Works (44)

Updated: December 1st, 2023 05:02

2021 journal article

Fine‐Feature Modifications to Strained Ruthenium Complexes Radically Alter Their Hypoxic Anticancer Activity

Photochemistry and Photobiology, 98(1), 73–84.

By: H. Cole*, J. Roque*, L. Lifshits*, R. Hodges*, P. Barrett*, D. Havrylyuk*, D. Heidary*, E. Ramasamy* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Coordination Complexes / chemistry; Coordination Complexes / pharmacology; Ligands; Ruthenium / chemistry; Ruthenium / pharmacology; Singlet Oxygen / chemistry
Sources: ORCID, Crossref
Added: January 28, 2023

2020 journal article

Avobenzone incorporation in a diverse range of Ru(ii) scaffolds produces potent potential antineoplastic agents

Dalton Transactions, 49(35), 12161–12167.

co-author countries: United States of America 🇺🇸
MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Cell Line, Tumor; Coordination Complexes / chemistry; Coordination Complexes / pharmacology; Humans; Ligands; Photochemotherapy; Propiophenones / chemistry; Ruthenium / chemistry; Structure-Activity Relationship
Sources: ORCID, Crossref
Added: January 28, 2023

2020 journal article

Bis-tridentate N-Heterocyclic Carbene Ru(II) Complexes are Promising New Agents for Photodynamic Therapy.

Inorganic Chemistry.

Source: ORCID
Added: November 30, 2023

2018 journal article

Bacterial Cytological Profiling Reveals the Mechanism of Action of Anticancer Metal Complexes

Molecular Pharmaceutics, 15(8), 3404–3416.

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: November 30, 2023

2018 journal article

Molecular Determinants of Substrate Affinity and Enzyme Activity of a Cytochrome P450BM3 Variant

Biophysical Journal, 115(7), 1251–1263.

co-author countries: United States of America 🇺🇸

Contributors: I. Geronimo*, C. Denning*, D. Heidary*, E. Glazer* & C. Payne*

Source: ORCID
Added: November 30, 2023

2018 journal article

Ru(ii) complexes with diazine ligands: Electronic modulation of the coordinating group is key to the design of "dual action" photoactivated agents

Chemical Communications, 54(88), 12487–12490.

By: D. Havrylyuk*, M. Deshpande*, S. Parkin* & E. Glazer*

co-author countries: United States of America 🇺🇸

Contributors: D. Havrylyuk*, M. Deshpande*, S. Parkin* & E. Glazer*

Source: ORCID
Added: January 23, 2023

2018 journal article

Structure-activity relationships of anticancer ruthenium(II) complexes with substituted hydroxyquinolines

European Journal of Medicinal Chemistry, 156, 790–799.

By: D. Havrylyuk*, B. Howerton*, L. Nease*, S. Parkin*, D. Heidary* & E. Glazer*

co-author countries: United States of America 🇺🇸

Contributors: D. Havrylyuk*, B. Howerton*, L. Nease*, S. Parkin*, D. Heidary* & E. Glazer*

author keywords: Cytotoxic; Ruthenium; Cancer; Coordination chemistry; Translation
MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Cell Line, Tumor; Coordination Complexes / chemistry; Coordination Complexes / pharmacology; Humans; Hydroxyquinolines / chemistry; Hydroxyquinolines / pharmacology; Ligands; Models, Molecular; Neoplasms / drug therapy; Neoplasms / genetics; Protein Biosynthesis / drug effects; Ruthenium / chemistry; Ruthenium / pharmacology; Structure-Activity Relationship; Transcription, Genetic / drug effects
Sources: ORCID, Crossref
Added: January 29, 2023

2018 journal article

Superior photodynamic effect of carbon quantum dots through both type I and type II pathways: Detailed comparison study of top-down-synthesized and bottom-up-synthesized carbon quantum dots

Carbon, 140, 616–623.

