Elizabeth Jean Sacho

Works (4)

Updated: July 5th, 2023 15:43

2015 journal article

MutL traps MutS at a DNA mismatch

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(35), 10914–10919.

By: R. Qiu n, M. Sakato*, E. Sacho n, H. Wilkins*, X. Zhang*, P. Modrichd, M. Hingorani *, D. Erie *, K. Weninger n 

author keywords: DNA mismatch repair; MutS; MutL; FRET
MeSH headings : Bacterial Proteins / genetics; Base Pair Mismatch; Genes, Bacterial; Thermus / genetics
TL;DR: It is discovered that MutL fundamentally changes the properties of mismatch-bound MutS by preventing it from sliding away from the mismatch, which it normally does when isolated, and suggests a mechanism for localizing the activity of repair proteins near the mismatch. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Phosphorylation-induced Conformational Ensemble Switching in an Intrinsically Disordered Cancer/Testis Antigen

JOURNAL OF BIOLOGICAL CHEMISTRY, 290(41), 25090–25102.

By: Y. He *, Y. Chen *, S. Mooney *, K. Rajagopalan *, A. Bhargava, E. Sacho n, keith, P. Bryan * ...

MeSH headings : Amino Acid Sequence; Antigens, Neoplasm / chemistry; Antigens, Neoplasm / metabolism; Cell Line, Tumor; Humans; Male; Models, Molecular; Molecular Sequence Data; Phosphorylation; Prostatic Neoplasms / pathology; Protein Conformation
TL;DR: It is shown that the PAGE4 polypeptide chain has local and long-range conformational preferences that are perturbed by site-specific phosphorylation at Thr-51, which is critical for potentiating c-Jun transactivation, an important factor in controlling cell growth, apoptosis, and stress response. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Cancer/Testis Antigen PAGE4, a Regulator of c-Jun Transactivation, Is Phosphorylated by Homeodomain-Interacting Protein Kinase 1, a Component of the Stress-Response Pathway

BIOCHEMISTRY, 53(10), 1670–1679.

By: S. Mooney *, R. Qiu n, J. Kim *, E. Sacho n, K. Rajagopalan *, D. Johng, T. Shiraishi*, P. Kulkarni, K. Weninger n 

MeSH headings : Amino Acid Motifs; Antigens, Neoplasm / chemistry; Antigens, Neoplasm / genetics; Antigens, Neoplasm / metabolism; Cell Line, Tumor; Humans; Male; Phosphorylation; Prostatic Neoplasms / enzymology; Prostatic Neoplasms / genetics; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / physiopathology; Protein Binding; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Proto-Oncogene Proteins c-jun / genetics; Proto-Oncogene Proteins c-jun / metabolism; Signal Transduction; Stress, Physiological; Testis / metabolism; Transcriptional Activation
TL;DR: The present results clearly implicate PAGE4 as a component of the stress-response pathway and uncover a novel link between components of this pathway and prostatic development and disease. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1842(2), 154–163.

By: K. Rajagopalan *, R. Qiu n, S. Mooney *, S. Rao*, T. Shiraishi*, E. Sacho n, H. Huang*, E. Shapiro* ...

author keywords: PAGE4; Cancer/Testis Antigen; c-Jun; smFRET; Prostate cancer; Intrinsically disordered protein
MeSH headings : 3' Untranslated Regions / genetics; Antigens, Neoplasm / chemistry; Antigens, Neoplasm / genetics; Antigens, Neoplasm / metabolism; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p27 / genetics; Cyclin-Dependent Kinase Inhibitor p27 / metabolism; Fluorescence Resonance Energy Transfer; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; MicroRNAs / genetics; MicroRNAs / metabolism; Mutation; Prostate / embryology; Prostate / growth & development; Prostate / metabolism; Prostatic Neoplasms / genetics; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology; Protein Binding; Protein Conformation; Proto-Oncogene Mas; Proto-Oncogene Proteins c-jun / genetics; Proto-Oncogene Proteins c-jun / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Stress, Physiological; Transcriptional Activation
TL;DR: PAGE4 specifically interacts with c-Jun and that, conformational dynamics may account for its observed pleiotropic functions, the first report demonstrating crosstalk between a CTA and a proto-oncogene. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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