Works (4)
Updated: July 5th, 2023 15:52
2022 journal article
Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy
NATIONAL SCIENCE REVIEW, 9(3).
author keywords: drug delivery; CAR T therapy; microneedle patch; solid tumor treatment; cell delivery
TL;DR:
A porous microneedle patch is implemented that accommodates CAR T cells and allows in situ penetration-mediated seeding ofCAR T cells when implanted in the tumor bed or in the post-surgical resection cavity.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: March 28, 2022
2021 article
Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets
Hu, Q., Li, H., Archibong, E., Chen, Q., Ruan, H., Ahn, S., … Gu, Z. (2021, April 26). NATURE BIOMEDICAL ENGINEERING.
MeSH headings : Animals; Antibodies, Monoclonal, Humanized; Blood Platelets; Cell-Derived Microparticles; Hydrogels; Immunotherapy, Adoptive; Mice; Neoplasm Recurrence, Local / prevention & control; T-Lymphocytes; Tumor Microenvironment
TL;DR:
A hydrogel implanted into the cavity of a resected tumour and releasing CAR-T cells and platelets conjugated with a checkpoint inhibitor inhibits local tumour recurrence and the growth of distant tumours in mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 10, 2021
2017 journal article
Synthetic beta cells for fusion-mediated dynamic insulin secretion
Nature Chemical Biology, 14(1), 86–93.
MeSH headings : Animals; Artificial Cells; Biomimetic Materials / chemistry; Blood Glucose / analysis; Cell Engineering / methods; Diabetes Mellitus, Experimental / blood; Diabetes Mellitus, Experimental / drug therapy; Diabetes Mellitus, Type 1 / blood; Diabetes Mellitus, Type 1 / drug therapy; Hydrogen-Ion Concentration; Insulin / blood; Insulin / metabolism; Insulin Secretion; Insulin-Secreting Cells / metabolism; Male; Membrane Fusion; Mice, Inbred C57BL
TL;DR:
The construction of artificial beta cells with a multicompartmental 'vesicles-in-vesicle' superstructure equipped with a glucose-metabolism system and membrane-fusion machinery is described, which can effectively distinguish between high and normal glucose levels.
(via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018
1989 journal article
DEVELOPMENT OF PORCINE EMBRYOS FROM ONE-CELL AND 2-CELL STAGES TO BLASTOCYSTS IN CULTURE-MEDIUM SUPPLEMENTED WITH PORCINE OVIDUCTAL FLUID
BIOLOGY OF REPRODUCTION, 41(6), 1076–1083.
MeSH headings : Animals; Blastocyst / physiology; Body Fluids / physiology; Culture Media; Culture Techniques; Embryo, Mammalian / physiology; Fallopian Tubes / physiology; Female; Luteal Phase / physiology; Swine / embryology
TL;DR:
Investigation of in vitro development of 1-cell and 2-cell porcine embryos in a modified Kreb's Ringer bicarbonate medium found development to blastocyst stage was lowest among embryos cultured in OVF and highest among those cultured in CM-OVF.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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