By: T. Pillar-Little*, N. Wanninayake*, L. Nease*, D. Heidary*, E. Glazer* & D. Kim*

co-author countries: United States of America 🇺🇸

Contributors: T. Pillar-Little*, N. Wanninayake*, L. Nease*, D. Heidary*, E. Glazer* & D. Kim*

Source: ORCID
Added: November 30, 2023

2017 journal article

A high-throughput screening assay using a photoconvertable protein for identifying inhibitors of transcription, translation, or proteasomal degradation

SLAS Discovery, 22(4), 399–407.

co-author countries: United States of America 🇺🇸

Contributors: D. Heidary*, A. Fox*, C. Richards* & E. Glazer*

Source: ORCID
Added: November 30, 2023

2017 journal article

Combining a Ru(II) “Building Block” and Rapid Screening Approach to Identify DNA Structure-Selective “Light Switch” Compounds

ACS Combinatorial Science, 19(2), 85–95.

By: E. Wachter*, D. Moyá* & E. Glazer*

co-author countries: United States of America 🇺🇸

Contributors: E. Wachter*, D. Moyá* & E. Glazer*

Source: ORCID
Added: November 30, 2023

2017 journal article

Panchromatic Osmium Complexes for Photodynamic Therapy: Solutions to Existing Problems and New Questions

Photochemistry and Photobiology, 93(5), 1326–1328.

co-author countries: United States of America 🇺🇸

Contributors: E. Glazer*

Source: ORCID
Added: November 30, 2023

2017 journal article

Photochemical Properties and Structure–Activity Relationships of RuII Complexes with Pyridylbenzazole Ligands as Promising Anticancer Agents

European Journal of Inorganic Chemistry, 2017(12), 1687–1694.

co-author countries: United States of America 🇺🇸

Contributors: D. Havrylyuk*, D. Heidary*, L. Nease*, S. Parkin* & E. Glazer*

author keywords: Synthesis; Photochemistry; Cytotoxicity; DNA damage; Ruthenium
Source: ORCID
Added: January 23, 2023

2017 journal article

Photochemical and Photobiological Activity of Ru(II) Homoleptic and Heteroleptic Complexes Containing Methylated Bipyridyl-type Ligands

Inorganic Chemistry, 56(20), 12214–12223.

By: L. Kohler*, L. Nease*, P. Vo*, J. Garofolo*, D. Heidary*, R. Thummel*, E. Glazer*

co-author countries: United States of America 🇺🇸

Contributors: L. Kohler*, L. Nease*, P. Vo*, J. Garofolo*, D. Heidary*, R. Thummel*, E. Glazer*

Source: ORCID
Added: November 30, 2023

2017 journal article

Ruthenium-containing P450 inhibitors for dual enzyme inhibition and DNA damage

Dalton Transactions, 46(7), 2165–2173.

By: A. Zamora*, C. Denning*, D. Heidary*, E. Wachter*, L. Nease*, J. Ruiz*, E. Glazer*

co-author countries: Spain 🇪🇸 United States of America 🇺🇸

Contributors: A. Zamora*, C. Denning*, D. Heidary*, E. Wachter*, L. Nease*, J. Ruiz*, E. Glazer*

Source: ORCID
Added: November 30, 2023

2016 journal article

An exceptional 5:4 enantiomeric structure

Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials, 72(2), 223–231.

co-author countries: United States of America 🇺🇸

Contributors: E. Wachter*, E. Glazer*, S. Parkin* & C. Brock*

Source: ORCID
Added: November 30, 2023

2016 journal article

Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants

Biochemistry, 55(25), 3594–3606.

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: November 30, 2023

2016 journal article

Geometry matters: Inverse cytotoxic relationship for: Cis / trans -Ru(II) polypyridyl complexes from cis / trans -[PtCl2(NH3)2]

Chemical Communications, 52(66), 10121–10124.

By: E. Wachter*, A. Zamora*, D. Heidary*, J. Ruiz* & E. Glazer*

co-author countries: Spain 🇪🇸 United States of America 🇺🇸

Contributors: E. Wachter*, A. Zamora*, D. Heidary*, J. Ruiz* & E. Glazer*

Source: ORCID
Added: November 30, 2023

2016 journal article

Light-sensitive ruthenium complex-loaded cross-linked polymeric nanoassemblies for the treatment of cancer

Journal of Materials Chemistry B, 4(3), 394–408.

co-author countries: United States of America 🇺🇸

Contributors: M. Dickerson*, B. Howerton*, Y. Bae* & E. C. Glazer*

Source: ORCID
Added: November 30, 2023

2016 journal article

Ruthenium Complex "Light Switches" that are Selective for Different G-Quadruplex Structures

Chemistry - A European Journal, 22(2), 550–559.

