Works (42)
Updated: July 25th, 2023 21:17
2016 personal communication
Bias-Variance Tradeoffs in Recombination Rate Estimation
Stone, E. A., & Singh, N. D. (2016, February).
MeSH headings : Alleles; Animals; Bias; Drosophila melanogaster / genetics; Gene Frequency; Genetic Variation; Models, Genetic; Models, Statistical; Recombination, Genetic
TL;DR:
To extract the signal of recombination in high-throughput sequence data, a nonparametric smoothing procedure was adopted, reducing variance at the cost of biasing individual recombination rates.
(via Semantic Scholar)
open access via www.genetics.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Enhanced diversity and aflatoxigenicity in interspecific hybrids ofAspergillus flavusandAspergillus parasiticus
Molecular Ecology, 24(8), 1889–1909.
author keywords: allopolyploid; array comparative genome hybridization; flow cytometry; meiosis; population
MeSH headings : Aflatoxins / biosynthesis; Aspergillus / classification; Aspergillus / genetics; Aspergillus flavus / genetics; Comparative Genomic Hybridization; Genes, Mating Type, Fungal; Genotype; Genotyping Techniques; Hybridization, Genetic; Molecular Sequence Data; Phenotype; Phylogeny; Sequence Analysis, DNA; Sterigmatocystin / analogs & derivatives; Sterigmatocystin / biosynthesis
TL;DR:
The results suggest that hybridization is an important diversifying force resulting in the genesis of novel toxin profiles in these agriculturally important fungi.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2015 review
Recent progress and open questions in Drosophila dosage compensation
[Review of ]. FLY, 9(1), 29–35.
author keywords: chromatin; dosage compensation; Drosophila; epigenetics; male-specific lethal; MSL complex; review
MeSH headings : Animals; Biological Evolution; Dosage Compensation, Genetic; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Sex Chromosomes
TL;DR:
Recent progress in the field of Drosophila dosage compensation is synthesized as a means to highlight open questions, including how the MSL complex targets the X chromosome, how dosage compensation has shaped evolution of X-linked genes, and the degree to whichMSL complex-mediated dosage compensation varies in activity across somatic tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Sporadic, Global Linkage Disequilibrium Between Unlinked Segregating Sites
GENETICS, 202(2), 427-+.
author keywords: linkage disequilibrium; genome-wide association study; genetically indistinguishable
MeSH headings : Algorithms; Alleles; Animals; Arabidopsis / genetics; Computer Simulation; Drosophila / genetics; Genetic Linkage; Genetic Loci; Genetic Variation; Genetics, Population; Genome-Wide Association Study; Linkage Disequilibrium; Models, Genetic; Models, Statistical; Polymorphism, Single Nucleotide
TL;DR:
It is shown that sample size and minor allele frequency are the major determinants of the prevalence of perfect LD between unlinked loci but that demographic factors, such as deviations from random mating, can produce significant effects as well.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
The 100-genomes strains, an S. cerevisiae resource that illuminates its natural phenotypic and genotypic variation and emergence as an opportunistic pathogen
GENOME RESEARCH, 25(5), 762–774.
MeSH headings : Contig Mapping / methods; Genome, Fungal; Genotype; Phenotype; Phylogeny; Polymorphism, Genetic; Saccharomyces cerevisiae / classification; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / pathogenicity; Sequence Alignment / methods; Virulence / genetics
TL;DR:
The 100-genomes strains are a novel, multipurpose resource to advance the study of S. cerevisiae population genetics, quantitative genetics, and the emergence of an opportunistic pathogen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
X-to-autosome expression and msl-2 transcript abundance correlate among Drosophila melanogaster somatic tissues
PEERJ, 3.
author keywords: H4K16Ac; Male-Specific Lethal complex; Drosophila melanogaster; Dosage compensation complex; Dosage compensation
TL;DR:
It is hypothesize the degree, up to but not exceeding 2-fold, to which the MSL complex upregulates male X-linked genes varies quantitatively by tissue type, and finds X-to-autosome expression correlates with the tissue-specific expression of msl-2 which encodes an essential male-specific component of theMSL complex.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Genome-wide analysis in Drosophila reveals age-specific effects of SNPs on fitness traits
NATURE COMMUNICATIONS, 5.
