Flora Meilleur

Joint X-ray/neutron structure of Lentinus similis AA9_A at room temperature

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 79, 1–7.

Capture of activated dioxygen intermediates at the copper-active site of a lytic polysaccharide monooxygenase

Schroder, G. C., William B. O'Dell, Webb, S. P., Agarwal, P. K., & Meilleur, F. (2022, November 2). CHEMICAL SCIENCE, Vol. 11.

Changes in active-site geometry on X-ray photo-reduction of a lytic polysaccharide monooxygenase active-site copper and saccharide binding

IUCRJ, 9(5), 666–681.

Complementarity of neutron, XFEL and synchrotron crystallography for defining the structures of metalloenzymes at room temperature

IUCRJ, 9, 610–624.

Mapping H+ in the Nanoscale (A(2)C(4))(2)-Ag-8 Fluorophore

David, F., Setzler, C., Sorescu, A., Lieberman, R. L., Meilleur, F., & Petty, J. T. (2022, December 1). JOURNAL OF PHYSICAL CHEMISTRY LETTERS, Vol. 12.

Teaching and Education highlighted

Dawe, L. N., Manuel Garcia-Ruiz, J., Hadju, J., McIntyre, G. J., Meilleur, F., & Stephenson, L. (2022, April). JOURNAL OF APPLIED CRYSTALLOGRAPHY, Vol. 55, pp. 215–217.

The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition

Sacco, M. D., Hu, Y., Gongora, M. V., Meilleur, F., Kemp, M. T., Zhang, X., … Chen, Y. (2022, March 15). CELL RESEARCH, Vol. 3.

The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature

SCIENCE ADVANCES, 8(21).

Capture of activated dioxygen intermediates at the copper-active site of a lytic polysaccharide monooxygenase

Schröder, G. C., O'Dell, W. B., Webb, S. P., Agarwal, P. K., & Meilleur, F. (2021, December 13).

Metalloprotein catalysis: structural and mechanistic insights into oxidoreductases from neutron protein crystallography

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 77(10), 1251–1269.

Preliminary results of neutron and X-ray diffraction data collection on a lytic polysaccharide monooxygenase under reduced and acidic conditions

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 77(4), 128–133.

A beginner’s guide to neutron macromolecular crystallography

The Biochemist, 42(6), 16–20.

Dynamic nuclear polarization enhanced neutron crystallography: Amplifying hydrogen in biological crystals

NEUTRON CRYSTALLOGRAPHY IN STRUCTURAL BIOLOGY, Vol. 634, pp. 153–175.

IMAGINE: The neutron protein crystallography beamline at the high flux isotope reactor

NEUTRON CRYSTALLOGRAPHY IN STRUCTURAL BIOLOGY, Vol. 634, pp. 69–85.

Neutron Crystallography Data Collection and Processing for Modelling Hydrogen Atoms in Protein Structures

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 12(166).

A prototype system for dynamically polarized neutron protein crystallography

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 940, 430–434.

Neutron and X-ray analysis of the Fenna-Matthews-Olson photosynthetic antenna complex from Prosthecochloris aestuarii

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 75(3), 171–175.

Titration of ionizable groups in proteins using multiple neutron data sets from a single crystal: application to the small GTPase Ras

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 75(2), 111–115.

A suite-level review of the neutron single-crystal diffraction instruments at Oak Ridge National Laboratory

[Review of ]. REVIEW OF SCIENTIFIC INSTRUMENTS, 89(9).

Modulating Enzyme Activity by Altering Protein Dynamics with Solvent

Biochemistry, 57(29), 4263–4275.

Neutron scattering in the biological sciences: progress and prospects

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 74, 1129–1168.

Next-generation diamond cell and applications to single-crystal neutron diffraction

REVIEW OF SCIENTIFIC INSTRUMENTS, 89(9).

Structural investigation of cellobiose dehydrogenase IIA: Insights from small angle scattering into intra- and intermolecular electron transfer mechanisms

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1862(4), 1031–1039.

