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Works (1)
Updated: April 5th, 2024 17:11
2023 journal article
Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation
ELIFE, 12.
author keywords: endothelial cells; nuclear LINC complex; SUN1; microtubules; adherens junctions; blood vessels; GEF-H1; Nesprin-1; angiogenesis; Rho; contractility; Endothelial cell; Mouse; Zebrafish
MeSH headings : Animals; Mice; Microtubule-Associated Proteins / metabolism; Endothelial Cells / metabolism; Zebrafish / metabolism; Nuclear Proteins / metabolism; Microtubules / metabolism; Intercellular Junctions / metabolism
TL;DR:
It is shown that the nuclear-localized LINC complex protein SUN1 regulates vascular sprouting and barrier function via effects on endothelial cell-cell junction morphology and function and long-range communication from the nucleus to the cell periphery is important for vascular development and function.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: May 1, 2023
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