Edward A. Havell

Works (16)

Updated: August 23rd, 2023 21:15

2017 journal article

Antibacterial efficacy and cytotoxicity of low intensity direct current activated silver-titanium implant system prototype

BIOMETALS, 30(1), 113–125.

By: Z. Tan n, E. Havell n, P. Orndorff n & R. Shirwaiker n 

Contributors: Z. Tan n, E. Havell n, P. Orndorff n & R. Shirwaiker n 

author keywords: Low intensity direct current; Silver-titanium implant; Orthopaedic application; Antimicrobial efficacy; Cytotoxicity
MeSH headings : Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacology; Cell Proliferation / drug effects; Ions / chemistry; Methicillin-Resistant Staphylococcus aureus / drug effects; Methicillin-Resistant Staphylococcus aureus / pathogenicity; Silver / chemistry; Silver / pharmacology; Staphylococcal Infections / drug therapy; Staphylococcal Infections / microbiology; Titanium / chemistry; Titanium / pharmacology
TL;DR: The in vitro antibacterial efficacy and cytotoxicity of a low intensity direct current (LIDC)-activated silver–titanium implant system prototype designed for localized generation and delivery of silver ions at the implantation site showed high antimicrobial efficacy against MRSA, but was also toxic to human cells immediately surrounding the electrodes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Listeria monocytogenes wall teichoic acid decoration in virulence and cell-to-cell spread

MOLECULAR MICROBIOLOGY, 101(5), 714–730.

By: P. Spears n, E. Havell n, T. Hamrick*, J. Goforth*, A. Levine*, S. Abraham*, C. Heiss *, P. Azadi *, P. Orndorff n

MeSH headings : Animals; Bacteriophages / metabolism; Cell Membrane / metabolism; Cell Wall / metabolism; Female; Listeria monocytogenes / metabolism; Listeria monocytogenes / pathogenicity; Listeriosis / microbiology; Liver / microbiology; Mice; Mutation; Peptidoglycan / metabolism; Spleen / microbiology; Teichoic Acids / metabolism; Virulence
TL;DR: Identification and interruption of WTA decoration pathways may provide a general strategy to discover non‐antibiotic therapeutics for gram positive infections. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Extrauterine Listeriosis in the gravid mouse influences embryonic growth and development

PLoS One, 8(8).

By: M. Suyemoto, T. Hamrick, P. Spears, J. Horton, I. Washington, E. Havell, L. Borst , P. Orndorff

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

In Vitro Properties of a Listeria monocytogenes Bacteriophage-Resistant Mutant Predict Its Efficacy as a Live Oral Vaccine Strain

INFECTION AND IMMUNITY, 79(12), 5001–5009.

By: P. Spears n, M. Suyemoto n, T. Hamrick*, R. Wolf n, E. Havell n & P. Orndorff n

MeSH headings : Administration, Oral; Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Bacterial Vaccines / administration & dosage; Bacterial Vaccines / immunology; Bacterial Vaccines / standards; Bacteriophages / physiology; Cells, Cultured; Enterocytes / microbiology; Female; Listeria monocytogenes / genetics; Listeria monocytogenes / virology; Listeriosis / microbiology; Listeriosis / prevention & control; Mice; Mice, Inbred BALB C; Mutagenesis, Insertional; Mutation; Time Factors; Vaccines, Attenuated / administration & dosage; Vaccines, Attenuated / standards
TL;DR: The results indicate that oral administration of a profoundly attenuated listeria monocytogenes glcV mutant can safely elicit solid protective immunity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Factors Associated with the Acquisition and Severity of Gestational Listeriosis

PLOS ONE, 5(9).

