Emily Medlin Martin

Works (11)

Updated: March 24th, 2025 05:00

2024 journal article

Clinicopathologic Parameters of Peritoneal Fluid as Predictors of Gastrointestinal Lesions, Complications, and Outcomes in Equine Colic Patients: A Retrospective Study

Animals, 15(1), 12.

By: E. Martin n , K. Sarkan*, A. Viall *, S. Hostetter* & K. Epstein *

author keywords: equine; peritoneal fluid; neutrophil; colic; gastric reflux; SIRS
topics (OpenAlex): Veterinary Equine Medical Research; Animal health and immunology; Streptococcal Infections and Treatments
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: January 21, 2025

2024 conference paper

Equine Bone Marrow-Derived Mesenchymal Stem Cell Extracellular Vesicles Enhance Production of Neutrophil-Derived Antibacterial Reactive Oxygen Species in Vitro

Veterinary Surgery, 53, O1–O73.

By: E. Martin , J. Gordon, J. Schirmer & J. Peroni

Event: ACVS Surgery Summit at Phoenix, Arizona on October 24-26, 2024

topics (OpenAlex): Aortic Thrombus and Embolism; Diabetic Foot Ulcer Assessment and Management; Reconstructive Surgery and Microvascular Techniques
Sources: NC State University Libraries, NC State University Libraries
Added: March 22, 2025

2024 journal article

Evaluation of pharmacokinetics of metoclopramide administered via subcutaneous bolus and intravenous constant rate infusion to adult horses

Veterinary Surgery, 53(6), 1111–1122.

By: A. Brandon*, J. Williams *, J. Davis*, E. Martin n , A. Capper* & N. Crabtree *

topics (OpenAlex): Veterinary Equine Medical Research; Veterinary Pharmacology and Anesthesia; Anesthesia and Pain Management
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: July 8, 2024

2024 journal article

Use of extracorporeal hemoperfusion therapy in an adult horse with <i>Clostridioides difficile</i> colitis and severe systemic inflammatory response syndrome

Journal of Veterinary Internal Medicine, 38(5), 2790–2794.

By: K. Hobbs n , A. Le Sueur n, K. Hallowell n, E. Martin n , M. Sheats  n & Y. Ueda n 

author keywords: cytokines; equine; hemodialysis; hemoperfusion; immunology; renal/urinary tract
topics (OpenAlex): Clostridium difficile and Clostridium perfringens research; Streptococcal Infections and Treatments; Nosocomial Infections in ICU
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 15, 2024

2021 conference paper

Clinicopathologic parameters of equine abdominal fluid as predictors of postoperative reflux and survival: a retrospective analysis

Proceedings of the International Veterinary Emergency and Critical Care Symposium. Presented at the International Veterinary Emergency and Critical Care Symposium.

By: E. Martin , K. Sarkan, G. Macy, A. Viall, S. Hostetter & K. Epstein

Event: International Veterinary Emergency and Critical Care Symposium

Source: NC State University Libraries
Added: March 22, 2025

2018 journal article

Pharmacokinetics and ex vivo anti‐inflammatory effects of oral misoprostol in horses

Equine Veterinary Journal, 51(3), 415–421.

By: E. Martin n , J. Schirmer n, S. Jones n  & J. Davis *

author keywords: horse; leucocyte; E prostanoid receptor agonist; pharmacokinetics; inflammation; tumour necrosis factor-
MeSH headings : Abortifacient Agents, Nonsteroidal / administration & dosage; Abortifacient Agents, Nonsteroidal / pharmacokinetics; Administration, Oral; Animals; Area Under Curve; Cells, Cultured; Horse Diseases / drug therapy; Horse Diseases / metabolism; Horses / blood; Horses / metabolism; Inflammation / drug therapy; Inflammation / metabolism; Inflammation / veterinary; Leukocytes / drug effects; Leukocytes / metabolism; Misoprostol / administration & dosage; Misoprostol / pharmacokinetics
topics (OpenAlex): Veterinary Equine Medical Research; Veterinary Pharmacology and Anesthesia; Veterinary medicine and infectious diseases
TL;DR: Misoprostol is rapidly absorbed following oral administration in horses, and a single 5 μg/kg dose had no significant inhibitory effect on ex vivo LPS‐stimulated TNFα mRNA production in leucocytes. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: May 6, 2019

2018 journal article

Pharmacokinetics, pharmacodynamics and clinical use of trazodone and its active metabolite <i>m‐</i>chlorophenylpiperazine in the horse

Journal of Veterinary Pharmacology and Therapeutics, 41(3), 393–401.

