Works (17)

Updated: April 3rd, 2024 20:03

2022 journal article

Sex-Specific Neural Networks of Cued Threat Conditioning: A Pilot Study

FRONTIERS IN SYSTEMS NEUROSCIENCE, 16.

By: K. Plessis n, S. Basu n, T. Rumbell* & E. Lucas n

author keywords: fear conditioning; classical conditioning; associative memory; memory encoding; immediate early gene; functional connectivity; graph theory; negative valence systems
TL;DR: Preliminary evidence of sex differences in the individual circuit components and broader global networks of threat conditioning that may confer female vulnerability to fear-based psychiatric disease is provided. (via Semantic Scholar)
Source: Web Of Science
Added: June 13, 2022

2019 journal article

Prazosin during fear conditioning facilitates subsequent extinction in male C57Bl/6N mice

PSYCHOPHARMACOLOGY, 236(1), 273–279.

By: E. Lucas*, W. Wu*, C. Roman-Ortiz* & R. Clem*

author keywords: ADRA1A; Terazosin; Exposure therapy
MeSH headings : Adrenergic alpha-1 Receptor Antagonists / pharmacology; Adrenergic alpha-1 Receptor Antagonists / therapeutic use; Animals; Anxiety / drug therapy; Anxiety / psychology; Basolateral Nuclear Complex / drug effects; Conditioning, Psychological / drug effects; Conditioning, Psychological / physiology; Extinction, Psychological / drug effects; Extinction, Psychological / physiology; Fear / drug effects; Fear / physiology; Fear / psychology; Male; Memory / drug effects; Memory / physiology; Mice; Mice, Inbred C57BL; Prazosin / pharmacology; Prazosin / therapeutic use; Prefrontal Cortex / drug effects; Prefrontal Cortex / physiology
TL;DR: The results indicate that α1-AR activity during aversive conditioning is dispensable for memory acquisition but renders conditioned fear more impervious to extinction, which suggests that behavioral flexibility is constrained by noradrenaline at the time of initial learning via activation of a specific AR isoform. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 11, 2019

2018 journal article

GABAergic interneurons: the orchestra or the conductor in fear learning and memory?

Brain Research Bulletin, 141, 13–19.

author keywords: Emotional learning; Inhibitory microcircuit; Parvalbumin; Somatostatin; Basolateral amygdala; Central amygdala; Medial prefrontal cortex; Auditory cortex
MeSH headings : Animals; Brain / physiology; Fear / physiology; GABAergic Neurons / physiology; Interneurons / physiology; Learning / physiology; gamma-Aminobutyric Acid / metabolism
TL;DR: Emerging evidence that genetically-defined interneurons play important subtype-specific roles in processing of fear-related stimuli and that these dynamics shape PN firing through both inhibition and disinhibition warrants discarding the notion of interneeurons as passive bystanders in long-term memory. (via Semantic Scholar)
Source: Web Of Science
Added: August 30, 2019

2016 journal article

Multimodal and Site-Specific Plasticity of Amygdala Parvalbumin Interneurons after Fear Learning

Neuron, 91(3), 629–643.

MeSH headings : Amygdala / cytology; Amygdala / metabolism; Amygdala / physiology; Animals; Conditioning, Psychological / physiology; Fear; Interneurons / physiology; Male; Mice; Neural Pathways / physiology; Neuronal Plasticity / physiology; Neurons / physiology; Parvalbumins / metabolism; gamma-Aminobutyric Acid / metabolism
TL;DR: Examining synaptic connections between afferent pathways, PV-INs, and principal excitatory neurons in the basolateral amygdala reveals previously overlooked specializations of amygdala PV-Ins and indicates specific circuit mechanisms for inhibitory plasticity during the encoding of associative fear memories. (via Semantic Scholar)
Source: Crossref
Added: July 27, 2019

2015 journal article

Cerebellar transcriptional alterations with Purkinje cell dysfunction and loss in mice lacking PGC-1α

Frontiers in Cellular Neuroscience, Special Issue, Neurodegeneration: from Genetics to Molecules, 441(8), 1–13.

By: E. Lucas*, C. Reid*, L. McMeekin*, S. Dougherty* & R. Cowell*

author keywords: PPARGC1A; cerebellum; ataxia; Catwalk; stereology; Refsum disease; Friedreich Ataxia
TL;DR: It is shown here that mice lacking PGC-1α exhibit ataxia in addition to the previously described deficits in motor coordination, and this data suggest that dysfunction in multiple cell types contribute to motor deficits in the context of P GC-1 α deficiency. (via Semantic Scholar)
Source: Web Of Science
Added: September 9, 2019

2015 journal article

Cortical PGC-1α-Dependent Transcripts Are Reduced in Postmortem Tissue From Patients With Schizophrenia