The Neutron Macromolecular Crystallography Instruments at Oak Ridge National Laboratory: Advances, Challenges, and Opportunities

[Review of ]. CRYSTALS, 8(10).

An extended N-H bond, driven by a conserved second-order interaction, orients the flavin N5 orbital in cholesterol oxidase

Scientific Reports, 7(1), 40517,

Crystallization of a fungal lytic polysaccharide monooxygenase expressed from glycoengineered Pichia pastoris for X-ray and neutron diffraction

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 73(2), 70–78.

Innentitelbild: Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase (Angew. Chem. 3/2017)

Angewandte Chemie.

Neutron crystallographic studies of T4 lysozyme at cryogenic temperature

PROTEIN SCIENCE, 26(10), 2098–2104.

Neutron structure of the T26H mutant of T4 phage lysozyme provides insight into the catalytic activity of the mutant enzyme and how it differs from that of wild type

PROTEIN SCIENCE, 26(10), 1953–1963.

Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56(3), 767–770.

Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase

Angewandte Chemie, 129(3), 785–788.

Structural studies of Neurospora crassa LPMO9D and redox partner CDHIIA using neutron crystallography and small-angle scattering

CARBOHYDRATE RESEARCH, 448, 200–204.

Crystal structures of wild-type Trichoderma reesei Cel7A catalytic domain in open and closed states

FEBS LETTERS, 590(23), 4429–4438.

Detection of Mycoplasma haemocanis, Mycoplasma haematoparvum, Mycoplasma suis and other vector-borne pathogens in dogs from Córdoba and Santa Fé, Argentina

Parasites & Vectors, 9(1).

Inside Cover: Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase (Angew. Chem. Int. Ed. 3/2017)

Angewandte Chemie International Edition, 56(3), 658–658.

Neutron protein crystallography: A complementary tool for locating hydrogens in proteins

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 602, 48–60.

Crystal structure and thermal expansion of a CsCe2Cl7 scintillator

Journal of Solid State Chemistry, 227, 142–149.

Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP gamma-Phosphate

JOURNAL OF BIOLOGICAL CHEMISTRY, 290(52), 31025–31036.

Production and characterization of recombinant perdeuterated cholesterol oxidase

ANALYTICAL BIOCHEMISTRY, 485, 102–108.

Crystallization and preliminary X-ray diffraction analysis of Hypocrea jecorina Cel7A in two new crystal forms

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 70(Pt 6), 773–776.

Neutron structure of the cyclic glucose-bound xylose isomerase E186Q mutant

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 70(Pt 2), 414–420.

ORNL hosts the participants of the 4thNeutrons in Structural Biology Workshop and the IMAGINE single crystal neutron diffractometer first external users

Neutron News, 25(1), 12–12.

Refinement of macromolecular structures against neutron data with SHELXL2013

Gruene, T., Hahn, H. W., Luebben, A. V., Meilleur, F., & Sheldrick, G. M. (2014, January). JOURNAL OF APPLIED CRYSTALLOGRAPHY, Vol. 47, pp. 462–466.

The Neutrons in Structural Biology Workshop celebrates its 5th edition

Neutron News, 25(4), 11–11.

Neutron Scattering Techniques and Applications in Structural Biology

Ankner, J. F., Heller, W. T., Herwig, K. W., Meilleur, F., & Myles, D. A. A. (2013, April). Current Protocols in Protein Science.

New insight into the structure of RNA in red clover necrotic mosaic virus and the role of divalent cations revealed by small-angle neutron scattering

ARCHIVES OF VIROLOGY, 158(8), 1661–1669.

The IMAGINE instrument: first neutron protein structure and new capabilities for neutron macromolecular crystallography.

Biological Crystallography, 69(Pt 10), 2157–2160,

Third School on the Applications of Neutron Scattering Techniques in Structural Biology, Oak Ridge, TN

Neutron News, 24(1), 4–4.

Conformational Changes in Sindbis Virus Induced by Decreased pH Are Revealed by Small-Angle Neutron Scattering

JOURNAL OF VIROLOGY, 86(4), 1982–1987.

