Flora Meilleur

https://orcid.org/0000-0001-9313-8989

protein crystallography, neutron diffraction, enzymatic mechanism, metallo-enzyme, LPMO, P450

Works (75)

Updated: August 29th, 2023 11:24

2023 journal article

Joint X-ray/neutron structure of Lentinus similis AA9_A at room temperature

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 79, 1–7.

By: T. Tandrup*, L. Lo Leggio* & F. Meilleur n

co-author countries: Denmark 🇩🇰 United States of America 🇺🇸
author keywords: lytic polysaccharide mono-oxygenases; Lentinus similis AA9_A; copper metalloenzymes; protonation states; neutron crystallography
MeSH headings : X-Rays; Copper; Temperature; Crystallography, X-Ray; Polysaccharides / chemistry
Sources: ORCID, Web Of Science
Added: November 25, 2022

2023 article

Neutron Scattering in the Biological Sciences: Techniques And Applications

Meilleur, F. (2023, January). JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, Vol. 1.

By: F. Meilleur n

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: June 12, 2023

2022 article

Capture of activated dioxygen intermediates at the copper-active site of a lytic polysaccharide monooxygenase

Schroder, G. C., William B. O'Dell, Webb, S. P., Agarwal, P. K., & Meilleur, F. (2022, November 2). CHEMICAL SCIENCE, Vol. 11.

co-author countries: United States of America 🇺🇸
Sources: ORCID, Web Of Science
Added: November 3, 2022

2022 journal article

Changes in active-site geometry on X-ray photo-reduction of a lytic polysaccharide monooxygenase active-site copper and saccharide binding

IUCRJ, 9(5), 666–681.

co-author countries: Denmark 🇩🇰 France 🇫🇷 United States of America 🇺🇸
Sources: ORCID, Web Of Science
Added: August 17, 2022

2022 journal article

Complementarity of neutron, XFEL and synchrotron crystallography for defining the structures of metalloenzymes at room temperature

IUCRJ, 9, 610–624.

By: T. Moreno-Chicano*, L. Carey n, D. Axford*, J. Beale*, R. Doak*, H. Duyvesteyn*, A. Ebrahim*, R. Henning* ...

co-author countries: Germany 🇩🇪 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Japan 🇯🇵 United States of America 🇺🇸
author keywords: serial femtosecond crystallography; serial synchrotron crystallography; neutron crystallography; XFELs; room temperature; metalloenzymes
Sources: Web Of Science, ORCID
Added: September 29, 2022

2022 article

Mapping H+ in the Nanoscale (A(2)C(4))(2)-Ag-8 Fluorophore

David, F., Setzler, C., Sorescu, A., Lieberman, R. L., Meilleur, F., & Petty, J. T. (2022, December 1). JOURNAL OF PHYSICAL CHEMISTRY LETTERS, Vol. 12.

By: F. David*, C. Setzler*, A. Sorescu*, R. Lieberman*, F. Meilleur n & J. Petty*

co-author countries: United States of America 🇺🇸
Sources: ORCID, Web Of Science
Added: December 2, 2022

2022 article

Teaching and Education highlighted

Dawe, L. N., Manuel Garcia-Ruiz, J., Hadju, J., McIntyre, G. J., Meilleur, F., & Stephenson, L. (2022, April). JOURNAL OF APPLIED CRYSTALLOGRAPHY, Vol. 55, pp. 215–217.

By: L. Dawe, J. Manuel Garcia-Ruiz, J. Hadju, G. McIntyre, F. Meilleur* & L. Stephenson

author keywords: teaching; education
Sources: ORCID, Web Of Science
Added: April 14, 2022

2022 article

The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition

Sacco, M. D., Hu, Y., Gongora, M. V., Meilleur, F., Kemp, M. T., Zhang, X., … Chen, Y. (2022, March 15). CELL RESEARCH, Vol. 3.

co-author countries: United States of America 🇺🇸
MeSH headings : COVID-19; Catalysis; Humans; Mutation / genetics; Peptide Hydrolases; SARS-CoV-2
Sources: Web Of Science, ORCID
Added: April 4, 2022

2022 journal article

The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature

SCIENCE ADVANCES, 8(21).

By: G. Correy*, D. Kneller, G. Phillips, S. Pant, S. Russi*, A. Cohen*, G. Meigs*, J. Holton* ...

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: June 20, 2022

2021 article

Capture of activated dioxygen intermediates at the copper-active site of a lytic polysaccharide monooxygenase

Schröder, G. C., O'Dell, W. B., Webb, S. P., Agarwal, P. K., & Meilleur, F. (2021, December 13).

co-author countries: Egypt 🇪🇬 United States of America 🇺🇸
Source: ORCID
Added: December 14, 2021

2021 journal article

Metalloprotein catalysis: structural and mechanistic insights into oxidoreductases from neutron protein crystallography

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 77(10), 1251–1269.

By: G. Schroeder & F. Meilleur n

co-author countries: United States of America 🇺🇸
author keywords: neutron protein crystallography; X-ray diffraction; metalloproteins; enzymatic mechanisms; protonation; radiation damage
MeSH headings : Animals; Catalysis; Crystallography, X-Ray / methods; Humans; Metalloproteins / chemistry; Models, Molecular; Neutron Diffraction / methods; Neutrons; Oxidoreductases / chemistry
Sources: ORCID, Web Of Science
Added: September 28, 2021

2021 journal article

Preliminary results of neutron and X-ray diffraction data collection on a lytic polysaccharide monooxygenase under reduced and acidic conditions

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 77(4), 128–133.

