Erika Pambianchi

Works (21)

Updated: April 25th, 2025 18:00

2024 article

Vitamin C compounds mixture prevents skin barrier alterations and inflammatory responses upon real life multi pollutant exposure

Ferrara, F., Pecorelli, A., Pambianchi, E., White, S., Choudhary, H., Casoni, A., & Valacchi, G. (2024, January 1). Experimental Dermatology, Vol. 33.

By: F. Ferrara*, A. Pecorelli* , E. Pambianchi*, S. White*, H. Choudhary*, A. Casoni*, G. Valacchi* 

author keywords: 4HNE; COX2; inflammation; pollution; skin barrier
MeSH headings : Humans; Ascorbic Acid / pharmacology; Ultraviolet Rays / adverse effects; Environmental Pollutants; Vitamins; Antioxidants / pharmacology; Particulate Matter / toxicity; Air Pollutants
topics (OpenAlex): Skin Protection and Aging; Air Quality and Health Impacts; Climate Change and Health Impacts
TL;DR: This study is among the first to investigate the combined effects of three of the most harmful outdoor stressors on human skin and confirms that daily topical of an antioxidant application may prevent pollution-induced skin damage. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 29, 2024

2023 article

Evaluation of Anti-Oxinflammatory and ACE-Inhibitory Properties of Protein Hydrolysates Obtained from Edible Non-Mulberry Silkworm Pupae (Antheraea assama and Philosomia ricinii)

Sarkar, P., Pecorelli, A., Woodby, B., Pambianchi, E., Ferrara, F., Duary, R. K., & Valacchi, G. (2023, February 19). Nutrients, Vol. 15.

By: P. Sarkar *, A. Pecorelli* , B. Woodby*, E. Pambianchi*, F. Ferrara*, R. Duary *, G. Valacchi* 

author keywords: non-mulberry silkworm pupae; angiotensin converting enzyme-inhibitory peptides; antioxidative peptides; ultrafiltration; anti-inflammatory peptides
MeSH headings : Animals; Angiotensin-Converting Enzyme Inhibitors / pharmacology; Antioxidants / pharmacology; Protein Hydrolysates / pharmacology; Bombyx; Pupa; Endothelial Cells; Lipopolysaccharides; Peptides / pharmacology; Hypertension; Hydrolysis
topics (OpenAlex): Insect Utilization and Effects; Protein Hydrolysis and Bioactive Peptides; Neurobiology and Insect Physiology Research
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 20, 2023

2023 article

Tension as a key factor in skin responses to pollution

Pambianchi, E., Hagenberg, Z., Pecorelli, A., Pasqui, A., Therrien, J.-P., & Valacchi, G. (2023, September 25). Scientific Reports, Vol. 13.

By: E. Pambianchi n, Z. Hagenberg n, A. Pecorelli n , A. Pasqui*, J. Therrien n & G. Valacchi n 

MeSH headings : Animals; Humans; Skin; Epidermis; Integumentary System; Aggression; Antimicrobial Peptides
topics (OpenAlex): Skin Protection and Aging; Thermoregulation and physiological responses; Circadian rhythm and melatonin
TL;DR: The present work demonstrates that cutaneous exposure to ozone induces AMPs gene and protein levels and that the presence of tension can further modulate their expression, confirming the ability of pollution to induce the cutaneous expression of AMPs via redox signaling and corroborates the principle that skin explants are a good and reliable model to study skin responses. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 22, 2024

2023 article

Topical Application of M89PF Containing Vichy Mineralising Water and Probiotic Fractions Prevents Cutaneous Damage Induced by Exposure to UV and O3

Benedusi, M., Kerob, D., Guiotto, A., Cervellati, F., Ferrara, F., & Pambianchi, E. (2023, July 1). Clinical Cosmetic and Investigational Dermatology.

By: M. Benedusi *, D. Kerob *, A. Guiotto*, F. Cervellati *, F. Ferrara* & E. Pambianchi n

author keywords: ultraviolet radiation; ozone; skin barrier; oxidative stress; inflammation
topics (OpenAlex): Skin Protection and Aging; Dermatology and Skin Diseases; Psoriasis: Treatment and Pathogenesis
TL;DR: M89PF prevents skin barrier damage, as well as oxidative stress and inflammatory markers induced by exposome factors, such as UV, O3, or both combined. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: July 24, 2023

2022 article

MicroRNA Alterations Induced in Human Skin by Diesel Fumes, Ozone, and UV Radiation

Valacchi, G., Pambianchi, E., Coco, S., Pulliero, A., & Izzotti, A. (2022, January 28). Journal of Personalized Medicine, Vol. 2, p. 176.