By: M. Suyemoto n, P. Spears n, T. Hamrick*, J. Barnes n, E. Havell n & P. Orndorff n

MeSH headings : Animals; Disease Models, Animal; Female; Humans; Listeria / physiology; Listeriosis / embryology; Listeriosis / microbiology; Listeriosis / pathology; Liver / microbiology; Liver / pathology; Mice; Pregnancy; Pregnancy Complications, Infectious / microbiology; Pregnancy Complications, Infectious / pathology; Severity of Illness Index; Spleen / microbiology; Spleen / pathology
TL;DR: It was determined in mice that increased susceptibility to lethal infection following oral inoculation begins surprisingly early in pregnancy and extends through embryonic development, and the window of listeriosis susceptibility afforded by pregnancy may be open longer than previously appreciated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

A Listeria monocytogenes mutant defective in bacteriophage attachment is attenuated in orally inoculated mice and impaired in enterocyte intracellular growth

INFECTION AND IMMUNITY, 76(9), 4046–4054.

By: P. Spears n, M. Suyemoto n, A. Palermo n, J. Horton n, T. Hamrick*, E. Havell n, P. Orndorff n

MeSH headings : Animals; Bacterial Adhesion; Bacteriophages / physiology; DNA Transposable Elements; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; Enterocytes / microbiology; Female; Genetic Complementation Test; Glycosyltransferases / genetics; Listeria monocytogenes / pathogenicity; Listeria monocytogenes / virology; Listeriosis / microbiology; Liver / microbiology; Mice; Mice, Inbred A; Molecular Sequence Data; Mutagenesis, Insertional; Receptors, Virus / genetics; Sequence Analysis, DNA; Spleen / microbiology; Survival Analysis; Viral Plaque Assay; Virulence; Virulence Factors / genetics; Virus Attachment
TL;DR: Interestingly, the glcV lesion, while preventing phage attachment, did not alter the mutant's ability to bind to cultured mouse enterocyte monolayers, rather, the mutation appeared to alter a subsequent step in intracellular replication measured by a reduction in plaque-forming efficiency and plaque size. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 review

Host and bacterial factors in listeriosis pathogenesis

[Review of ]. VETERINARY MICROBIOLOGY, 114(1-2), 1–15.

By: P. Orndorff n, T. Hamrick*, I. Smoak n & E. Havell n

author keywords: listeria; pathogenesis; pregnancy; predisposition; veterinary
MeSH headings : Animals; Cytosol / microbiology; Disease Susceptibility / microbiology; Environment; Female; Food Microbiology; Humans; Immunity, Cellular / immunology; Listeria / growth & development; Listeria / pathogenicity; Listeriosis / immunology; Listeriosis / microbiology; Listeriosis / transmission; Mice; Pregnancy; Pregnancy Complications, Infectious / immunology; Pregnancy Complications, Infectious / microbiology; Vacuoles / microbiology
TL;DR: There are many features of the pathogenesis of listeriosis that have remained mysterious despite the extensive use of the microorganism in the study of cell-mediated immunity and intracellular growth, and Informational advances such as the sequence of the mouse and listerial genomes, and technical advancessuch as the discovery of listersia-susceptible mouse strains, may renew interest in the project. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

A specific gene expression program triggered by gram-positive bacteria in the cytosol

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(31), 11386–11391.

By: R. McCaffrey n, P. Fawcett n, . M O'Riordan, K. Lee n, E. Havell n, P. Brown  n, D. Portnoy  n

MeSH headings : Adaptor Proteins, Signal Transducing; Animals; Antigens, Differentiation / genetics; Bacillus subtilis / genetics; Cell Cycle / physiology; Cytosol / microbiology; Cytosol / physiology; Female; Gene Expression Regulation, Bacterial / physiology; Interferons / physiology; Listeria monocytogenes / genetics; Listeriosis / microbiology; Macrophages / microbiology; Membrane Glycoproteins / metabolism; Mice; Mice, Mutant Strains; Myeloid Differentiation Factor 88; NF-kappa B / metabolism; Oligonucleotide Array Sequence Analysis; Receptors, Cell Surface / metabolism; Receptors, Immunologic / genetics; Staphylococcus aureus / genetics; Toll-Like Receptors; Transcription, Genetic / physiology; Vacuoles / microbiology; Vacuoles / physiology
TL;DR: This study identified a cytosol-specific transcriptional program independent of TLR signaling through MyD88, and its points of convergence with TLR- and IFN-dependent pathways will enhance the understanding of the means by which mammals detect and respond to pathogens. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Influence of extracellular bactericidal agents on bacteria within macrophages

INFECTION AND IMMUNITY, 71(2), 1016–1019.

