Elizabeth Benson

Works (1)

Updated: April 5th, 2024 17:11

2023 journal article

Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation

ELIFE, 12.

By: D. Buglak *, P. Bougaran *, M. Kulikauskas *, Z. Liu *, E. Monaghan-Benson n, A. Gold *, A. Marvin *, A. Burciu* ...

author keywords: endothelial cells; nuclear LINC complex; SUN1; microtubules; adherens junctions; blood vessels; GEF-H1; Nesprin-1; angiogenesis; Rho; contractility; Endothelial cell; Mouse; Zebrafish
MeSH headings : Animals; Mice; Microtubule-Associated Proteins / metabolism; Endothelial Cells / metabolism; Zebrafish / metabolism; Nuclear Proteins / metabolism; Microtubules / metabolism; Intercellular Junctions / metabolism
topics (OpenAlex): Nuclear Structure and Function; RNA Research and Splicing; Cellular Mechanics and Interactions
TL;DR: It is shown that the nuclear-localized LINC complex protein SUN1 regulates vascular sprouting and barrier function via effects on endothelial cell-cell junction morphology and function and long-range communication from the nucleus to the cell periphery is important for vascular development and function. (via Semantic Scholar)
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Source: Web Of Science
Added: May 1, 2023

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