By: G. Valacchi n , E. Pambianchi n, S. Coco *, A. Pulliero * & A. Izzotti *

author keywords: microRNAs; environmental risk factors; cutaneous tissues; ozone exposure
topics (OpenAlex): MicroRNA in disease regulation; Circular RNAs in diseases; Epigenetics and DNA Methylation
TL;DR: Investigation in human skin biopsies exposed to diesel fumes, ozone, and UV light for over 24 h of exposure found UV and ozone-induced microRNA alteration right after exposure, while the peak of their deregulations induced by diesel fumes was reached only at the end of the 24 h. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 4, 2022

2022 article

Ubiquitination as a key regulatory mechanism for O3-induced cutaneous redox Inflammasome activation

Ferrara, F., Cordone, V., Pecorelli, A., Benedusi, M., Pambianchi, E., Guiotto, A., … Valacchi, G. (2022, November 1). Free Radical Biology and Medicine, Vol. 192, p. 28.

By: F. Ferrara*, V. Cordone *, A. Pecorelli n , M. Benedusi *, E. Pambianchi n, A. Guiotto *, A. Vallese* , F. Cervellati*, G. Valacchi n 

topics (OpenAlex): Redox biology and oxidative stress; Heme Oxygenase-1 and Carbon Monoxide; S100 Proteins and Annexins
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 6, 2023

2022 article

Ubiquitination as a key regulatory mechanism for O3-induced cutaneous redox inflammasome activation

Ferrara, F., Cordone, V., Pecorelli, A., Benedusi, M., Pambianchi, E., Guiotto, A., … Valacchi, G. (2022, August 21). Redox Biology, Vol. 56, p. [""].

By: F. Ferrara*, V. Cordone *, A. Pecorelli* , M. Benedusi *, E. Pambianchi*, A. Guiotto *, A. Vallese* , F. Cervellati *, G. Valacchi* 

Contributors: F. Ferrara*, V. Cordone *, A. Pecorelli* , M. Benedusi *, E. Pambianchi*, A. Guiotto *, A. Vallese* , F. Cervellati *, G. Valacchi* 

author keywords: Inflammasomes; OxInflammation; Proteasome; UBR2; N-end rule pathway
MeSH headings : Adaptor Proteins, Signal Transducing / metabolism; Air Pollutants; Apoptosis Regulatory Proteins / genetics; Catalase / metabolism; Cytokines / metabolism; Environmental Pollutants; Humans; Hydrogen Peroxide / metabolism; Inflammasomes / metabolism; NLR Proteins / metabolism; Oxidation-Reduction; Ozone / metabolism; Particulate Matter; Reactive Oxygen Species / metabolism; Ubiquitin-Protein Ligases / metabolism; Ubiquitination
topics (OpenAlex): Heme Oxygenase-1 and Carbon Monoxide; Inflammasome and immune disorders; Medical and Biological Ozone Research
TL;DR: It is reported for the first time that O3, one of the most toxic pollutants, activates the NLRP1 inflammasome in human keratinocytes via oxidative stress mediators as hydrogen peroxide (H2O2) and 4-hydroxy-nonenal (4HNE). (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 12, 2022

2021 article

Alaskan Bog Blueberry (Vaccinium uliginosum) Extract as an Innovative Topical Approach to Prevent UV-Induced Skin Damage

Pambianchi, E., Hagenberg, Z., Pecorelli, A., Grace, M., Therrien, J.-P., Lila, M. A., & Valacchi, G. (2021, November 27). Cosmetics, Vol. 12.

By: E. Pambianchi n, Z. Hagenberg n, A. Pecorelli n , M. Grace n , J. Therrien n, M. Lila n , G. Valacchi n 

author keywords: cosmeceuticals; environmental stressor; oxidation; inflammation; antioxidant; OxInflammation; phytochemicals
topics (OpenAlex): Skin Protection and Aging; Dermatology and Skin Diseases; Phytochemicals and Antioxidant Activities
TL;DR: It is observed that the topical application of BB extract on human ex vivo skin explants averted the UV-induced cutaneous OxInflammatory phenomenon by quenching the increase in the oxidative and inflammatory marker levels. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 2, 2021

2021 article

Alterations in oxygen metabolism are associated to lung toxicity triggered by silver nanoparticles exposure

Garcés, M., Magnani, N. D., Pecorelli, A., Calabró, V., Marchini, T., Cáceres, L., … Evelson, P. (2021, February 16). Free Radical Biology and Medicine, Vol. 166, pp. 324–336.