By: G. Schroder n, . William B. O'Dell n, P. Swartz n & F. Meilleur n

co-author countries: United States of America 🇺🇸
author keywords: lytic polysaccharide monooxygenases; Neurospora crassa; neutron protein crystallography; reduction; protonation; enzymatic mechanism.
MeSH headings : Data Collection / methods; Hydrogen-Ion Concentration; Mixed Function Oxygenases / analysis; Mixed Function Oxygenases / chemistry; Neurospora crassa / chemistry; Neutron Diffraction / methods; Polysaccharides / analysis; Polysaccharides / chemistry; Protein Structure, Secondary; X-Ray Diffraction / methods
Sources: ORCID, Web Of Science
Added: April 1, 2021

2020 journal article

A beginner’s guide to neutron macromolecular crystallography

The Biochemist, 42(6), 16–20.

By: F. Meilleur n

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: November 24, 2020

2020 article

Dynamic nuclear polarization enhanced neutron crystallography: Amplifying hydrogen in biological crystals

NEUTRON CRYSTALLOGRAPHY IN STRUCTURAL BIOLOGY, Vol. 634, pp. 153–175.

By: J. Pierce*, M. Cuneo*, A. Jennings*, L. Li*, F. Meilleur n, J. Zhao*, D. Myles*

co-author countries: United States of America 🇺🇸
MeSH headings : Crystallography; Hydrogen; Neutron Diffraction; Neutrons; Protons
Sources: Web Of Science, ORCID
Added: August 24, 2020

2020 article

IMAGINE: The neutron protein crystallography beamline at the high flux isotope reactor

NEUTRON CRYSTALLOGRAPHY IN STRUCTURAL BIOLOGY, Vol. 634, pp. 69–85.

By: F. Meilleur n, A. Kovalevsky* & D. Myles*

co-author countries: United States of America 🇺🇸
MeSH headings : Crystallography; Crystallography, X-Ray; Neutron Diffraction; Neutrons; Proteins; Synchrotrons
Sources: Web Of Science, ORCID
Added: August 24, 2020

2020 journal article

Neutron Crystallography Data Collection and Processing for Modelling Hydrogen Atoms in Protein Structures

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 12(166).

By: G. Schroeder & F. Meilleur n

co-author countries: United States of America 🇺🇸
MeSH headings : Amino Acids / chemistry; Buffers; Crystallization; Crystallography, X-Ray; Data Collection; Deuterium / chemistry; Hydrogen / chemistry; Hydrogen-Ion Concentration; Mixed Function Oxygenases / chemistry; Models, Molecular; Neurospora crassa / enzymology; Neutron Diffraction; Particle Size; Polysaccharides / chemistry; Proteins / chemistry; Signal-To-Noise Ratio; User-Computer Interface; Water / chemistry
Sources: Web Of Science, ORCID
Added: June 10, 2021

2019 journal article

A prototype system for dynamically polarized neutron protein crystallography

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 940, 430–434.

By: J. Pierce*, L. Crow*, M. Cuneo*, M. Edwards*, K. Herwig*, A. Jennings*, A. Jones*, L. Li* ...

co-author countries: United States of America 🇺🇸
author keywords: Polarized target; Dynamic nuclear polarization; Protein crystallography; Neutron scattering
Sources: Web Of Science, ORCID
Added: July 29, 2019

2019 journal article

Neutron and X-ray analysis of the Fenna-Matthews-Olson photosynthetic antenna complex from Prosthecochloris aestuarii

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 75(3), 171–175.

By: X. Lu*, B. Selvaraj*, S. Ghimire-Rijal*, G. Orf*, F. Meilleur n, R. Blankenship*, M. Cuneo*, D. Myles*

co-author countries: United States of America 🇺🇸
author keywords: neutron crystallography; photosynthesis; hydrogen; site energy; neutron diffraction; Fenna-Matthews-Olson protein; Prosthecochloris aestuarii
MeSH headings : Chlorobi / chemistry; Chlorobi / physiology; Light-Harvesting Protein Complexes / chemistry; Neutron Diffraction / methods; Photosynthesis; Protein Conformation; X-Ray Diffraction / methods
Sources: Web Of Science, ORCID
Added: March 25, 2019

2019 journal article

Titration of ionizable groups in proteins using multiple neutron data sets from a single crystal: application to the small GTPase Ras

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 75(2), 111–115.

By: R. Knihtila*, A. Volmar*, F. Meilleur n & C. Mattos*

co-author countries: United States of America 🇺🇸
author keywords: in crystallo titration; neutron crystallography; pK(a); protonation; radiation damage
MeSH headings : Crystallization; Humans; Hydrogen-Ion Concentration; Models, Molecular; Monomeric GTP-Binding Proteins / chemistry; Neutron Diffraction / methods; Protein Binding; Protein Conformation
Sources: Web Of Science, ORCID
Added: February 18, 2019

2018 review

A suite-level review of the neutron single-crystal diffraction instruments at Oak Ridge National Laboratory

[Review of ]. REVIEW OF SCIENTIFIC INSTRUMENTS, 89(9).

By: L. Coates*, H. Cao*, B. Chakoumakos*, M. Frontzek*, C. Hoffmann*, A. Kovalevsky*, Y. Liu*, F. Meilleur n ...

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: October 16, 2018

2018 journal article

Modulating Enzyme Activity by Altering Protein Dynamics with Solvent

Biochemistry, 57(29), 4263–4275.

By: M. Duff*, J. Borreguero*, M. Cuneo*, A. Ramanathan*, J. He*, G. Kamath*, S. Chennubhotla*, F. Meilleur n ...

co-author countries: United States of America 🇺🇸
MeSH headings : 2-Propanol / metabolism; Crystallography, X-Ray / methods; Enzyme Activation / drug effects; Escherichia coli / chemistry; Escherichia coli / enzymology; Escherichia coli / metabolism; Kinetics; Molecular Dynamics Simulation; Protein Conformation / drug effects; Solvents / metabolism; Static Electricity; Tetrahydrofolate Dehydrogenase / chemistry; Tetrahydrofolate Dehydrogenase / metabolism; Viscosity; Water / metabolism
Sources: Crossref, ORCID
Added: February 18, 2020

2018 journal article

Neutron scattering in the biological sciences: progress and prospects

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 74, 1129–1168.

co-author countries: China 🇨🇳 France 🇫🇷 United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
author keywords: neutron scattering; biological systems; structure and dynamics
MeSH headings : Animals; Crystallography / methods; Deuterium / analysis; Deuterium Exchange Measurement / methods; Humans; Models, Molecular; Neutron Diffraction / methods; Neutrons; Proteins / chemistry
Sources: Web Of Science, ORCID
Added: January 21, 2019

2018 journal article

Next-generation diamond cell and applications to single-crystal neutron diffraction

REVIEW OF SCIENTIFIC INSTRUMENTS, 89(9).

