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Works (12)
Updated: April 5th, 2024 00:40
2016 journal article
Intracellular and Extracellular Expression of Bacillus thuringiensis Crystal Protein Cry5B in Lactococcus lactis for Use as an Anthelminthic
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 82(4), 1286–1294.
MeSH headings : Animals; Anthelmintics / metabolism; Anthelmintics / pharmacology; Bacillus thuringiensis Toxins; Bacterial Proteins / biosynthesis; Bacterial Proteins / genetics; Bacterial Proteins / pharmacology; Blotting, Western; Caenorhabditis elegans / drug effects; Cloning, Molecular; Endotoxins / biosynthesis; Endotoxins / genetics; Endotoxins / pharmacology; Gene Dosage; Gene Expression; Genetic Vectors; Hemolysin Proteins / biosynthesis; Hemolysin Proteins / genetics; Hemolysin Proteins / pharmacology; Lactococcus lactis / genetics; Lactococcus lactis / metabolism; Microbial Viability; Nisin / metabolism; Plasmids; Promoter Regions, Genetic; Protein Transport; Recombinant Proteins / biosynthesis; Recombinant Proteins / genetics; Recombinant Proteins / pharmacology; Survival Analysis; Transcriptional Activation / drug effects
TL;DR:
Results indicate that active Cry5B proteins can be expressed intracellularly in and released extracellularly from L. lactis, showing potential for future use as an anthelminthic that could be delivered orally in a food-grade microbe.
(via Semantic Scholar)
aem.asm.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Spontaneously Induced Prophages in Lactobacillus gasseri Contribute to Horizontal Gene Transfer
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 80(11), 3508–3517.
MeSH headings : Bacteriophages / genetics; Bacteriophages / isolation & purification; Bacteriophages / physiology; DNA, Viral / chemistry; DNA, Viral / genetics; Gene Transfer, Horizontal; Host Specificity; Lactobacillus / virology; Molecular Sequence Data; Plasmids; Prophages / genetics; Prophages / isolation & purification; Prophages / physiology; Sequence Analysis, DNA; Transduction, Genetic; Virus Activation
TL;DR:
The common occurrence of multiple prophages in L. gasseri genomes, their propensity for spontaneous induction, and the high degree of homology among phages within multiple species of Lactobacillus suggest that temperate bacteriophages likely contribute to horizontal gene transfer (HGT) in commensal lactobacilli.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Targeted expression of anthrax protective antigen by Lactobacillus gasseri as an anthrax vaccine
FUTURE MICROBIOLOGY, 5(8), 1289–1296.
author keywords: anthrax vaccine; dendritic cell; high copy expression; Lactobacillus gasseri; oral vaccine delivery; probiotic
MeSH headings : Administration, Oral; Animals; Anthrax / prevention & control; Anthrax Vaccines / administration & dosage; Anthrax Vaccines / genetics; Anthrax Vaccines / immunology; Antibodies, Bacterial / blood; Antibodies, Neutralizing / blood; Antigens, Bacterial / genetics; Antigens, Bacterial / immunology; Antitoxins / blood; Bacterial Toxins / genetics; Bacterial Toxins / immunology; Genetic Vectors; Lactobacillus / genetics; Lactobacillus / immunology; Mice; Plasmids; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / immunology; Survival Analysis; T-Lymphocytes / immunology
TL;DR:
Improvement of this improved expression vaccine strategy reduced the number of inoculations and length of the boosting period, leading to animal protection via efficacious bacterial adjuvanticity and safe oral delivery of this vaccine to mucosal immune cells, including dendritic cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Development and Application of a upp-Based Counterselective Gene Replacement System for the Study of the S-Layer Protein SlpX of Lactobacillus acidophilus NCFM
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 75(10), 3093–3105.
MeSH headings : Anti-Bacterial Agents / pharmacology; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Drug Resistance, Bacterial; Fluorouracil / pharmacology; Gene Deletion; Genetic Complementation Test; Lactobacillus acidophilus / genetics; Membrane Glycoproteins / genetics; Molecular Sequence Data; Mutagenesis, Insertional / methods; Pentosyltransferases / genetics; Pentosyltransferases / metabolism; Plasmids; Recombination, Genetic; Selection, Genetic
TL;DR:
Use of the upp-encoded uracil phosphoribosyltransferase (UPRTase) of L. acidophilus NCFM was explored as a counterselection marker to positively select for recombinants that have resolved from chromosomal integration of pORI-based plasmids.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 article
Genome sequence and characteristics of Lrm1, a prophage from industrial Lactobacillus rhamnosus strain M1
Durmaz, E., Miller, M. J., Azcarate-Peril, M. A., Toon, S. P., & Klaenhammer, T. R. (2008, August). APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol. 74, pp. 4601–4609.