By: E. Wachter*, D. Moyá*, S. Parkin* & E. Glazer*

co-author countries: United States of America 🇺🇸

Contributors: E. Wachter*, D. Moyá*, S. Parkin* & E. Glazer*

Source: ORCID
Added: November 30, 2023

2016 journal article

So-called "dual emission" for 3MLCT luminescence in ruthenium complex ions: What is really happening?

Coordination Chemistry Reviews, 306, 447–467.

By: D. Magde*, M. Magde* & E. Glazer*

co-author countries: United States of America 🇺🇸

Contributors: D. Magde*, M. Magde* & E. Glazer*

Source: ORCID
Added: November 30, 2023

2014 journal article

A light-activated metal complex targets both DNA and RNA in a fluorescent in vitro transcription and translation assay

ChemBioChem, 15(4), 507–511.

co-author countries: United States of America 🇺🇸

Contributors: D. Heidary* & E. Glazer*

Source: ORCID
Added: November 30, 2023

2014 journal article

A new type of DNA "light-switch": A dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

Chemical Communications, 50(3), 311–313.

By: E. Wachter*, B. Howerton*, E. Hall*, S. Parkin* & E. Glazer*

co-author countries: United States of America 🇺🇸

Contributors: E. Wachter*, B. Howerton*, E. Hall*, S. Parkin* & E. Glazer*

Source: ORCID
Added: November 30, 2023

2014 journal article

Coordination of hydroxyquinolines to a ruthenium bis-dimethyl-phenanthroline scaffold radically improves potency for potential as antineoplastic agents

Journal of Medicinal Chemistry, 57(21), 8936–8946.

By: D. Heidary*, B. Howerton* & E. Glazer*

co-author countries: United States of America 🇺🇸

Contributors: D. Heidary*, B. Howerton* & E. Glazer*

Source: ORCID
Added: November 30, 2023

2014 journal article

Mechanistic study on the photochemical "light switch" behavior of [Ru(bpy)2dmdppz]2+

Journal of Physical Chemistry A, 118(45), 10474–10486.

By: E. Wachter* & E. Glazer*

co-author countries: United States of America 🇺🇸

Contributors: E. Wachter* & E. Glazer*

Source: ORCID
Added: November 30, 2023

2014 journal article

Modifying charge and hydrophilicity of simple Ru(II) polypyridyl complexes radically alters biological activities: Old complexes, surprising new tricks

Inorganic Chemistry, 53(19), 10370–10377.

co-author countries: United States of America 🇺🇸

Contributors: M. Dickerson*, Y. Sun*, B. Howerton* & E. Glazer*

Source: ORCID
Added: November 30, 2023

2014 journal article

Photoactive Ru(II) complexes with dioxinophenanthroline ligands are potent cytotoxic agents

Inorganic Chemistry, 53(19), 10030–10032.

By: A. Hidayatullah*, E. Wachter*, D. Heidary*, S. Parkin* & E. Glazer*

co-author countries: United States of America 🇺🇸

Contributors: A. Hidayatullah*, E. Wachter*, D. Heidary*, S. Parkin* & E. Glazer*

Source: ORCID
Added: November 30, 2023

2013 journal article

Light-activated metal complexes that covalently modify DNA

Israel Journal of Chemistry, 53(6-7), 391–400.

co-author countries: United States of America 🇺🇸

Contributors: E. Glazer*

Source: ORCID
Added: November 30, 2023

2012 journal article

Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window

Chemical Communications, 48(77), 9649–9651.

By: E. Wachter*, D. Heidary*, B. Howerton*, S. Parkin* & E. Glazer*

co-author countries: United States of America 🇺🇸

Contributors: E. Wachter*, D. Heidary*, B. Howerton*, S. Parkin* & E. Glazer*

Source: ORCID
Added: November 30, 2023

2012 journal article

Strained ruthenium complexes are potent light-activated anticancer agents

Journal of the American Chemical Society, 134(20), 8324–8327.