By: M. Garcés *, N. Magnani *, A. Pecorelli* , V. Calabró *, T. Marchini *, L. Cáceres *, E. Pambianchi*, J. Galdoporpora* ...

author keywords: Nanoparticles; Lung epithelium; Nanotoxicology; Oxidative metabolism; NADPH oxidase; Mitochondria
MeSH headings : Animals; Hydrogen Peroxide; Lung; Metal Nanoparticles / toxicity; Mice; Oxygen; Silver
topics (OpenAlex): Nanoparticles: synthesis and applications; Acute Kidney Injury Research; Traumatic Brain Injury and Neurovascular Disturbances
TL;DR: Results show that AgNP exposure alters O2 metabolism leading to a redox imbalance, which may be responsible for the impaired lung function observed due to alveolar epithelial injury. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 19, 2021

2021 article

Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure

Pambianchi, E., Ferrara, F., Pecorelli, A., Benedusi, M., Choudhary, H., Therrien, J.-P., & Valacchi, G. (2021, November 30). Antioxidants, Vol. 12.

By: E. Pambianchi n, F. Ferrara*, A. Pecorelli n , M. Benedusi *, H. Choudhary*, J. Therrien*, G. Valacchi n 

author keywords: cosmeceuticals; pollution; iron-chelator
topics (OpenAlex): Skin Protection and Aging; Air Quality and Health Impacts; Contact Dermatitis and Allergies
TL;DR: It is suggested that iron plays a key role in DEE-induced skin damage and its chelation could be an adjuvant strategy to reinforce antioxidant topical formulations. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 24, 2022

2021 article

Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage

Hoskin, R., Pambianchi, E., Pecorelli, A., Grace, M., Therrien, J.-P., Valacchi, G., & Lila, M. A. (2021, June 22). Molecules, Vol. 7, p. 3781.

By: R. Hoskin n , E. Pambianchi n, A. Pecorelli n , M. Grace n , J. Therrien*, G. Valacchi n , M. Lila n 

author keywords: cosmeceuticals; pollution; phytochemicals; herbs
MeSH headings : Antioxidants / chemistry; Antioxidants / pharmacology; Cells, Cultured; Chlorella / chemistry; Cinnamates / chemistry; Depsides / chemistry; Environmental Exposure / adverse effects; Filaggrin Proteins; Humans; Rosmarinus / chemistry; Skin / injuries; Skin / metabolism; Skin / pathology; Skin Aging / drug effects
topics (OpenAlex): Skin Protection and Aging; Bee Products Chemical Analysis; Phytochemicals and Antioxidant Activities
TL;DR: The ex-vivo data clearly demonstrated the ability of RSP gel to prevent an oxinflammatory phenomenon in cutaneous tissue by decreasing the levels of 4-hydroxynonenal protein adducts and active matrix metalloproteinase-9 (MMP-9) by limiting the loss of filaggrin induced by DEE exposure. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 23, 2021

2021 article

The nitrate-nitrite-nitric oxide pathway improves neurovascular coupling under cerebral hypoperfusion conditions

Ferrara, F., Pecorelli, A., Benedusi, M., Pambianchi, E., Guiotto, A., Cervellati, F., & Valacchi, G. (2021, March 1). Free Radical Biology and Medicine, Vol. 165.

By: F. Ferrara, A. Pecorelli , M. Benedusi, E. Pambianchi, A. Guiotto, F. Cervellati, G. Valacchi 

topics (OpenAlex): Traumatic Brain Injury and Neurovascular Disturbances; Neurological Disease Mechanisms and Treatments; Optical Imaging and Spectroscopy Techniques
Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021

2020 article

Mechanisms involved in the unbalanced redox homeostasis in osteoblastic cellular model of Alkaptonuria

Schiavone, M. L., Pecorelli, A., Woodby, B., Ferrara, F., Pambianchi, E., Santucci, A., & Valacchi, G. (2020, June 2). Archives of Biochemistry and Biophysics, Vol. 690.

