Fadia Jamal Milhem

Works (4)

Updated: April 24th, 2025 09:24

2024 article

Biomarkers of Metabolic Adaptation to High Dietary Fats in a Mouse Model of Obesity Resistance

Milhem, F., Hamilton, L. M., Skates, E., Wilson, M., Johanningsmeier, S. D., & Komarnytsky, S. (2024, January 20). Metabolites, Vol. 14.

By: F. Milhem n, L. Hamilton  n, E. Skates n, M. Wilson n, S. Johanningsmeier n & S. Komarnytsky n 

author keywords: body composition; metabolic inflexibility; metabolic rate; dietary fats; skeletal muscle remodeling; glucose tolerance; microbiome
topics (OpenAlex): Adipose Tissue and Metabolism; Diet and metabolism studies; Adipokines, Inflammation, and Metabolic Diseases
TL;DR: It is shown that NR mice developed healthier fat/lean body mass ratios compared with the obesity-prone (super-responder, SR) phenotypes by upregulating gene expression networks that promote the accumulation of type 2a, fast-twitch, oxidative muscle tissues. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 26, 2024

2024 article

Obesity-Resistant Mice on a High-Fat Diet Display a Distinct Phenotype Linked to Enhanced Lipid Metabolism

Milhem, F., Skates, E., Wilson, M., & Komarnytsky, S. (2024, January 4). Nutrients, Vol. 16.

By: F. Milhem n, E. Skates*, M. Wilson* & S. Komarnytsky n 

author keywords: dietary fats; energy substrate; body composition; metabolic rate; individual variability; personalized nutrition
MeSH headings : Animals; Mice; Diet, High-Fat / adverse effects; Lipid Metabolism; Mice, Inbred C57BL; Mice, Obese; Obesity / etiology; Phenotype
topics (OpenAlex): Diet and metabolism studies; Adipose Tissue and Metabolism; Dietary Effects on Health
TL;DR: NR mice showed an increased ability to metabolize excessive dietary fats in skeletal muscle at the expense of reduced exercise capacity that persisted for the duration of the study, underscore the need for further comprehensive investigations into the mechanisms of obesity resistance. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 22, 2024

2024 article

The biochemical effects of carotenoids in orange carrots on the colonic proteome in a mouse model of diet-induced obesity

Balbuena, E., Milhem, F., Kiremitci, B. Z., Williams, T. I., Collins, L., Shu, Q., & Eroglu, A. (2024, November 11). Frontiers in Nutrition, Vol. 11.

By: E. Balbuena n, F. Milhem n, B. Kiremitci n, T. Williams n , L. Collins n , Q. Shu n , A. Eroglu n 

Contributors: E. Balbuena n, F. Milhem n, B. Kiremitci n, T. Williams n , L. Collins n , Q. Shu n , A. Eroglu n 

author keywords: carotenoids; quantitative proteomics; colon; intestinal barrier; diet-induced obesity
topics (OpenAlex): Antioxidant Activity and Oxidative Stress; Cholesterol and Lipid Metabolism; Adipokines, Inflammation, and Metabolic Diseases
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 2, 2024

2023 article

Progression to Obesity: Variations in Patterns of Metabolic Fluxes, Fat Accumulation, and Gastrointestinal Responses

Milhem, F., & Komarnytsky, S. (2023, September 15). Metabolites, Vol. 13.

By: F. Milhem n & S. Komarnytsky n 

author keywords: dietary obesity; weight gain; high-fat diet; lipid oxidation; metabolic inflexibility; metabolic rate; obesity-prone; obesity-resistant
topics (OpenAlex): Diet and metabolism studies; Adipose Tissue and Metabolism; Adipokines, Inflammation, and Metabolic Diseases
TL;DR: Pattern of fat accumulation with a focus on visceral and ectopic adipose tissue, microbiome composition, and the immune status of the gastrointestinal tract have emerged as the most promising targets that allow personalization of obesity and warrant further investigations into the critical issue of a wider and long-term weight control. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 27, 2023

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