MeSH headings : Aging / physiology; Animals; Drosophila melanogaster / genetics; Female; Fertility / genetics; Gene Ontology; Genetic Fitness / genetics; Genome-Wide Association Study; Male; Mutation; Polymorphism, Single Nucleotide
TL;DR:
The authors identify genetic variants in Drosophilathat that affect reproduction and lifespan in an age-specific manner, and provide support for the mutation accumulation theory of aging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines
Genome Research, 24(7), 1193–1208.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
No Evidence for a Global Male-Specific Lethal Complex-Mediated Dosage Compensation Contribution to the Demasculinization of the Drosophila melanogaster X Chromosome
PLOS ONE, 9(8).
MeSH headings : Animals; Chromosomal Proteins, Non-Histone / metabolism; Chromosome Mapping; Chromosomes, Insect / physiology; DNA Helicases / metabolism; DNA-Binding Proteins / metabolism; Dosage Compensation, Genetic / genetics; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Genes, X-Linked / physiology; Histone Acetyltransferases / metabolism; Male; Multiprotein Complexes / metabolism; Multiprotein Complexes / physiology; Nuclear Proteins / metabolism; Sex Differentiation / genetics; Transcription Factors / metabolism; Transcriptional Activation; X Chromosome / physiology
TL;DR:
The results do not corroborate previous observations supporting organismal-wide detrimental effects by dosage compensation on X-linked male-biased expressed genes and find no evidence that dosage compensation has played a role in the arrangement of dosage compensated male- biased genes on the X chromosome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 personal communication
Predictor performance with stratified data and imbalanced classes
Stone, E. A. (2014, August).
MeSH headings : Evolution, Molecular; Exome / genetics; Genetic Variation / genetics; HapMap Project; High-Throughput Nucleotide Sequencing; Humans
TL;DR:
The results provide strong evidence that machine-learning classifiers must incorporate all known biological knowledge and embrace differences in the level of functional importance of positions when assembling training and testing datasets and invalidate Vihinen's conclusion that the accuracy of the prediction of ultraconserved and lessconserved sites are lower.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Structural properties of the minimum cut of partially-supplied graphs
DISCRETE APPLIED MATHEMATICS, 177, 152–157.
author keywords: Graph theory; Minimum cut; Tree reconstruction
TL;DR:
This work considers pairs of graphs G and H, with respective Laplacian matrices L and M, and calls H partially supplied provided M is a Schur complement of L.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Differentially expressed microRNAs and affected biological pathways revealed by modulated modularity clustering (MMC) analysis of human preeclamptic and IUGR placentas
Placenta, 34(7), 599–605.
author keywords: Placenta; Preeclampsia; IUGR; MiR-194; MiR-149
MeSH headings : Down-Regulation; Female; Fetal Growth Retardation / genetics; Fetal Growth Retardation / metabolism; Humans; MicroRNAs / biosynthesis; Placenta / metabolism; Pre-Eclampsia / genetics; Pre-Eclampsia / metabolism; Pregnancy; Transcriptome
TL;DR:
Modulated modularity clustering (MMC) allowed the elucidation of a molecular signature associated with preeclampsia and a subset of IUGR samples, which allowed the identification of genes, pathways, and microRNAs affected in these diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2013 journal article
Fine-scale heterogeneity in crossover rate in the garnet-scalloped region of the Drosophila melanogaster X chromosome
Genetics, 194(2), 375–112.
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Population Genomic Analysis Reveals No Evidence for GC-Biased Gene Conversion in Drosophila melanogaster
MOLECULAR BIOLOGY AND EVOLUTION, 31(2), 425–433.
author keywords: GC-biased gene conversion; Drosophila melanogaster; whole genome; polymorphism and divergence data
MeSH headings : Alleles; Animals; Chromosomes, Insect; Cytosine / metabolism; Drosophila melanogaster / genetics; Evolution, Molecular; Gene Conversion; Genome, Insect; Genomics; Guanine / metabolism; Mutation Rate; Phylogeny; Polymorphism, Genetic
TL;DR:
It is suggested that this process of gene conversion in Drosophila melanogaster is unlikely to significantly contribute to patterns of polymorphism and divergence in this system, and the results provide no support for GC-biased gene conversion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Sexuality Generates Diversity in the Aflatoxin Gene Cluster: Evidence on a Global Scale
PLoS Pathogens, 9(8), e1003574.