By: M. Schiavone *, A. Pecorelli* , B. Woodby*, F. Ferrara*, E. Pambianchi*, A. Santucci *, G. Valacchi* 

author keywords: Alkaptonuria; Osteoblast; Oxidative stress; Nrf2; Mitochondria; NADPH oxidase
MeSH headings : Alkaptonuria / metabolism; Cell Line; DNA-Binding Proteins / metabolism; Homeostasis / physiology; Homogentisic Acid / metabolism; Humans; Hydrogen Peroxide / metabolism; Mitochondria / metabolism; Mitochondria / ultrastructure; NADPH Oxidases / metabolism; NF-E2-Related Factor 2 / metabolism; Osteoblasts / cytology; Oxidation-Reduction; Oxidative Stress / physiology; Signal Transduction; Superoxide Dismutase / metabolism; Thioredoxins / metabolism
topics (OpenAlex): Metabolism and Genetic Disorders; Biochemical Acid Research Studies; Alcoholism and Thiamine Deficiency
TL;DR: HGA is able to alter the cellular redox homeostasis by modulating the endogenous ROS production via NOX activation and mitochondrial dysfunctions and impair the cellular response mechanism, which can be useful for understanding the pathophysiology of AKU. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 19, 2021

2020 article

The PDE4 inhibitor CHF6001 affects keratinocyte proliferation via cellular redox pathways

Woodby, B., Sticozzi, C., Pambianchi, E., Villetti, G., Civelli, M., Valacchi, G., & Facchinetti, F. (2020, April 5). Archives of Biochemistry and Biophysics, Vol. 685.

By: B. Woodby n, C. Sticozzi*, E. Pambianchi n, G. Villetti, M. Civelli, G. Valacchi n , F. Facchinetti

author keywords: NOX; NF-kappa B; Cyclin D1; Skin; p21
MeSH headings : Aldehydes / metabolism; Cell Line; Cell Proliferation / drug effects; Cell Survival / drug effects; Cyclin D1 / metabolism; Humans; Keratinocytes / drug effects; Lipid Peroxidation / drug effects; NADPH Oxidases / metabolism; Oxidative Stress / drug effects; Phosphodiesterase 4 Inhibitors / pharmacology; Phosphodiesterase 4 Inhibitors / toxicity; Psoriasis / drug therapy; Sulfonamides / pharmacology; Sulfonamides / toxicity; Transcription Factor RelA / metabolism; para-Aminobenzoates / pharmacology; para-Aminobenzoates / toxicity
topics (OpenAlex): Asthma and respiratory diseases; Mast cells and histamine; Psoriasis: Treatment and Pathogenesis
TL;DR: CHF6001 has the potential to treat skin disorders associated with hyperproliferative keratinocytes, such as psoriasis by targeting oxidative stress, abnormal re-epithelization, and inflammation. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 8, 2020

2019 article

Blueberries Topical Application Prevents Ozone Induced Cutaneous Inflammasome Activation

Pambianchi, E., Francesca, F., Pecorelli, A., Woodby, B., Lila, M., & Valacchi, G. (2019, November 15). Free Radical Biology and Medicine, Vol. 145, pp. S148–S148.

By: E. Pambianchi, F. Francesca, A. Pecorelli , B. Woodby, M. Lila  & G. Valacchi 

topics (OpenAlex): Medical and Biological Ozone Research; Skin Protection and Aging
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 article

Redox Regulation of Antimicrobial Peptides

Woodby, B., Pambianchi, E., Francesca, F., Messano, N., Pecorelli, A., Therrien, J. P., & Valacchii, G. (2019, November 15). Free Radical Biology and Medicine, Vol. 145, pp. S54–S55.

By: B. Woodby, E. Pambianchi, F. Francesca, N. Messano, A. Pecorelli , J. Therrien, G. Valacchii 

topics (OpenAlex): Simulation-Based Education in Healthcare; Innovations in Medical Education; Education and Critical Thinking Development
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4. Quality Education (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 article

Redox Regulation of Cutaneous Inflammasome Pathway by Ozone Exposure

Ferrara, F., Pecorelli, A., Woodby, B., Pambianchi, E., Messano, N., Therrien, J. P., & Valacchi, G. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S22–S23.

By: F. Ferrara, A. Pecorelli , B. Woodby, E. Pambianchi, N. Messano, J. Therrien, G. Valacchi 

topics (OpenAlex): Medical and Biological Ozone Research; Vitamin D Research Studies
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 article

Redox regulation of cutaneous inflammasome by ozone exposure

Ferrara, F., Pambianchi, E., Pecorelli, A., Woodby, B., Messano, N., Therrien, J.-P., … Valacchi, G. (2019, November 25). Free Radical Biology and Medicine, Vol. 152, pp. 561–570.

