Flora Meilleur

Journal of Applied Crystallography welcomes eight new Co-editors

Hajdu, J., McIntyre, G. J., & Meilleur, F. (2025, January 31). Journal of Applied Crystallography, Vol. 58, pp. 1–3.

Contrast Matching Biopolymers: A SANS-Based Approach to Structural Characterization of Chitosan

Kosgallana, C., Leite, W., Yuan, Y., & Meilleur, F. (2025, January 1). SSRN Electronic Journal, Vol. 1.

Identification and characterization of substrate- and product-selective nylon hydrolases

Drufva, E. E., Cahill, J. F., Saint-Vincent, P. M. B., Williams, A. N., Bocharova, V., Capra, N., … Michener, J. K. (2025, June 13). Chem Catalysis, Vol. 5.

Unraveling the molecular mechanism of polysaccharide lyases for efficient alginate degradation

Rivas-Fernández, J. P., Vuillemin, M., Pilgaard, B., Klau, L. J., Fredslund, F., Lund-Hanssen, C., … Wilkens, C. (2025, March 18). Nature Communications, Vol. 16.

Identification and characterization of substrate- and product-selective nylon hydrolases

Drufva, E. E., Cahill, J. F., Saint-Vincent, P. M. B., Williams, A. N., Bocharova, V., Capra, N., … Michener, J. K. (2024, November 14).

Neutrons in Structural Biology: Challenges and Opportunities (Workshop Report)

Science, U. S. D. O. E. O., Kovalevskyi, A., Meilleur, F., Myles, D., & O'Neill, H. (2024, December 1).

Unraveling the Molecular mechanism of Polysaccharide Lyases for Efficient Alginate Degradation

BioRxiv.

Equilibration of precipitants in a counter-diffusion apparatus for protein crystallization

Kober, U. A., Ogbuoji, E. A., Hutchinson, J. A., Mueser, T. C., Schall, C. A., & Meilleur, F. (2023, June 23). Journal of Applied Crystallography, Vol. 56, pp. 1057–1065.

Experimental setup for high-resolution characterization of crystal optics for coherent X-ray beam applications

Halavanau, A., Margraf, R., Robles, R., Macarthur, J., Qu, Z., Marcus, G., … Meilleur, F. (2023, January 9). Journal of Applied Crystallography, Vol. 56, pp. 155–159.

Neutron Scattering in the Biological Sciences: Techniques And Applications

Meilleur, F. (2023, January 20). Journal of Visualized Experiments, Vol. 1.

Structural analysis and functional evaluation of the disordered ß–hexosyltransferase region from Hamamotoa (Sporobolomyces) singularis

Dagher, S. F., Vaishnav, A., Stanley, C. B., Meilleur, F., Edwards, B. F. P., & Bruno-Bárcena, J. M. (2023, December 14). Frontiers in Bioengineering and Biotechnology, Vol. 11.

Capture of activated dioxygen intermediates at the copper-active site of a lytic polysaccharide monooxygenase

Schröder, G. C., O'Dell, W. B., Webb, S. P., Agarwal, P. K., & Meilleur, F. (2022, January 1). Chemical Science, Vol. 11.

Changes in active-site geometry on X-ray photoreduction of a lytic polysaccharide monooxygenase active-site copper and saccharide binding

Tandrup, T., Muderspach, S. J., Banerjee, S., Santoni, G., Ipsen, J., Hernández-Rollán, C., … Moffat, K. (2022, August 16). IUCrJ, Vol. 9, pp. 666–681.

Complementarity of neutron, XFEL and synchrotron crystallography for defining the structures of metalloenzymes at room temperature

Moreno-Chicano, T., Carey, L. M., Axford, D., Beale, J. H., Doak, R. B., Duyvesteyn, H. M. E., … Hough, M. A. (2022, July 25). IUCrJ, Vol. 9, pp. 610–624.

Extending MIEZE spectroscopy towards thermal wavelengths

Jochum, J. K., Franz, C., Keller, T., Pfleiderer, C., & Meilleur, F. (2022, October 27). Journal of Applied Crystallography, Vol. 55, pp. 1424–1431.