Ed(s): B. McDonald
MeSH headings : Aflatoxins / biosynthesis; Aflatoxins / genetics; Aspergillus flavus / genetics; Aspergillus flavus / metabolism; Fungal Proteins / genetics; Fungal Proteins / metabolism; Genes, Fungal / physiology; Multigene Family / physiology; Repressor Proteins / genetics; Repressor Proteins / metabolism; Species Specificity
TL;DR:
It is shown that the reproductive nature of the population (more sexual versus more asexual) is predictive of aflatoxin chemotype diversity in these agriculturally important fungi.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
Age-specific variation in immune response in drosophila melanogaster has a genetic basis
Genetics, 191(3), 989–584.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
An eigenvector interlacing property of graphs that arise from trees by Schur complementation of the Laplacian
LINEAR ALGEBRA AND ITS APPLICATIONS, 438(3), 1078–1094.
author keywords: Trees; Schur complement; Eigenvectors; Harmonic functions; Partially-supplied graph; Nodal domains; Interlacing
TL;DR:
This paper specialize to where G is a tree with points of articulation r ∈ R and considers the partially-supplied graph G* derived from G by taking the Schur complement with respect to R in L.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Joint genotyping on the fly: Identifying variation among a sequenced panel of inbred lines
GENOME RESEARCH, 22(5), 966–974.
MeSH headings : Algorithms; Animals; Chromosome Mapping; Computer Simulation; Drosophila melanogaster / genetics; Genetic Variation; Genotyping Techniques / standards; Inbreeding; Likelihood Functions; Models, Genetic; Polymorphism, Single Nucleotide; Reference Standards; Sequence Analysis, DNA
TL;DR:
This work presents the Joint Genotyper for Inbred Lines (JGIL) as a method for obtaining genotypes and identifying variation among a large panel of inbred strains or lines, and illustrates how JGIL is robust to moderate levels of error.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
A population genetic approach to mapping neurological disorder genes using deep resequencing
PLoS Genetics, 7(2).
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Effect of sexual recombination on population diversity in aflatoxin production by Aspergillus flavus and evidence for cryptic heterokaryosis
MOLECULAR ECOLOGY, 21(6), 1453–1476.
author keywords: array comparative genome hybridization; biological control; heritability; multilocus sequence typing; non-Mendelian segregation; vegetative compatibility group
MeSH headings : Aflatoxins / biosynthesis; Aspergillus flavus / genetics; Aspergillus flavus / metabolism; Comparative Genomic Hybridization; Fungal Proteins / genetics; Genes, Mating Type, Fungal / genetics; Genetic Variation; Karyotyping; Molecular Sequence Data; Multigene Family; Recombination, Genetic; Sequence Analysis, DNA
TL;DR:
Results from experimental matings indicate that sexual recombination is driving genetic and functional hyperdiversity in A. flavus, and have significant implications for managing AF contamination of crops and for improving biocontrol strategies using nonaflatoxigenic strains of A. Flavus.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Identification of RNA binding motif proteins essential for cardiovascular development
BMC DEVELOPMENTAL BIOLOGY, 11.
MeSH headings : Animals; Animals, Genetically Modified; Binding Sites; Cardiovascular System / embryology; Embryo, Nonmammalian / metabolism; Gene Expression Regulation, Developmental; Morphogenesis / genetics; RNA / metabolism; RNA-Binding Proteins / genetics; RNA-Binding Proteins / metabolism; Zebrafish / embryology; Zebrafish / genetics; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
The functional data support the hypothesis that rbm24a and rBM24b are key developmental cardiac genes with unequal roles in cardiovascular formation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
The Effects of Weak Genetic Perturbations on the Transcriptome of the Wing Imaginal Disc and Its Association With Wing Shape in Drosophila melanogaster
GENETICS, 187(4), 1171–U314.
MeSH headings : Animals; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genes, Insect; Genetic Variation; Genome, Insect; Genotype; Heterozygote; Linear Models; Multigene Family; Mutation; Phenotype; Transcriptional Activation; Wings, Animal / growth & development
TL;DR:
Weak mutational perturbations in genes affecting wing development in Drosophila melanogaster that influence wing shape relative to a co-isogenic wild type are used to examine overall patterns of covariation between phenotypic variables of interest and underlying aspects of gene activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
The non-random clustering of non-synonymous substitutions and its relationship to evolutionary rate
BMC GENOMICS, 12.
