Erin Marie Slabaugh

Works (9)

Updated: July 5th, 2023 15:43

2021 journal article

Phenotypic effects of changes in the FTVTxK region of an Arabidopsis secondary wall cellulose synthase compared with results from analogous mutations in other isoforms

PLANT DIRECT, 5(8).

By: J. Burris n, M. Makarem*, E. Slabaugh n, A. Chaves *, E. Pierce n, J. Lee *, S. Kiemle*, A. Kwansa n ...

author keywords: AtCesA7; cellulose synthesis complex; genetic complementation; irx3-1 mutant; PpCesA5; protein engineering; sum frequency generation spectroscopy
TL;DR: The cumulative results show that the FTVTxK region is important for the function of an angiosperm secondary wall CesA as well as widely divergent primary wall CesAs, while differences in complementation results between isomers may reflect functional differences that can be explored in further work. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2021

2019 journal article

Analysis of differential gene expression and alternative splicing is significantly influenced by choice of reference genome

RNA, 25(6), 669–684.

By: E. Slabaugh n, J. Desai n, R. Sartor n, L. Lawas *, S. Krishna Jagadish * & C. Doherty n 

author keywords: Oryza sativa; differential gene expression; splicing; reference genome; RNA-seq; transcriptome analysis
MeSH headings : Alternative Splicing; Base Sequence; Chromosome Mapping / methods; Gene Expression Profiling / standards; Genes, Essential; Genome, Plant; High-Throughput Nucleotide Sequencing; Oryza / classification; Oryza / genetics; Oryza / metabolism; Polymorphism, Single Nucleotide; RNA, Messenger / genetics; RNA, Messenger / metabolism; Reference Standards; Sequence Alignment; Transcriptome
TL;DR: It is concluded that even between two closely related genomes of similar quality, using the reference genome that is most closely related to the species being sampled significantly improves transcriptome analysis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 4, 2019

2018 journal article

Neural Net Classification Combined With Movement Analysis to Evaluate Setaria viridis as a Model System for Time of Day of Anther Appearance

FRONTIERS IN PLANT SCIENCE, 9.

By: J. Desai n, E. Slabaugh n, D. Liebelt n, J. Fredenberg n, B. Gray*, S. Jagadish *, O. Wilkins *, C. Doherty n 

author keywords: flower opening time; spikelet opening time; timing of anthesis; setaria; developmental stage; image analysis of plants; biological image classification
TL;DR: The suitability of Setaria viridis, the model for C4 photosynthesis, for such a role is examined, and an imaging system to monitor the temporal regulation of growth, flower opening time, and other physiological characteristics in Setaria is developed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 12, 2018

2018 journal article

TGNap1 is required for microtubule-dependent homeostasis of a subpopulation of the plant trans-Golgi network

NATURE COMMUNICATIONS, 9.

By: L. Renna *, G. Stefano *, E. Slabaugh n, C. Wormsbaecher*, A. Sulpizio*, K. Zienkiewicz *, F. Brandizzi *

MeSH headings : Adenosine Triphosphatases / metabolism; Arabidopsis / genetics; Arabidopsis / metabolism; Arabidopsis Proteins / metabolism; Carrier Proteins; Cell Membrane / metabolism; Endocytosis / physiology; Genes, Plant; Golgi Apparatus / metabolism; Homeostasis; Microtubules / metabolism; Protein Domains; Protein Interaction Domains and Motifs; Protein Transport; rab GTP-Binding Proteins / metabolism; trans-Golgi Network / genetics; trans-Golgi Network / metabolism
TL;DR: Renna et al. show that the TGNap1 protein acts in microtubule-dependent biogenesis, tracking and function of a TGN subset, highlighting diversification within the plant TGN. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: December 31, 2018

2016 journal article

Comparative Structural and Computational Analysis Supports Eighteen Cellulose Synthases in the Plant Cellulose Synthesis Complex

Scientific Reports, 6(1).

By: B. Nixon *, K. Mansouri  n, A. Singh n, J. Du *, J. Davis n, J. Lee n, E. Slabaugh n, V. Vandavasi* ...

Contributors: B. Nixon *, K. Mansouri  n, A. Singh n, J. Du *, J. Davis n, J. Lee n, E. Slabaugh n, V. Vandavasi* ...

