Benjamin Randall

Works (3)

Updated: July 14th, 2023 11:15

2021 journal article

Global sensitivity analysis informed model reduction and selection applied to a Valsalva maneuver model

JOURNAL OF THEORETICAL BIOLOGY, 526.

By: E. Randall n, N. Randolph  n, A. Alexanderian n & M. Olufsen n

MeSH headings : Bayes Theorem; Blood Pressure; Heart Rate; Valsalva Maneuver
TL;DR: This study compares four GSA methods based on Sobol' indices (SIs) quantifying the parameter influence on the difference between the model output and the heart rate data and shows that it is necessary to incorporate both the aortic and carotid regions to model the VM. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: July 26, 2021

2020 journal article

Persistent instability in a nonhomogeneous delay differential equation system of the Valsalva maneuver

MATHEMATICAL BIOSCIENCES, 319.

By: E. Randall n, N. Randolph  n & M. Olufsen n

author keywords: Nonautonomous delay differential equation; Transcritical bifurcation; Hopf bifurcation; Postural orthostatic tachycardia syndrome (POTS); Cardiovascular regulation
MeSH headings : Adult; Autonomic Nervous System / physiology; Autonomic Nervous System / physiopathology; Blood Pressure / physiology; Heart Rate / physiology; Humans; Models, Neurological; Models, Theoretical; Postural Orthostatic Tachycardia Syndrome / physiopathology; Valsalva Maneuver / physiology
TL;DR: Analysis of a nonlinear, nonautonomous, nonhomogeneous open-loop neurological control model describing the autonomic nervous system response to the Valsalva maneuver suggests that instability caused from overactive sympathetic signaling may result in autonomic dysfunction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 3, 2020

2019 journal article

A model-based analysis of autonomic nervous function in response to the Valsalva maneuver

JOURNAL OF APPLIED PHYSIOLOGY, 127(5), 1386–1402.

By: E. Randall n, A. Billeschou*, L. Brinth *, J. Mehlsen * & M. Olufsen n

author keywords: baroreflex mechanism; carotid and aortic baroreceptors; mathematical modeling; parameter estimation; sympathetic and parasympathetic activity
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Autonomic Nervous System / physiology; Baroreflex / physiology; Blood Pressure / physiology; Female; Heart Rate / physiology; Humans; Male; Models, Theoretical; Respiratory Sinus Arrhythmia / physiology; Valsalva Maneuver / physiology; Young Adult
TL;DR: A mathematical model that can predict sympathetic and parasympathetic dynamics and simulates various VM responses is introduced and, by combining indices and model predictions, the pathologies for 5 AD patients are studied. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: December 9, 2019

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.