Joint X-ray/neutron structure of Lentinus similis AA9_A at room temperature

Tandrup, T., Lo Leggio, L., Meilleur, F., & Romao, M. J. (2022, November 24). Acta Crystallographica Section F Structural Biology Communications, Vol. 79, pp. 1–7.

Mapping H⁺ in the Nanoscale (A₂C₄)₂-Ag₈ Fluorophore

David, F., Setzler, C., Sorescu, A., Lieberman, R. L., Meilleur, F., & Petty, J. T. (2022, December 1). The Journal of Physical Chemistry Letters, Vol. 12, pp. 11317–11322.

Pressure cells for in situ neutron total scattering: time and real-space resolution during deuterium absorption

Ikeda, K., Ohshita, H., Otomo, T., Sakaki, K., Kim, H., Nakamura, Y., … Meilleur, F. (2022, November 11). Journal of Applied Crystallography, Vol. 55, pp. 1631–1639.

Teaching and Education highlighted

Dawe, L. N., García-Ruiz, J. M., Hajdu, J., McIntyre, G. J., Meilleur, F., & Stephenson, L. (2022, April 1). Journal of Applied Crystallography, Vol. 55, pp. 215–217.

The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition

Sacco, M. D., Hu, Y., Gongora, M. V., Meilleur, F., Kemp, M. T., Zhang, X., … Chen, Y. (2022, March 15). Cell Research, Vol. 3, pp. 498–500.

The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition

Sacco, M. D., Hu, Y., Gongora, M. V., Meilleur, F., Kemp, M. T., Zhang, X., … Chen, Y. (2022, January 27). BioRxiv.

The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and X-ray diffraction at room temperature

Correy, G. J., Kneller, D. W., Phillips, G., Pant, S., Russi, S., Cohen, A. E., … Fraser, J. S. (2022, February 9). BioRxiv.

The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature

Correy, G. J., Kneller, D. W., Phillips, G., Pant, S., Russi, S., Cohen, A. E., … Fraser, J. S. (2022, May 27). Science Advances, Vol. 5.

Two-step GISAXS characterization of NiSi₂ nanoplates and Ni nanocrystals embedded in a silicon wafer covered with a silica thin film

Da Silva Costa, D., Kellermann, G., Craievich, A. F., & Meilleur, F. (2022, November 30). Journal of Applied Crystallography, Vol. 56, pp. 95–102.

Capture of activated dioxygen intermediates at the copper-active site of a lytic polysaccharide monooxygenase

Schröder, G. C., O'Dell, W. B., Webb, S. P., Agarwal, P. K., & Meilleur, F. (2021, December 13). ChemRxiv.

Characterization of biomass-degrading enzymes using neutron diffraction and scattering

Meilleur, F. (2021, January 2). Neutron News, Vol. 32, pp. 13–14.

Metalloprotein catalysis: structural and mechanistic insights into oxidoreductases from neutron protein crystallography

Schröder, G. C., & Meilleur, F. (2021, September 27). Acta Crystallographica Section D Structural Biology, Vol. 77, pp. 1251–1269.

Preliminary results of neutron and X-ray diffraction data collection on a lytic polysaccharide monooxygenase under reduced and acidic conditions

Schröder, G. C., O'Dell, W. B., Swartz, P. D., & Meilleur, F. (2021, March 31). Acta Crystallographica Section F Structural Biology Communications, Vol. 77, pp. 128–133.

A beginner’s guide to neutron macromolecular crystallography

Meilleur, F. (2020, November 20). The Biochemist, Vol. 42, pp. 16–20.

Dynamic nuclear polarization enhanced neutron crystallography: Amplifying hydrogen in biological crystals

Pierce, J., Cuneo, M. J., Jennings, A., Li, L., Meilleur, F., Zhao, J., & Myles, D. A. A. (2020, January 1). Methods in Enzymology on CD-ROM/Methods in Enzymology, Vol. 634, pp. 153–175.

HANDS 2019 - A decade of neutron scattering education in structural biology at Oak Ridge National Laboratory

Flora Meilleur. (2020, October 1). Neutron News, Vol. 31, pp. 9–10.