MeSH headings : Cellulose / biosynthesis; Cellulose / chemistry; Glucosyltransferases / chemistry; Models, Molecular; Plant Proteins / chemistry; Protein Domains; Protein Folding; Protein Structure, Quaternary
TL;DR: Improved transmission electron microscopy images and image averages of the rosette-type CSC are obtained, revealing the frequent triangularity and average cross-sectional area in the plasma membrane of its individual lobes and multifaceted data support a rosettes CSC with 18 CESAs that mediates the synthesis of a fundamental microfibril composed of 18 glucan chains. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

Prediction of the structures of the plant-specific regions of vascular plant cellulose synthases and correlated functional analysis

Cellulose, 23(1), 145–161.

By: L. Sethaphong n, J. Davis n, E. Slabaugh n, A. Singh n, C. Haigler n  & Y. Yingling n 

Contributors: Y. Yingling n , C. Haigler n , A. Singh n, E. Slabaugh n, J. Davis n & L. Sethaphong n

author keywords: Arabidopsis thaliana; Cellulose synthesis; Computational protein structure prediction; Isoform specificity; Mutant complementation
TL;DR: Modeling of the mutant P-CR of Atcesa8R362K (fra6) suggested that changes in local structural stability and surface electrostatics may cause the mutant phenotype, and results provide structural clues about the function of plant-specific regions of CESA. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

The valine and lysine residues in the conserved FxVTxK motif are important for the function of phylogenetically distant plant cellulose synthases

Glycobiology, 26(5), 509–519.

By: E. Slabaugh n, T. Scavuzzo-Duggan*, A. Chaves *, L. Wilson*, C. Wilson n, J. Davis n, D. Cosgrove *, C. Anderson *, A. Roberts *, C. Haigler n 

author keywords: cellulose synthesis; gametophore formation; phenotypic complementation; root elongation; site-directed mutagenesis
MeSH headings : Amino Acid Motifs; Arabidopsis / enzymology; Arabidopsis / genetics; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Bryopsida / enzymology; Bryopsida / genetics; Glucosyltransferases / genetics; Glucosyltransferases / metabolism; Lysine / genetics; Lysine / metabolism; Valine / genetics; Valine / metabolism
TL;DR: The results support the possibility that the FxVTxK region functions similarly in CESA and BcsA, and show that Physcomitrella provides an efficient model for assessing the effects of engineered CESA mutations affecting primary cell wall synthesis and that diverse testing systems can lead to nuanced insights into CESA structure-function relationships. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Cellulose synthases: new insights from crystallography and modeling

Trends in Plant Science, 19(2), 99–106.

By: E. Slabaugh n, J. Davis n, C. Haigler n , Y. Yingling n  & J. Zimmer *

Contributors: J. Zimmer *, Y. Yingling n , C. Haigler n , J. Davis n & E. Slabaugh n

MeSH headings : Catalytic Domain; Crystallography; Glucosyltransferases / chemistry; Models, Molecular; Plant Proteins / chemistry
TL;DR: It is shown how the structures of CelS proteins can be used to generate hypotheses for experiments testing mechanisms of glucan synthesis and translocation in plant CelS, and how these structures impact the understanding of the synthesis of cellulose and other extracellular polysaccharides. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Computational and genetic evidence that different structural conformations of a non-catalytic region affect the function of plant cellulose synthase

Journal of Experimental Botany, 65(22), 6645–6653.

By: E. Slabaugh n, L. Sethaphong n, C. Xiao *, J. Amick n, C. Anderson *, C. Haigler n , Y. Yingling n 

Contributors: E. Slabaugh n, L. Sethaphong n, C. Xiao *, J. Amick n, C. Anderson *, C. Haigler n , Y. Yingling n 

author keywords: Cellulose biosynthesis; CESA; genetic complementation; protein structural modelling; rsw1 mutant; transmembrane helix
MeSH headings : Amino Acid Sequence; Arabidopsis / enzymology; Arabidopsis / genetics; Arabidopsis Proteins / chemistry; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Biocatalysis; Computational Biology; Glucosyltransferases / chemistry; Glucosyltransferases / genetics; Glucosyltransferases / metabolism; Molecular Sequence Data; Mutant Proteins / metabolism; Mutation; Phenotype; Protein Structure, Secondary; Recombinant Fusion Proteins / metabolism; Sequence Alignment; Structure-Activity Relationship
TL;DR: Computational modelling of peptide structure, genetic complementation in Arabidopsis thaliana, and confocal microscopy provide evidence that a region between two transmembrane helices may adopt two predominant structural conformations that affect the function of plant cellulose synthase. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

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