MeSH headings : Amino Acid Sequence; Amino Acid Substitution; Animals; Cluster Analysis; Evolution, Molecular; Humans; Molecular Sequence Data; Proteins / chemistry; Proteins / genetics; Sequence Alignment
TL;DR:
It is shown that clustering is a non-redundant predictor of evolutionary rate, and it is speculated that conflicting signals of clustering and constraint may be indicative of a historical period of relaxed selection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Variation in genome-wide mutation rates within and between human families
Nature Genetics, 43(7), 712–137.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Why the Phylogenetic Regression Appears Robust to Tree Misspecification
SYSTEMATIC BIOLOGY, 60(3), 245–260.
author keywords: Comparative method; independent contrasts; phylogenetic regression; robustness
MeSH headings : Animals; Biological Evolution; Computer Simulation; Linear Models; Models, Genetic; Phylogeny; Primates / classification
TL;DR:
This manuscript aims to elucidate how tree misspecification is propagated through a comparative analysis with a focus on the phylogenetic regression under a Brownian motion model of evolution and considers the effect of local phylogenetic perturbations on the regression fit.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia
Proceedings of the National Academy of Sciences of the United States of America, 107(17), 7863–7868.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Direct measure of the de novo mutation rate in autism and schizophrenia cohorts
American Journal of Human Genetics, 87(3), 316–324.
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Modulated Modularity Clustering as an Exploratory Tool for Functional Genomic Inference
PLOS GENETICS, 5(5).
MeSH headings : Animals; Cluster Analysis; Computer Simulation; Data Interpretation, Statistical; Databases, Genetic; Drosophila melanogaster / genetics; Gene Expression Profiling / statistics & numerical data; Genetic Techniques; Genomics / statistics & numerical data; Humans; Lymphocytes / immunology; Lymphocytes / metabolism; Models, Genetic; Multigene Family; Systems Biology
TL;DR:
A new objective-based clustering method, modulated modularity clustering (MMC), which modulates the connection strengths of edges in a weighted graph to maximize an objective function (called modularity) that quantifies community structure in graphical data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
On the Fiedler vectors of graphs that arise from trees by Schur complementation of the Laplacian
LINEAR ALGEBRA AND ITS APPLICATIONS, 431(10), 1869–1880.
author keywords: Trees; Graph Laplacians; Fiedler vectors; Perron components
TL;DR:
This paper considers a point of articulation r in the graph G and derives a related graph G whose Laplacian matrix is L and shows how Fiedler vectors of G relate to the structure of G and provides bounds for the algebraic connectivity of G{r} in terms of the connected components at r in G.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
ProPhylER: A curated online resource for protein function and structure based on evolutionary constraint analyses
GENOME RESEARCH, 20(1), 142–154.
MeSH headings : Databases, Protein; Eukaryota / genetics; Eukaryota / metabolism; Evolution, Molecular; Internet; Phylogeny; Polymorphism, Single Nucleotide; Proteins / chemistry; Proteins / genetics; Proteins / metabolism; Structure-Activity Relationship; User-Computer Interface
TL;DR:
The high accuracy of ProPhylER's regional analysis complements the high resolution of its single-site analysis to effectively guide and inform structure-function investigations and predict the impact of polymorphisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
SIMULATION FROM ENDPOINT-CONDITIONED, CONTINUOUS-TIME MARKOV CHAINS ON A FINITE STATE SPACE, WITH APPLICATIONS TO MOLECULAR EVOLUTION
ANNALS OF APPLIED STATISTICS, 3(3), 1204–1231.
author keywords: Continuous-time Markov chains; simulation; molecular evolution
TL;DR:
This work considers the generation of sample paths, including intermediate states and times of transition, from a CTMC whose beginning and ending states are known across a time interval of length T, and introduces and compares three applications of CTMCs to demonstrate the pitfalls of choosing an inefficient sampler.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Estimates of natural selection due to protein tertiary structure inform the ancestry of biallelic loci
Gene, 441(1-2), 45–52.
MeSH headings : Evolution, Molecular; Gene Frequency; Humans; Polymorphism, Single Nucleotide; Protein Structure, Tertiary; Proteins / genetics; Selection, Genetic
TL;DR:
This work focuses on 140 nonsynonymous single nucleotide polymorphisms of humans that are in proteins with known tertiary structures and finds that the technique for employing protein tertiary structure information yields some biologically plausible results but that it does not substantially improve the inference of ancestral human allele types.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2007 journal article
Constructing a meaningful evolutionary average at the phylogenetic center of mass
BMC BIOINFORMATICS, 8.