IMAGINE: The neutron protein crystallography beamline at the high flux isotope reactor

Meilleur, F., Kovalevsky, A., & Myles, D. A. A. (2020, January 1). Methods in Enzymology on CD-ROM/Methods in Enzymology, Vol. 634, pp. 69–85.

Neutron Crystallography Data Collection and Processing for Modelling Hydrogen Atoms in Protein Structures

Schröder, G. C., & Meilleur, F. (2020, December 1). Journal of Visualized Experiments, Vol. 12, pp. 1–38.

ORNL hosts first virtual HANDS workshop

Flora Meilleur. (2020, October 1). Neutron News, Vol. 31, pp. 11–12.

A prototype system for dynamically polarized neutron protein crystallography

Pierce, J., Crow, L., Cuneo, M., Edwards, M., Herwig, K. W., Jennings, A., … Zhao, J. K. (2019, June 13). Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment, Vol. 940, pp. 430–434.

Neutron and X-ray analysis of the Fenna–Matthews–Olson photosynthetic antenna complex from Prosthecochloris aestuarii

Lu, X., Selvaraj, B., Ghimire-Rijal, S., Orf, G. S., Meilleur, F., Blankenship, R. E., … Myles, D. A. A. (2019, February 20). Acta Crystallographica Section F Structural Biology Communications, Vol. 75, pp. 171–175.

Titration of ionizable groups in proteins using multiple neutron data sets from a single crystal: application to the small GTPase Ras

Knihtila, R., Volmar, A. Y., Meilleur, F., & Mattos, C. (2019, January 23). Acta Crystallographica Section F Structural Biology Communications, Vol. 75, pp. 111–115.

A suite-level review of the neutron single-crystal diffraction instruments at Oak Ridge National Laboratory

Coates, L., Cao, H. B., Chakoumakos, B. C., Frontzek, M. D., Hoffmann, C., Kovalevsky, A. Y., … Ye, F. (2018, September 1). Review of Scientific Instruments, Vol. 89.

IMAGINE: neutrons reveal enzyme chemistry

Schröder, G. C., O'Dell, W. B., Myles, D. A. A., Kovalevsky, A., & Meilleur, F. (2018, July 17). Acta Crystallographica Section D Structural Biology, Vol. 74, pp. 778–786.

Modulating Enzyme Activity by Altering Protein Dynamics with Solvent

Biochemistry, 57(29), 4263–4275.

Neutron scattering in the biological sciences: progress and prospects

Ashkar, R., Bilheux, H. Z., Bordallo, H., Briber, R., Callaway, D. J. E., Cheng, X., … Smith, J. C. (2018, December 1). Acta Crystallographica Section D Structural Biology, Vol. 74, pp. 1129–1168.

Next-generation diamond cell and applications to single-crystal neutron diffraction

Haberl, B., Dissanayake, S., Wu, Y., Myles, D. A. A., Santos, A. M., Loguillo, M., … Boehler, R. (2018, September 1). Review of Scientific Instruments, Vol. 89.

Structural investigation of cellobiose dehydrogenase IIA: Insights from small angle scattering into intra- and intermolecular electron transfer mechanisms

Bodenheimer, A. M., O'Dell, W. B., Oliver, R. C., Qian, S., Stanley, C. B., & Meilleur, F. (2018, January 31). Biochimica Et Biophysica Acta (BBA) - General Subjects, Vol. 1862, pp. 1031–1039.

The Neutron Macromolecular Crystallography Instruments at Oak Ridge National Laboratory: Advances, Challenges, and Opportunities

Meilleur, F., Coates, L., Cuneo, M. J., Kovalevsky, A., & Myles, D. A. A. (2018, October 11). Crystals, Vol. 8.

An extended N-H bond, driven by a conserved second-order interaction, orients the flavin N5 orbital in cholesterol oxidase

Scientific Reports, 7(1), 40517,

Crystallization of a fungal lytic polysaccharide monooxygenase expressed from glycoengineeredPichia pastorisfor X-ray and neutron diffraction

O'Dell, W. B., Swartz, P. D., Weiss, K. L., & Meilleur, F. (2017, January 19). Acta Crystallographica Section F Structural Biology Communications, Vol. 73, pp. 70–78.

