Elizabeth Irvin

College of Sciences

Works (4)

Updated: July 9th, 2024 05:01

2024 journal article

Single-molecule fluorescence imaging of DNA maintenance protein binding dynamics and activities on extended DNA

CURRENT OPINION IN STRUCTURAL BIOLOGY, 87.

By: E. Irvin n & H. Wang n 

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Sources: Web Of Science, NC State University Libraries
Added: July 8, 2024

2023 journal article

High-speed AFM imaging reveals DNA capture and loop extrusion dynamics by cohesin-NIPBL

JOURNAL OF BIOLOGICAL CHEMISTRY, 299(11).

By: P. Kaur n, X. Lu *, Q. Xu *, E. Irvin n, C. Pappas n, H. Zhang *, I. Finkelstein *, Z. Shi * ...

TL;DR: High-speed atomic force microscopy imaging reveals that cohesin-NIPBL captures DNA through arm extension, assisted by feet (shorter protrusions), and followed by transfer of DNA to its lower compartment (SMC heads, RAD21, SA1, and NIPBL). (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: December 11, 2023

2023 journal article

Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures

DNA REPAIR, 128.

By: E. Irvin n & H. Wang n 

author keywords: Single-molecule imaging; High-speed AFM imaging; Mitochondrial DNA replication; Cohesin; Shelterin; Protein-DNA interactions
TL;DR: This review highlights how the lab has used SMI techniques over the past decade to study protein-nucleic acid interactions involved in DNA repair, mitochondrial DNA replication, and telomere maintenance, and discusses how DNA substrates containing specific DNA sequences or structures that emulate DNA repair intermediates or telomeres were generated and validated. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 7, 2023

2022 journal article

Densely methylated DNA traps Methyl-CpG-binding domain protein 2 but permits free diffusion by Methyl-CpG-binding domain protein 3

JOURNAL OF BIOLOGICAL CHEMISTRY, 298(10).

By: G. Leighton *, E. Irvin n, P. Kaur n, M. Liu n, C. You *, D. Bhattaram *, J. Piehler *, R. Riehn n  ...

MeSH headings : CpG Islands; DNA Methylation; DNA-Binding Proteins / metabolism; Mi-2 Nucleosome Remodeling and Deacetylase Complex / genetics; Mi-2 Nucleosome Remodeling and Deacetylase Complex / metabolism; Nucleosomes; Protein Binding; Transcription Factors / metabolism; Humans; Single Molecule Imaging
TL;DR: These studies support a model in which MBD2-NuRD strongly localizes to and compacts methylated CpG islands while MBD3-NURD can freely mobilize nucleosomes independent of methylation status. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 29, 2022

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