By: B. Haberl*, S. Dissanayake*, Y. Wu*, D. Myles*, A. Santos*, M. Loguillo*, G. Rucker*, D. Armitage* ...

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: October 16, 2018

2018 journal article

Structural investigation of cellobiose dehydrogenase IIA: Insights from small angle scattering into intra- and intermolecular electron transfer mechanisms

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1862(4), 1031–1039.

By: A. Bodenheimer n, W. ODell n, R. Oliver*, S. Qian*, C. Stanley* & F. Meilleur n

co-author countries: United States of America 🇺🇸
author keywords: Intramolecular electron transfer (IaET); Intermolecular electron transfer (IeET); Redox complex; Oxidative cellulose degradation; Small-angle scattering; Modeling
MeSH headings : Ascomycota / enzymology; Ascomycota / genetics; Calcium / chemistry; Calcium / metabolism; Carbohydrate Dehydrogenases / chemistry; Carbohydrate Dehydrogenases / genetics; Carbohydrate Dehydrogenases / metabolism; Cellulose / chemistry; Cellulose / metabolism; Electron Transport; Fungal Proteins / chemistry; Fungal Proteins / genetics; Fungal Proteins / metabolism; Hydrogen-Ion Concentration; Models, Molecular; Neurospora crassa / enzymology; Neurospora crassa / genetics; Oxidation-Reduction; Protein Binding; Protein Conformation; Scattering, Small Angle; X-Ray Diffraction
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 review

The Neutron Macromolecular Crystallography Instruments at Oak Ridge National Laboratory: Advances, Challenges, and Opportunities

[Review of ]. CRYSTALS, 8(10).

By: F. Meilleur n, L. Coates*, M. Cuneo*, A. Kovalevsky* & D. Myles*

co-author countries: United States of America 🇺🇸
author keywords: neutron; crystallography; macromolecules; Laue diffraction; hydrogen; proton; deuteration
Sources: Web Of Science, ORCID
Added: November 19, 2018

2017 journal article

An extended N-H bond, driven by a conserved second-order interaction, orients the flavin N5 orbital in cholesterol oxidase

Scientific Reports, 7(1), 40517,

co-author countries: Australia 🇦🇺 France 🇫🇷 United States of America 🇺🇸
MeSH headings : Amides / chemistry; Binding Sites; Biocatalysis; Cholesterol Oxidase / metabolism; Conserved Sequence; Crystallography, X-Ray; Flavin-Adenine Dinucleotide / metabolism; Flavins / chemistry; Flavins / metabolism; Hydrogen Bonding; Models, Molecular; Oxidation-Reduction; Substrate Specificity
Sources: ORCID, Crossref
Added: January 6, 2020

2017 journal article

Crystallization of a fungal lytic polysaccharide monooxygenase expressed from glycoengineered Pichia pastoris for X-ray and neutron diffraction

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 73(2), 70–78.

By: . William B. O'Dell n, P. Swartz n, K. Weiss* & F. Meilleur n

co-author countries: United States of America 🇺🇸
author keywords: lytic polysaccharide monooxygenases; Pichia pastoris; glycoengineering; neutron proteincrystallography
MeSH headings : Amino Acid Sequence; Catalytic Domain; Cloning, Molecular; Crystallography; Fungal Polysaccharides / chemistry; Fungal Polysaccharides / metabolism; Fungal Proteins / chemistry; Fungal Proteins / genetics; Fungal Proteins / metabolism; Gene Expression; Genetic Engineering; Mixed Function Oxygenases / chemistry; Mixed Function Oxygenases / genetics; Mixed Function Oxygenases / metabolism; Models, Molecular; Neurospora crassa / chemistry; Neurospora crassa / enzymology; Neutron Diffraction; Pichia / enzymology; Pichia / genetics; Plasmids / chemistry; Plasmids / metabolism; Protein Binding; Protein Conformation, beta-Strand; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Substrate Specificity; X-Ray Diffraction
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Innentitelbild: Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase (Angew. Chem. 3/2017)

Angewandte Chemie.

By: W. O'Dell n, P. Agarwal* & F. Meilleur n

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: January 6, 2020

2017 journal article

Neutron crystallographic studies of T4 lysozyme at cryogenic temperature

PROTEIN SCIENCE, 26(10), 2098–2104.

By: L. Li*, S. Shukla*, F. Meilleur n, R. Standaert*, J. Pierce*, D. Myles*, M. Cuneo*

co-author countries: United States of America 🇺🇸
author keywords: T4-lysozyme; neutron; structure; X-ray; hydrogen
MeSH headings : Cold Temperature; Hydrogen / chemistry; Models, Molecular; Muramidase / chemistry; Neutron Diffraction; Protein Conformation; Water / chemistry
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Neutron structure of the T26H mutant of T4 phage lysozyme provides insight into the catalytic activity of the mutant enzyme and how it differs from that of wild type

PROTEIN SCIENCE, 26(10), 1953–1963.

By: T. Hiromoto*, F. Meilleur n, R. Shimizu*, C. Shibazaki*, M. Adachi*, T. Tamada*, R. Kuroki*

co-author countries: Japan 🇯🇵 United States of America 🇺🇸
author keywords: lysozyme; hydrolysis; perdeuteration; neutron crystallography
MeSH headings : Bacteriophage T4 / enzymology; Bacteriophage T4 / genetics; Binding Sites / genetics; Crystallography, X-Ray; Hydrolysis; Models, Molecular; Muramidase / chemistry; Muramidase / genetics; Muramidase / metabolism; Muramidase / ultrastructure; Mutation / genetics; Neutrons; Protein Conformation
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56(3), 767–770.

