Elizabeth Jean Sacho

Works (4)

Updated: July 5th, 2023 15:43

2015 article

MutL traps MutS at a DNA mismatch

Qiu, R., Sakato, M., Sacho, E. J., Wilkins, H., Zhang, X., Modrich, P., … Weninger, K. R. (2015, August 17). Proceedings of the National Academy of Sciences, Vol. 112, pp. 10914–10919.

By: R. Qiu n, M. Sakato*, E. Sacho n, H. Wilkins*, X. Zhang*, P. Modrich *, M. Hingorani *, D. Erie *, K. Weninger n 

author keywords: DNA mismatch repair; MutS; MutL; FRET
MeSH headings : Bacterial Proteins / genetics; Base Pair Mismatch; Genes, Bacterial; Thermus / genetics
topics (OpenAlex): Genetic factors in colorectal cancer; RNA Research and Splicing; RNA and protein synthesis mechanisms
TL;DR: It is discovered that MutL fundamentally changes the properties of mismatch-bound MutS by preventing it from sliding away from the mismatch, which it normally does when isolated, and suggests a mechanism for localizing the activity of repair proteins near the mismatch. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 article

Phosphorylation-induced Conformational Ensemble Switching in an Intrinsically Disordered Cancer/Testis Antigen

He, Y. N., Chen, Y. H., Mooney, S. M., Rajagopalan, K., Bhargava, A., Sacho, E., … al. (2015, August 5). Journal of Biological Chemistry, Vol. 290, pp. 25090–25102.

By: Y. He *, Y. Chen *, S. Mooney *, K. Rajagopalan *, A. Bhargava, E. Sacho n, keith, P. Bryan * ...

MeSH headings : Amino Acid Sequence; Antigens, Neoplasm / chemistry; Antigens, Neoplasm / metabolism; Cell Line, Tumor; Humans; Male; Models, Molecular; Molecular Sequence Data; Phosphorylation; Prostatic Neoplasms / pathology; Protein Conformation
topics (OpenAlex): Protein Structure and Dynamics; Microtubule and mitosis dynamics; Advanced Proteomics Techniques and Applications
TL;DR: It is shown that the PAGE4 polypeptide chain has local and long-range conformational preferences that are perturbed by site-specific phosphorylation at Thr-51, which is critical for potentiating c-Jun transactivation, an important factor in controlling cell growth, apoptosis, and stress response. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

Cancer/Testis Antigen PAGE4, a Regulator of c-Jun Transactivation, Is Phosphorylated by Homeodomain-Interacting Protein Kinase 1, a Component of the Stress-Response Pathway

Mooney, S. M., Qiu, R., Kim, J. J., Sacho, E. J., Rajagopalan, K., Johng, D., … Weninger, K. R. (2014, February 23). Biochemistry, Vol. 53, pp. 1670–1679.

By: S. Mooney *, R. Qiu n, J. Kim *, E. Sacho n, K. Rajagopalan *, D. Johng, T. Shiraishi*, P. Kulkarni, K. Weninger n 

MeSH headings : Amino Acid Motifs; Antigens, Neoplasm / chemistry; Antigens, Neoplasm / genetics; Antigens, Neoplasm / metabolism; Cell Line, Tumor; Humans; Male; Phosphorylation; Prostatic Neoplasms / enzymology; Prostatic Neoplasms / genetics; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / physiopathology; Protein Binding; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Proto-Oncogene Proteins c-jun / genetics; Proto-Oncogene Proteins c-jun / metabolism; Signal Transduction; Stress, Physiological; Testis / metabolism; Transcriptional Activation
topics (OpenAlex): Sperm and Testicular Function; Immunotherapy and Immune Responses; Prostate Cancer Treatment and Research
TL;DR: The present results clearly implicate PAGE4 as a component of the stress-response pathway and uncover a novel link between components of this pathway and prostatic development and disease. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 article

The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation

Rajagopalan, K., Qiu, R. Y., Mooney, S. M., Rao, S., Shiraishi, T., Sacho, E., … al. (2013, November 21). Biochimica Et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1842, pp. 154–163.

By: K. Rajagopalan *, R. Qiu n, S. Mooney *, S. Rao*, T. Shiraishi*, E. Sacho n, H. Huang*, E. Shapiro* ...

author keywords: PAGE4; Cancer/Testis Antigen; c-Jun; smFRET; Prostate cancer; Intrinsically disordered protein
MeSH headings : 3' Untranslated Regions / genetics; Antigens, Neoplasm / chemistry; Antigens, Neoplasm / genetics; Antigens, Neoplasm / metabolism; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p27 / genetics; Cyclin-Dependent Kinase Inhibitor p27 / metabolism; Fluorescence Resonance Energy Transfer; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; MicroRNAs / genetics; MicroRNAs / metabolism; Mutation; Prostate / embryology; Prostate / growth & development; Prostate / metabolism; Prostatic Neoplasms / genetics; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology; Protein Binding; Protein Conformation; Proto-Oncogene Mas; Proto-Oncogene Proteins c-jun / genetics; Proto-Oncogene Proteins c-jun / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Stress, Physiological; Transcriptional Activation
topics (OpenAlex): Prostate Cancer Treatment and Research; Ubiquitin and proteasome pathways; Immunotherapy and Immune Responses
TL;DR: PAGE4 specifically interacts with c-Jun and that, conformational dynamics may account for its observed pleiotropic functions, the first report demonstrating crosstalk between a CTA and a proto-oncogene. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2026) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.