Neutron protein crystallography at ultra-low (< 15 K) temperatures

Neutron protein crystallography at ultra-low (< 15 K) temperatures. JOURNAL OF APPLIED CRYSTALLOGRAPHY, 45(4), 686–692.

Open Conformation of Ezrin Bound to Phosphatidylinositol 4,5-Bisphosphate and to F-actin Revealed by Neutron Scattering

JOURNAL OF BIOLOGICAL CHEMISTRY, 287(44), 37119–37133.

Rapid visualization of hydrogen positions in protein neutron crystallographic structures

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 68(Pt 1), 35–41.

Molecular and Serological Diagnosis of Bartonella Infection in 61 Dogs from the United States

Journal of Veterinary Internal Medicine, 25(4), 805–810.

Redox-Promoting Protein Motions in Rubredoxin

JOURNAL OF PHYSICAL CHEMISTRY B, 115(28), 8925–8936.

Scattering functions of Platonic solids

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 44, 545–557.

Crystallization and preliminary X-ray diffraction analysis of red clover necrotic mosaic virus

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 66(Pt 11), 1458–1462.

The Structure of Sindbis Virus Produced from Vertebrate and Invertebrate Hosts as Determined by Small-Angle Neutron Scattering

JOURNAL OF VIROLOGY, 84(10), 5270–5276.

Unambiguous determination of H-atom positions: comparing results from neutron and high-resolution X-ray crystallography

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 66(Pt 5), 558–567.

Deuterium Labeling for Neutron Structure-Function-Dynamics Analysis

Micro and Nano Technologies in Bioanalysis, pp. 281–292.

Erratum to “New sources and instrumentation for neutrons in biology” [Chem. Phys. 345 (2008) 133–151]

Chemical Physics, 351(1-3), 170.

New sources and instrumentation for neutrons in biology

Teixeira, S. C. M., Zaccai, G., Ankner, J., Bellissent-Funel, M. C., Bewley, R., Blakeley, M. P., … Weiss, K. (2008, April 18). CHEMICAL PHYSICS, Vol. 345, pp. 133–151.

New sources and instrumentation for neutrons in biology (vol 345, pg 133, 2008)

Chemical Physics, Vol. 351, pp. 170–170.

Preliminary neutron crystallographic analysis of selectively CH3-protonated deuterated rubredoxin from Pyrococcus furiosus

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 64(Pt 6), 537–540.

Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase.

Proceedings of the National Academy of Sciences of the United States of America, 105(6), 1844–1848,

Expression, purification, assay, and crystal structure of perdeuterated human arginase I

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 465(1), 82–89.

A preliminary neutron diffraction study of rasburicase, a recombinant urate oxidase enzyme, complexed with 8-azaxanthin.

Structural Biology and Crystallization Communications, 62(Pt 3), 306–309,

A quasi-Laue neutron crystallographic study of d-xylose isomerase

European Biophysics Journal, 35(7), 601–609.

Comparison of hydrogen determination with X-ray and neutron crystallography in a human aldose reductase-inhibitor complex.

European Biophysics Journal : EBJ, 35(7), 577–583,

Neutron Laue macromolecular crystallography

European Biophysics Journal, 35(7), 611–620.

High-resolution neutron protein crystallography with radically small crystal volumes: application of perdeuteration to human aldose reductase.

Biological Crystallography, 61(Pt 10), 1413–1417,

Preliminary neutron diffraction studies of Escherichia coli dihydrofolate reductase bound to the anticancer drug methotrexate.

61(Pt 5), 574–579,

Production and X-ray crystallographic analysis of fully deuterated cytochrome P450cam.

Biological Crystallography, 61(Pt 5), 539–544,

Structural Stability and Dynamics of Hydrogenated and Perdeuterated Cytochrome P450cam (CYP101)†

Biochemistry, 43(27), 8744–8753.

Interplay of intrinsic and environmental effects on the magnetic properties of free radicals issuing from H-atom addition to cytosine.

Journal of the American Chemical Society, 123(29), 7113–7117,