By: . William B. O'Dell n, P. Agarwal* & F. Meilleur n

co-author countries: United States of America 🇺🇸
author keywords: copper; oxidoreductases; oxygen activation; polysaccharide monooxygenases; protein structures
MeSH headings : Catalytic Domain; Mixed Function Oxygenases / chemistry; Mixed Function Oxygenases / metabolism; Models, Molecular; Neurospora crassa / enzymology; Oxygen / chemistry; Oxygen / metabolism; Polysaccharides / chemistry; Polysaccharides / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase

Angewandte Chemie, 129(3), 785–788.

By: W. O'Dell n, P. Agarwal* & F. Meilleur n

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: January 6, 2020

2017 journal article

Structural studies of Neurospora crassa LPMO9D and redox partner CDHIIA using neutron crystallography and small-angle scattering

CARBOHYDRATE RESEARCH, 448, 200–204.

co-author countries: United States of America 🇺🇸
author keywords: Polysaccharide monooxygenases; Cellobiose dehydrogenases; Neutron diffraction; Neutron scattering; X-ray induced photoreduction
MeSH headings : Carbohydrate Dehydrogenases / chemistry; Carbohydrate Dehydrogenases / metabolism; Catalytic Domain; Crystallography, X-Ray; Mixed Function Oxygenases / chemistry; Mixed Function Oxygenases / metabolism; Models, Molecular; Neurospora crassa / enzymology; Oxidation-Reduction; Scattering, Small Angle
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Crystal structures of wild-type Trichoderma reesei Cel7A catalytic domain in open and closed states

FEBS LETTERS, 590(23), 4429–4438.

By: A. Bodenheimer n & F. Meilleur n

co-author countries: United States of America 🇺🇸
author keywords: Cel7A; cellulase; closed state; processivity; product-binding site; Trichoderma reesei
MeSH headings : Binding Sites; Catalytic Domain; Crystallography, X-Ray; Glycoside Hydrolases / chemistry; Glycoside Hydrolases / genetics; Glycoside Hydrolases / metabolism; Molecular Dynamics Simulation; Mutation; Trichoderma / enzymology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Detection of Mycoplasma haemocanis, Mycoplasma haematoparvum, Mycoplasma suis and other vector-borne pathogens in dogs from Córdoba and Santa Fé, Argentina

Parasites & Vectors, 9(1).

By: P. Mascarelli n, G. Tartara*, N. Pereyra* & R. Maggi n

co-author countries: Argentina 🇦🇷 United States of America 🇺🇸
author keywords: Dogs; Babesia vogeli; Anaplasma phagocytophilum; Anaplasma platys; Ehrlichia canis; Mycoplasma haemocanis; Mycoplasma haematoparvum; Mycoplasma suis; Bartonella spp.; Argentina
MeSH headings : Animals; Argentina / epidemiology; Dog Diseases / epidemiology; Dog Diseases / microbiology; Dogs; Female; Male; Mycoplasma / classification; Mycoplasma / genetics; Mycoplasma / isolation & purification; Mycoplasma / physiology; Mycoplasma Infections / epidemiology; Mycoplasma Infections / microbiology; Mycoplasma Infections / veterinary; Tick-Borne Diseases / epidemiology; Tick-Borne Diseases / microbiology; Tick-Borne Diseases / veterinary
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2016 journal article

Inside Cover: Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase (Angew. Chem. Int. Ed. 3/2017)

Angewandte Chemie International Edition, 56(3), 658–658.

By: W. O'Dell n, P. Agarwal* & F. Meilleur n

co-author countries: United States of America 🇺🇸
Sources: ORCID, Crossref
Added: January 6, 2020

2016 journal article

Neutron protein crystallography: A complementary tool for locating hydrogens in proteins

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 602, 48–60.

By: . William B. O'Dell n, A. Bodenheimer n & F. Meilleur n

co-author countries: United States of America 🇺🇸
author keywords: Neutron; Crystallography; Hydrogen; Enzyme; Protonation; Water
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Crystal structure and thermal expansion of a CsCe2Cl7 scintillator

Journal of Solid State Chemistry, 227, 142–149.

By: M. Zhuravleva*, A. Lindsey*, B. Chakoumakos*, R. Custelcean*, F. Meilleur*, R. Hughes*, W. Kriven*, C. Melcher*

co-author countries: United States of America 🇺🇸
author keywords: X-ray diffraction; Crystal structure; Thermal expansion; Scintillator; Crystal growth
Sources: Crossref, ORCID
Added: September 4, 2020

2015 journal article

Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP gamma-Phosphate

JOURNAL OF BIOLOGICAL CHEMISTRY, 290(52), 31025–31036.

By: R. Knihtila*, G. Holzapfel n, K. Weiss*, F. Meilleur n & C. Mattos n

co-author countries: United States of America 🇺🇸
MeSH headings : Catalysis; Guanosine Triphosphate / analogs & derivatives; Guanosine Triphosphate / chemistry; Guanosine Triphosphate / genetics; Guanosine Triphosphate / metabolism; Humans; Hydrolysis; Neutrons; Protein Structure, Tertiary; Proto-Oncogene Proteins p21(ras) / chemistry; Proto-Oncogene Proteins p21(ras) / genetics; Proto-Oncogene Proteins p21(ras) / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Production and characterization of recombinant perdeuterated cholesterol oxidase

ANALYTICAL BIOCHEMISTRY, 485, 102–108.