By: B. Howerton*, D. Heidary* & E. Glazer*

co-author countries: United States of America 🇺🇸

Contributors: B. Howerton*, D. Heidary* & E. Glazer*

Source: ORCID
Added: November 30, 2023

2011 journal article

Three clusters of conformational states in P450cam reveal a multistep pathway for closing of the substrate access channel

Biochemistry, 50(5), 693–703.

By: Y. Lee*, E. Glazer*, R. Wilson*, C. Stout* & D. Goodin*

co-author countries: United States of America 🇺🇸

Contributors: Y. Lee*, E. Glazer*, R. Wilson*, C. Stout* & D. Goodin*

Source: ORCID
Added: November 30, 2023

2008 journal article

Probing inducible nitric oxide synthase with a pterin-ruthenium(II) sensitizer wire

Angewandte Chemie - International Edition, 47(5), 898–901.

By: E. Glazer*, Y. Le Nguyen, H. Gray* & D. Goodin*

co-author countries: United States of America 🇺🇸

Contributors: E. Glazer*, Y. Le Nguyen, H. Gray* & D. Goodin*

Source: ORCID
Added: November 30, 2023

2007 book

Conjugates of heme-thiolate enzymes with photoactive metal-diimine wires

In Structure and Bonding (Vol. 123, pp. 177–203).

By: S. Contakes*, Y. Nguyen*, H. Gray*, E. Glazer*, A. Hays* & D. Goodin*

co-author countries: United States of America 🇺🇸

Contributors: S. Contakes*, Y. Nguyen*, H. Gray*, E. Glazer*, A. Hays* & D. Goodin*

Source: ORCID
Added: November 30, 2023

2007 journal article

Ruthenium complexes that break the rules: Structural features controlling dual emission

Journal of the American Chemical Society, 129(27), 8544–8551.

By: E. Glazer*, D. Magde* & Y. Tor*

co-author countries: United States of America 🇺🇸

Contributors: E. Glazer*, D. Magde* & Y. Tor*

Source: ORCID
Added: November 30, 2023

2006 journal article

Photodimerizable ditopic ligand

Organic Letters, 8(10), 1987–1990.

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: November 30, 2023

2005 journal article

A simple synthesis of isotopically pure 2,2′-dipyridyl-d8

Inorganic Chemistry Communications, 8(6), 517–519.

By: E. Glazer*, B. Belyea* & Y. Tor*

co-author countries: United States of America 🇺🇸

Contributors: E. Glazer*, B. Belyea* & Y. Tor*

Source: ORCID
Added: November 30, 2023

2005 journal article

Dual emission from a family of conjugated dinuclear RuII complexes

Journal of the American Chemical Society, 127(12), 4190–4192.

By: E. Glazer*, D. Magde* & Y. Tor*

co-author countries: United States of America 🇺🇸

Contributors: E. Glazer*, D. Magde* & Y. Tor*

Source: ORCID
Added: November 30, 2023

2005 journal article

Redox couples of inducible nitric oxide synthase

Journal of the American Chemical Society, 127(32), 11212–11213.

By: A. Udit*, W. Belliston-Bittner*, E. Glazer*, Y. Le Nguyen, J. Gillan*, M. Hill*, M. Marletta*, D. Goodin*, H. Gray*

co-author countries: United States of America 🇺🇸

Contributors: A. Udit*, W. Belliston-Bittner*, E. Glazer*, Y. Le Nguyen, J. Gillan*, M. Hill*, M. Marletta*, D. Goodin*, H. Gray*

Source: ORCID
Added: November 30, 2023

2004 journal article

Symmetrical dinuclear complexes with high DNA affinity based on Ru(dpq)2(phen)2+

Chemical Communications, 10(8), 1018–1019. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442536689&partnerID=MN8TOARS

By: J. Aldrich-Wright, C. Brodie, E. Glazer, N. Luedtke, L. Elson-Schwab & Y. Tor

Contributors: J. Aldrich-Wright, C. Brodie, E. Glazer, N. Luedtke, L. Elson-Schwab & Y. Tor

Source: ORCID
Added: November 30, 2023

2002 journal article

Eilatin Ru(II) complexes display anti-HIV activity and enantiomeric diversity in the binding of RNA

ChemBioChem, 3(8), 766–771.

