Elias Patrick Rosen

Works (5)

Updated: July 5th, 2023 21:17

2018 journal article

Evaluation of Digital Image Recognition Methods for Mass Spectrometry Imaging Data Analysis

Journal of The American Society for Mass Spectrometry, 29(12), 2467–2470.

By: M. Ekelöf n, K. Garrard n, R. Judd n, E. Rosen*, D. Xie n , A. Kashuba *, D. Muddiman n 

author keywords: Mass spectrometry imaging; Image recognition; SSIM
MeSH headings : Algorithms; Animals; Image Processing, Computer-Assisted / methods; Lymph Nodes / chemistry; Lymph Nodes / metabolism; Macaca mulatta; Maraviroc / pharmacokinetics; Mass Spectrometry / methods; Models, Theoretical; Molecular Imaging / methods; Plant Leaves / chemistry; Tissue Distribution
TL;DR: A method for comprehensive, semi-targeted discovery of molecular distributions of interest from mass spectrometry imaging data, using widely available image similarity scoring algorithms to rank images by spatial correlation is presented. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: December 10, 2018

2015 journal article

Influence of C-Trap Ion Accumulation Time on the Detectability of Analytes in IR-MALDESI MSI

ANALYTICAL CHEMISTRY, 87(20), 10483–10490.

By: E. Rosen n, M. Bokhart n, M. Nazari n & D. Muddiman n 

MeSH headings : Ions / chemistry; Lasers; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Infrared; Time Factors; Xenobiotics / analysis
TL;DR: Reducing the C-trap ion accumulation time resulted in increased ion abundance by up to 3 orders of magnitude for analytes ranging from xenobiotics to endogenous lipids, and facilitated the reduction of voxel-to-voxel variability by more than 3-fold. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Influence of Desorption Conditions on Analyte Sensitivity and Internal Energy in Discrete Tissue or Whole Body Imaging by IR-MALDESI

Journal of The American Society for Mass Spectrometry, 26(6), 899–910.

By: E. Rosen n, M. Bokhart n, H. Ghashghaei  n & D. Muddiman n 

author keywords: IR-MALDESI; Mass spectrometry imaging; Laser desorption whole body imaging; Lipids; Xenobiotics
MeSH headings : Anesthetics, Local / analysis; Anesthetics, Local / pharmacokinetics; Animals; Cocaine / analysis; Cocaine / pharmacokinetics; Infrared Rays; Lipid Metabolism; Lipids / analysis; Mice; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Whole Body Imaging / methods
TL;DR: Optimized desorption conditions have been used to conduct an untargeted lipidomic analysis of whole body sagittal sections of neonate mouse, with enhanced lipid coverage received by varying the laser wavelength used for mass spectrometry imaging (MSI). (via Semantic Scholar)
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7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2015 journal article

Mass Spectrometry Imaging Reveals Heterogeneous Efavirenz Distribution within Putative HIV Reservoirs

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 59(5), 2944–2948.

By: C. Thompson *, M. Bokhart n, C. Sykes*, L. Adamson *, Y. Fedoriw *, P. Luciw*, D. Muddiman n , A. Kashuba *, E. Rosen n

MeSH headings : Alkynes; Animals; Anti-Retroviral Agents / pharmacokinetics; Benzoxazines / pharmacokinetics; Cyclopropanes; Gray Matter / metabolism; Lymph Nodes / metabolism; Macaca; Mass Spectrometry / methods
TL;DR: Intratissue efavirenz distribution was heterogeneous, with the drug concentrating in the lamina propria of the colon, the primary follicles of lymph nodes, and the brain gray matter, the first imaging data of an antiretroviral drug in active viral reservoirs. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Quantitative mass spectrometry imaging of emtricitabine in cervical tissue model using infrared matrix-assisted laser desorption electrospray ionization

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 407(8), 2073–2084.

By: M. Bokhart n, E. Rosen n, C. Thompson *, C. Sykes*, A. Kashuba * & D. Muddiman n 

author keywords: Mass spectrometry imaging; IR-MALDESI; Absolute quantification; Drug distribution; HIV; Selected reaction monitoring
MeSH headings : Diagnostic Imaging / instrumentation; Diagnostic Imaging / methods; Female; Humans; Papillomavirus Vaccines / chemistry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Uterine Cervical Neoplasms / chemistry; Uterine Cervical Neoplasms / diagnosis
TL;DR: A quantitative mass spectrometry imaging technique using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) is demonstrated for the antiretroviral (ARV) drug emtricitabine in incubated human cervical tissue, leading to a gain in sensitivity and removal of interferences for several ARV drugs. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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