By: E. Golden*, P. Attwood*, A. Duff*, F. Meilleur n & A. Vrielink*

co-author countries: Australia 🇦🇺 United States of America 🇺🇸
author keywords: Flavoenzyme; Perdeuteration; Thermal stability; Protein expression; Enzyme kinetics; Protein structure
MeSH headings : Cholesterol Oxidase / biosynthesis; Cholesterol Oxidase / chemistry; Cholesterol Oxidase / genetics; Crystallography, X-Ray; Deuterium / chemistry; Escherichia coli / chemistry; Escherichia coli / enzymology; Escherichia coli / genetics; Isotope Labeling / methods; Recombinant Proteins / biosynthesis; Recombinant Proteins / chemistry; Recombinant Proteins / genetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Crystallization and preliminary X-ray diffraction analysis of Hypocrea jecorina Cel7A in two new crystal forms

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 70(Pt 6), 773–776.

By: A. Bodenheimer n, M. Cuneo*, P. Swartz n, J. He*, H. O'Neill*, D. Myles*, B. Evans*, F. Meilleur n, F. Section

co-author countries: United States of America 🇺🇸
MeSH headings : Cellulose 1,4-beta-Cellobiosidase / chemistry; Crystallization; Crystallography, X-Ray; Electrophoresis, Polyacrylamide Gel; Hypocrea / chemistry
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Neutron structure of the cyclic glucose-bound xylose isomerase E186Q mutant

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 70(Pt 2), 414–420.

By: P. Munshi*, E. Snell*, Woerd, J. Mj, M. Ra n, R. Da, M. Z, A. F, D.

co-author countries: United States of America 🇺🇸
MeSH headings : Aldose-Ketose Isomerases / chemistry; Aldose-Ketose Isomerases / genetics; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Catalytic Domain; Glucose / analogs & derivatives; Glucose / chemistry; Hydrogen Bonding; Models, Molecular; Mutation; Neutron Diffraction; Protein Binding; Protein Conformation; Protons; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Scattering, Small Angle; Streptomyces / chemistry; Streptomyces / enzymology; X-Ray Diffraction
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

ORNL hosts the participants of the 4thNeutrons in Structural Biology Workshop and the IMAGINE single crystal neutron diffractometer first external users

Neutron News, 25(1), 12–12.

By: F. Meilleur n

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: January 6, 2020

2014 article

Refinement of macromolecular structures against neutron data with SHELXL2013

Gruene, T., Hahn, H. W., Luebben, A. V., Meilleur, F., & Sheldrick, G. M. (2014, January). JOURNAL OF APPLIED CRYSTALLOGRAPHY, Vol. 47, pp. 462–466.

By: T. Gruene*, H. Hahn*, A. Luebben*, F. Meilleur n & G. Sheldrick*

co-author countries: Germany 🇩🇪 United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

The Neutrons in Structural Biology Workshop celebrates its 5th edition

Neutron News, 25(4), 11–11.

By: F. Meilleur n

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: January 6, 2020

2013 article

Neutron Scattering Techniques and Applications in Structural Biology

Ankner, J. F., Heller, W. T., Herwig, K. W., Meilleur, F., & Myles, D. A. A. (2013, April). Current Protocols in Protein Science.

By: J. Ankner*, W. Heller*, K. Herwig*, F. Meilleur n & D. Myles*

co-author countries: United States of America 🇺🇸
MeSH headings : Cell Membrane / chemistry; Deuterium; Models, Molecular; Molecular Biology / methods; Neutron Diffraction / methods; Neutrons; Proteins / chemistry
Source: ORCID
Added: January 6, 2020

2013 journal article

New insight into the structure of RNA in red clover necrotic mosaic virus and the role of divalent cations revealed by small-angle neutron scattering

ARCHIVES OF VIROLOGY, 158(8), 1661–1669.

By: S. Martin n, L. He*, F. Meilleur n, R. Guenther n, T. Sit n, S. Lommel n, W. Heller*

co-author countries: United States of America 🇺🇸

Contributors: S. Martin n, L. He*, F. Meilleur n, R. Guenther n, T. Sit n, S. Lommel n, W. Heller*

Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

The IMAGINE instrument: first neutron protein structure and new capabilities for neutron macromolecular crystallography.

Biological Crystallography, 69(Pt 10), 2157–2160,

By: F. Meilleur n, P. Munshi*, L. Robertson*, A. Stoica*, L. Crow*, A. Kovalevsky*, T. Koritsanszky*, B. Chakoumakos* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Archaeal Proteins / chemistry; Crystallography, X-Ray / instrumentation; Crystallography, X-Ray / methods; Hydrogen Bonding; Macromolecular Substances / chemistry; Neutrons; Pyrococcus furiosus / chemistry; Rubredoxins / chemistry; Scattering, Radiation; X-Ray Diffraction
Source: ORCID
Added: January 6, 2020

2013 journal article

Third School on the Applications of Neutron Scattering Techniques in Structural Biology, Oak Ridge, TN

Neutron News, 24(1), 4–4.

By: F. Meilleur n

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: January 6, 2020

2012 journal article

Conformational Changes in Sindbis Virus Induced by Decreased pH Are Revealed by Small-Angle Neutron Scattering

JOURNAL OF VIROLOGY, 86(4), 1982–1987.

By: L. He*, A. Piper n, F. Meilleur n, R. Hernandez n, W. Heller* & D. Brown n

co-author countries: United States of America 🇺🇸
MeSH headings : Hydrogen-Ion Concentration; RNA, Viral / chemistry; RNA, Viral / genetics; RNA, Viral / metabolism; Scattering, Small Angle; Sindbis Virus / chemistry; Sindbis Virus / genetics; Sindbis Virus / metabolism; Viral Proteins / chemistry; Viral Proteins / genetics; Virion / chemistry; Virion / genetics; Virion / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Neutron protein crystallography at ultra-low (< 15 K) temperatures

Neutron protein crystallography at ultra-low (< 15 K) temperatures. JOURNAL OF APPLIED CRYSTALLOGRAPHY, 45(4), 686–692.