Neutron crystallographic studies of T4 lysozyme at cryogenic temperature

Li, L., Shukla, S., Meilleur, F., Standaert, R. F., Pierce, J., Myles, D. A. A., & Cuneo, M. J. (2017, July 14). Protein Science, Vol. 26, pp. 2098–2104.

Neutron structure of the T26H mutant of T4 phage lysozyme provides insight into the catalytic activity of the mutant enzyme and how it differs from that of wild type

Hiromoto, T., Meilleur, F., Shimizu, R., Shibazaki, C., Adachi, M., Tamada, T., & Kuroki, R. (2017, July 14). Protein Science, Vol. 26, pp. 1953–1963.

Structural studies of Neurospora crassa LPMO9D and redox partner CDHIIA using neutron crystallography and small-angle scattering

Bodenheimer, A. M., O'Dell, W. B., Stanley, C. B., & Meilleur, F. (2017, March 5). Carbohydrate Research, Vol. 3, pp. 200–204.

Crystal structures of wild‐type Trichoderma reesei Cel7A catalytic domain in open and closed states

Bodenheimer, A. M., & Meilleur, F. (2016, October 19). FEBS Letters, Vol. 590, pp. 4429–4438.

Detection of Mycoplasma haemocanis, Mycoplasma haematoparvum, Mycoplasma suis and other vector-borne pathogens in dogs from Córdoba and Santa Fé, Argentina

Parasites & Vectors, 9(1).

Dynamically polarized samples for neutron protein crystallography at the Spallation Neutron Source

Zhao, J., Pierce, J., Myles, D., Robertson, J. L., Herwig, K. W., Standaert, B., … Meilleur, F. (2016, September 1). Journal of Physics Conference Series, Vol. 746.

Innentitelbild: Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase (Angew. Chem. 3/2017)

O'Dell, W. B., Agarwal, P. K., & Meilleur, F. (2016, December 22). Angewandte Chemie.

Inside Cover: Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase (Angew. Chem. Int. Ed. 3/2017)

Angewandte Chemie International Edition, 56(3), 658–658.

Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase

O'Dell, W. B., Agarwal, P. K., & Meilleur, F. (2016, December 22). Angewandte Chemie International Edition, Vol. 56, pp. 767–770.

Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase

O'Dell, W. B., Agarwal, P. K., & Meilleur, F. (2016, December 22). Angewandte Chemie, Vol. 129, pp. 785–788.

Crystal structure and thermal expansion of a CsCe2Cl7 scintillator

Journal of Solid State Chemistry, 227, 142–149.

Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP γ-Phosphate

Knihtila, R., Holzapfel, G., Weiss, K., Meilleur, F., & Mattos, C. (2015, October 29). Journal of Biological Chemistry, Vol. 290, pp. 31025–31036.

Neutron protein crystallography: A complementary tool for locating hydrogens in proteins

O'Dell, W. B., Bodenheimer, A. M., & Meilleur, F. (2015, November 22). Archives of Biochemistry and Biophysics, Vol. 602, pp. 48–60.

Production and characterization of recombinant perdeuterated cholesterol oxidase

Golden, E., Attwood, P. V., Duff, A. P., Meilleur, F., & Vrielink, A. (2015, June 13). Analytical Biochemistry, Vol. 485, pp. 102–108.

Crystallization and preliminary X-ray diffraction analysis ofHypocrea jecorinaCel7A in two new crystal forms

Bodenheimer, A. M., Cuneo, M. J., Swartz, P. D., He, J., O'Neill, H. M., Myles, D. A., … Section, F. (2014, May 9). Acta Crystallographica Section F Structural Biology Communications, Vol. 70, pp. 773–776.

Neutron structure of the cyclic glucose-bound xylose isomerase E186Q mutant

Munshi, P., Snell, E. H., Woerd, Mj, J., Ra, M., Da, R., … D. (2014, January 28). Acta Crystallographica Section D Biological Crystallography, Vol. 70, pp. 414–420.