Evan Lawrence Willis

College of Sciences

Works (2)

Updated: April 25th, 2025 17:46

2025 article

Metallo-azapeptides: Controlled Metal Chelation to Peptide Backbone Nitrogen

Bowles, M. O., Willis, E. L., Trombley, M. D., Chen, C.-H., & Proulx, C. (2025, January 6). Journal of the American Chemical Society, Vol. 1.

By: M. Bowles n, E. Willis n, M. Trombley n, C. Chen * & C. Proulx n 

MeSH headings : Chelating Agents / chemistry; Chelating Agents / chemical synthesis; Nitrogen / chemistry; Nickel / chemistry; Peptides / chemistry; Crystallography, X-Ray; Palladium / chemistry; Models, Molecular; Aza Compounds / chemistry; Coordination Complexes / chemistry
topics (OpenAlex): Chemical Synthesis and Analysis; Axial and Atropisomeric Chirality Synthesis; Asymmetric Synthesis and Catalysis
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Sources: Web Of Science, NC State University Libraries
Added: January 13, 2025

2019 article

Aza-Amino Acids Disrupt β-Sheet Secondary Structures

McMechen, M. A., Willis, E. L., Gourville, P. C., & Proulx, C. (2019, May 18). Molecules, Vol. 24.

By: M. McMechen n, E. Willis n, P. Gourville n & C. Proulx n 

author keywords: peptidomimetics; azapeptides; aza-amino acids; -hairpin; -sheet
MeSH headings : Amino Acid Sequence; Amino Acids / chemistry; Aza Compounds / chemistry; Aza Compounds / pharmacology; Hydrogen Bonding; Molecular Structure; Peptides / chemical synthesis; Peptides / chemistry; Protein Folding; Protein Structure, Secondary / drug effects; Proteins / chemistry; Solid-Phase Synthesis Techniques
topics (OpenAlex): Chemical Synthesis and Analysis; RNA and protein synthesis mechanisms; Click Chemistry and Applications
TL;DR: The effect of a single aza-amino acid incorporation located in the upper β-strand at a hydrogen-bonded (HB) site of a β-hairpin model peptide (H-Arg-Tyr-Val-Glu- Val-d-Pro-Gly-Orn-Lys-Ile-Leu-Gln-NH2) is reported. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 1, 2019

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