By: J. Davis *, J. Schirmer n & E. Medlin n

author keywords: adverse drug reaction; equine; sedative; serotonin antagonist and reuptake inhibitor
MeSH headings : Administration, Oral; Animals; Anti-Anxiety Agents / administration & dosage; Anti-Anxiety Agents / pharmacokinetics; Anti-Anxiety Agents / pharmacology; Area Under Curve; Cross-Over Studies; Dose-Response Relationship, Drug; Half-Life; Horses / blood; Male; Piperazines / administration & dosage; Piperazines / pharmacokinetics; Piperazines / pharmacology; Serotonin Receptor Agonists / administration & dosage; Serotonin Receptor Agonists / pharmacokinetics; Serotonin Receptor Agonists / pharmacology; Trazodone / administration & dosage; Trazodone / pharmacokinetics; Trazodone / pharmacology
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Pharmacological Effects and Assays; Veterinary Equine Medical Research
TL;DR: Trazodone was successful in modifying behavioural problems to some degree in 17 of 18 clinical cases and Tolerance and subsequent lack of drug effect occurred in two of 18clinical cases following 14 or 21 days of use. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2017 journal article

Inhibition of microsomal prostaglandin E-synthase-1 (mPGES-1) selectively suppresses PGE 2 in an in vitro equine inflammation model

Veterinary Immunology and Immunopathology, 192, 33–40.

By: E. Martin n  & S. Jones n 

author keywords: Prostaglandin E-2; Prostaglandin E-synthase; Leukocyte; Anti-inflammatory; NSAID; Horse
MeSH headings : Animals; Blotting, Western / veterinary; Dinoprostone / antagonists & inhibitors; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay / veterinary; Horses; Inflammation / metabolism; Inflammation / physiopathology; Inflammation / veterinary; Leukocytes / metabolism; Microsomes / enzymology; Prostaglandin-E Synthases / antagonists & inhibitors; Prostaglandin-E Synthases / metabolism; Prostaglandin-E Synthases / physiology; Real-Time Polymerase Chain Reaction / veterinary
topics (OpenAlex): Inflammatory mediators and NSAID effects; Veterinary medicine and infectious diseases; Veterinary Equine Medical Research
TL;DR: It is demonstrated that mPGES-1 is a potentially safer and effective therapeutic target for treatment of equine inflammatory disease when compared to traditional non-steroidal anti-inflammatory drugs. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2017 journal article

Misoprostol Inhibits Equine Neutrophil Adhesion, Migration, and Respiratory Burst in an In Vitro Model of Inflammation

Frontiers in Veterinary Science, 4.

By: E. Martin n , R. Till n, M. Sheats  n & S. Jones n 

author keywords: horse; leukocyte; chemotaxis; reactive oxygen species; inflammation; anti-inflammatory; NSAID
topics (OpenAlex): Immune Response and Inflammation; Neutrophil, Myeloperoxidase and Oxidative Mechanisms; Neuropeptides and Animal Physiology
TL;DR: Data indicate that misoprostol-targeting of E-prostanoid (EP) receptors potently inhibits equine neutrophil effector functions in vitro, and suggest misop frostol may hold promise as a novel anti-inflammatory therapeutic in the horse. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: July 20, 2019

2017 journal article

Misoprostol Inhibits Lipopolysaccharide-Induced Pro-inflammatory Cytokine Production by Equine Leukocytes

Frontiers in Veterinary Science, 4.

By: E. Martin n , K. Messenger  n, M. Sheats  n & S. Jones n 

author keywords: horse; leukocyte; chemokine; inflammation; anti-inflammatory; non-steroidal anti-inflammatory drug
topics (OpenAlex): Immune Response and Inflammation; Veterinary Equine Medical Research; Veterinary medicine and infectious diseases
TL;DR: Results indicate that misoprostol exerts anti-inflammatory effects on equine leukocytes when applied before or after a pro-inflammatory stimulus, and these effects were cytokine-specific and sometimes differed at the mRNA and protein levels. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019

2013 journal article

Value of faculty-provided materials in an introductory equine science course

Journal of Equine Veterinary Science, 33(5), 393.

By: S. Pratt-Phillips & E. Medlin n

topics (OpenAlex): Educational Games and Gamification
TL;DR: The game provides students with an opportunity to learn some of the basics of horse management, sport and science, and users can work towards owning a “virtual” horse with which they can compete at different events. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020

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