Elizabeth Irvin
College of Sciences
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Works (3)
Updated: April 5th, 2024 16:18
2023 journal article
High-speed AFM imaging reveals DNA capture and loop extrusion dynamics by cohesin-NIPBL
JOURNAL OF BIOLOGICAL CHEMISTRY, 299(11).
TL;DR:
High-speed atomic force microscopy imaging reveals that cohesin-NIPBL captures DNA through arm extension, assisted by feet (shorter protrusions), and followed by transfer of DNA to its lower compartment (SMC heads, RAD21, SA1, and NIPBL).
(via Semantic Scholar)
www.ncbi.nlm.nih.gov (repository)
Sources: Web Of Science, NC State University Libraries
Added: December 11, 2023
2023 journal article
Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures
DNA REPAIR, 128.
author keywords: Single-molecule imaging; High-speed AFM imaging; Mitochondrial DNA replication; Cohesin; Shelterin; Protein-DNA interactions
TL;DR:
This review highlights how the lab has used SMI techniques over the past decade to study protein-nucleic acid interactions involved in DNA repair, mitochondrial DNA replication, and telomere maintenance, and discusses how DNA substrates containing specific DNA sequences or structures that emulate DNA repair intermediates or telomeres were generated and validated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 7, 2023
2022 journal article
Densely methylated DNA traps Methyl-CpG-binding domain protein 2 but permits free diffusion by Methyl-CpG-binding domain protein 3
JOURNAL OF BIOLOGICAL CHEMISTRY, 298(10).
MeSH headings : CpG Islands; DNA Methylation; DNA-Binding Proteins / metabolism; Mi-2 Nucleosome Remodeling and Deacetylase Complex / genetics; Mi-2 Nucleosome Remodeling and Deacetylase Complex / metabolism; Nucleosomes; Protein Binding; Transcription Factors / metabolism; Humans; Single Molecule Imaging
TL;DR:
These studies support a model in which MBD2-NuRD strongly localizes to and compacts methylated CpG islands while MBD3-NURD can freely mobilize nucleosomes independent of methylation status.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 29, 2022
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