Schizophrenia Bulletin, 42(4), 1009–1017.

author keywords: transcriptional regulation; interneuron; maturation
MeSH headings : Adult; Autopsy; Cerebral Cortex / metabolism; Female; Gene Expression; Humans; Male; Middle Aged; NF-E2-Related Factor 1 / metabolism; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism; Schizophrenia / metabolism; Young Adult
TL;DR: The data suggest that schizophrenia involves a disruption in PGC-1α and/or NRF-1-associated transcriptional programs in the cortex and that approaches to enhance the activity of P GC-1 α or transcriptional regulators like NRf-1 should be considered with the goal of restoring normal gene programs and improving cortical function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 27, 2019

2015 journal article

Interneuron Transcriptional Dysregulation Causes Frequency-Dependent Alterations in the Balance of Inhibition and Excitation in Hippocampus

Journal of Neuroscience, 35(46), 15276–15290.

MeSH headings : Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / pharmacology; Excitatory Postsynaptic Potentials / drug effects; Excitatory Postsynaptic Potentials / physiology; Female; Gene Expression Regulation / drug effects; Gene Expression Regulation / genetics; Gene Expression Regulation / physiology; Hippocampus / cytology; In Vitro Techniques; Inhibitory Postsynaptic Potentials / drug effects; Inhibitory Postsynaptic Potentials / physiology; Interneurons / physiology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Net / drug effects; Nerve Net / physiology; Nesting Behavior / physiology; Neural Inhibition / physiology; Neurotransmitter Agents / pharmacology; Parvalbumins / metabolism; Patch-Clamp Techniques; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Transcription Factors / genetics; Voltage-Sensitive Dye Imaging
TL;DR: It is shown that transcriptional dysregulation in hippocampal interneurons causes frequency-dependent alterations in the I/E ratio and in circuit function in hippocampus, suggesting that PGC-1α deficiency in psychiatric and neurological disorders contributes to disease by causing functionally relevant alterations in I-E balance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 27, 2019

2014 journal article

Mice lacking TrkB in parvalbumin-positive cells exhibit sexually dimorphic behavioral phenotypes

Behavioural Brain Research, 274, 219–225.

By: E. Lucas*, A. Jegarl* & R. Clem*

author keywords: Ntrk2; Fear conditioning; Extinction; Vestibular; Circling
MeSH headings : Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Behavior, Animal / physiology; Brain / cytology; Brain-Derived Neurotrophic Factor / metabolism; Exploratory Behavior / physiology; Extinction, Psychological / physiology; Female; Interneurons / metabolism; Learning Disabilities / genetics; Luminescent Proteins / genetics; Luminescent Proteins / metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Parvalbumins / genetics; Parvalbumins / metabolism; Phenotype; Receptor, trkB / deficiency; Receptor, trkB / genetics; Sex Characteristics; Signal Transduction / genetics; Stereotypic Movement Disorder / genetics; Vestibular Diseases / genetics
TL;DR: These findings complement evidence from human and rodent studies suggesting that BDNF signaling promotes consolidation of extinction and point to PV-positive neurons as a discrete population that mediates these effects in a sex-specific manner. (via Semantic Scholar)
Source: Crossref
Added: July 27, 2019

2014 journal article

Mice lacking the transcriptional coactivator PGC-1α exhibit alterations in inhibitory synaptic transmission in the motor cortex

Neuroscience, 271, 137–148.

By: S. Dougherty*, A. Bartley*, E. Lucas*, J. Hablitz*, L. Dobrunz* & R. Cowell*

author keywords: peroxisome proliferator-activated receptor gamma coactivator 1 alpha; parvalbumin; inhibitory neurotransmission; motor cortex; interneuron
MeSH headings : Action Potentials / physiology; Animals; Electric Stimulation; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Inhibitory Postsynaptic Potentials / physiology; Interneurons / pathology; Interneurons / physiology; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Motor Cortex / pathology; Motor Cortex / physiology; Neural Inhibition / physiology; Neurons / pathology; Neurons / physiology; Parvalbumins / metabolism; Patch-Clamp Techniques; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pyramidal Cells / pathology; Pyramidal Cells / physiology; Synaptic Transmission / physiology; Tissue Culture Techniques; Transcription Factors / deficiency; Transcription Factors / genetics; Transcription Factors / metabolism; gamma-Aminobutyric Acid / metabolism
TL;DR: It is shown that mice lacking PGC-1α exhibit increased amplitudes and decreased frequency of spontaneous inhibitory postsynaptic currents in layer V pyramidal neurons, and the essential role of PV-positive interneurons in maintenance of cortical excitatory:inhibitory balance is maintained. (via Semantic Scholar)
Source: Crossref
Added: July 27, 2019

2014 journal article

PGC-1  Provides a Transcriptional Framework for Synchronous Neurotransmitter Release from Parvalbumin-Positive Interneurons

Journal of Neuroscience, 34(43), 14375–14387.