By: D. Myles*, F. Dauvergne*, M. Blakeley* & F. Meilleur n

co-author countries: France 🇫🇷 United States of America 🇺🇸
author keywords: neutron protein crystallography; flash cooling; cryocrystallography
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Open Conformation of Ezrin Bound to Phosphatidylinositol 4,5-Bisphosphate and to F-actin Revealed by Neutron Scattering

JOURNAL OF BIOLOGICAL CHEMISTRY, 287(44), 37119–37133.

By: J. Jayasundar*, J. Ju*, L. He*, D. Liu*, F. Meilleur n, J. Zhao*, D. Callaway*, Z. Bu*

co-author countries: United States of America 🇺🇸
MeSH headings : Actins / chemistry; Amino Acid Substitution; Cytoskeletal Proteins / chemistry; Cytoskeletal Proteins / genetics; Humans; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Neutron Diffraction; Phosphatidylinositol 4,5-Diphosphate / chemistry; Phosphoproteins / chemistry; Phosphoproteins / genetics; Protein Binding; Protein Structure, Quaternary; Protein Structure, Tertiary; Scattering, Small Angle; Sodium-Hydrogen Exchangers / chemistry; Surface Plasmon Resonance; X-Ray Diffraction
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Rapid visualization of hydrogen positions in protein neutron crystallographic structures

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 68(Pt 1), 35–41.

By: P. Munshi*, S. Chung*, M. Blakeley*, K. Weiss*, D. Myles*, F. Meilleur n, D. Section

co-author countries: France 🇫🇷 United States of America 🇺🇸
MeSH headings : Hydrogen / analysis; Hydrogen / chemistry; Models, Molecular; Neutron Diffraction / methods; Protein Structure, Tertiary; Proteins / chemistry; Time Factors
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Molecular and Serological Diagnosis of Bartonella Infection in 61 Dogs from the United States

Journal of Veterinary Internal Medicine, 25(4), 805–810.

By: C. Pérez n, R. Maggi n, P. Diniz n & E. Breitschwerdt n

co-author countries: United States of America 🇺🇸
author keywords: Bacteria; BAPGM; Bartonella; Blood culture
MeSH headings : Animals; Antibodies, Bacterial / blood; Bartonella / genetics; Bartonella / isolation & purification; Bartonella Infections / blood; Bartonella Infections / diagnosis; Bartonella Infections / microbiology; Bartonella Infections / veterinary; Culture Media; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; Dog Diseases / blood; Dog Diseases / diagnosis; Dog Diseases / microbiology; Dogs; Fluorescent Antibody Technique, Indirect / veterinary; Logistic Models; Multivariate Analysis; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; Retrospective Studies
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2011 journal article

Redox-Promoting Protein Motions in Rubredoxin

JOURNAL OF PHYSICAL CHEMISTRY B, 115(28), 8925–8936.

By: J. Borreguero*, J. He*, F. Meilleur n, K. Weiss*, C. Brown*, D. Myles*, K. Herwig*, P. Agarwal*

co-author countries: United States of America 🇺🇸
MeSH headings : Computer Simulation; Models, Molecular; Molecular Dynamics Simulation; Oxidation-Reduction; Rubredoxins / chemistry; Static Electricity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Scattering functions of Platonic solids

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 44, 545–557.

By: X. Li*, C. Shew*, L. He*, F. Meilleur n, D. Myles*, E. Liu*, Y. Zhang*, G. Smith* ...

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Crystallization and preliminary X-ray diffraction analysis of red clover necrotic mosaic virus

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 66(Pt 11), 1458–1462.

By: S. Martin n, R. Guenther n, T. Sit n, P. Swartz n, F. Meilleur n, S. Lommel n, R. Rose n, F. Section

co-author countries: United States of America 🇺🇸

Contributors: S. Martin n, R. Guenther n, T. Sit n, P. Swartz n, F. Meilleur n, S. Lommel n, R. Rose n

author keywords: red clover necrotic mosaic virus; dianthoviruses; viruses
MeSH headings : Crystallization; Crystallography, X-Ray; Microscopy, Electron, Transmission; Tombusviridae / chemistry; Tombusviridae / ultrastructure; Virion / chemistry; Virion / ultrastructure
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

The Structure of Sindbis Virus Produced from Vertebrate and Invertebrate Hosts as Determined by Small-Angle Neutron Scattering

JOURNAL OF VIROLOGY, 84(10), 5270–5276.

By: L. He*, A. Piper n, F. Meilleur n, D. Myles*, R. Hernandez n, D. Brown n, W. Heller*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Cell Line; Cricetinae; Culicidae; Scattering, Small Angle; Sindbis Virus / chemistry; Sindbis Virus / growth & development; Virion / chemistry; Virion / isolation & purification
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Unambiguous determination of H-atom positions: comparing results from neutron and high-resolution X-ray crystallography

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 66(Pt 5), 558–567.

By: A. Gardberg*, D. Castillo*, W. Ar, M. Kl, B. F n, M. Mp, A. Da, D.

co-author countries: France 🇫🇷 United States of America 🇺🇸
MeSH headings : Bacterial Proteins / chemistry; Crystallography, X-Ray / methods; Neutron Diffraction / methods; Pyrococcus furiosus / chemistry; Rubredoxins / chemistry; X-Ray Diffraction / methods
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 article

Deuterium Labeling for Neutron Structure-Function-Dynamics Analysis

Micro and Nano Technologies in Bioanalysis, pp. 281–292.

By: F. Meilleur n, K. Weiss* & D. Myles*

co-author countries: United States of America 🇺🇸
author keywords: Protein; Membrane; Nucleic acid; Deuterium labeling; Cell culture; Over-expression; Deuterium exchange; Crystallography; Reflectometry; Small angle scattering; Contrast variation
MeSH headings : Bacteria / metabolism; Binding Sites; Bioreactors; Crystallography; Deuterium / chemistry; Neutron Diffraction / methods; Proteins / chemistry; Recombinant Proteins / biosynthesis; Recombinant Proteins / chemistry
Source: ORCID
Added: January 6, 2020

2008 journal article

Erratum to “New sources and instrumentation for neutrons in biology” [Chem. Phys. 345 (2008) 133–151]

Chemical Physics, 351(1-3), 170.