By: F. Ferrara*, E. Pambianchi*, A. Pecorelli* , B. Woodby*, N. Messano *, J. Therrien, M. Lila* , G. Valacchi* 

MeSH headings : Caspase 1 / metabolism; Humans; Hydrogen Peroxide; Inflammasomes / metabolism; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; NLR Family, Pyrin Domain-Containing 3 Protein / genetics; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Oxidation-Reduction; Ozone / toxicity; Reactive Oxygen Species
topics (OpenAlex): Inflammasome and immune disorders; Heme Oxygenase-1 and Carbon Monoxide; Medical and Biological Ozone Research
TL;DR: It is demonstrated that O3 can activate cutaneous inflammasome in a redox dependent manner suggesting a possible role of this new pathway in pollution induced inflammatory skin conditions. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 13, 2020

2018 article

LB1553 AtmO3spheric skin damage: The oxInflammation phenomena

Valacchi, G., Pecorelli, A., Pambianchi, E., Ferrara, F., & Lila, M. (2018, August 22). Journal of Investigative Dermatology, Vol. 138, pp. B15–15.

By: G. Valacchi n , A. Pecorelli* , E. Pambianchi*, F. Ferrara n & M. Lila* 

topics (OpenAlex): Medical and Biological Ozone Research; Skin Protection and Aging
Sources: Web Of Science, NC State University Libraries
Added: October 19, 2018

2017 article

First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents

Brogi, S., Ramunno, A., Savi, L., Chemi, G., Alfano, G., Pecorelli, A., … Brindisi, M. (2017, June 10). European Journal of Medicinal Chemistry, Vol. 138, pp. 438–457.

By: S. Brogi *, A. Ramunno *, L. Savi*, G. Chemi *, G. Alfano*, A. Pecorelli n , E. Pambianchi n, P. Galatello* ...

author keywords: Antioxidant agents; Glycogen synthase kinase 3 beta (GSK-3 beta); Adenosine kinase (AK); Dual inhibitors; Molecular docking
MeSH headings : Adenosine Kinase / antagonists & inhibitors; Adenosine Kinase / metabolism; Antioxidants / chemical synthesis; Antioxidants / chemistry; Antioxidants / pharmacology; Cell Line, Tumor; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3 beta / antagonists & inhibitors; Glycogen Synthase Kinase 3 beta / metabolism; Humans; Hydrogen Peroxide / antagonists & inhibitors; Hydrogen Peroxide / pharmacology; Molecular Structure; Neuroblastoma / metabolism; Neuroblastoma / pathology; Neuroprotective Agents / chemical synthesis; Neuroprotective Agents / chemistry; Neuroprotective Agents / pharmacology; Oxidative Stress / drug effects; Protein Kinase Inhibitors / chemical synthesis; Protein Kinase Inhibitors / chemistry; Protein Kinase Inhibitors / pharmacology; Reactive Oxygen Species / metabolism; Structure-Activity Relationship
topics (OpenAlex): Bioactive Compounds and Antitumor Agents; Click Chemistry and Applications; Enzyme function and inhibition
TL;DR: The identification of compound 5l, as the first dual hAK/hGSK-3β inhibitor reported to date, holds promise for the development of new series of potential therapeutic agents for the treatment of neurodegenerative diseases characterized by an innovative pharmacological profile. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 article

Potassium Ascorbate with Ribose: Promising Therapeutic Approach for Melanoma Treatment

Cavicchio, C., Benedusi, M., Pambianchi, E., Pecorelli, A., Cervellati, F., Savelli, V., … Valacchi, G. (2017, January 1). Oxidative Medicine and Cellular Longevity.

By: C. Cavicchio*, M. Benedusi *, E. Pambianchi n, A. Pecorelli n , F. Cervellati *, V. Savelli *, D. Calamandrei*, E. Maellaro * ...

MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Ascorbic Acid / chemistry; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; Connexin 43 / genetics; Connexin 43 / metabolism; Humans; Melanoma / drug therapy; Melanoma / pathology; Microscopy, Electron, Scanning; Potassium / chemistry; Ribose / chemistry; Spheroids, Cellular / drug effects; Spheroids, Cellular / ultrastructure
topics (OpenAlex): Vitamin C and Antioxidants Research; Nanoparticles: synthesis and applications; bioluminescence and chemiluminescence research
TL;DR: The results suggest that PAR could be used as a safe adjuvant approach in support to conventional therapies for the treatment of melanoma. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

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