By: E. Lucas*, S. Dougherty*, L. McMeekin*, C. Reid*, L. Dobrunz*, A. West*, J. Hablitz*, R. Cowell*

author keywords: Barnes maze; cortical development; Huntington disease; ppargc1a; schizophrenia; strontium
MeSH headings : Animals; Cell Line, Tumor; Humans; Interneurons / metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Parvalbumins / biosynthesis; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Transcription Factors / biosynthesis; Transcription, Genetic / physiology; gamma-Aminobutyric Acid / metabolism
TL;DR: Conditional deletion of PGC-1α in PV-positive neurons significantly decreased cortical transcript expression of these genes, promoted asynchronous GABA release, and impaired long-term memory, demonstrating that loss of P GC-1 α in this interneuron subpopulation could contribute to cortical dysfunction in disease states. (via Semantic Scholar)
Source: Crossref
Added: July 27, 2019

2013 journal article

Abnormal expression of glutamate transporters in temporal lobe areas in elderly patients with schizophrenia

Schizophrenia Research, 144(1-3), 1–8.

By: D. Shan*, E. Lucas*, J. Drummond*, V. Haroutunian*, J. Meador-Woodruff* & R. McCullumsmith*

author keywords: Excitatory amino acid transporter (EAAT); Vesicular glutamate transporter (VGLUT); Superior temporal gyrus; Hippocampus; Schizophrenia; Glutamate
MeSH headings : Aged; Aged, 80 and over; Animals; Antipsychotic Agents / administration & dosage; Disease Models, Animal; Excitatory Amino Acid Transporter 1 / biosynthesis; Excitatory Amino Acid Transporter 1 / genetics; Excitatory Amino Acid Transporter 2 / biosynthesis; Excitatory Amino Acid Transporter 2 / genetics; Excitatory Amino Acid Transporter 3 / biosynthesis; Excitatory Amino Acid Transporter 3 / genetics; Female; Gene Expression Regulation / drug effects; Glutamate Plasma Membrane Transport Proteins / biosynthesis; Glutamate Plasma Membrane Transport Proteins / genetics; Glutamic Acid / genetics; Glutamic Acid / metabolism; Haloperidol / administration & dosage; Hippocampus / drug effects; Hippocampus / metabolism; Hippocampus / pathology; Humans; Male; Rats; Rats, Sprague-Dawley; Schizophrenia / drug therapy; Schizophrenia / genetics; Schizophrenia / metabolism; Temporal Lobe / drug effects; Temporal Lobe / metabolism; Temporal Lobe / pathology; Vesicular Glutamate Transport Protein 1 / biosynthesis; Vesicular Glutamate Transport Protein 1 / genetics; Vesicular Glutamate Transport Protein 2 / biosynthesis; Vesicular Glutamate Transport Protein 2 / genetics; Vesicular Glutamate Transport Proteins / biosynthesis; Vesicular Glutamate Transport Proteins / genetics
TL;DR: The findings suggest that buffering and reuptake, but not presynaptic release, of glutamate is altered in glutamate synapses in the temporal lobe in schizophrenia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 27, 2019

2012 journal article

Developmental Alterations in Motor Coordination and Medium Spiny Neuron Markers in Mice Lacking PGC-1α

PLoS ONE, 7(8), e42878.

By: E. Lucas*, S. Dougherty*, L. McMeekin*, A. Trinh*, C. Reid* & R. Cowell*

Ed(s): M. Coleman

MeSH headings : Animals; Biomarkers / metabolism; Chromatography, High Pressure Liquid; Corpus Striatum / metabolism; Dopamine / metabolism; Gene Expression Profiling; Huntington Disease / metabolism; Huntington Disease / physiopathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons / metabolism; Neurons / physiology; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Psychomotor Performance; RNA, Messenger / genetics; Reverse Transcriptase Polymerase Chain Reaction; Rotarod Performance Test; Trans-Activators / genetics; Trans-Activators / physiology; Transcription Factors; Transcription, Genetic
TL;DR: It is shown that young P GC-1α −/− mice exhibit severe rotarod deficits, decreased rearing behavior, and increased occurrence of tremor in addition to the previously described hindlimb clasping, and that developmental disruption of PGC-1 α leads to long-term alterations in motor functioning. (via Semantic Scholar)
Source: Crossref
Added: July 28, 2019

2012 journal article

Disruption of Purkinje cell function prior to huntingtin accumulation and cell loss in an animal model of Huntington Disease

Experimental Neurology, 236(1), 171–178.

