Drew W Koch

Works (5)

Updated: April 22nd, 2024 07:45

2023 journal article

A Case Report of Uterine Body Constriction Precluding Normal Parturition Leading to Dystocia in a Mare

VETERINARY SCIENCES, 10(2).

By: J. Willette*, A. Gerras*, D. Sledge* & D. Koch n

author keywords: equine; dystocia; uterus; broad ligament; constriction
TL;DR: This case report is the first case report to describe uterine body constriction that precluded vaginal delivery of a fetus in a late gestation mare, ultimately resulting in fetal mortality with humane euthanasia of the mare. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 27, 2023

2023 journal article

Pneumatic compression therapy using the EQ Press accelerates lymphatic flow in healthy equine forelimbs as determined by lymphoscintigraphy

AMERICAN JOURNAL OF VETERINARY RESEARCH, 84(4).

By: D. Koch n, L. Schnabel n, J. Reynolds n & C. Berry n

MeSH headings : Horses; Animals; Lymphoscintigraphy / veterinary; Technetium Tc 99m Sulfur Colloid; Lymph Nodes; Lymphedema / diagnostic imaging; Lymphedema / therapy; Lymphedema / veterinary; Forelimb / diagnostic imaging; Radiopharmaceuticals; Horse Diseases / pathology
TL;DR: Pneumatic compression therapy as provided by an equine-specific device encouraged lymphatic flow in healthy, nonedematous equine forelimbs and data support further study of the EQ Press for pneumatic compressor therapy in horses clinically affected by lymphedema and lymphatic drainage disorders. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: May 22, 2023

2023 journal article

Use of mesenchymal stem cells for tendon healing in veterinary and human medicine: getting to the "core" of the problem through a one health approach

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 261(10), 1435–1442.

By: L. V. Schnabel  n & D. Koch n

author keywords: mesenchymal stem cell; Achilles tendon; superficial digital flexor tendon; core lesion; one health
TL;DR: Why the equine superficial digital flexor tendon core lesion might be considered optimal for stem cell delivery and stem cell interaction with the injury environment is reviewed and the concept of stem cell licensing for future evaluation is introduced. (via Semantic Scholar)
Source: Web Of Science
Added: March 4, 2024

2022 journal article

Interleukin-1 beta in tendon injury enhances reparative gene and protein expression in mesenchymal stem cells

FRONTIERS IN VETERINARY SCIENCE, 9.

By: D. Koch n, A. Berglund n, K. Messenger n, J. Gilbertie n, I. Ellis n & L. Schnabel n

author keywords: tendon; cytokine; ultrafiltration probe; mesenchymal stem cell; licensing
TL;DR: The defined temporal cytokine microenvironment in a surgically induced model of equine tendon injury and changes in MSC gene and protein expression following in vitro inflammatory licensing with cytokines of similar concentration as identified in vivo support the need to further study the benefit of MSCs administered within the inflamed tendon microenvironment or exogenously licensed with IL-1β in vitro prior to treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: December 12, 2022

2022 journal article

TGF-beta 2 enhances expression of equine bone marrow-derived mesenchymal stem cell paracrine factors with known associations to tendon healing

STEM CELL RESEARCH & THERAPY, 13(1).

By: D. Koch n, L. Schnabel n, I. Ellis n, R. Bates n & A. Berglund n

author keywords: Mesenchymal stem cell; Tenocyte; TGF-beta 2; Equine; Tendon; RNA-sequencing; Paracrine factors; Extracellular matrix
MeSH headings : Animals; Bone Marrow / metabolism; Collagen Type I / metabolism; Cytokines / metabolism; Horses; Mesenchymal Stem Cells / metabolism; Paracrine Communication; RNA / metabolism; Tenascin / genetics; Tenascin / metabolism; Tendons / metabolism; Transforming Growth Factor beta2 / genetics; Transforming Growth Factors / metabolism
TL;DR: Treating equine BM-MSCs with TGF-β2 significantly increases production of paracrine factors and extracellular matrix molecules important for tendon healing and promotes the migration of tenocytes in vitro. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: September 26, 2022

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