By: T. Hamrick n, A. Diaz n, E. Havell n, . Horton  n & P. Orndorff n

MeSH headings : Adhesins, Escherichia coli / metabolism; Animals; Anti-Bacterial Agents / pharmacology; Bacteriophage lambda / pathogenicity; Drug Resistance, Bacterial; Escherichia coli / drug effects; Escherichia coli / growth & development; Escherichia coli / virology; Fimbriae Proteins / metabolism; Gentamicins / pharmacology; Macrophages, Peritoneal / microbiology; Mice; Mice, Inbred BALB C; Phagocytosis
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Influence of pregnancy on the pathogenesis of listeriosis in mice inoculated intragastrically

INFECTION AND IMMUNITY, 71(9), 5202–5209.

By: T. Hamrick n, . Horton  n, P. Spears n, E. Havell n, I. Smoak n & P. Orndorff n

MeSH headings : Animals; Base Sequence; Colon / microbiology; Colony Count, Microbial; DNA, Bacterial / genetics; Enterocytes / microbiology; Female; Listeria monocytogenes / genetics; Listeria monocytogenes / isolation & purification; Listeria monocytogenes / pathogenicity; Listeriosis / complications; Listeriosis / etiology; Liver / microbiology; Mice; Mutagenesis, Insertional; Pregnancy; Pregnancy Complications, Infectious / etiology; Risk Factors; Spleen / microbiology; Virulence / genetics
TL;DR: The ability of the 4nonb strain to produce a lethal infection in pregnant animals did not correlate with an increased incidence or level of liver and spleen colonization over that in nonpregnant females, but the lethality rate did correlate well with the rate at which embryos and their surrounding decidual covering became infected, suggesting that intrauterine infection could be responsible for the increased disease severity in the gravid females. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Characterization of Escherichia coli type 1 pilus mutants with altered binding specificities

JOURNAL OF BACTERIOLOGY, 183(13), 4099–4102.

By: S. Harris n, P. Spears n, E. Havell n, T. Hamrick n, . Horton  n & P. Orndorff n

MeSH headings : Adhesins, Bacterial / genetics; Adhesins, Bacterial / metabolism; Adhesins, Escherichia coli; Alleles; Chromosomes, Bacterial; Escherichia coli / physiology; Fimbriae Proteins; Fimbriae, Bacterial / genetics; Fimbriae, Bacterial / metabolism; Molecular Sequence Data; Mutation; Phenotype; Plasmids; Recombination, Genetic
TL;DR: PCR mutagenesis and a unique enrichment scheme were used to obtain two mutants, each with a single lesion in fimH, the chromosomal gene that encodes the adhesin protein (FimH) of Escherichia coli type 1 pili that were noteworthy in part because both were altered in the normal range of cell types bound by FimH. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Genetic characterization of Escherichia coli type 1 pilus adhesin mutants and identification of a novel binding phenotype

JOURNAL OF BACTERIOLOGY, 182(14), 4012–4021.

By: T. Hamrick n, S. Harris n, P. Spears n, E. Havell n, . Horton  n, P. Russell n, P. Orndorff n

MeSH headings : Adhesins, Bacterial / genetics; Adhesins, Escherichia coli; Animals; Bacterial Adhesion / genetics; Base Sequence; Chromosome Mapping; Erythrocytes / microbiology; Escherichia coli / genetics; Escherichia coli / pathogenicity; Fimbriae Proteins; Guinea Pigs; Hemagglutination Tests; Macrophages / microbiology; Mice; Molecular Sequence Data; Phenotype; Point Mutation
TL;DR: Temperature shift experiments revealed that new FimH biosynthesis was required for the phenotypic change, and a temperature-sensitive (ts) fimH mutant that agglutinated guinea pig erythrocytes but not at 42 degrees C was chosen for further study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Host and bacterial factors involved in the innate ability of mouse macrophages to eliminate internalized unopsonized Escherichia coli

INFECTION AND IMMUNITY, 68(1), 125–132.