By: S. Teixeira*, G. Zaccai*, J. Ankner*, M. Bellissent-Funel*, R. Bewley*, M. Blakeley*, P. Callow*, L. Coates* ...

co-author countries: Germany 🇩🇪 France 🇫🇷 United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
Sources: Crossref, ORCID
Added: September 9, 2020

2008 article

New sources and instrumentation for neutrons in biology

Teixeira, S. C. M., Zaccai, G., Ankner, J., Bellissent-Funel, M. C., Bewley, R., Blakeley, M. P., … Weiss, K. (2008, April 18). CHEMICAL PHYSICS, Vol. 345, pp. 133–151.

By: S. Teixeira*, G. Zaccai*, J. Ankner*, M. Bellissent-Funel*, R. Bewley*, M. Blakeley*, P. Callow*, L. Coates* ...

co-author countries: Germany 🇩🇪 France 🇫🇷 United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
author keywords: neutron scattering; neutron crystallography; small angle neutron scattering; reflectometry; inelastic neutron scattering; quasi-elastic neutron scattering; proteins; membranes; macromolecular structure and dynamics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 article

New sources and instrumentation for neutrons in biology (vol 345, pg 133, 2008)

Chemical Physics, Vol. 351, pp. 170–170.

By: S. Teixeira, G. Zaccai, J. Ankner, M. Bellissent-Funel, R. Bewley, M. Blakeley, P. Callow, L. Coates ...

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Preliminary neutron crystallographic analysis of selectively CH3-protonated deuterated rubredoxin from Pyrococcus furiosus

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 64(Pt 6), 537–540.

By: K. Weiss*, F. Meilleur n, M. Blakeley*, D. Myles* & F. Section

co-author countries: France 🇫🇷 United States of America 🇺🇸
MeSH headings : Amino Acid Sequence; Cysteine / chemistry; Deuterium Exchange Measurement; Escherichia coli / genetics; Hydrogen Bonding; Iron / chemistry; Molecular Sequence Data; Neutron Diffraction; Protons; Pyrococcus furiosus / chemistry; Pyrococcus furiosus / genetics; Pyrococcus furiosus / isolation & purification; Rubredoxins / chemistry; Rubredoxins / isolation & purification; Sulfur / chemistry
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase.

Proceedings of the National Academy of Sciences of the United States of America, 105(6), 1844–1848,

By: M. Blakeley*, F. Ruiz*, R. Cachau*, I. Hazemann*, F. Meilleur*, A. Mitschler*, S. Ginell*, P. Afonine* ...

co-author countries: France 🇫🇷 United States of America 🇺🇸 Uruguay 🇺🇾
author keywords: enzymatic mechanism; helium cooling; subatomic resolution crystallography; x-ray plus neutrons joint refinement
MeSH headings : Aldehyde Reductase / chemistry; Aldehyde Reductase / metabolism; Catalysis; Models, Molecular; Neutrons; Protons; Quantum Theory; X-Ray Diffraction / methods
Source: ORCID
Added: January 6, 2020

2007 journal article

Expression, purification, assay, and crystal structure of perdeuterated human arginase I

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 465(1), 82–89.

By: L. Di Costanzo*, M. Moulin*, M. Haertlein*, F. Meilleur n & D. Christianson*

co-author countries: France 🇫🇷 United States of America 🇺🇸
MeSH headings : Arginase / chemistry; Arginase / ultrastructure; Computer Simulation; Deuterium / chemistry; Escherichia coli / genetics; Escherichia coli / metabolism; Humans; Models, Chemical; Models, Molecular; Protein Conformation; Protein Engineering; Recombinant Proteins / chemistry; Recombinant Proteins / isolation & purification; Substrate Specificity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2006 journal article

A preliminary neutron diffraction study of rasburicase, a recombinant urate oxidase enzyme, complexed with 8-azaxanthin.

Structural Biology and Crystallization Communications, 62(Pt 3), 306–309,

By: M. Budayova-Spano*, F. Bonneté, N. Ferté, M. El Hajji*, F. Meilleur*, M. Blakeley*, B. Castro*, F. Section

co-author countries: France 🇫🇷
MeSH headings : Binding Sites; Crystallization / methods; Deuterium Oxide; Neutron Diffraction / methods; Recombinant Proteins / chemistry; Saccharomyces cerevisiae / metabolism; Urate Oxidase / chemistry; Xanthines / chemistry
Source: ORCID
Added: January 6, 2020

2006 journal article

A quasi-Laue neutron crystallographic study of d-xylose isomerase

European Biophysics Journal, 35(7), 601–609.

By: F. Meilleur*, E. Snell*, M. Woerd*, R. Judge* & D. Myles*

co-author countries: France 🇫🇷 United States of America 🇺🇸
MeSH headings : Aldose-Ketose Isomerases / chemistry; Aldose-Ketose Isomerases / metabolism; Binding Sites; Catalysis; Crystallography, X-Ray; Hydrogen / chemistry; Models, Chemical; Neutron Diffraction; Neutrons; Protein Binding; Streptomyces / enzymology; Xylose / metabolism
Source: ORCID
Added: January 6, 2020

2006 journal article

Comparison of hydrogen determination with X-ray and neutron crystallography in a human aldose reductase-inhibitor complex.

European Biophysics Journal : EBJ, 35(7), 577–583,

By: M. Blakeley*, A. Mitschler*, I. Hazemann*, F. Meilleur*, D. Myles* & A. Podjarny*

co-author countries: France 🇫🇷 United States of America 🇺🇸
MeSH headings : Aldehyde Reductase / antagonists & inhibitors; Aldehyde Reductase / chemistry; Aldehyde Reductase / metabolism; Binding Sites; Crystallization; Crystallography, X-Ray; Deuterium / chemistry; Humans; Hydrogen / chemistry; Hydrogen Bonding; Models, Molecular; Molecular Structure; NADP / metabolism; Neutron Diffraction; Protein Conformation; Protons
Source: ORCID
Added: January 6, 2020

2006 journal article

Neutron Laue macromolecular crystallography

European Biophysics Journal, 35(7), 611–620.