By: N. Luedtke*, J. Hwang*, E. Glazer*, D. Gut*, M. Kol* & Y. Tor*

co-author countries: Israel 🇮🇱 United States of America 🇺🇸

Contributors: N. Luedtke*, J. Hwang*, E. Glazer*, D. Gut*, M. Kol* & Y. Tor*

Source: ORCID
Added: November 30, 2023

2002 journal article

RuII complexes of "large-surface" ligands

Angewandte Chemie - International Edition, 41(21), 4022–4026.

co-author countries: United States of America 🇺🇸

Contributors: E. Glazer* & Y. Tor*

Source: ORCID
Added: November 30, 2023

2000 journal article

High speed PVK-based photorefractive polymer composites

Molecular Crystals and Liquid Crystals Science and Technology Section B: Nonlinear Optics, 25(1-4), 189–194. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034454642&partnerID=MN8TOARS

By: M. Díaz-García, D. Wright, J. Casperson, B. Smith, E. Glazer, W. Moerner, L. Sukhomlinova, R. Twieg

Contributors: M. Díaz-García, D. Wright, J. Casperson, B. Smith, E. Glazer, W. Moerner, L. Sukhomlinova, R. Twieg

Source: ORCID
Added: November 30, 2023

1999 conference paper

Chiral metal-containing polymers

American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, 40(1), 513–514. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033089595&partnerID=MN8TOARS

By: E. Glazer & Y. Tor

Contributors: E. Glazer & Y. Tor

Source: ORCID
Added: November 30, 2023

1999 journal article

Photorefractive properties of poly(N-vinyl carbazole)-based composites for high-speed applications

Chemistry of Materials, 11(7), 1784–1791. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001188375&partnerID=MN8TOARS

By: M. Díaz-García, D. Wright, J. Casperson, B. Smith, E. Glazer, W. Moerner, L. Sukhomlinova, R. Twieg

Contributors: M. Díaz-García, D. Wright, J. Casperson, B. Smith, E. Glazer, W. Moerner, L. Sukhomlinova, R. Twieg

Source: ORCID
Added: November 30, 2023

1999 conference paper

Understanding trapping in photorefractive polymer composites for optical processing applications

IQEC, International Quantum Electronics Conference Proceedings, 186–187. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032645912&partnerID=MN8TOARS

By: W. Moerner, A. Grunnet-Jepsen, D. Wright, J. Casperson, E. Glazer, M. DeClue, J. Siegel, R. Twieg

Contributors: W. Moerner, A. Grunnet-Jepsen, D. Wright, J. Casperson, E. Glazer, M. DeClue, J. Siegel, R. Twieg

Source: ORCID
Added: November 30, 2023

Employment

Updated: February 17th, 2023 13:18

2023 - present

North Carolina State University Raleigh, North Carolina, US
Professor Chemistry

Education

Updated: September 14th, 2021 12:07

University of California, San Diego San Diego, California, US
PhD Chemistry and Biochemistry

Williams College Williamstown, MA, US
BA Chemistry

Funding History

Funding history based on the linked ORCID record. Updated: September 14th, 2021 12:05

grant September 1, 2020 - June 30, 2024
Role of small molecule interactions and multiprotein assemblies in CYP1B1 disease-associated function and dysfunction
National Institute of General Medical Sciences
grant August 15, 2020 - July 31, 2023
Inorganic-aptamer hybrids for live cell imaging
Directorate for Mathematical & Physical Sciences
grant March 24, 2018 - March 23, 2019
2018 Metals in Medicine Gordon Research Conference
National Center for Advancing Translational Sciences
grant August 15, 2016 - July 31, 2019
MRI: Acquisition of a Single-Crystal Diffractometer for Chemistry and Materials Research
Directorate for Mathematical & Physical Sciences
grant August 1, 2014 - July 31, 2020
Light-responsive ruthenium compounds for applications in disease
National Institute of General Medical Sciences
grant January 1, 2006 - June 30, 2007
Ru(II)-Containing Wires for ET Studies in Metalloenzymes
National Institute of General Medical Sciences