MeSH headings : Biological Evolution; Chromosome Mapping / methods; Computer Simulation; Evolution, Molecular; Genetic Variation / genetics; Genetics, Population; Models, Genetic; Models, Statistical; Phylogeny
TL;DR:
The BranchManager defines both an average and a novel taxon weighting scheme, and devise a framework for comparison and introduces the concept of a representative point at which the average is situated, a choice which has both intuitive and practical appeal.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Mixture modeling of transcript abundance classes in natural populations
GENOME BIOLOGY, 8(6).
MeSH headings : Animals; California; Cell Line, Tumor; Drosophila melanogaster / genetics; Female; Gene Expression Profiling; Genetics, Population; Humans; Male; North Carolina; Transcription, Genetic
TL;DR:
Population surveys of gene expression may complement genetical genomics as a general approach to quantifying sources of transcriptional variation by exploring the distributions of cis-acting and trans-acting factors and their relative contributions to expression of transcripts that exhibit two or more classes of abundance within populations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
RET is constitutively activated by novel tandem mutations that alter the active site resulting in multiple endocrine neoplasia type 2B
CANCER RESEARCH, 66(20), 10179–10187.
MeSH headings : Amino Acid Sequence; Base Sequence; Binding Sites; Cell Transformation, Neoplastic / genetics; Enzyme Activation; Female; Humans; Middle Aged; Models, Molecular; Molecular Sequence Data; Multiple Endocrine Neoplasia Type 2b / enzymology; Multiple Endocrine Neoplasia Type 2b / genetics; Mutation; Pedigree; Protein Conformation; Protein Structure, Tertiary; Proto-Oncogene Proteins c-ret / chemistry; Proto-Oncogene Proteins c-ret / genetics; Proto-Oncogene Proteins c-ret / metabolism; Sequence Alignment; Sequence Homology, Amino Acid
TL;DR:
It is predicted that RET804 constitutes a critical gatekeeper residue that, when mutated in combination with RET805, induces a conformational change in the hinge region that locks the active site in a position permissive for ATP hydrolysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
journal article
Epistasis dominates the genetic architecture of Drosophila quantitative traits
Huang, W., Richards, S., Carbone, M. A., Zhu, D. H., Anholt, R. R. H., Ayroles, J. F., … Muzny, D. Proceedings of the National Academy of Sciences of the United States of America, 109(39), 15553–15559.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Functional genome annotation of Drosophila seminal fluid proteins using transcriptional genetic networks
Ayroles, J. F., Laflamme, B. A., Stone, E. A., Wolfner, M. F., & Mackay, T. F. C. Genetical Research, 93(6), 387–395.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Genetic basis of transcriptome diversity in Drosophila melanogaster
Huang, W., Carbone, M. A., Magwire, M. M., Peiffer, J. A., Lyman, R. F., Stone, E. A., … Mackay, T. F. C. Proceedings of the National Academy of Sciences of the United States of America, 112(44), E6010–6019.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Genomic variation and its impact on gene expression in Drosophila melanogaster
Massouras, A., Waszak, S. M., Albarca-Aguilera, M., Hens, K., Holcombe, W., Ayroles, J. F., … Deplancke, B. PLoS Genetics, 8(11).
Source: NC State University Libraries
Added: August 6, 2018
journal article
Plasticity of the chemoreceptor repertoire in Drosophila melanogaster
Zhou, S. S., Stone, E. A., Mackay, T. F. C., & Anholt, R. R. H. PLoS Genetics, 5(10).
Source: NC State University Libraries
Added: August 6, 2018
journal article
The Drosophila melanogaster genetic reference panel
Mackay, T. F. C., Richards, S., Stone, E. A., Barbadilla, A., Ayroles, J. F., Zhu, D. H., … Carbone, M. A. Nature, 482(7384), 173–178.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Using whole-genome sequence data to predict quantitative trait phenotypes in Drosophila melanogaster
Ober, U., Ayroles, J. F., Stone, E. A., Richards, S., Zhu, D. H., Gibbs, R. A., … Simianer, H. PLoS Genetics, 8(5).
Source: NC State University Libraries
Added: August 6, 2018
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