By: S. Dougherty*, J. Reeves*, E. Lucas*, K. Gamble*, M. Lesort* & R. Cowell*

author keywords: Cerebellum; Gene expression; Motor impairment; Stereology; Glutamic acid decarboxylase 67; Calbindin; Parvalbumin; Loose patch electrophysiology
MeSH headings : Age Factors; Animals; Disease Models, Animal; Huntingtin Protein; Huntington Disease / genetics; Huntington Disease / metabolism; Huntington Disease / pathology; Male; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Phenotype; Purkinje Cells / pathology
TL;DR: Qualitative real time PCR, Western blot analysis, and immunohistochemistry experiments suggest that early PC dysfunction potentially contributes to motor impairment in this model of HD. (via Semantic Scholar)
Source: Crossref
Added: July 28, 2019

2010 journal article

Neuronal Inactivation of Peroxisome Proliferator-activated Receptor γ Coactivator 1α (PGC-1α) Protects Mice from Diet-induced Obesity and Leads to Degenerative Lesions

Journal of Biological Chemistry, 285(50), 39087–39095.

MeSH headings : Animal Feed; Animals; Brain / metabolism; Constriction, Pathologic; Gene Expression Regulation; Liver / metabolism; Mice; Mice, Transgenic; Neurodegenerative Diseases / metabolism; Neurons / metabolism; Obesity / genetics; Oxygen Consumption; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Trans-Activators / metabolism; Transcription Factors; Transcription, Genetic; Triglycerides / metabolism
TL;DR: A physiological role for neuronal PGC-1α in the control of energy balance is demonstrated and CaMKIIα-positive neurons as an important part of the neural circuitry that governs energy expenditure in vivo are implicate. (via Semantic Scholar)
Source: Crossref
Added: July 28, 2019

2010 journal article

Parvalbumin Deficiency and GABAergic Dysfunction in Mice Lacking PGC-1α

Journal of Neuroscience, 30(21), 7227–7235.

By: E. Lucas*, S. Markwardt*, S. Gupta*, J. Meador-Woodruff*, J. Lin*, L. Overstreet-Wadiche*, R. Cowell*

MeSH headings : Analysis of Variance; Animals; Animals, Newborn; Biophysics; Cells, Cultured; DNA-Binding Proteins / metabolism; Electric Stimulation / methods; GTP Phosphohydrolases / metabolism; Gene Expression Regulation, Developmental / genetics; Glutamate Decarboxylase / metabolism; Heart; High Mobility Group Proteins / metabolism; Hippocampus / cytology; Humans; Inhibitory Postsynaptic Potentials / drug effects; Inhibitory Postsynaptic Potentials / genetics; Interneurons / metabolism; Long-Term Potentiation / drug effects; Long-Term Potentiation / genetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium / metabolism; Parvalbumins / deficiency; Patch-Clamp Techniques / methods; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; RNA, Messenger / metabolism; Shaw Potassium Channels / metabolism; Trans-Activators / deficiency; Trans-Activators / metabolism; Transcription Factors / metabolism; Transfection / methods; gamma-Aminobutyric Acid / metabolism
TL;DR: Findings indicate that PGC-1α is a novel regulator of interneuron gene expression and function and a potential therapeutic target for neurological disorders associated with Interneuron dysfunction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: September 9, 2019

2009 journal article

Do Visually Salient Stimuli Reduce Children’s Risky Decisions?

Journal of Clinical Psychology in Medical Settings, 16(3), 223–232.

By: D. Schwebel*, E. Lucas* & A. Pearson*

author keywords: Risk-taking; Safety; Injury; Perception; Ability estimation; Fluorescence
MeSH headings : Attention; Child; Female; Fluorescence; Humans; Judgment; Male; Multivariate Analysis; Regression Analysis; Risk-Taking; Safety; Self Concept; Temperament; Visual Perception; Wounds and Injuries / prevention & control; Wounds and Injuries / psychology
TL;DR: Results suggest the two groups judged similarly, but children took longer to judge perceptually ambiguous tasks when those tasks were visually salient, and visual salience increased decision-making time but not accuracy of judgment. (via Semantic Scholar)
Source: Crossref
Added: July 28, 2019

2007 journal article

Unintentional Injury Risk in Children with Externalizing Behavior Disorders at Summer Camp

Journal of Clinical Psychology in Medical Settings, 14(2), 145–151.

By: D. Schwebel*, C. Tavares*, E. Lucas*, E. Bowling* & J. Hodgens*

author keywords: injury; safety; attention-deficit; hyperactivity disorder (ADHD); oppositional defiant disorder (ODD); externalizing behavior
TL;DR: Symptoms of ODD and CD—violations and intentional aggression in particular—were related to injury incidence but symptoms of ADHD were not, consistent with a growing body of evidence that oppositional, noncompliant, and aggressive behavior patterns might be primarily responsible for increased risk for injury among children with externalizing behavior disorders. (via Semantic Scholar)
Source: Crossref
Added: July 28, 2019

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