MeSH headings : Aerobiosis; Bacillus / growth & development; Bacillus / virology; DNA, Viral / genetics; DNA, Viral / isolation & purification; DNA, Viral / ultrastructure; Gene Amplification; Genes, Viral / genetics; Genome, Viral; Industry; Kinetics; Microscopy, Electron; Mitomycin / pharmacology; Polymerase Chain Reaction; Prophages / drug effects; Prophages / genetics; Prophages / growth & development; Prophages / ultrastructure
TL;DR:
The presence of a defective prophage in an industrial strain could provide superinfection immunity to the host but could also contribute DNA in recombination events to produce new phages potentially infective for the host strain in a large-scale fermentation environment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 patent
AbiZ phage resistance gene
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2007 journal article
Abortive phage resistance mechanism AbiZ speeds the lysis clock to cause premature lysis of phage-infected Lactococcus lactis
JOURNAL OF BACTERIOLOGY, 189(4), 1417–1425.
MeSH headings : Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Bacteriophages; Cloning, Molecular; Lactococcus lactis / metabolism; Lactococcus lactis / virology; Open Reading Frames; Plasmids / genetics; Plasmids / physiology
TL;DR:
Results suggest that AbiZ may interact cooperatively with holin to cause premature lysis in phages of the P335 group, through reduction in either plaque size, EOP, or both.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Lactococcus lactis lytic bacteriophages of the p335 group are inhibited by overexpression of a truncated CI repressor
JOURNAL OF BACTERIOLOGY, 184(23), 6532–6543.
MeSH headings : Amino Acid Sequence; Base Sequence; Cloning, Molecular; DNA-Binding Proteins; Gene Expression Regulation, Viral; Lactococcus lactis / virology; Lysogeny; Molecular Sequence Data; Mutation; Operator Regions, Genetic; Repressor Proteins / chemistry; Repressor Proteins / genetics; Repressor Proteins / metabolism; Siphoviridae / genetics; Siphoviridae / physiology; Viral Proteins / chemistry; Viral Proteins / genetics; Viral Proteins / metabolism; Viral Regulatory and Accessory Proteins
TL;DR:
It is demonstrated that a number of different P335 phages, lytic for L. lactis NCK203, have a common operator region which can be targeted by a truncated derivative of a dysfunctional CI repressor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Genetic analysis of chromosomal regions of Lactococcus lactis acquired by recombinant lytic phages
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 66(3), 895–903.
MeSH headings : Bacteriolysis; Bacteriophages / genetics; Chromosome Mapping; Chromosomes, Bacterial / genetics; DNA, Viral / genetics; Genetic Variation; Lactococcus lactis / genetics; Lactococcus lactis / virology; Mitomycin; Plasmids / genetics; Proviruses; Recombination, Genetic; Replication Origin; Sequence Analysis, DNA; Virus Activation; Virus Integration
TL;DR:
It is demonstrated that recombinant phages can acquire DNA cassettes from different regions of the chromosome in order to overcome Abi defenses and alter the types and diversity of new phages that appear during phage-host interactions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1995 journal article
A starter culture rotation strategy incorporating paired restriction/modification and abortive infection bacteriophage defenses in a single Lactococcus lactis strain
Applied and Environmental Microbiology, 61(4), 1266.
Source: NC State University Libraries
Added: August 6, 2018
1992 journal article
MOLECULAR CHARACTERIZATION OF A 2ND ABORTIVE PHAGE RESISTANCE GENE PRESENT IN LACTOCOCCUS-LACTIS SUBSP LACTIS ME2
JOURNAL OF BACTERIOLOGY, 174(22), 7463–7469.
MeSH headings : Amino Acid Sequence; Bacterial Proteins / genetics; Bacteriophages / genetics; Bacteriophages / growth & development; Base Sequence; Binding Sites; Cloning, Molecular; DNA Replication; Escherichia coli / genetics; Genes, Bacterial; Lactococcus lactis / genetics; Lactococcus lactis / growth & development; Molecular Sequence Data; Plasmids; Restriction Mapping
TL;DR:
The fifth phage resistance factor from the prototype phage-insensitive strain Lactococcus lactis subsp.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1991 journal article
A fourth mechanism for bacteriophage resistance in Lactococcus lactis subsp. lactis ME2
Journal of Dairy Science, 74, 120.
Source: NC State University Libraries
Added: August 6, 2018
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