: Why the equine superficial digital flexor tendon core lesion might be considered optimal for stem cell delivery and stem cell interaction with the injury environment is reviewed and the concept of stem cell licensing for future evaluation is introduced. (via Semantic Scholar)
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Source: Web Of Science
Added: March 4, 2024

2022 journal article

Interleukin-1 beta in tendon injury enhances reparative gene and protein expression in mesenchymal stem cells

FRONTIERS IN VETERINARY SCIENCE, 9.

By: D. Koch n, A. Berglund n, K. Messenger n, J. Gilbertie n, I. Ellis n & L. Schnabel n

author keywords: tendon; cytokine; ultrafiltration probe; mesenchymal stem cell; licensing
TL;DR: The defined temporal cytokine microenvironment in a surgically induced model of equine tendon injury and changes in MSC gene and protein expression following in vitro inflammatory licensing with cytokines of similar concentration as identified in vivo support the need to further study the benefit of MSCs administered within the inflamed tendon microenvironment or exogenously licensed with IL-1β in vitro prior to treatment. (via Semantic Scholar)
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Source: Web Of Science
Added: December 12, 2022

2022 journal article

TGF-beta 2 enhances expression of equine bone marrow-derived mesenchymal stem cell paracrine factors with known associations to tendon healing

STEM CELL RESEARCH & THERAPY, 13(1).

By: D. Koch n, L. Schnabel n, I. Ellis n, R. Bates n & A. Berglund n

author keywords: Mesenchymal stem cell; Tenocyte; TGF-beta 2; Equine; Tendon; RNA-sequencing; Paracrine factors; Extracellular matrix
MeSH headings : Animals; Bone Marrow / metabolism; Collagen Type I / metabolism; Cytokines / metabolism; Horses; Mesenchymal Stem Cells / metabolism; Paracrine Communication; RNA / metabolism; Tenascin / genetics; Tenascin / metabolism; Tendons / metabolism; Transforming Growth Factor beta2 / genetics; Transforming Growth Factors / metabolism
TL;DR: Treating equine BM-MSCs with TGF-β2 significantly increases production of paracrine factors and extracellular matrix molecules important for tendon healing and promotes the migration of tenocytes in vitro. (via Semantic Scholar)
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Source: Web Of Science
Added: September 26, 2022

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