By: F. Meilleur*, D. Myles* & M. Blakeley*

co-author countries: France 🇫🇷 United States of America 🇺🇸
MeSH headings : Crystallography / trends; Deuterium / chemistry; Forecasting; Hydrogen Bonding; Macromolecular Substances / chemistry; Models, Molecular; Neutron Diffraction; Neutrons
Source: ORCID
Added: January 6, 2020

2005 journal article

High-resolution neutron protein crystallography with radically small crystal volumes: application of perdeuteration to human aldose reductase.

Biological Crystallography, 61(Pt 10), 1413–1417,

By: I. Hazemann, M. Dauvergne, M. Blakeley, F. Meilleur*, M. Haertlein, A. Van Dorsselaer, A. Mitschler, D. Myles, A. Podjarny, D. Section

MeSH headings : Aldehyde Reductase / chemistry; Binding Sites; Crystallization; Crystallography; Crystallography, X-Ray / methods; Humans; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Molecular Structure; Neutron Diffraction; Neutrons; Protein Conformation; Protons; Spectrometry, Mass, Electrospray Ionization
Source: ORCID
Added: January 6, 2020

2005 journal article

Preliminary neutron diffraction studies of Escherichia coli dihydrofolate reductase bound to the anticancer drug methotrexate.

61(Pt 5), 574–579,

By: B. Bennett*, F. Meilleur*, D. Myles*, E. Howell*, C. Dealwis*, D. Section, B. crystallography

co-author countries: France 🇫🇷 United States of America 🇺🇸
MeSH headings : Antimetabolites, Antineoplastic / chemistry; Antimetabolites, Antineoplastic / metabolism; Crystallization; Deuterium Oxide / chemistry; Escherichia coli / enzymology; Folic Acid Antagonists / chemistry; Folic Acid Antagonists / metabolism; Hydrogen / chemistry; Methotrexate / chemistry; Methotrexate / metabolism; Neutron Diffraction; Plasmids / genetics; Protein Binding; Tetrahydrofolate Dehydrogenase / chemistry; Tetrahydrofolate Dehydrogenase / metabolism
Source: ORCID
Added: January 6, 2020

2005 journal article

Production and X-ray crystallographic analysis of fully deuterated cytochrome P450cam.

Biological Crystallography, 61(Pt 5), 539–544,

By: F. Meilleur*, M. Dauvergne*, I. Schlichting*, D. Myles* & D. Section

co-author countries: Germany 🇩🇪 France 🇫🇷 United States of America 🇺🇸
MeSH headings : Camphor 5-Monooxygenase / biosynthesis; Camphor 5-Monooxygenase / chemistry; Camphor 5-Monooxygenase / genetics; Crystallization; Crystallography, X-Ray; Deuterium; Escherichia coli / chemistry; Hydrogen / chemistry; Isotope Labeling; Models, Molecular; Neutrons; Protein Conformation; Pseudomonas putida / enzymology; Water / chemistry
Source: ORCID
Added: January 6, 2020

2004 journal article

Structural Stability and Dynamics of Hydrogenated and Perdeuterated Cytochrome P450cam (CYP101)†

Biochemistry, 43(27), 8744–8753.

By: F. Meilleur*, J. Contzen*, D. Myles* & C. Jung*

co-author countries: Germany 🇩🇪
MeSH headings : Binding Sites; Camphor 5-Monooxygenase / chemistry; Camphor 5-Monooxygenase / genetics; Camphor 5-Monooxygenase / metabolism; Carbon Monoxide / metabolism; Deuterium / chemistry; Enzyme Stability; Hydrogen / chemistry; Kinetics; Phase Transition; Photolysis; Point Mutation / genetics; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Pseudomonas putida / enzymology; Pseudomonas putida / genetics; Spectroscopy, Fourier Transform Infrared; Temperature
Source: ORCID
Added: January 6, 2020

2001 journal article

Interplay of intrinsic and environmental effects on the magnetic properties of free radicals issuing from H-atom addition to cytosine.

Journal of the American Chemical Society, 123(29), 7113–7117,

By: C. Adamo*, M. Heitzmann*, F. Meilleur*, N. Rega*, G. Scalmani*, A. Grand*, J. Cadet*, V. Barone*

co-author countries: France 🇫🇷
MeSH headings : Cytosine / chemistry; Free Radicals / chemistry; Hydrogen Bonding; Magnetics; Models, Molecular; Protons; Quantum Theory; Water / chemistry
Source: ORCID
Added: January 6, 2020

Employment

Updated: November 6th, 2017 13:41

2015 - present

North Carolina State University Raleigh, NC, US
Associate Professor Molecular and Structural Biochemistry

2007 - present

Oak Ridge National Laboratory Oak Ridge, TN, US
Instrument Scientist - Macromolecular Crystallography Neutron Sciences Directorate

2007 - 2015

North Carolina State University Raleigh, NC, US
Assistant Professor Molecular and Structural Biochemistry

2004 - 2006

Institut Laue-Langevin Grenoble, Rhône-Alpes, FR

Education

Updated: September 24th, 2018 14:14

2000 - 2004

Université Grenoble Alpes Saint-Martin-d'Heres, Rhône-Alpes, FR
Ph. D.

2000 - 2004

European Molecular Biology Laboratory Grenoble, FR
Ph. D.

Funding History

Funding history based on the linked ORCID record. Updated: March 15th, 2017 14:23

grant September 1, 2011 - August 31, 2017
IGERT: Neutron Scattering for the Science and Engineering of the 21st Century
National Science Foundation - Directorate for Education and Human Resources
grant August 1, 2009 - July 31, 2013
MRI: Acquisition of a Neutron Single Crystal Diffractometer
National Science Foundation - Directorate for Mathematical & Physical Sciences