By: T. Hamrick n, E. Havell n, . Horton  n & P. Orndorff n

MeSH headings : Adhesins, Bacterial / immunology; Adhesins, Escherichia coli; Animals; Cell Line; Cytotoxicity, Immunologic; Escherichia coli / immunology; Fimbriae Proteins; Macrophages, Peritoneal / immunology; Macrophages, Peritoneal / microbiology; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Phagocytosis; Species Specificity
TL;DR: Host and bacterial factors involved in the nonopsonic phagocytosis and killing of Escherichia coli K-12 by mouse macrophages were examined to better understand genetic and cellular factors that influence innate immunity and there was no correlation between the bacteriocidal effectiveness of amacrophage population and the number of bacteria bound per macrophage. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Woodchuck lymphotoxin-alpha, -beta and tumor necrosis factor genes: structure, characterization and biological activity

GENE, 242(1-2), 295–305.

By: D. Li  n, E. Havell n, C. Brown n & J. Cullen n

author keywords: cDNA; cytotoxicity; gene; LT; TNF; transcription factor binding site
MeSH headings : Animals; Base Sequence; Binding Sites; Cell Line; DNA / chemistry; DNA / genetics; DNA / metabolism; DNA, Complementary / chemistry; DNA, Complementary / genetics; DNA, Complementary / isolation & purification; Exons; Gene Expression; Genes / genetics; Glutathione Transferase / genetics; Glutathione Transferase / metabolism; Humans; Introns; Lymphotoxin-alpha / genetics; Lymphotoxin-alpha / metabolism; Lymphotoxin-alpha / pharmacology; Lymphotoxin-beta; Marmota / genetics; Membrane Proteins / genetics; Membrane Proteins / metabolism; Molecular Sequence Data; Polymorphism, Genetic; Promoter Regions, Genetic; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Recombinant Fusion Proteins / pharmacology; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid; Transcription Factors / metabolism; Tumor Cells, Cultured / cytology; Tumor Cells, Cultured / drug effects; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism; Tumor Necrosis Factor-alpha / pharmacology
TL;DR: The data obtained from this study will be useful to future investigations of the TNF and LT anti-tumor and anti-viral activities, and their therapeutic potential in the woodchuck model for human hepatitis B virus (HBV). (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

The mucosal phase of Listeria infection

IMMUNOBIOLOGY, 201(2), 164–177.

By: E. Havell n, G. Beretich n & P. Carter n

MeSH headings : Animals; Bacterial Translocation; Cells, Cultured; Colon / microbiology; Colony Count, Microbial; Enterocytes / immunology; Enterocytes / microbiology; Humans; Interferon Type I / metabolism; Intestinal Mucosa / cytology; Intestinal Mucosa / microbiology; Listeria monocytogenes / isolation & purification; Listeria monocytogenes / metabolism; Listeria monocytogenes / physiology; Liver / microbiology; Lymph Nodes / microbiology; Mesentery / microbiology; Mice; Peyer's Patches / microbiology; Spleen / microbiology; Time Factors
TL;DR: Results indicate that PP are not required for listerial translocation from the intestinal lumen, and that listeriae were capable of entering cultured mouse small intestine enterocytes and spreading intracellularly between enterocytes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Roles for tumor necrosis factor and gamma interferon in resistance to enteric listeriosis

Infection and Immunity, 66(5), 2368–2373.

By: G. Beretich, P. Carter & E. Havell

Source: NC State University Libraries
Added: August 6, 2018

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