Erik A. Feldmann

Works (3)

Updated: July 5th, 2023 15:40

2020 journal article

The Solution Structures and Interaction of SinR and SinI: Elucidating the Mechanism of Action of the Master Regulator Switch for Biofilm Formation in Bacillus subtilis

JOURNAL OF MOLECULAR BIOLOGY, 432(2), 343–357.

By: M. Milton *, G. Draughn n, B. Bobay n, S. Stowe n, A. Olson n, E. Feldmann n, R. Thompson*, K. Myers n ...

author keywords: Biofilms; Bacillus subtilis; Transcriptional regulation; NMR solution structure
MeSH headings : Amino Acid Sequence / genetics; Bacillus subtilis / genetics; Bacillus subtilis / ultrastructure; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / ultrastructure; Biofilms / growth & development; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / ultrastructure; Gene Expression Regulation, Bacterial / genetics; Molecular Docking Simulation; Mutation / genetics; Protein Binding / genetics; Protein Conformation
TL;DR: This work presents the first full-length structural model of tetrameric SinR using a hybrid approach combining high-resolution solution NMR, chemical crosslinking, mass spectrometry, and molecular docking, and provides an evidence-based mechanism that confirms how disruption of the SinR tetramer by SinI regulates gene expression. (via Semantic Scholar)
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Added: February 27, 2020

2017 journal article

Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds

MOLECULAR MICROBIOLOGY, 106(2), 223–235.

By: M. Milton *, C. Allen  n, E. Feldmann n, B. Bobay n, D. Jung*, M. Stephens n, R. Melander n, K. Theisen  n ...

MeSH headings : Anti-Bacterial Agents / pharmacology; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Bacterial Proteins / ultrastructure; Biofilms / drug effects; Francisella tularensis / metabolism; Gene Expression Regulation, Bacterial / genetics; Imidazoles / metabolism; Imidazoles / pharmacology; Protein Binding; Virulence / drug effects; Virulence Factors / genetics; Virulence Factors / metabolism
TL;DR: It is shown that QseB interacts with 2‐aminoimidazole based compounds that impede its function, and this information will assist in tailoring compounds to act as adjuvants that will enhance the effect of antibiotics. (via Semantic Scholar)
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Added: August 6, 2018

2015 article

Teaching old drugs new tricks: Addressing resistance in Francisella

Feldmann, E. A., & Cavanagh, J. (2015, July 4). VIRULENCE, Vol. 6, pp. 414–416.

By: E. Feldmann n & J. Cavanagh n

MeSH headings : Animals; Biofilms / drug effects; Female; Francisella / drug effects; Maprotiline / chemistry; Maprotiline / pharmacology; Protein Kinases / metabolism; Tularemia / drug therapy
TL;DR: A proposed model suggests that Francisella sensor kinases may not necessarily discriminate for a single response regulator partner, but rather phosphorylate their targets more “promiscuously”. (via Semantic Scholar)
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Added: August 6, 2018

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